Gene description for OCRL
Gene name oculocerebrorenal syndrome of Lowe
Gene symbol OCRL
Other names/aliases INPP5F
LOCR
NPHL2
OCRL-1
OCRL1
Species Homo sapiens
 Database cross references - OCRL
ExoCarta ExoCarta_4952
Vesiclepedia VP_4952
Entrez Gene 4952
HGNC 8108
MIM 300535
UniProt Q01968  
 OCRL identified in exosomes derived from the following tissue/cell type
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Mesenchymal stem cells 36408942    
Thymus 23844026    
 Gene ontology annotations for OCRL
Molecular Function
    phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity GO:0004439 IBA
    phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity GO:0004439 TAS
    GTPase activator activity GO:0005096 IDA
    protein binding GO:0005515 IPI
    small GTPase binding GO:0031267 IPI
    phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase activity GO:0034485 IEA
    phosphatidylinositol phosphate 4-phosphatase activity GO:0034596 TAS
    phosphatidylinositol-3,5-bisphosphate 5-phosphatase activity GO:0043813 TAS
    inositol-1,4,5-trisphosphate 5-phosphatase activity GO:0052658 TAS
    inositol-1,3,4,5-tetrakisphosphate 5-phosphatase activity GO:0052659 IEA
    inositol phosphate phosphatase activity GO:0052745 IDA
    inositol phosphate phosphatase activity GO:0052745 NAS
Biological Process
    in utero embryonic development GO:0001701 IEA
    lipid metabolic process GO:0006629 NAS
    phosphatidylinositol biosynthetic process GO:0006661 TAS
    signal transduction GO:0007165 IEA
    phosphatidylinositol-3-phosphate biosynthetic process GO:0036092 IEA
    inositol phosphate metabolic process GO:0043647 TAS
    phosphatidylinositol dephosphorylation GO:0046856 IEA
    cilium assembly GO:0060271 IMP
    membrane organization GO:0061024 TAS
Subcellular Localization
    photoreceptor outer segment GO:0001750 IDA
    nucleus GO:0005634 IDA
    cytoplasm GO:0005737 IBA
    cytoplasm GO:0005737 IDA
    lysosome GO:0005764 IEA
    early endosome GO:0005769 IDA
    Golgi stack GO:0005795 TAS
    Golgi-associated vesicle GO:0005798 TAS
    trans-Golgi network GO:0005802 IDA
    cytosol GO:0005829 TAS
    plasma membrane GO:0005886 IDA
    clathrin-coated pit GO:0005905 IEA
    membrane GO:0016020 IBA
    clathrin-coated vesicle GO:0030136 IDA
    phagocytic vesicle membrane GO:0030670 IEA
    early endosome membrane GO:0031901 IEA
    neuron projection GO:0043005 IBA
 Experiment description of studies that identified OCRL in exosomes
1
Experiment ID 489
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 6
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
2
Experiment ID 490
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 7
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
3
Experiment ID 491
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 8
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
4
Experiment ID 492
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 9
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
5
Experiment ID 488
MISEV standards
✔
EM
Biophysical techniques
✔
CD9|CD81|CD63|GAPDH|SDCBP|LAMP1|TFRC|UCHL1|FLOT2|LAMP2|FLOT1|ICAM1|RAB5B|CD151|RAB35|TSG101|RAB5A|CD82
Enriched markers
✔
CANX
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Homo sapiens
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Mesenchymal stem cells
Sample name UCMSC
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
6
Experiment ID 217
MISEV standards
✔
EM
Biophysical techniques
✔
TSG101|CD81|CD9|CD63
Enriched markers
✘ Negative markers
✔
NTA
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23844026    
Organism Homo sapiens
Experiment description Characterization of human thymic exosomes.
Authors "Skogberg G, Gudmundsdottir J, van der Post S, Sandstrom K, Bruhn S, Benson M, Mincheva-Nilsson L, Baranov V, Telemo E, Ekwall O."
