Gene description for RBX1
Gene name ring-box 1, E3 ubiquitin protein ligase
Gene symbol RBX1
Other names/aliases BA554C12.1
RNF75
ROC1
Species Homo sapiens
 Database cross references - RBX1
ExoCarta ExoCarta_9978
Vesiclepedia VP_9978
Entrez Gene 9978
HGNC 9928
MIM 603814
UniProt P62877  
 RBX1 identified in sEVs derived from the following tissue/cell type
Breast cancer cells 34108659    
Breast cancer cells 34108659    
Embryonic kidney cells 34108659    
Embryonic kidney cells 34108659    
Gastric cancer cells 33991177    
Gastric cancer cells 33991177    
Gastric cancer cells 33991177    
Pancreatic cancer cells 34108659    
Pancreatic cancer cells 34108659    
Thymus 23844026    
 Gene ontology annotations for RBX1
Molecular Function
    ubiquitin-protein transferase activity GO:0004842 IDA
    protein binding GO:0005515 IPI
    zinc ion binding GO:0008270 IEA
    NEDD8 transferase activity GO:0019788 TAS
    ubiquitin protein ligase binding GO:0031625 IDA
    ubiquitin-ubiquitin ligase activity GO:0034450 IDA
    molecular adaptor activity GO:0060090 EXP
    RNA polymerase II-specific DNA-binding transcription factor binding GO:0061629 IPI
    ubiquitin protein ligase activity GO:0061630 IBA
    ubiquitin protein ligase activity GO:0061630 IDA
    ubiquitin protein ligase activity GO:0061630 TAS
    NEDD8 ligase activity GO:0061663 IDA
    cullin family protein binding GO:0097602 IBA
    cullin family protein binding GO:0097602 IDA
    cullin family protein binding GO:0097602 IPI
Biological Process
    MAPK cascade GO:0000165 TAS
    protein polyubiquitination GO:0000209 IDA
    DNA repair GO:0006281 IEA
    ubiquitin-dependent protein catabolic process GO:0006511 IBA
    ubiquitin-dependent protein catabolic process GO:0006511 IDA
    protein monoubiquitination GO:0006513 IDA
    DNA damage response GO:0006974 EXP
    DNA damage response GO:0006974 ISS
    spermatogenesis GO:0007283 IDA
    protein ubiquitination GO:0016567 IBA
    protein ubiquitination GO:0016567 IDA
    protein ubiquitination GO:0016567 IPI
    SCF-dependent proteasomal ubiquitin-dependent protein catabolic process GO:0031146 IDA
    SCF-dependent proteasomal ubiquitin-dependent protein catabolic process GO:0031146 ISS
    positive regulation of proteasomal ubiquitin-dependent protein catabolic process GO:0032436 IPI
    negative regulation of type I interferon production GO:0032480 IDA
    cellular response to oxidative stress GO:0034599 IDA
    cellular response to UV GO:0034644 EXP
    cellular response to UV GO:0034644 ISS
    T cell activation GO:0042110 IDA
    positive regulation of canonical NF-kappaB signal transduction GO:0043123 IDA
    proteasome-mediated ubiquitin-dependent protein catabolic process GO:0043161 IC
    proteasome-mediated ubiquitin-dependent protein catabolic process GO:0043161 IDA
    post-translational protein modification GO:0043687 TAS
    protein neddylation GO:0045116 IDA
    positive regulation of protein catabolic process GO:0045732 IDA
    cellular response to chemical stress GO:0062197 TAS
    protein K48-linked ubiquitination GO:0070936 IC
    protein K48-linked ubiquitination GO:0070936 IDA
    cellular response to amino acid stimulus GO:0071230 IDA
    negative regulation of canonical Wnt signaling pathway GO:0090090 TAS
    ubiquitin-dependent protein catabolic process via the C-end degron rule pathway GO:0140627 IDA
    regulation of cellular response to insulin stimulus GO:1900076 IC
    positive regulation of protein autoubiquitination GO:1902499 IMP
    negative regulation of response to oxidative stress GO:1902883 IDA
    positive regulation of TORC1 signaling GO:1904263 IDA
Subcellular Localization
    nucleus GO:0005634 IBA
    nucleus GO:0005634 IC
    nucleus GO:0005634 IDA
    nucleus GO:0005634 NAS
    nucleoplasm GO:0005654 IDA
    nucleoplasm GO:0005654 TAS
    cytoplasm GO:0005737 IC
    cytoplasm GO:0005737 IDA
    cytosol GO:0005829 ISS
    cytosol GO:0005829 TAS
    SCF ubiquitin ligase complex GO:0019005 IDA
    SCF ubiquitin ligase complex GO:0019005 ISS
    cullin-RING ubiquitin ligase complex GO:0031461 IBA
    cullin-RING ubiquitin ligase complex GO:0031461 IDA
    Cul2-RING ubiquitin ligase complex GO:0031462 IDA
    Cul3-RING ubiquitin ligase complex GO:0031463 IDA
    Cul4A-RING E3 ubiquitin ligase complex GO:0031464 EXP
    Cul4A-RING E3 ubiquitin ligase complex GO:0031464 IDA
    Cul4B-RING E3 ubiquitin ligase complex GO:0031465 IDA
    Cul5-RING ubiquitin ligase complex GO:0031466 IDA
    Cul7-RING ubiquitin ligase complex GO:0031467 IDA
 Experiment description of studies that identified RBX1 in sEVs
1
Experiment ID 426
MISEV standards
✘ Biophysical techniques
✔
SDCBP|FLOT1|CD81|CD9|CD151|FLOT2|TSG101|LAMP1|TFRC|RAB5A|RAB35|GAPDH|UCHL1|ICAM1
Enriched markers
✔
CANX
Negative markers
✘ Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 34108659    
Organism Homo sapiens
Experiment description Quantitative Proteomics Identifies the Core Proteome of Exosomes with Syntenin-1 as the highest abundant protein and a Putative Universal Biomarker
Authors "Kugeratski FG, Hodge K, Lilla S, McAndrews KM, Zhou X, Hwang RF, Zanivan S, Kalluri R."
