Gene description for ERBB2
Gene name	erb-b2 receptor tyrosine kinase 2
Gene symbol	ERBB2
Other names/aliases	CD340 HER-2 HER-2/neu HER2 MLN 19 NEU NGL TKR1
Species	Homo sapiens
Database cross references - ERBB2
ExoCarta	ExoCarta_2064
Vesiclepedia	VP_2064
Entrez Gene	2064
HGNC	3430
MIM	164870
UniProt	P04626
ERBB2 identified in sEVs derived from the following tissue/cell type
Bone marrow mesenchymal stem cells	36408942
Bone marrow mesenchymal stem cells	36408942
Bone marrow mesenchymal stem cells	36408942
Bone marrow mesenchymal stem cells	36408942
Breast cancer cells	16302729
Colorectal cancer cells	23161513
Colorectal cancer cells	23161513
Colorectal cancer cells	23161513
Colorectal cancer cells	34887515
Endothelial cells	26027894
Gastric cancer cells	33991177
Gastric cancer cells	33991177
Gastric cancer cells	33991177
Malignant ascites	12147373
Ovarian cancer cells	23333927
Ovarian cancer cells	23333927
Retinal pigment epithelial cells	35333565
Retinal pigment epithelial cells	35333565
Squamous carcinoma cells	20124223

Gene ontology annotations for ERBB2

Molecular Function     RNA polymerase I core binding GO:0001042 IDA     protein tyrosine kinase activity GO:0004713 IDA     protein tyrosine kinase activity GO:0004713 TAS     transmembrane receptor protein tyrosine kinase activity GO:0004714 IBA     transmembrane receptor protein tyrosine kinase activity GO:0004714 IDA     transmembrane signaling receptor activity GO:0004888 IDA     GPI-linked ephrin receptor activity GO:0005004 IEA     transmembrane-ephrin receptor activity GO:0005005 IEA     epidermal growth factor receptor activity GO:0005006 IEA     fibroblast growth factor receptor activity GO:0005007 IEA     hepatocyte growth factor receptor activity GO:0005008 IEA     insulin receptor activity GO:0005009 IEA     insulin-like growth factor receptor activity GO:0005010 IEA     macrophage colony-stimulating factor receptor activity GO:0005011 IEA     platelet-derived growth factor alpha-receptor activity GO:0005018 IEA     platelet-derived growth factor beta-receptor activity GO:0005019 IEA     stem cell factor receptor activity GO:0005020 IEA     vascular endothelial growth factor receptor activity GO:0005021 IEA     signaling receptor binding GO:0005102 IPI     protein binding GO:0005515 IPI     ATP binding GO:0005524 IEA     boss receptor activity GO:0008288 IEA     coreceptor activity GO:0015026 ISS     growth factor binding GO:0019838 IDA     receptor tyrosine kinase binding GO:0030971 IPI     histone H3Y41 kinase activity GO:0035401 IEA     placental growth factor receptor activity GO:0036332 IEA     protein tyrosine kinase collagen receptor activity GO:0038062 IEA     identical protein binding GO:0042802 IPI     ErbB-3 class receptor binding GO:0043125 IPI     protein heterodimerization activity GO:0046982 IPI     brain-derived neurotrophic factor receptor activity GO:0060175 IEA     histone H2AXY142 kinase activity GO:0140801 IEA Biological Process     positive regulation of protein phosphorylation GO:0001934 ISS     chromatin remodeling GO:0006338 IEA     protein phosphorylation GO:0006468 TAS     signal transduction GO:0007165 IDA     cell surface receptor signaling pathway GO:0007166 IDA     enzyme-linked receptor protein signaling pathway GO:0007167 TAS     cell surface receptor protein tyrosine kinase signaling pathway GO:0007169 IBA     cell surface receptor protein tyrosine kinase signaling pathway GO:0007169 IDA     multicellular organism development GO:0007275 IBA     heart development GO:0007507 IEA     neuromuscular junction development GO:0007528 IEA     motor neuron axon guidance GO:0008045 IEA     cell population proliferation