Journal name PLoS One
Publication year 2013
Sample Thymus
Sample name Normal-Thymus
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for OCRL
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 AP2S1 1175
Affinity Capture-MS Homo sapiens
2 AP2B1 163
Affinity Capture-MS Homo sapiens
3 SNRPE 6635
Affinity Capture-MS Homo sapiens
4 RAB1A 5861
Reconstituted Complex Homo sapiens
Affinity Capture-MS Homo sapiens
5 MARCKS 4082
Proximity Label-MS Homo sapiens
6 EIF3C 8663
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
7 ATG9A 79065
Proximity Label-MS Homo sapiens
8 GJA1 2697
Proximity Label-MS Homo sapiens
9 PAK2 5062
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
10 ARF3 377
Proximity Label-MS Homo sapiens
11 C9orf78 51759
Affinity Capture-MS Homo sapiens
12 TAB1 10454
Affinity Capture-MS Homo sapiens
13 LAMP2 3920
Proximity Label-MS Homo sapiens
14 CLTB 1212
Affinity Capture-MS Homo sapiens
15 SNRPF 6636
Affinity Capture-MS Homo sapiens
16 PCBP3 54039
Affinity Capture-MS Homo sapiens
17 FAM109B  
Affinity Capture-Western Homo sapiens
Co-localization Homo sapiens
Co-purification Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Two-hybrid Homo sapiens
18 POTEE 445582
Affinity Capture-MS Homo sapiens
19 RNPS1 10921
Affinity Capture-MS Homo sapiens
20 BTN2A1 11120
Affinity Capture-MS Homo sapiens
21 SCN2B  
Affinity Capture-MS Homo sapiens
22 AP2A1 160
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
23 CHCHD2  
Affinity Capture-MS Homo sapiens
24 RAB3B 5865
Proximity Label-MS Homo sapiens
25 QPCTL 54814
Affinity Capture-MS Homo sapiens
26 EIF3E 3646
Affinity Capture-MS Homo sapiens
27 OCLN 100506658
Proximity Label-MS Homo sapiens
28 STX6 10228
Proximity Label-MS Homo sapiens
29 DNAJC7 7266
Affinity Capture-MS Homo sapiens
30 CLTC 1213
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
31 GTSE1 51512
Affinity Capture-MS Homo sapiens
32 RAB6B 51560
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
33 Sec24c  
Affinity Capture-MS Mus musculus
34 THOC1 9984
Affinity Capture-MS Homo sapiens
35 EBAG9 9166
Proximity Label-MS Homo sapiens
36 LAMTOR1 55004
Proximity Label-MS Homo sapiens
37 LSM12 124801
Affinity Capture-MS Homo sapiens
38 RAB1B 81876
Affinity Capture-MS Homo sapiens
39 LAMP3  
Proximity Label-MS Homo sapiens
40 VSIG4  
Affinity Capture-MS Homo sapiens
41 PFN1 5216
Proximity Label-MS Homo sapiens
Affinity Capture-MS Homo sapiens
42 ENPP6 133121
Affinity Capture-MS Homo sapiens
43 MANSC1 54682
Affinity Capture-MS Homo sapiens
44 SNX33 257364
Affinity Capture-MS Homo sapiens
45 PRPH 5630
Proximity Label-MS Homo sapiens
46 RAB14 51552
Reconstituted Complex Homo sapiens
47 PARK2  
Affinity Capture-MS Homo sapiens
48 IL1R2  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
49 RAB4A 5867
Proximity Label-MS Homo sapiens
50 NTRK1 4914
Affinity Capture-MS Homo sapiens
51 Inpp5b  
Affinity Capture-MS Mus musculus
52 LHX3  
Two-hybrid Homo sapiens
53 S100A8 6279
Affinity Capture-MS Homo sapiens
54 PEX14 5195
Proximity Label-MS Homo sapiens
55 BICD2 23299
Proximity Label-MS Homo sapiens
56 ENO1 2023
Cross-Linking-MS (XL-MS) Homo sapiens
57 AAMDC  
Affinity Capture-MS Homo sapiens
58 DHX9 1660
Affinity Capture-MS Homo sapiens
59 MRPS14  
Affinity Capture-MS Homo sapiens
60 CACNG4  
Affinity Capture-MS Homo sapiens
61 RMDN3 55177
Proximity Label-MS Homo sapiens
62 WDR82 80335