Journal name Nat Cell Biol
Publication year 2021
Sample Breast cancer cells
Sample name MDA-MB-231 - Exo-rich fractions 7-10 pooled
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Size exclusion chromatography
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
2
Experiment ID 427
MISEV standards
✘ Biophysical techniques
✔
CD81|SDCBP|FLOT1|CD9|CD151|FLOT2|TSG101|LAMP1|TFRC|RAB5A|RAB35|GAPDH|UCHL1|ICAM1
Enriched markers
✔
CANX
Negative markers
✘ Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 34108659    
Organism Homo sapiens
Experiment description Quantitative Proteomics Identifies the Core Proteome of Exosomes with Syntenin-1 as the highest abundant protein and a Putative Universal Biomarker
Authors "Kugeratski FG, Hodge K, Lilla S, McAndrews KM, Zhou X, Hwang RF, Zanivan S, Kalluri R."
Journal name Nat Cell Biol
Publication year 2021
Sample Breast cancer cells
Sample name MDA-MB-231 - Exo-rich fractions 1-6 pooled
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
OptiPrep density gradient centrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
3
Experiment ID 419
MISEV standards
✘ Biophysical techniques
✔
SDCBP|FLOT1|CD81|CD9|CD151|FLOT2|TSG101|LAMP1|TFRC|RAB5A|RAB35|GAPDH|UCHL1|ICAM1
Enriched markers
✔
CANX
Negative markers
✘ Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 34108659    
Organism Homo sapiens
Experiment description Quantitative Proteomics Identifies the Core Proteome of Exosomes with Syntenin-1 as the highest abundant protein and a Putative Universal Biomarker
Authors "Kugeratski FG, Hodge K, Lilla S, McAndrews KM, Zhou X, Hwang RF, Zanivan S, Kalluri R."
Journal name Nat Cell Biol
Publication year 2021
Sample Embryonic kidney cells
Sample name HEK293T - Exo-rich fractions 7-10 pooled
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Size exclusion chromatography
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
4
Experiment ID 419
MISEV standards
✘ Biophysical techniques
✔
SDCBP|FLOT1|CD81|CD9|CD151|FLOT2|TSG101|LAMP1|TFRC|RAB5A|RAB35|GAPDH|UCHL1|ICAM1
Enriched markers
✔
CANX
Negative markers
✘ Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 34108659    
Organism Homo sapiens
Experiment description Quantitative Proteomics Identifies the Core Proteome of Exosomes with Syntenin-1 as the highest abundant protein and a Putative Universal Biomarker
Authors "Kugeratski FG, Hodge K, Lilla S, McAndrews KM, Zhou X, Hwang RF, Zanivan S, Kalluri R."
Journal name Nat Cell Biol
Publication year 2021
Sample Embryonic kidney cells
Sample name HEK293T - Exo-rich fractions 7-10 pooled
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Size exclusion chromatography
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
5
Experiment ID 420
MISEV standards
✘ Biophysical techniques
✔
CD81|SDCBP|FLOT1|CD9|CD151|FLOT2|TSG101|LAMP1|TFRC|RAB5A|RAB35|GAPDH|UCHL1|ICAM1
Enriched markers
✔
CANX
Negative markers
✘ Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 34108659    
Organism Homo sapiens
Experiment description Quantitative Proteomics Identifies the Core Proteome of Exosomes with Syntenin-1 as the highest abundant protein and a Putative Universal Biomarker
Authors "Kugeratski FG, Hodge K, Lilla S, McAndrews KM, Zhou X, Hwang RF, Zanivan S, Kalluri R."
