Experiment description of studies that identified GRB2 in exosomes

1 Experiment ID 79 ISEV standards ✘ EV Biophysical techniques ✘ EV Cytosolic markers ✔ CD81|MHCII EV Membrane markers ✘ EV Negative markers ✘ EV Particle analysis Identified molecule protein Identification method Mass spectrometry PubMed ID 20458337     Organism Homo sapiens Experiment description MHC class II-associated proteins in B-cell exosomes and potential functional implications for exosome biogenesis - Sample 1 Authors Buschow SI, van Balkom BW, Aalberts M, Heck AJ, Wauben M, Stoorvogel W. Journal name ICB Publication year 2010 Sample B cells Sample name RN (HLA-DR15) Isolation/purification methods Differential centrifugation Sucrose density gradient Immunobeads (MHC Class II) Flotation density - Molecules identified in the study Protein Methods used in the study Mass spectrometry [FT-ICR] Western blotting

2 Experiment ID 80 ISEV standards ✘ EV Biophysical techniques ✘ EV Cytosolic markers ✔ CD81|MHCII EV Membrane markers ✘ EV Negative markers ✘ EV Particle analysis Identified molecule protein Identification method Mass spectrometry PubMed ID 20458337     Organism Homo sapiens Experiment description MHC class II-associated proteins in B-cell exosomes and potential functional implications for exosome biogenesis -Sample 2 Authors Buschow SI, van Balkom BW, Aalberts M, Heck AJ, Wauben M, Stoorvogel W. Journal name ICB Publication year 2010 Sample B cells Sample name RN (HLA-DR15) Isolation/purification methods Differential centrifugation Sucrose density gradient Immunobeads (MHC Class II) Flotation density - Molecules identified in the study Protein Methods used in the study Mass spectrometry [FT-ICR] Western blotting

3 Experiment ID 81 ISEV standards ✘ EV Biophysical techniques ✘ EV Cytosolic markers ✔ CD81|MHCII EV Membrane markers ✘ EV Negative markers ✘ EV Particle analysis Identified molecule protein Identification method Mass spectrometry PubMed ID 20458337     Organism Homo sapiens Experiment description MHC class II-associated proteins in B-cell exosomes and potential functional implications for exosome biogenesis - Sample 3 Authors Buschow SI, van Balkom BW, Aalberts M, Heck AJ, Wauben M, Stoorvogel W. Journal name ICB Publication year 2010 Sample B cells Sample name RN (HLA-DR15) Isolation/purification methods Differential centrifugation Sucrose density gradient Immunobeads (MHC Class II) Flotation density - Molecules identified in the study Protein Methods used in the study Mass spectrometry [FT-ICR] Western blotting

4 Experiment ID 207 ISEV standards ✔ EM EV Biophysical techniques ✔ TSG101|HSP70 EV Cytosolic markers ✔ FLOT1 EV Membrane markers ✔ VDAC EV Negative markers ✔ NTA EV Particle analysis Identified molecule protein Identification method Mass spectrometry PubMed ID 23161513     Organism Homo sapiens Experiment description Proteomic analysis of exosomes from mutant KRAS colon cancer cells identifies intercellular transfer of mutant KRAS. Authors Demory Beckler M, Higginbotham JN, Franklin JL, Ham AJ, Halvey PJ, Imasuen IE, Whitwell C, Li M, Liebler DC, Coffey RJ. Journal name Mol Cell Proteomics Publication year 2012 Sample Colorectal cancer cells Sample name DKO-1 Isolation/purification methods Differential centrifugation Filtration Flotation density - Molecules identified in the study Protein Methods used in the study Mass spectrometry

5 Experiment ID 208 ISEV standards ✔ EM EV Biophysical techniques ✔ TSG101|HSP70 EV Cytosolic markers ✔ FLOT1 EV Membrane markers ✔ VDAC EV Negative markers ✔ NTA EV Particle analysis Identified molecule protein Identification method Mass spectrometry PubMed ID 23161513     Organism Homo sapiens Experiment description Proteomic analysis of exosomes from mutant KRAS colon cancer cells identifies intercellular transfer of mutant KRAS. Authors Demory Beckler M, Higginbotham JN, Franklin JL, Ham AJ, Halvey PJ, Imasuen IE, Whitwell C, Li M, Liebler DC, Coffey RJ. Journal name Mol Cell Proteomics Publication year 2012 Sample Colorectal cancer cells Sample name Dks-8 Isolation/purification methods Differential centrifugation Filtration Flotation density - Molecules identified in the study Protein Methods used in the study Mass spectrometry