Affinity Capture-MS Homo sapiens
63 RAB6A 5870
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
64 CANX 821
Affinity Capture-MS Homo sapiens
65 XPO1 7514
Affinity Capture-MS Homo sapiens
66 C16orf70  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
67 CLTA 1211
Proximity Label-MS Homo sapiens
Affinity Capture-MS Homo sapiens
68 NME2 4831
Affinity Capture-MS Homo sapiens
69 ANXA1 301
Affinity Capture-MS Homo sapiens
70 ELANE 1991
Affinity Capture-MS Homo sapiens
71 CD6 923
Affinity Capture-MS Homo sapiens
72 HMGB1 3146
Affinity Capture-MS Homo sapiens
73 RAB35 11021
Proximity Label-MS Homo sapiens
74 SNX9 51429
Affinity Capture-MS Homo sapiens
75 NXF1 10482
Affinity Capture-RNA Homo sapiens
76 AP2M1 1173
Affinity Capture-MS Homo sapiens
77 SF3A1 10291
Affinity Capture-MS Homo sapiens
78 CTSG 1511
Affinity Capture-MS Homo sapiens
79 MAPK6  
Affinity Capture-MS Homo sapiens
80 MYL6B 140465
Affinity Capture-MS Homo sapiens
81 RPA3 6119
Proximity Label-MS Homo sapiens
82 DYNC1LI1 51143
Proximity Label-MS Homo sapiens
83 RAB9A 9367
Proximity Label-MS Homo sapiens
84 AP2A2 161
Affinity Capture-MS Homo sapiens
85 IMPAD1 54928
Affinity Capture-MS Homo sapiens
86 EIF3CL 728689
Affinity Capture-MS Homo sapiens
87 SNX21  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
88 BICD1 636
Proximity Label-MS Homo sapiens
89 MFN2 9927
Proximity Label-MS Homo sapiens
90 RHOB 388
Proximity Label-MS Homo sapiens
91 TPCN2  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
92 INPP5B 3633
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
93 NUDT21 11051
Affinity Capture-MS Homo sapiens
94 RAB5A 5868
Proximity Label-MS Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-MS Homo sapiens
95 RAB11A 8766
Proximity Label-MS Homo sapiens
96 SF3B5 83443
Affinity Capture-MS Homo sapiens
97 MYCBP 26292
Affinity Capture-MS Homo sapiens
98 APPL1 26060
Affinity Capture-MS Homo sapiens
99 GRB2 2885
Reconstituted Complex Homo sapiens
100 TP53 7157
Affinity Capture-MS Homo sapiens
101 G6PD 2539
Affinity Capture-MS Homo sapiens
102 DNAJA2 10294
Affinity Capture-MS Homo sapiens
103 LCK 3932
Proximity Label-MS Homo sapiens
104 SQSTM1 8878
Proximity Label-MS Homo sapiens
Proximity Label-MS Homo sapiens
105 PLEKHJ1  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
106 ELAVL1 1994
Affinity Capture-RNA Homo sapiens
107 FAM109A  
Affinity Capture-Western Homo sapiens
Co-localization Homo sapiens
Co-purification Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Two-hybrid Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
108 S100A9 6280
Affinity Capture-MS Homo sapiens
109 BOLA2 552900
Affinity Capture-MS Homo sapiens
110 RAB8A 4218
Reconstituted Complex Homo sapiens
111 GOLGA5 9950
Two-hybrid Homo sapiens
112 CDK9 1025
Affinity Capture-MS Homo sapiens
113 RDX 5962
Proximity Label-MS Homo sapiens
114 EPHA2 1969
Proximity Label-MS Homo sapiens
115 KRAS 3845
Proximity Label-MS Homo sapiens
116 RAB5C 5878
Proximity Label-MS Homo sapiens
117 LTF 4057
Affinity Capture-MS Homo sapiens
118 GPX7 2882
Affinity Capture-MS Homo sapiens
119 HMGB2 3148
Affinity Capture-MS Homo sapiens
120 SPINT2 10653
Affinity Capture-MS Homo sapiens
View the network image/svg+xml



Perform bioinformatics analysis of your extracellular vesicle data set using FunRich, a open access standalone tool. NEW UPDATED VERSION OF FunRich available for download (12/09/2016) from here