Journal name Nat Cell Biol
Publication year 2021
Sample Embryonic kidney cells
Sample name HEK293T - Exo-rich fractions 1-6 pooled
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
OptiPrep density gradient centrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
6
Experiment ID 420
MISEV standards
✘ Biophysical techniques
✔
CD81|SDCBP|FLOT1|CD9|CD151|FLOT2|TSG101|LAMP1|TFRC|RAB5A|RAB35|GAPDH|UCHL1|ICAM1
Enriched markers
✔
CANX
Negative markers
✘ Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 34108659    
Organism Homo sapiens
Experiment description Quantitative Proteomics Identifies the Core Proteome of Exosomes with Syntenin-1 as the highest abundant protein and a Putative Universal Biomarker
Authors "Kugeratski FG, Hodge K, Lilla S, McAndrews KM, Zhou X, Hwang RF, Zanivan S, Kalluri R."
Journal name Nat Cell Biol
Publication year 2021
Sample Embryonic kidney cells
Sample name HEK293T - Exo-rich fractions 1-6 pooled
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
OptiPrep density gradient centrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
7
Experiment ID 363
MISEV standards
✘ Biophysical techniques
✔
TSG101|GAPDH|AQP1|CD151|CD81|CD82|CD9|EPCAM|FLOT1|FLOT2|ICAM1|ITGA2B|LAMP2|RAB35|RAB5A|RAB5B|SDCBP|TFRC|UCHL1
Enriched markers
✔
DCLK1
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 33991177    
Organism Homo sapiens
Experiment description Cancer stem cell marker DCLK1 reprograms small extracellular vesicles toward migratory phenotype in gastric cancer cells
Authors "Carli ALE, Afshar-Sterle S, Rai A, Fang H, O'Keefe R, Tse J, Ferguson FM, Gray NS, Ernst M, Greening DW, Buchert M."
Journal name Proteomics
Publication year 2021
Sample Gastric cancer cells
Sample name MKN1 - 100K pellet
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
8
Experiment ID 364
MISEV standards
✘ Biophysical techniques
✔
TSG101|GAPDH|AQP1|CD151|CD81|CD82|CD9|EPCAM|FLOT1|FLOT2|ICAM1|ITGA2B|LAMP2|RAB35|RAB5A|RAB5B|SDCBP|TFRC|UCHL1
Enriched markers
✔
DCLK1
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 33991177    
Organism Homo sapiens
Experiment description Cancer stem cell marker DCLK1 reprograms small extracellular vesicles toward migratory phenotype in gastric cancer cells
Authors "Carli ALE, Afshar-Sterle S, Rai A, Fang H, O'Keefe R, Tse J, Ferguson FM, Gray NS, Ernst M, Greening DW, Buchert M."
Journal name Proteomics
Publication year 2021
Sample Gastric cancer cells
Sample name MKN1 - 100K pellet
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
9
Experiment ID 365
MISEV standards
✘ Biophysical techniques
✔
TSG101|GAPDH|AQP1|CD151|CD81|CD82|CD9|EPCAM|FLOT1|FLOT2|ICAM1|ITGA2B|LAMP2|RAB35|RAB5A|RAB5B|SDCBP|TFRC|UCHL1
Enriched markers
✔
DCLK1
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 33991177    
Organism Homo sapiens
Experiment description Cancer stem cell marker DCLK1 reprograms small extracellular vesicles toward migratory phenotype in gastric cancer cells
Authors "Carli ALE, Afshar-Sterle S, Rai A, Fang H, O'Keefe R, Tse J, Ferguson FM, Gray NS, Ernst M, Greening DW, Buchert M."
Journal name Proteomics
Publication year 2021
Sample Gastric cancer cells
Sample name MKN1 - 100K pellet
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
10
Experiment ID 434
MISEV standards
✘ Biophysical techniques
✔
SDCBP|FLOT1|CD81|CD9|CD151|FLOT2|TSG101|LAMP1|TFRC|RAB5A|RAB35|GAPDH|UCHL1|ICAM1
Enriched markers
✔
CANX
Negative markers
✘ Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 34108659    
Organism Homo sapiens
Experiment description Quantitative Proteomics Identifies the Core Proteome of Exosomes with Syntenin-1 as the highest abundant protein and a Putative Universal Biomarker
Authors "Kugeratski FG, Hodge K, Lilla S, McAndrews KM, Zhou X, Hwang RF, Zanivan S, Kalluri R."
Journal name Nat Cell Biol
Publication year 2021
Sample Pancreatic cancer cells
Sample name PANC-1 - Exo-rich fractions 7-10 pooled
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Size exclusion chromatography
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
11
Experiment ID 435
MISEV standards
✘ Biophysical techniques
✔
CD81|SDCBP|FLOT1|CD9|CD151|FLOT2|TSG101|LAMP1|TFRC|RAB5A|RAB35|GAPDH|UCHL1|ICAM1
Enriched markers
✔
CANX
Negative markers
✘ Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 34108659    
Organism Homo sapiens
Experiment description Quantitative Proteomics Identifies the Core Proteome of Exosomes with Syntenin-1 as the highest abundant protein and a Putative Universal Biomarker
Authors "Kugeratski FG, Hodge K, Lilla S, McAndrews KM, Zhou X, Hwang RF, Zanivan S, Kalluri R."