6 Experiment ID 209 ISEV standards ✘ EV Biophysical techniques ✔ TSG101|HSP70 EV Cytosolic markers ✔ FLOT1 EV Membrane markers ✔ VDAC EV Negative markers ✔ NTA EV Particle analysis Identified molecule protein Identification method Mass spectrometry PubMed ID 23161513     Organism Homo sapiens Experiment description Proteomic analysis of exosomes from mutant KRAS colon cancer cells identifies intercellular transfer of mutant KRAS. Authors Demory Beckler M, Higginbotham JN, Franklin JL, Ham AJ, Halvey PJ, Imasuen IE, Whitwell C, Li M, Liebler DC, Coffey RJ. Journal name Mol Cell Proteomics Publication year 2012 Sample Colorectal cancer cells Sample name DLD-1 Isolation/purification methods Differential centrifugation Filtration Flotation density - Molecules identified in the study Protein Methods used in the study Mass spectrometry

7 Experiment ID 236 ISEV standards ✔ EM EV Biophysical techniques ✔ TSG101|Alix|HSC70|GAPDH EV Cytosolic markers ✘ EV Membrane markers ✔ HSP90B1 EV Negative markers ✔ qNano EV Particle analysis Identified molecule protein Identification method Mass spectrometry PubMed ID 26054723     Organism Homo sapiens Experiment description Hepatocellular carcinoma-derived exosomes promote motility of immortalized hepatocyte through transfer of oncogenic proteins and RNAs Authors He M, Qin H, Poon TC, Sze SC, Ding X, Co NN, Ngai SM, Chan TF, Wong N Journal name Carcinogenesis Publication year 2015 Sample Hepatocellular carcinoma cells Sample name MHCC97L Isolation/purification methods Differential centrifugation Filtration Ultracentrifugation Sucrose density gradient Flotation density 1.13-1.19 g/mL Molecules identified in the study Protein RNA Methods used in the study Western blotting Mass spectrometry RT-PCR RNA Sequencing

8 Experiment ID 237 ISEV standards ✔ EM EV Biophysical techniques ✔ TSG101|Alix|HSC70|GAPDH EV Cytosolic markers ✘ EV Membrane markers ✔ HSP90B1 EV Negative markers ✔ qNano EV Particle analysis Identified molecule mRNA Identification method RNA Sequencing PubMed ID 26054723     Organism Homo sapiens Experiment description Hepatocellular carcinoma-derived exosomes promote motility of immortalized hepatocyte through transfer of oncogenic proteins and RNAs Authors He M, Qin H, Poon TC, Sze SC, Ding X, Co NN, Ngai SM, Chan TF, Wong N Journal name Carcinogenesis Publication year 2015 Sample Hepatocytes Sample name MIHA Isolation/purification methods Differential centrifugation Filtration Ultracentrifugation Sucrose density gradient Flotation density 1.13-1.19 g/mL Molecules identified in the study Protein RNA Methods used in the study Western blotting Mass spectrometry RNA Sequencing

9 Experiment ID 211 ISEV standards ✔ EM EV Biophysical techniques ✔ TSG101|Alix EV Cytosolic markers ✔ EpCAM|TFRC EV Membrane markers ✔ cytochrome c|GOLGA2 EV Negative markers ✘ EV Particle analysis Identified molecule protein Identification method Mass spectrometry PubMed ID 23333927     Organism Homo sapiens Experiment description Characterization and proteomic analysis of ovarian cancer-derived exosomes. Authors Liang B, Peng P, Chen S, Li L, Zhang M, Cao D, Yang J, Li H, Gui T, Li X, Shen K. Journal name J Proteomics Publication year 2013 Sample Ovarian cancer cells Sample name IGROV1 Isolation/purification methods Differential centrifugation Ultracentrifugation Sucrose density gradient Flotation density 1.09-1.15 g/mL Molecules identified in the study Protein Methods used in the study Mass spectrometry

10 Experiment ID 212 ISEV standards ✔ CEM EV Biophysical techniques ✔ TSG101|Alix EV Cytosolic markers ✔ EpCAM|TFRC EV Membrane markers ✔ Cytochrome C|GOLGA2 EV Negative markers ✘ EV Particle analysis Identified molecule protein Identification method Mass spectrometry PubMed ID 23333927     Organism Homo sapiens Experiment description Characterization and proteomic analysis of ovarian cancer-derived exosomes. Authors Liang B, Peng P, Chen S, Li L, Zhang M, Cao D, Yang J, Li H, Gui T, Li X, Shen K. Journal name J Proteomics Publication year 2013 Sample Ovarian cancer cells Sample name OVCAR-3 Isolation/purification methods Differential centrifugation Ultracentrifugation Sucrose density gradient Flotation density 1.09-1.15 g/mL Molecules identified in the study Protein Methods used in the study Mass spectrometry

