Gene description for ZAP70
Gene name	zeta-chain (TCR) associated protein kinase 70kDa
Gene symbol	ZAP70
Other names/aliases	SRK STCD STD TZK ZAP-70
Species	Homo sapiens
Database cross references - ZAP70
ExoCarta	ExoCarta_7535
Entrez Gene	7535
HGNC	12858
MIM	176947
UniProt	P43403
ZAP70 identified in exosomes derived from the following tissue/cell type
Thymus	23844026

Gene ontology annotations for ZAP70

Molecular Function     non-membrane spanning protein tyrosine kinase activity GO:0004715 TAS     receptor binding GO:0005102 IBA     phosphotyrosine binding GO:0001784 IEA     ATP binding GO:0005524 NAS     protein tyrosine kinase activity GO:0004713 TAS     protein binding GO:0005515 IPI Biological Process     T cell activation GO:0042110 TAS     T cell migration GO:0072678 TAS     adaptive immune response GO:0002250 TAS     innate immune response GO:0045087 IBA     positive thymic T cell selection GO:0045059 IDA     positive regulation of alpha-beta T cell proliferation GO:0046641 IBA     T cell differentiation GO:0030217 NAS     immune response GO:0006955 IDA     transmembrane receptor protein tyrosine kinase signaling pathway GO:0007169 IBA     intracellular signal transduction GO:0035556 NAS     positive regulation of alpha-beta T cell differentiation GO:0046638 IEA     T cell receptor signaling pathway GO:0050852 TAS     B cell activation GO:0042113 TAS     negative thymic T cell selection GO:0045060 IEA     beta selection GO:0043366 IEA     positive regulation of T cell differentiation GO:0045582 IDA     peptidyl-tyrosine phosphorylation GO:0018108 IMP     T cell aggregation GO:0070489 TAS     cell differentiation GO:0030154 IBA     peptidyl-tyrosine autophosphorylation GO:0038083 IBA     protein phosphorylation GO:0006468 NAS     positive regulation of calcium-mediated signaling GO:0050850 IEA Subcellular Localization     cytoplasm GO:0005737 TAS     cytosol GO:0005829 TAS     extrinsic component of cytoplasmic side of plasma membrane GO:0031234 IBA     membrane raft GO:0045121 IDA     cell-cell junction GO:0005911 IEA     T cell receptor complex GO:0042101 IDA     plasma membrane GO:0005886 TAS     immunological synapse GO:0001772 IBA