Journal name Nat Cell Biol
Publication year 2021
Sample Pancreatic cancer cells
Sample name PANC-1 - Exo-rich fractions 1-6 pooled
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
OptiPrep density gradient centrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
12
Experiment ID 217
MISEV standards
✔
EM
Biophysical techniques
✔
TSG101|CD81|CD9|CD63
Enriched markers
✘ Negative markers
✔
NTA
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23844026    
Organism Homo sapiens
Experiment description Characterization of human thymic exosomes.
Authors "Skogberg G, Gudmundsdottir J, van der Post S, Sandstrom K, Bruhn S, Benson M, Mincheva-Nilsson L, Baranov V, Telemo E, Ekwall O."
Journal name PLoS One
Publication year 2013
Sample Thymus
Sample name Normal-Thymus
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for RBX1
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 CRBN  
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
2 PSMA6 5687
Affinity Capture-Western Homo sapiens
3 RIT1 6016
Negative Genetic Homo sapiens
4 CDC34 997
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
5 HNRNPH1 3187
Co-fractionation Homo sapiens
6 Cul1 26965
Affinity Capture-MS Mus musculus
7 Atrx  
Affinity Capture-MS Mus musculus
8 HDAC2 3066
Affinity Capture-Western Homo sapiens
9 MYO5B 4645
Affinity Capture-MS Homo sapiens
10 TCEB1 6921
Affinity Capture-Western Homo sapiens
11 CBFB 865
Affinity Capture-MS Homo sapiens
12 STAT2 6773
Affinity Capture-Western Homo sapiens
13 FBXO7 25793
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
14 FBXO4 26272
Affinity Capture-MS Homo sapiens
15 OS9 10956
Two-hybrid Homo sapiens
16 KCTD10 83892
Affinity Capture-MS Homo sapiens
17 UTP11L  
Affinity Capture-MS Homo sapiens
18 UBE2M 9040
Reconstituted Complex Homo sapiens
Two-hybrid Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Biochemical Activity Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
19 VPRBP 9730
Reconstituted Complex Homo sapiens
20 FBXO25  
Affinity Capture-Western Homo sapiens
21 MKNK2 2872
Two-hybrid Homo sapiens
22 MAP4 4134
Co-fractionation Homo sapiens
23 CORO7 79585
Affinity Capture-Western Homo sapiens
24 TAB1 10454
Two-hybrid Homo sapiens
25 HSPB1 3315
Two-hybrid Homo sapiens
Co-fractionation Homo sapiens
26 VHL  
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Co-purification Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
27 CAND1 55832
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
28 FBXO42  
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
29 SESN1  
Affinity Capture-Western Homo sapiens
30 WDTC1 23038
Affinity Capture-Western Homo sapiens
31 BTBD9  
Affinity Capture-MS Homo sapiens
32 UBE2G2  
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
33 UBE2D4  
Reconstituted Complex Homo sapiens
34 CAPZB 832
Affinity Capture-MS Homo sapiens
35 ING3  
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
36 CASP1  
Affinity Capture-Western Homo sapiens
37 HOXB4  
Affinity Capture-Western Homo sapiens
38 PTGS2 5743
Affinity Capture-Western Homo sapiens
39 LRRC14 9684
Affinity Capture-MS Homo sapiens
40 UBE2E2  
Reconstituted Complex Homo sapiens
41 GFPT1 2673
Co-fractionation Homo sapiens
42 KLHL24  
Affinity Capture-MS Homo sapiens
43 CASP3 836
Affinity Capture-Western Homo sapiens
44 TBL1XR1 79718
Affinity Capture-Western Homo sapiens
45 COPS6 10980
Affinity Capture-MS Homo sapiens
46 RAB40C 57799
Affinity Capture-MS Homo sapiens
47 Dtl  
Affinity Capture-MS Mus musculus
48 KLHDC10 23008
Affinity Capture-MS Homo sapiens
49 COPS5 10987
Affinity Capture-MS Homo sapiens
50 FBXW7  
Co-purification Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
51 FBXO17 115290
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
52 RHOB 388
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
53 VRK2 7444
Reconstituted Complex Homo sapiens
54 FEM1B 10116
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
55 FBXW8 26259
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
56 SERTAD1  
Two-hybrid Homo sapiens
57 OBSL1 23363
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
58 FBXO18 84893
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
59 CUL4A 8451
Affinity Capture-Western Homo sapiens
Two-hybrid Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Co-fractionation Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Co-fractionation Homo sapiens
Co-purification Homo sapiens
Reconstituted Complex Homo sapiens
Co-purification Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Two-hybrid Homo sapiens
Affinity Capture-Western Homo sapiens
Biochemical Activity Homo sapiens
Biochemical Activity Homo sapiens
Biochemical Activity Homo sapiens
Affinity Capture-MS Homo sapiens
60 AHCY 191