11 Experiment ID 231 ISEV standards ✘ EV Biophysical techniques ✔ Alix EV Cytosolic markers ✔ CD63|CD9 EV Membrane markers ✘ EV Negative markers ✔ NTA EV Particle analysis Identified molecule protein Identification method Mass spectrometry PubMed ID 25332113     Organism Homo sapiens Experiment description Lipidomic and proteomic characterization of platelet extracellular vesicle subfractions from senescent platelets Authors Pienimaeki-Roemer A, Kuhlmann K, Bottcher A, Konovalova T, Black A, Orso E, Liebisch G, Ahrens M, Eisenacher M, Meyer HE, Schmitz G. Journal name Transfusion Publication year 2015 Sample Platelets Sample name PL-Exs - Rep 1 Isolation/purification methods Differential centrifugation Filtration Ultracentrifugation Optiprep density gradient Flotation density 1.12-1.15 g/mL Molecules identified in the study Protein Lipids Methods used in the study Western blotting Mass spectrometry

12 Experiment ID 232 ISEV standards ✘ EV Biophysical techniques ✘ EV Cytosolic markers ✘ EV Membrane markers ✘ EV Negative markers ✘ EV Particle analysis Identified molecule protein Identification method Mass spectrometry PubMed ID 25332113     Organism Homo sapiens Experiment description Lipidomic and proteomic characterization of platelet extracellular vesicle subfractions from senescent platelets Authors Pienimaeki-Roemer A, Kuhlmann K, Bottcher A, Konovalova T, Black A, Orso E, Liebisch G, Ahrens M, Eisenacher M, Meyer HE, Schmitz G. Journal name Transfusion Publication year 2015 Sample Platelets Sample name PL-Exs - Rep 2 Isolation/purification methods Differential centrifugation Filtration Ultracentrifugation Optiprep density gradient Flotation density 1.12-1.15 g/mL Molecules identified in the study Protein Methods used in the study Mass spectrometry

13 Experiment ID 233 ISEV standards ✘ EV Biophysical techniques ✘ EV Cytosolic markers ✘ EV Membrane markers ✘ EV Negative markers ✘ EV Particle analysis Identified molecule protein Identification method Mass spectrometry PubMed ID 25332113     Organism Homo sapiens Experiment description Lipidomic and proteomic characterization of platelet extracellular vesicle subfractions from senescent platelets Authors Pienimaeki-Roemer A, Kuhlmann K, Bottcher A, Konovalova T, Black A, Orso E, Liebisch G, Ahrens M, Eisenacher M, Meyer HE, Schmitz G. Journal name Transfusion Publication year 2015 Sample Platelets Sample name PL-Exs - Rep 3 Isolation/purification methods Differential centrifugation Filtration Ultracentrifugation Optiprep density gradient Flotation density 1.12-1.15 g/mL Molecules identified in the study Protein Methods used in the study Mass spectrometry

14 Experiment ID 275 ISEV standards ✔ EM EV Biophysical techniques ✔ TSG101|Alix|RAB5A EV Cytosolic markers ✔ CD9|CD82|CD63|CD81 EV Membrane markers ✔ AIF EV Negative markers ✔ NTA EV Particle analysis Identified molecule protein Identification method Mass spectrometry PubMed ID 25844599     Organism Homo sapiens Experiment description Molecular profiling of prostate cancer derived exosomes may reveal a predictive signature for response to docetaxel. Authors Kharaziha P, Chioureas D, Rutishauser D, Baltatzis G, Lennartsson L, Fonseca P, Azimi A, Hultenby K, Zubarev R, Ullen A, Yachnin J, Nilsson S, Panaretakis T. Journal name Oncotarget Publication year 2015 Sample Prostate cancer cells Sample name DU145 - Docetaxel sensitive Isolation/purification methods Filtration Ultracentrifugation Sucrose density gradient Flotation density 1.12-1.19 g/mL Molecules identified in the study Protein Methods used in the study Mass spectrometry/Flow cytometry/Western blotting

