Gene description for CUL3
Gene name	cullin 3
Gene symbol	CUL3
Other names/aliases	CUL-3 PHA2E
Species	Homo sapiens
Database cross references - CUL3
ExoCarta	ExoCarta_8452
Entrez Gene	8452
HGNC	2553
MIM	603136
UniProt	Q13618
CUL3 identified in exosomes derived from the following tissue/cell type
Hepatocellular carcinoma cells	26054723
Neuroblastoma cells	25944692
Thymus	23844026
Urine	19056867

Gene ontology annotations for CUL3

Molecular Function     protein binding GO:0005515 IPI     cyclin binding GO:0030332 IEA     ubiquitin-protein transferase activity GO:0004842 IDA     POZ domain binding GO:0031208 IDA     ubiquitin protein ligase binding GO:0031625 IEA     ubiquitin protein ligase activity GO:0061630 IBA     protein homodimerization activity GO:0042803 IEA     protein heterodimerization activity GO:0046982 IEA Biological Process     stress fiber assembly GO:0043149 IMP     positive regulation of cytokinesis GO:0032467 IMP     protein monoubiquitination GO:0006513 IDA     G1/S transition of mitotic cell cycle GO:0000082 TAS     cell cycle arrest GO:0007050 TAS     mitotic metaphase plate congression GO:0007080 IMP     Wnt signaling pathway GO:0016055 IEA     ER to Golgi vesicle-mediated transport GO:0006888 IDA     COPII vesicle coating GO:0048208 IMP     embryonic cleavage GO:0040016 ISS     positive regulation of cell proliferation GO:0008284 TAS     trophectodermal cellular morphogenesis GO:0001831 IEA     negative regulation of canonical Wnt signaling pathway GO:0090090 TAS     intrinsic apoptotic signaling pathway GO:0097193 TAS     stem cell division GO:0017145 ISS     positive regulation of mitotic metaphase/anaphase transition GO:0045842 IMP     protein ubiquitination involved in ubiquitin-dependent protein catabolic process GO:0042787 IBA     protein ubiquitination GO:0016567 IDA     negative regulation of cyclin-dependent protein serine/threonine kinase by cyclin degradation GO:0008054 IDA     proteasome-mediated ubiquitin-dependent protein catabolic process GO:0043161 IDA     integrin-mediated signaling pathway GO:0007229 ISS     negative regulation of Rho protein signal transduction GO:0035024 IMP     cell migration GO:0016477 IMP     gastrulation GO:0007369 IEA     protein polyubiquitination GO:0000209 IDA Subcellular Localization     cytosol GO:0005829 TAS     membrane GO:0016020 IDA     Cul3-RING ubiquitin ligase complex GO:0031463 IDA     extracellular exosome GO:0070062 IDA     nucleoplasm GO:0005654 TAS     polar microtubule GO:0005827 IDA     Golgi membrane GO:0000139 IMP