Co-fractionation Homo sapiens
61 FBXO11  
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
62 DEDD  
Affinity Capture-MS Homo sapiens
63 LRR1  
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
64 KBTBD7  
Affinity Capture-MS Homo sapiens
65 PHF1  
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
66 CUL1 8454
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Co-crystal Structure Homo sapiens
Two-hybrid Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Co-fractionation Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Co-crystal Structure Homo sapiens
Co-fractionation Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Two-hybrid Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Biochemical Activity Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Biochemical Activity Homo sapiens
Biochemical Activity Homo sapiens
Affinity Capture-Western Homo sapiens
Biochemical Activity Homo sapiens
Biochemical Activity Homo sapiens
Biochemical Activity Homo sapiens
Affinity Capture-Western Homo sapiens
Biochemical Activity Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
67 BTRC 8945
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
68 ARIH2 10425
Co-fractionation Homo sapiens
69 GPS1 2873
Affinity Capture-Western Homo sapiens
70 SERBP1 26135
Affinity Capture-MS Homo sapiens
71 PLS3 5358
Co-fractionation Homo sapiens
72 NEDD4 4734
Affinity Capture-Western Homo sapiens
73 KLHL41 10324
Affinity Capture-Western Homo sapiens
74 EEF1A1 1915
Affinity Capture-Western Homo sapiens
75 UVRAG  
Affinity Capture-Western Homo sapiens
76 MAT2A 4144
Co-fractionation Homo sapiens
77 MAPK8IP2  
Two-hybrid Homo sapiens
78 CDKN1B 1027
Co-fractionation Homo sapiens
Biochemical Activity Homo sapiens
79 KLHDC2  
Biochemical Activity Homo sapiens
80 FBXL5  
Affinity Capture-Western Homo sapiens
Co-purification Homo sapiens
81 MYO5C 55930
Affinity Capture-MS Homo sapiens
82 KIAA1715 80856
Affinity Capture-MS Homo sapiens
83 GARS 2617
Co-fractionation Homo sapiens
84 FBXO32  
Affinity Capture-Western Homo sapiens
85 UBE2E3 10477
Reconstituted Complex Homo sapiens
86 Lrr1  
Affinity Capture-MS Mus musculus
87 DIO2  
Affinity Capture-Western Homo sapiens
88 S100A2 6273
Co-fractionation Homo sapiens
89 GSTM3 2947
Co-fractionation Homo sapiens
90 MIB1 57534
Proximity Label-MS Homo sapiens
91 HIST1H4A 8359
Co-fractionation Homo sapiens
Affinity Capture-MS Homo sapiens
92 RBX1 9978
Biochemical Activity Homo sapiens
Biochemical Activity Homo sapiens
93 CUL3 8452
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Biochemical Activity Homo sapiens
Affinity Capture-Western Homo sapiens
Biochemical Activity Homo sapiens
94 KLHL3  
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
95 CUL4B 8450
Co-fractionation Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Two-hybrid Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-MS Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-MS Homo sapiens
Biochemical Activity Homo sapiens
Affinity Capture-MS Homo sapiens
Reconstituted Complex Homo sapiens
96 PGAM5 192111
Affinity Capture-Western Homo sapiens
97 CCNF  
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
98 RAI14 26064
Affinity Capture-MS Homo sapiens
99 TUFM 7284
Co-fractionation Homo sapiens
100 DCUN1D5 84259
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
101 MCM10 55388
Affinity Capture-Western Homo sapiens
102 RPS6KB1 6198
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
103 RAG1  
Affinity Capture-Western Homo sapiens
104 ZEB2  
Affinity Capture-Western Homo sapiens
105 Srp72  
Affinity Capture-MS Mus musculus
106 TUBA1B 10376
Affinity Capture-MS Homo sapiens
107 CNOT1 23019
Co-fractionation Homo sapiens
108 PMAIP1  
Affinity Capture-MS Homo sapiens
109 SERPINC1 462
Affinity Capture-Western Homo sapiens
110 TRIM21 6737
Co-fractionation Homo sapiens
111 UBE2L3 7332
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
112 SMAD3 4088
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Two-hybrid Homo sapiens
113 MTA1 9112
Affinity Capture-Western Homo sapiens
114 CCND1 595
Affinity Capture-Western Homo sapiens
115 FLNB 2317
Co-fractionation Homo sapiens
116 HIST1H1C 3006
Affinity Capture-MS Homo sapiens
Reconstituted Complex Homo sapiens
117 IP6K1 9807
Affinity Capture-Western Homo sapiens
118 CSNK1E 1454
Two-hybrid Homo sapiens
119 COPS3 8533
Affinity Capture-MS Homo sapiens
120 UBE2D3 7323
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
121 GATA2  
Affinity Capture-Western Homo sapiens
122 CUL2 8453
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Co-fractionation Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Two-hybrid Homo sapiens
Affinity Capture-MS Homo sapiens
Biochemical Activity Homo sapiens
Biochemical Activity Homo sapiens