15 Experiment ID 274 ISEV standards ✔ EM EV Biophysical techniques ✔ TSG101|Alix|RAB5A EV Cytosolic markers ✔ CD9|CD82|CD63|CD81 EV Membrane markers ✔ AIF EV Negative markers ✔ NTA EV Particle analysis Identified molecule protein Identification method Mass spectrometry PubMed ID 25844599     Organism Homo sapiens Experiment description Molecular profiling of prostate cancer derived exosomes may reveal a predictive signature for response to docetaxel. Authors Kharaziha P, Chioureas D, Rutishauser D, Baltatzis G, Lennartsson L, Fonseca P, Azimi A, Hultenby K, Zubarev R, Ullen A, Yachnin J, Nilsson S, Panaretakis T. Journal name Oncotarget Publication year 2015 Sample Prostate cancer cells Sample name DU145 - Docetaxel resistant Isolation/purification methods Filtration Ultracentrifugation Sucrose density gradient Flotation density 1.13-1.18 g/mL Molecules identified in the study Protein Methods used in the study Mass spectrometry Flow cytometry Western blotting

16 Experiment ID 217 ISEV standards ✔ EM EV Biophysical techniques ✔ TSG101 EV Cytosolic markers ✔ CD81|CD9|CD63 EV Membrane markers ✘ EV Negative markers ✔ NTA EV Particle analysis Identified molecule protein Identification method Mass spectrometry PubMed ID 23844026     Organism Homo sapiens Experiment description Characterization of human thymic exosomes. Authors Skogberg G, Gudmundsdottir J, van der Post S, Sandstrom K, Bruhn S, Benson M, Mincheva-Nilsson L, Baranov V, Telemo E, Ekwall O. Journal name PLoS One Publication year 2013 Sample Thymus Sample name Normal-Thymus Isolation/purification methods Differential centrifugation Filtration Ultracentrifugation Flotation density - Molecules identified in the study Protein Methods used in the study Mass spectrometry

17 Experiment ID 63 ISEV standards ✘ EV Biophysical techniques ✘ EV Cytosolic markers ✔ AQP2 EV Membrane markers ✘ EV Negative markers ✘ EV Particle analysis Identified molecule protein Identification method Mass spectrometry PubMed ID 19056867     Organism Homo sapiens Experiment description Large-scale proteomics and phosphoproteomics of urinary exosomes. Authors Gonzales PA, Pisitkun T, Hoffert JD, Tchapyjnikov D, Star RA, Kleta R, Wang NS, Knepper MA Journal name JASN Publication year 2009 Sample Urine Sample name Urine - Normal Isolation/purification methods Differential centrifugation Flotation density - Molecules identified in the study Protein Methods used in the study Mass spectrometry [LTQ] Western blotting