GO:0008283 IDA     positive regulation of cell population proliferation GO:0008284 IBA     insulin receptor signaling pathway GO:0008286 IEA     fibroblast growth factor receptor signaling pathway GO:0008543 IEA     Schwann cell development GO:0014044 IEA     peptidyl-tyrosine phosphorylation GO:0018108 IDA     neurogenesis GO:0022008 IBA     neuron differentiation GO:0030182 IBA     positive regulation of cell growth GO:0030307 IMP     brain-derived neurotrophic factor receptor signaling pathway GO:0031547 IEA     regulation of microtubule-based process GO:0032886 IDA     immature T cell proliferation in thymus GO:0033080 IEA     negative regulation of immature T cell proliferation in thymus GO:0033088 IEA     positive regulation of Rho protein signal transduction GO:0035025 ISS     intracellular signal transduction GO:0035556 IDA     platelet-derived growth factor receptor-alpha signaling pathway GO:0035790 IEA     platelet-derived growth factor receptor-beta signaling pathway GO:0035791 IEA     vascular endothelial growth factor receptor-1 signaling pathway GO:0036323 IEA     collagen-activated tyrosine kinase receptor signaling pathway GO:0038063 IEA     vascular endothelial growth factor signaling pathway GO:0038084 IEA     Kit signaling pathway GO:0038109 IEA     ERBB2-ERBB3 signaling pathway GO:0038133 IEA     ERBB2-EGFR signaling pathway GO:0038134 IDA     ERBB2-ERBB4 signaling pathway GO:0038135 IEA     macrophage colony-stimulating factor signaling pathway GO:0038145 IEA     wound healing GO:0042060 IDA     myelination GO:0042552 IEA     negative regulation of apoptotic process GO:0043066 IBA     positive regulation of MAP kinase activity GO:0043406 IDA     positive regulation of MAPK cascade GO:0043410 IBA     phosphatidylinositol 3-kinase/protein kinase B signal transduction GO:0043491 IDA     positive regulation of translation GO:0045727 IMP     regulation of angiogenesis GO:0045765 NAS     positive regulation of cell adhesion GO:0045785 IDA     positive regulation of transcription by RNA polymerase I GO:0045943 IMP     insulin-like growth factor receptor signaling pathway GO:0048009 IEA     hepatocyte growth factor receptor signaling pathway GO:0048012 IEA     ephrin receptor signaling pathway GO:0048013 IEA     oligodendrocyte differentiation GO:0048709 IEA     positive regulation of epithelial cell proliferation GO:0050679 IDA     regulation of ERK1 and ERK2 cascade GO:0070372 IMP     cellular response to growth factor stimulus GO:0071363 IDA     cellular response to epidermal growth factor stimulus GO:0071364 IMP     semaphorin-plexin signaling pathway GO:0071526 ISS     positive regulation of protein targeting to membrane GO:0090314 IDA     neurotransmitter receptor localization to postsynaptic specialization membrane GO:0099645 IEA Subcellular Localization     semaphorin receptor complex GO:0002116 ISS     nucleus GO:0005634 IDA     nucleoplasm GO:0005654 IDA     early endosome GO:0005769 IEA     cytosol GO:0005829 IDA     plasma membrane GO:0005886 IBA     plasma membrane GO:0005886 IDA     plasma membrane GO:0005886 NAS     plasma membrane GO:0005886 TAS     basal plasma membrane GO:0009925 IBA     endosome membrane GO:0010008 IDA     membrane GO:0016020 NAS     basolateral plasma membrane GO:0016323 IDA     apical plasma membrane GO:0016324 IEA     neuromuscular junction GO:0031594 IEA     ruffle membrane GO:0032587 IEA     ERBB3:ERBB2 complex GO:0038143 IDA     presynaptic membrane GO:0042734 IEA     myelin sheath GO:0043209 IEA     receptor complex GO:0043235 IBA     receptor complex GO:0043235 IDA     receptor complex GO:0043235 TAS     perinuclear region of cytoplasm GO:0048471 IEA