Biochemical Activity Homo sapiens
Affinity Capture-Western Homo sapiens
Biochemical Activity Homo sapiens
Affinity Capture-MS Homo sapiens
123 MBD3 53615
Affinity Capture-Western Homo sapiens
124 KCTD3  
Affinity Capture-MS Homo sapiens
125 UBE2D1 7321
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Protein-RNA Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
126 ACTG1 71
Affinity Capture-MS Homo sapiens
127 ENC1  
Affinity Capture-Western Homo sapiens
128 FBXO31 79791
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
129 MYH9 4627
Affinity Capture-MS Homo sapiens
130 LRCH3 84859
Affinity Capture-MS Homo sapiens
131 MAP4K1  
Affinity Capture-Western Homo sapiens
132 PEX6  
Affinity Capture-MS Homo sapiens
133 Rps6kb1  
Two-hybrid Rattus norvegicus
134 Brwd3  
Affinity Capture-MS Mus musculus
135 PABPC1 26986
Co-fractionation Homo sapiens
136 CGGBP1 8545
Affinity Capture-MS Homo sapiens
137 FBXL8 55336
Affinity Capture-Western Homo sapiens
138 GAN 8139
Affinity Capture-Western Homo sapiens
139 DTL  
Affinity Capture-MS Homo sapiens
140 ZAK 51776
Two-hybrid Homo sapiens
141 COPS7A 50813
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
142 FANCD2  
Affinity Capture-MS Homo sapiens
143 ERCC8  
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
144 KBTBD6  
Affinity Capture-MS Homo sapiens
145 KRT18 3875
Co-fractionation Homo sapiens
146 AMBRA1  
Affinity Capture-MS Homo sapiens
147 GLMN 11146
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
FRET Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-MS Homo sapiens
148 DOCK7 85440
Affinity Capture-MS Homo sapiens
149 UBXN7 26043
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
150 ERBB2IP 55914
Biochemical Activity Homo sapiens
151 FAM172A  
Affinity Capture-MS Homo sapiens
152 BTD 686
Co-fractionation Homo sapiens
153 FBXL15  
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
154 MYH14 79784
Affinity Capture-MS Homo sapiens
155 Cul3  
Affinity Capture-MS Mus musculus
156 KLHL18  
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
157 ASB6 140459
Affinity Capture-MS Homo sapiens
158 SNX18 112574
Affinity Capture-MS Homo sapiens
159 SKP2  
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
160 RICTOR 253260
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
161 DCAF13 25879
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
162 DDB2  
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-MS Homo sapiens
163 PSMA2 5683
Affinity Capture-MS Homo sapiens
164 EGFR 1956
Negative Genetic Homo sapiens
165 ZC3HC1  
Affinity Capture-Western Homo sapiens
166 DCUN1D2 55208
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
167 FRZB  
Two-hybrid Homo sapiens
168 FBXO6 26270
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
169 MYO5A 4644
Affinity Capture-MS Homo sapiens
170 MAP3K7  
Two-hybrid Homo sapiens
171 RIPK4  
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
172 UBE2R2 54926
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
173 FBXL12 54850
Affinity Capture-Western Homo sapiens
174 MTSS1 9788
Affinity Capture-Western Homo sapiens
175 MAGEC2  
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Co-localization Homo sapiens
176 ARID1B 57492
Affinity Capture-Western Homo sapiens
177 CDK2 1017
Co-fractionation Homo sapiens
178 UBE2D2 7322
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Biochemical Activity Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
179 CUL9  
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
180 ABTB2 25841
Affinity Capture-Western Homo sapiens
181 DCUN1D1 54165
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
182 EIF4E 1977
Co-fractionation Homo sapiens
183 LDLR 3949
Positive Genetic Homo sapiens
184 NLRP3  
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
185 FBXO2 26232
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
186 FBXO27  
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
187 CREB3L3  
Affinity Capture-Western Homo sapiens
188 Ddb1 13194
Affinity Capture-MS Mus musculus
189 SHKBP1  
Affinity Capture-MS Homo sapiens
190 TRIM27  
Two-hybrid Homo sapiens
191 HSPA1A 3303
Co-fractionation Homo sapiens
Affinity Capture-MS Homo sapiens
192 TBL1X 6907
Affinity Capture-Western Homo sapiens
193 HIST1H1A 3024
Affinity Capture-MS Homo sapiens
194 TCEB2 6923
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
195 DDB1 1642
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Co-crystal Structure Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Reconstituted Complex Homo sapiens
196 GHR  
Protein-peptide Homo sapiens
197 MFN2 9927
Cross-Linking-MS (XL-MS) Homo sapiens
198 DCUN1D3 123879
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
199 HAX1  
Two-hybrid Homo sapiens