Protein-protein interactions for GRB2

Protein Interactor ExoCarta ID Identification method PubMed Species 1 MTA1   Affinity Capture-MS Homo sapiens 2 AXL 558 Affinity Capture-MS Homo sapiens Far Western Homo sapiens 3 CALD1   Invitro Homo sapiens Affinity Capture-MS Homo sapiens 4 HNRNPC 3183 Invivo Homo sapiens Invitro Homo sapiens Affinity Capture-MS Homo sapiens 5 ITGA2B 3674 Invivo Homo sapiens Invitro Homo sapiens Reconstituted Complex Homo sapiens 6 ETV6   Affinity Capture-Western Homo sapiens Far Western Homo sapiens 7 SHC1 6464 Affinity Capture-Western Homo sapiens Affinity Capture-Western Homo sapiens Affinity Capture-Western Homo sapiens Affinity Capture-Western Homo sapiens Affinity Capture-Western Homo sapiens Affinity Capture-Western Homo sapiens Invivo Homo sapiens Invivo Homo sapiens Invivo Homo sapiens Invitro Homo sapiens Invitro Homo sapiens Invitro Homo sapiens Affinity Capture-MS Homo sapiens Affinity Capture-Western Homo sapiens Affinity Capture-Western Homo sapiens Reconstituted Complex Homo sapiens Affinity Capture-Western Homo sapiens 8 PTPN22   Affinity Capture-Western Homo sapiens 9 DAG1 1605 Affinity Capture-Western Homo sapiens Reconstituted Complex Homo sapiens 10 SGCA   Affinity Capture-MS Homo sapiens 11 RACGAP1 29127 Affinity Capture-MS Homo sapiens 12 CD72   Invitro Homo sapiens Affinity Capture-MS Homo sapiens 13 KRT17 3872 Affinity Capture-MS Homo sapiens 14 CRK 1398 Reconstituted Complex Homo sapiens Far Western Homo sapiens 15 ADRB2   Affinity Capture-Western Homo sapiens Reconstituted Complex Homo sapiens 16 CD2AP 23607 Invitro Homo sapiens 17 CLYBL   Affinity Capture-MS Homo sapiens 18 FLT3   Invivo Homo sapiens 19 SOCS1   Reconstituted Complex Homo sapiens 20 PSMD10 5716 Invivo Homo sapiens Invitro Homo sapiens Affinity Capture-MS Homo sapiens 21 PTPN1 5770 Invivo Homo sapiens Reconstituted Complex Homo sapiens Affinity Capture-MS Homo sapiens 22 SH2B1 25970 Affinity Capture-Western Homo sapiens Reconstituted Complex Homo sapiens 23 FGFR3 2261 Invivo Homo sapiens 24 RALGPS1   Invivo Homo sapiens Invitro Homo sapiens Affinity Capture-MS Homo sapiens 25 PTPN12   Invivo Homo sapiens Invitro Homo sapiens 26 WAS 7454 Affinity Capture-Western Homo sapiens Invivo Homo sapiens Affinity Capture-MS Homo sapiens Reconstituted Complex Homo sapiens Reconstituted Complex Homo sapiens Affinity Capture-Western Homo sapiens 27 USP6NL 9712 Invivo Homo sapiens Invitro Homo sapiens 28 TRAT1 50852 Reconstituted Complex Homo sapiens 29 ZAP70 7535 Affinity Capture-Western Homo sapiens 30 ERBB3 2065 Affinity Capture-MS Homo sapiens 31 IQGAP1 8826 Affinity Capture-MS Homo sapiens 32 MUC1 4582 Reconstituted Complex Homo sapiens Affinity Capture-Western Homo sapiens 33 SRC 6714 Invivo Homo sapiens Invitro Homo sapiens Affinity Capture-Western Homo sapiens Affinity Capture-MS Homo sapiens 34 KHDRBS1 10657 Invivo Homo sapiens Invitro Homo sapiens Reconstituted Complex Homo sapiens Affinity Capture-Western Homo sapiens Reconstituted Complex Homo sapiens Affinity Capture-Western Homo sapiens 35 SYK 6850 Invitro Homo sapiens Invivo Homo sapiens Affinity Capture-MS Homo sapiens Affinity Capture-Western Homo sapiens 36 MAPK14 1432 Affinity Capture-MS Homo sapiens 37 ADA 100 Invitro Homo sapiens Affinity Capture-MS Homo sapiens 38 PLCG1 5335 Affinity Capture-Western Homo sapiens Reconstituted Complex Homo sapiens Affinity Capture-Western Homo sapiens 39 TOM1L1 10040 Invivo Homo sapiens Invitro Homo sapiens 40 MST1R 4486 Invivo Homo sapiens Reconstituted Complex Homo sapiens 41 WASL 8976 Invivo Homo sapiens Invitro Homo sapiens 42 DOCK1 1793 Reconstituted Complex Homo sapiens Co-fractionation Homo sapiens 43 CD28   Invivo Homo sapiens Invitro Homo sapiens Reconstituted Complex Homo sapiens Reconstituted Complex Homo sapiens 44 USP8   Reconstituted