Gene description for GAB2
Gene name GRB2-associated binding protein 2
Gene symbol GAB2
Other names/aliases -
Species Homo sapiens
 Database cross references - GAB2
ExoCarta ExoCarta_9846
Entrez Gene 9846
HGNC 14458
MIM 606203
UniProt Q9UQC2  
 GAB2 identified in exosomes derived from the following tissue/cell type
Hepatocellular carcinoma cells 26054723    
 Gene ontology annotations for GAB2
Molecular Function
    protein binding GO:0005515 IPI
    phosphatidylinositol-3,4,5-trisphosphate binding GO:0005547 ISS
    transmembrane receptor protein tyrosine kinase adaptor activity GO:0005068 IDA
    phosphatidylinositol-3,4-bisphosphate binding GO:0043325 ISS
Biological Process
    positive regulation of cell proliferation GO:0008284 IDA
    Fc-epsilon receptor signaling pathway GO:0038095 TAS
    cell migration GO:0016477 IEA
    innate immune response GO:0045087 TAS
    phosphatidylinositol-mediated signaling GO:0048015 ISS
    transmembrane receptor protein tyrosine kinase signaling pathway GO:0007169 IDA
    osteoclast differentiation GO:0030316 IMP
    integrin-mediated signaling pathway GO:0007229 IEA
    positive regulation of mast cell degranulation GO:0043306 ISS
Subcellular Localization
    cytoplasm GO:0005737 IDA
    plasma membrane GO:0005886 IDA
    cytosol GO:0005829 TAS
 Experiment description of studies that identified GAB2 in exosomes
1
Experiment ID 236
ISEV standards
EM
EV Biophysical techniques
TSG101|Alix|HSC70|GAPDH
EV Cytosolic markers
EV Membrane markers
HSP90B1
EV Negative markers
qNano
EV Particle analysis
Identified molecule mRNA
Identification method RNA Sequencing
PubMed ID 26054723    
Organism Homo sapiens
Experiment description Hepatocellular carcinoma-derived exosomes promote motility of immortalized hepatocyte through transfer of oncogenic proteins and RNAs
Authors He M, Qin H, Poon TC, Sze SC, Ding X, Co NN, Ngai SM, Chan TF, Wong N
Journal name Carcinogenesis
Publication year 2015
Sample Hepatocellular carcinoma cells
Sample name MHCC97L
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.13-1.19 g/mL
Molecules identified in the study Protein
RNA
Methods used in the study Western blotting
Mass spectrometry
RT-PCR
RNA Sequencing
 Protein-protein interactions for GAB2
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 LYN 4067
Affinity Capture-Western Homo sapiens
2 CD247 919
Affinity Capture-Western Homo sapiens
3 GRAP2 9402
Invitro Homo sapiens
4 SRC 6714
Invitro Homo sapiens
5 PIK3R1 5295
Invivo Homo sapiens
Invitro Homo sapiens
6 LAT 27040
Affinity Capture-Western Homo sapiens
7 PTPN11 5781
Invivo Homo sapiens
Invivo Homo sapiens
Invitro Homo sapiens
Invitro Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
8 AKT1 207
Invitro Homo sapiens
9 PLCG2 5336
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
10 ETV6  
Affinity Capture-Western Homo sapiens
11 GRB2 2885
Affinity Capture-Western Homo sapiens
Invitro Homo sapiens
12 SHC1 6464
Affinity Capture-Western Homo sapiens
13 CRKL 1399
Invivo Homo sapiens
Invitro Homo sapiens
14 RICS  
Affinity Capture-Western Homo sapiens
Two-hybrid Homo sapiens
15 PTPN6 5777
Affinity Capture-Western Homo sapiens
16 BCR 613
Affinity Capture-Western Homo sapiens
17 ZAP70 7535
Affinity Capture-Western Homo sapiens
View the network image/svg+xml



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