200 CFLAR  
Protein-peptide Homo sapiens
201 MPRIP 23164
Affinity Capture-MS Homo sapiens
202 DET1  
Affinity Capture-Western Homo sapiens
203 HSPA9 3313
Co-fractionation Homo sapiens
204 PML 5371
Affinity Capture-Western Homo sapiens
Biochemical Activity Homo sapiens
205 MYB  
Reconstituted Complex Homo sapiens
206 HINT1 3094
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
207 POLR2A 5430
Affinity Capture-Western Homo sapiens
Co-fractionation Homo sapiens
208 C9orf72  
Affinity Capture-MS Homo sapiens
209 SIRT1  
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
210 CCDC8  
Affinity Capture-MS Homo sapiens
211 MYH11 4629
Affinity Capture-MS Homo sapiens
212 DSP 1832
Co-fractionation Homo sapiens
213 HIF1A 3091
Affinity Capture-Western Homo sapiens
214 APP 351
Reconstituted Complex Homo sapiens
215 DAB2IP 153090
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
216 Cbx1  
Affinity Capture-MS Mus musculus
217 DHX15 1665
Co-fractionation Homo sapiens
218 GRK5 2869
Affinity Capture-Western Homo sapiens
219 FBXW2  
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
220 ASB3 51130
Affinity Capture-MS Homo sapiens
221 FBXL6  
Affinity Capture-MS Homo sapiens
222 FBXW11  
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
223 CCND2  
Affinity Capture-Western Homo sapiens
224 SNAI1  
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
225 RHOBTB3 22836
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
226 TP53 7157
Affinity Capture-MS Homo sapiens
Co-fractionation Homo sapiens
227 KCTD18  
Affinity Capture-MS Homo sapiens
228 HSPA8 3312
Affinity Capture-MS Homo sapiens
229 KLHL8  
Affinity Capture-MS Homo sapiens
230 RFWD2  
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
231 TNFAIP1 7126
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
232 KLHDC3  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
233 FBXO21  
Affinity Capture-MS Homo sapiens
234 KEAP1 9817
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
235 CUL5 8065
Co-crystal Structure Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Two-hybrid Homo sapiens
Affinity Capture-Western Homo sapiens
Biochemical Activity Homo sapiens
Affinity Capture-Western Homo sapiens
236 SKP1 6500
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
237 MED8  
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
238 SAMHD1 25939
Affinity Capture-Western Homo sapiens
239 UBE2L6 9246
Reconstituted Complex Homo sapiens
240 SESN2 83667
Affinity Capture-Western Homo sapiens
241 ELAVL1 1994
Affinity Capture-RNA Homo sapiens
242 DCAF11  
Affinity Capture-MS Homo sapiens
243 HDAC1 3065
Affinity Capture-Western Homo sapiens
244 CCNK  
Reconstituted Complex Homo sapiens
245 FBXO44  
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
246 KLHL7  
Affinity Capture-Western Homo sapiens
247 DDX58 23586
Affinity Capture-RNA Homo sapiens
248 MTA3 57504
Affinity Capture-Western Homo sapiens
249 MTA2 9219
Affinity Capture-Western Homo sapiens
250 RNF126  
Two-hybrid Homo sapiens
251 ESR1  
Affinity Capture-Western Homo sapiens
252 KLHL42  
Affinity Capture-MS Homo sapiens
253 PRAME  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Reconstituted Complex Homo sapiens
254 TNFRSF10B 8795
Affinity Capture-Western Homo sapiens
255 HDAC3 8841
Affinity Capture-Western Homo sapiens
256 FBXO30 84085
Affinity Capture-MS Homo sapiens
257 EZH2  
Affinity Capture-MS Homo sapiens
258 AIRE  
Affinity Capture-Western Homo sapiens
259 FBXO9 26268
Affinity Capture-MS Homo sapiens
260 DDA1  
Affinity Capture-MS Homo sapiens
261 TRPC4AP  
Affinity Capture-Western Homo sapiens
262 FBXL18 80028
Affinity Capture-MS Homo sapiens
263 TRIM74  
Two-hybrid Homo sapiens
264 KCTD17 79734
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
265 DCUN1D4  
Affinity Capture-MS Homo sapiens
266 FBXO22 26263
Affinity Capture-MS Homo sapiens
267 CUL7 9820
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
268 KRAS 3845
Negative Genetic Homo sapiens
269 KDM2B 84678
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
270 COPS4 51138
Affinity Capture-MS Homo sapiens
271 UBE2G1 7326
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
272 FBXO38 81545
Affinity Capture-MS Homo sapiens
273 FBXO3  
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
274 PRPF38A 84950
Affinity Capture-MS Homo sapiens
275 ASB7  
Affinity Capture-MS Homo sapiens
276 NEDD8 4738
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
277 Cul4a  
Affinity Capture-MS Mus musculus
278 ARIH1 25820
Affinity Capture-MS Homo sapiens
279 PSMD3 5709
Co-fractionation Homo sapiens
280 CCND3  
Affinity Capture-Western Homo sapiens
View the network image/svg+xml
 Pathways in which RBX1 is involved
PathwayEvidenceSource
Adaptive Immune System TAS Reactome