Complex Homo sapiens 45 DNM1 1759 Invivo Homo sapiens Invivo Homo sapiens Invitro Homo sapiens Invitro Homo sapiens 46 PXN   Reconstituted Complex Homo sapiens 47 ERBB2 2064 Affinity Capture-MS Homo sapiens Affinity Capture-Western Homo sapiens 48 FGFR1 2260 Invivo Homo sapiens Affinity Capture-MS Homo sapiens 49 PDGFRA   Affinity Capture-Western Homo sapiens 50 PTPRC 5788 Invivo Homo sapiens Invitro Homo sapiens 51 PRNP 5621 Invivo Homo sapiens Invitro Homo sapiens Two-hybrid Homo sapiens Affinity Capture-MS Homo sapiens 52 CDKN1B 1027 Invivo Homo sapiens Invitro Homo sapiens Two-hybrid Homo sapiens Affinity Capture-MS Homo sapiens 53 TFAP2A   Affinity Capture-MS Homo sapiens 54 KRT8 3856 Affinity Capture-MS Homo sapiens 55 IRS4 8471 Affinity Capture-Western Homo sapiens 56 KIT 3815 Two-hybrid Homo sapiens Reconstituted Complex Homo sapiens 57 FASLG 356 Affinity Capture-Western Homo sapiens Invivo Homo sapiens Invitro Homo sapiens Reconstituted Complex Homo sapiens 58 VAV1 7409 Affinity Capture-Western Homo sapiens Reconstituted Complex Homo sapiens Affinity Capture-Western Homo sapiens Affinity Capture-MS Homo sapiens 59 NCKIPSD 51517 Invivo Homo sapiens Invitro Homo sapiens Affinity Capture-MS Homo sapiens Reconstituted Complex Homo sapiens Affinity Capture-Western Homo sapiens 60 MAPK12   Invitro Homo sapiens Affinity Capture-MS Homo sapiens 61 ITGA6 3655 Invivo Homo sapiens 62 PDE6G   Reconstituted Complex Homo sapiens 63 PDGFRB 5159 Affinity Capture-MS Homo sapiens Reconstituted Complex Homo sapiens Reconstituted Complex Homo sapiens 64 TUB   Invitro Homo sapiens 65 SOCS7   Invitro Homo sapiens 66 CBL 867 Affinity Capture-Western Homo sapiens Affinity Capture-Western Homo sapiens Affinity Capture-Western Homo sapiens Reconstituted Complex Homo sapiens Two-hybrid Homo sapiens Invivo Homo sapiens Invivo Homo sapiens Invivo Homo sapiens Invitro Homo sapiens Invitro Homo sapiens Invitro Homo sapiens Two-hybrid Homo sapiens Two-hybrid Homo sapiens Two-hybrid Homo sapiens Reconstituted Complex Homo sapiens 67 HTT 3064 Affinity Capture-Western Homo sapiens Reconstituted Complex Homo sapiens 68 SNTA1 6640 Invivo Homo sapiens Affinity Capture-Western Homo sapiens 69 SH3BP2   Reconstituted Complex Homo sapiens 70 CRKL 1399 Invivo Homo sapiens 71 PTK2B 2185 Invivo Homo sapiens Invivo Homo sapiens 72 SYNCRIP 10492 Reconstituted Complex Homo sapiens 73 DCTN1 1639 Affinity Capture-MS Homo sapiens Affinity Capture-Western Homo sapiens Reconstituted Complex Homo sapiens 74 REPS2   Reconstituted Complex Homo sapiens 75 PIK3R1 5295 Invivo Homo sapiens Invitro Homo sapiens Two-hybrid Homo sapiens Affinity Capture-Western Homo sapiens Reconstituted Complex Homo sapiens Affinity Capture-Western Homo sapiens Reconstituted Complex Homo sapiens 76 EPOR   Reconstituted Complex Homo sapiens 77 RAPGEF1 2889 Affinity Capture-Western Homo sapiens 78 SOS1   Invivo Homo sapiens Reconstituted Complex Homo sapiens Reconstituted Complex Homo sapiens Affinity Capture-MS Homo sapiens Reconstituted Complex Homo sapiens Affinity Capture-Western Homo sapiens Affinity Capture-Western Homo sapiens Affinity Capture-Western Homo sapiens Affinity Capture-Western Homo sapiens Affinity Capture-Western Homo sapiens Affinity Capture-Western Homo sapiens Affinity Capture-Western Homo sapiens Reconstituted Complex Homo sapiens 79 MAP4K1   Two-hybrid Homo sapiens Affinity Capture-Western Homo sapiens Invivo Homo sapiens Invitro Homo sapiens Reconstituted Complex Homo sapiens Reconstituted Complex Homo sapiens 80 EGF 1950 Invivo Homo sapiens 81 ARHGAP17 55114 Reconstituted Complex Homo sapiens 82 NEU3   Affinity Capture-Western Homo sapiens Affinity Capture-Western Homo sapiens 83 LAT 27040 Invivo Homo sapiens Invitro Homo sapiens Invivo Homo sapiens Invivo Homo sapiens Affinity Capture-Western