Antigen processing: Ubiquitination & Proteasome degradation TAS Reactome
Axon guidance IEA Reactome
Cell Cycle TAS Reactome
Cell Cycle, Mitotic TAS Reactome
Cellular response to chemical stress TAS Reactome
Cellular response to hypoxia TAS Reactome
Cellular response to hypoxia IEA Reactome
Cellular responses to stimuli TAS Reactome
Cellular responses to stimuli IEA Reactome
Cellular responses to stress TAS Reactome
Cellular responses to stress IEA Reactome
Class I MHC mediated antigen processing & presentation TAS Reactome
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants TAS Reactome
Constitutive Signaling by NOTCH1 PEST Domain Mutants TAS Reactome
Cytokine Signaling in Immune system TAS Reactome
Degradation of beta-catenin by the destruction complex TAS Reactome
Degradation of DVL TAS Reactome
Degradation of GLI1 by the proteasome TAS Reactome
Degradation of GLI2 by the proteasome IEA Reactome
Developmental Biology IEA Reactome
Disease TAS Reactome
Diseases of signal transduction by growth factor receptors and second messengers TAS Reactome
DNA Damage Bypass TAS Reactome
DNA Damage Recognition in GG-NER TAS Reactome
DNA Repair TAS Reactome
DNA Replication TAS Reactome
Dual Incision in GG-NER TAS Reactome
Dual incision in TC-NER TAS Reactome
Evasion by RSV of host interferon responses TAS Reactome
FBXL7 down-regulates AURKA during mitotic entry and in early mitosis TAS Reactome
FBXW7 Mutants and NOTCH1 in Cancer TAS Reactome
Formation of Incision Complex in GG-NER TAS Reactome
Formation of TC-NER Pre-Incision Complex TAS Reactome
G2/M Transition TAS Reactome
Gap-filling DNA repair synthesis and ligation in TC-NER TAS Reactome
Gene expression (Transcription) TAS Reactome
Generic Transcription Pathway TAS Reactome
GLI3 is processed to GLI3R by the proteasome TAS Reactome
Global Genome Nucleotide Excision Repair (GG-NER) TAS Reactome
GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2 TAS Reactome
Hedgehog 'off' state TAS Reactome
Hedgehog 'off' state IEA Reactome
Hedgehog 'on' state TAS Reactome
HIV Infection TAS Reactome
Host Interactions of HIV factors TAS Reactome
Immune System TAS Reactome
Infectious disease TAS Reactome
Interleukin-1 family signaling TAS Reactome
Interleukin-1 signaling TAS Reactome
KEAP1-NFE2L2 pathway TAS Reactome
Loss of Function of FBXW7 in Cancer and NOTCH1 Signaling TAS Reactome
MAPK family signaling cascades TAS Reactome
MAPK1/MAPK3 signaling TAS Reactome
Metabolism of proteins TAS Reactome
Mitotic G2-G2/M phases TAS Reactome
Neddylation TAS Reactome
Negative regulation of NOTCH4 signaling IEA Reactome
Nervous system development IEA Reactome
NOTCH1 Intracellular Domain Regulates Transcription IEA Reactome
Nuclear events mediated by NFE2L2 TAS Reactome
Nuclear events stimulated by ALK signaling in cancer TAS Reactome
Nucleotide Excision Repair TAS Reactome
Orc1 removal from chromatin TAS Reactome
Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha TAS Reactome
Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha IEA Reactome
Post-translational protein modification TAS Reactome
Potential therapeutics for SARS TAS Reactome
Prolactin receptor signaling TAS Reactome
RAF/MAP kinase cascade TAS Reactome
Recognition of DNA damage by PCNA-containing replication complex TAS Reactome
Regulation of BACH1 activity TAS Reactome
Regulation of expression of SLITs and ROBOs IEA Reactome
Regulation of RAS by GAPs TAS Reactome
Regulation of RUNX2 expression and activity TAS Reactome
Respiratory Syncytial Virus Infection Pathway TAS Reactome
RNA Polymerase II Transcription TAS Reactome
RSV-host interactions TAS Reactome
S Phase TAS Reactome
SARS-CoV Infections TAS Reactome
Signal Transduction TAS Reactome
Signal Transduction IEA Reactome
Signaling by ALK fusions and activated point mutants TAS Reactome
Signaling by ALK in cancer TAS Reactome
Signaling by Hedgehog TAS Reactome
Signaling by Hedgehog IEA Reactome
Signaling by Interleukins TAS Reactome
Signaling by NOTCH IEA Reactome
Signaling by NOTCH1 IEA Reactome
Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer TAS Reactome
Signaling by NOTCH1 in Cancer TAS Reactome
Signaling by NOTCH1 PEST Domain Mutants in Cancer TAS Reactome
Signaling by NOTCH4 IEA Reactome
Signaling by ROBO receptors IEA Reactome
Signaling by WNT TAS Reactome
Switching of origins to a post-replicative state TAS Reactome
Synthesis of DNA TAS Reactome
TCF dependent signaling in response to WNT TAS Reactome
Transcription-Coupled Nucleotide Excision Repair (TC-NER) TAS Reactome
Transcriptional regulation by RUNX2 TAS Reactome
Vif-mediated degradation of APOBEC3G TAS Reactome
Viral Infection Pathways TAS Reactome





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