Homo sapiens Affinity Capture-MS Homo sapiens 84 PTPN11 5781 Invivo Homo sapiens Invivo Homo sapiens Affinity Capture-MS Homo sapiens Affinity Capture-Western Homo sapiens Affinity Capture-Western Homo sapiens Far Western Homo sapiens Reconstituted Complex Homo sapiens Reconstituted Complex Homo sapiens 85 TFAP2B   Affinity Capture-MS Homo sapiens 86 CD22 933 Affinity Capture-Western Homo sapiens Affinity Capture-Western Homo sapiens Affinity Capture-Western Homo sapiens 87 PTPN6 5777 Invitro Homo sapiens Invivo Homo sapiens Affinity Capture-MS Homo sapiens Affinity Capture-Western Homo sapiens 88 Mta3   Reconstituted Complex Mus musculus 89 OCRL 4952 Reconstituted Complex Homo sapiens 90 PTPRA 5786 Invivo Homo sapiens Invitro Homo sapiens Affinity Capture-Western Homo sapiens Affinity Capture-MS Homo sapiens Reconstituted Complex Homo sapiens Reconstituted Complex Homo sapiens Affinity Capture-Western Homo sapiens 91 PRKAR1A 5573 Affinity Capture-MS Homo sapiens Affinity Capture-Western Homo sapiens Reconstituted Complex Homo sapiens 92 EPPK1 83481 Affinity Capture-MS Homo sapiens 93 TNFRSF1A 7132 Affinity Capture-MS Homo sapiens Affinity Capture-Western Homo sapiens 94 ERBB4 2066 Affinity Capture-MS Homo sapiens 95 CTTN 2017 Affinity Capture-MS Homo sapiens 96 EGFR 1956 Invivo Homo sapiens Invitro Homo sapiens Affinity Capture-MS Homo sapiens Affinity Capture-Western Homo sapiens Reconstituted Complex Homo sapiens Affinity Capture-Western Homo sapiens Reconstituted Complex Homo sapiens Affinity Capture-MS Homo sapiens Affinity Capture-Western Homo sapiens Affinity Capture-Western Homo sapiens Affinity Capture-Western Homo sapiens 97 MAP3K1 4214 Invivo Homo sapiens Invitro Homo sapiens 98 PTK2 5747 Invivo Homo sapiens Invitro Homo sapiens Affinity Capture-MS Homo sapiens Affinity Capture-Western Homo sapiens Reconstituted Complex Homo sapiens Reconstituted Complex Homo sapiens 99 CBLB   Affinity Capture-MS Homo sapiens Affinity Capture-Western Homo sapiens Affinity Capture-Western Homo sapiens Reconstituted Complex Homo sapiens 100 LAT2 7462 Affinity Capture-Western Homo sapiens Affinity Capture-MS Homo sapiens 101 PIK3C2B 5287 Invitro Homo sapiens 102 BCAR1 9564 Affinity Capture-Western Homo sapiens Reconstituted Complex Homo sapiens 103 GAB1   Two-hybrid Homo sapiens Affinity Capture-Western Homo sapiens Affinity Capture-Western Homo sapiens Reconstituted Complex Homo sapiens 104 SYP   Affinity Capture-Western Homo sapiens 105 ELK1   Invivo Homo sapiens 106 KDR   Affinity Capture-Western Homo sapiens 107 REPS1   Affinity Capture-MS Homo sapiens 108 RET 5979 Affinity Capture-MS Homo sapiens Reconstituted Complex Homo sapiens 109 JAK1 3716 Invivo Homo sapiens Affinity Capture-Western Homo sapiens 110 APS   Affinity Capture-Western Homo sapiens 111 MERTK   Invivo Homo sapiens 112 CCL5   Invivo Homo sapiens Affinity Capture-MS Homo sapiens 113 ITGB4 3691 Invivo Homo sapiens 114 LNK   Invivo Homo sapiens Affinity Capture-MS Homo sapiens 115 MET 4233 Invivo Homo sapiens Invivo Homo sapiens Invitro Homo sapiens Invitro Homo sapiens Reconstituted Complex Homo sapiens 116 IL2RB   Reconstituted Complex Homo sapiens Affinity Capture-MS Homo sapiens 117 GAB3   Reconstituted Complex Homo sapiens Reconstituted Complex Homo sapiens 118 FRS2   Invivo Homo sapiens Invitro Homo sapiens Affinity Capture-Western Homo sapiens Affinity Capture-Western Homo sapiens Affinity Capture-MS Homo sapiens Reconstituted Complex Homo sapiens 119 INPP5D 3635 Invitro Homo sapiens Invivo Homo sapiens Invivo Homo sapiens Invitro Homo sapiens 120 VAV2   Affinity Capture-MS Homo sapiens Affinity Capture-Western Homo sapiens 121 CSF1R   Invivo Homo sapiens Invitro Homo sapiens Two-hybrid Homo sapiens Two-hybrid Homo sapiens Reconstituted Complex Homo sapiens 122 ITK 3702 Reconstituted Complex Homo sapiens 123 SYN1   Reconstituted Complex Homo sapiens 124 CBLC   Affinity Capture-MS Homo sapiens 125 RAPSN   Affinity Capture-MS Homo sapiens 126 RASA1 5921 Invivo Homo sapiens Affinity Capture-MS Homo sapiens 127 KRT18 3875 Affinity Capture-MS Homo sapiens 128 BCL2A1   Invivo Homo sapiens Invitro Homo sapiens Affinity Capture-MS Homo sapiens 129 PTPRE   Invivo Homo sapiens 130 PRRC2A 7916 Two-hybrid Homo sapiens 131 DAB2 1601 Affinity Capture-MS Homo sapiens 132 GRB2 2885 Affinity Capture-MS Homo sapiens Co-crystal Structure Homo sapiens Affinity Capture-MS Homo sapiens Co-crystal Structure Homo sapiens 133 PLEC 5339 Affinity Capture-MS Homo sapiens 134 DRD3   Invivo Homo sapiens Invitro Homo sapiens 135 LAX1   Invivo Homo sapiens Invitro Homo sapiens 136 C6orf21   Reconstituted Complex Homo sapiens Affinity Capture-Western Homo sapiens 137 FLT4   Invivo Homo sapiens Invivo Homo sapiens Invitro Homo sapiens Invitro Homo sapiens Reconstituted Complex Homo sapiens 138 MAP2 4133 Reconstituted Complex Homo sapiens Reconstituted Complex Homo sapiens 139 GRB7 2886 Affinity Capture-MS Homo sapiens 140 TNK2   Affinity Capture-Western Homo sapiens Affinity Capture-MS Homo sapiens Affinity Capture-Western Homo sapiens 141 IRS2 8660 Invivo Homo sapiens 142 JAK2 3717 Affinity Capture-Western Homo sapiens Affinity Capture-Western Homo sapiens 143 EPHB1 2047 Invitro Homo sapiens 144 ABL1 25 Invitro Homo sapiens Affinity Capture-Western Homo sapiens 145 INSR 3643 Affinity Capture-Western Homo sapiens 146 ADAM15 8751 Invitro Homo sapiens Affinity Capture-MS Homo sapiens 147 GAB2 9846 Invitro Homo sapiens Affinity Capture-Western Homo sapiens 148 SPRY2   Invivo Homo sapiens Invitro Homo sapiens Affinity Capture-MS Homo sapiens 149 PAG1   Reconstituted Complex Homo sapiens 150 Mta1   Reconstituted Complex Mus musculus 151 VAV3   Affinity Capture-MS Homo sapiens Affinity Capture-Western Homo sapiens 152 SKAP1 8631 Invivo Homo sapiens 153 ACTA1 58 Affinity Capture-MS Homo sapiens 154 NTRK1   Invivo Homo sapiens Affinity Capture-Western Homo sapiens 155 LCP2 3937 Affinity Capture-Western Homo sapiens Affinity Capture-Western Homo sapiens 156 SHB   Affinity Capture-Western Homo sapiens 157 EPHA2 1969 Affinity Capture-Western Homo sapiens Reconstituted Complex Homo sapiens 158 SOS2 6655 Invivo Homo sapiens Invivo Homo sapiens 159 GHR   Invivo Homo sapiens 160 CSF3R   Affinity Capture-Western Homo sapiens Far Western Homo sapiens 161 DRD4   Invivo Homo sapiens 162 SH3KBP1 30011 Invivo Homo sapiens Invitro Homo sapiens Invivo Homo sapiens Invivo Homo sapiens Invitro Homo sapiens Invitro Homo sapiens Two-hybrid Homo sapiens Two-hybrid Homo sapiens Affinity Capture-MS Homo sapiens 163 ADAM12   Invivo Homo sapiens 164 BLNK   Invivo Homo sapiens Invitro Homo sapiens Affinity Capture-Western Homo sapiens Reconstituted Complex Homo sapiens Affinity Capture-MS Homo sapiens 165 ANXA2 302 Invitro Homo sapiens Affinity Capture-MS Homo sapiens 166 SELL 6402 Affinity Capture-Western Homo sapiens 167 DTX1   Invitro Homo sapiens Two-hybrid Homo sapiens 168 ALOX5   Invitro Homo sapiens Invitro Homo sapiens 169 IRS1 3667 Affinity Capture-Western Homo sapiens Affinity Capture-Western Homo sapiens Invivo Homo sapiens Affinity Capture-Western Homo sapiens Reconstituted Complex Homo sapiens 170 KRT7 3855 Affinity Capture-MS Homo sapiens 171 BCR 613 Affinity Capture-Western Homo sapiens Two-hybrid Homo sapiens Affinity Capture-Western Homo sapiens Far Western Homo sapiens Affinity Capture-Western Homo sapiens Affinity Capture-Western Homo sapiens Reconstituted Complex Homo sapiens 172 MED28   Affinity Capture-Western Homo sapiens Reconstituted Complex Homo sapiens 173 FRS3   Invivo Homo sapiens Invitro Homo sapiens View the network

Pathways in which GRB2 is involved

No pathways found