ExoCarta: Gene summary

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Gene description for FBXO2
Gene name	F-box protein 2
Gene symbol	FBXO2
Other names/aliases	FBG1 FBX2 Fbs1 NFB42 OCP1
Species	Homo sapiens
Database cross references - FBXO2
ExoCarta	ExoCarta_26232
Vesiclepedia	VP_26232
Entrez Gene	26232
HGNC	13581
MIM	607112
UniProt	Q9UK22
FBXO2 identified in exosomes derived from the following tissue/cell type
Gastric cancer cells	33991177
Gastric cancer cells	33991177
Gastric cancer cells	33991177
Hepatocytes	26054723
Thymus	23844026

Gene ontology annotations for FBXO2

Molecular Function
	amyloid-beta binding	GO:0001540	IEA
	ubiquitin-protein transferase activity	GO:0004842	TAS
	protein binding	GO:0005515	IPI
	carbohydrate binding	GO:0030246	IEA
	denatured protein binding	GO:0031249	IEA
	ubiquitin protein ligase activity	GO:0061630	IBA
Biological Process
	proteolysis	GO:0006508	TAS
	glycoprotein catabolic process	GO:0006516	IBA
	glycoprotein catabolic process	GO:0006516	ISS
	negative regulation of cell population proliferation	GO:0008285	IEA
	protein ubiquitination	GO:0016567	IEA
	protein ubiquitination	GO:0016567	ISS
	SCF-dependent proteasomal ubiquitin-dependent protein catabolic process	GO:0031146	IBA
	SCF-dependent proteasomal ubiquitin-dependent protein catabolic process	GO:0031146	ISS
	regulation of protein ubiquitination	GO:0031396	IEA
	protein modification process	GO:0036211	TAS
	ERAD pathway	GO:0036503	IBA
	regulation of protein catabolic process at postsynapse, modulating synaptic transmission	GO:0099576	IEA
Subcellular Localization
	cytoplasm	GO:0005737	IBA
	cytoplasm	GO:0005737	IDA
	endoplasmic reticulum	GO:0005783	IEA
	cytosol	GO:0005829	ISS
	cytosol	GO:0005829	TAS
	SCF ubiquitin ligase complex	GO:0019005	IBA
	SCF ubiquitin ligase complex	GO:0019005	ISS
	dendritic spine	GO:0043197	IEA
	extrinsic component of postsynaptic membrane	GO:0098890	IEA
	glutamatergic synapse	GO:0098978	IEA

Experiment description of studies that identified FBXO2 in exosomes

Experiment ID

363

MISEV standards
✘	Biophysical techniques
✔ TSG101\|GAPDH\|AQP1\|CD151\|CD81\|CD82\|CD9\|EPCAM\|FLOT1\|FLOT2\|ICAM1\|ITGA2B\|LAMP2\|RAB35\|RAB5A\|RAB5B\|SDCBP\|TFRC\|UCHL1	Enriched markers
✔ DCLK1	Negative markers
✔ NTA	Particle analysis

Identified molecule

Protein

Identification method

Mass spectrometry

PubMed ID

33991177

Organism

Homo sapiens

Experiment description

Cancer stem cell marker DCLK1 reprograms small extracellular vesicles toward migratory phenotype in gastric cancer cells

Authors

"Carli ALE, Afshar-Sterle S, Rai A, Fang H, O'Keefe R, Tse J, Ferguson FM, Gray NS, Ernst M, Greening DW, Buchert M."

Journal name

Proteomics

Publication year

2021

Sample

Gastric cancer cells

Sample name

MKN1 - 100K pellet

Isolation/purification methods

Differential centrifugation
Ultracentrifugation

Flotation density

Molecules identified in the study

Protein

Methods used in the study

Western blotting
Mass spectrometry

Experiment ID

364

MISEV standards
✘	Biophysical techniques
✔ TSG101\|GAPDH\|AQP1\|CD151\|CD81\|CD82\|CD9\|EPCAM\|FLOT1\|FLOT2\|ICAM1\|ITGA2B\|LAMP2\|RAB35\|RAB5A\|RAB5B\|SDCBP\|TFRC\|UCHL1	Enriched markers
✔ DCLK1	Negative markers
✔ NTA	Particle analysis

Identified molecule

Protein

Identification method

Mass spectrometry

PubMed ID

33991177

Organism

Homo sapiens

Experiment description

Cancer stem cell marker DCLK1 reprograms small extracellular vesicles toward migratory phenotype in gastric cancer cells

Authors

"Carli ALE, Afshar-Sterle S, Rai A, Fang H, O'Keefe R, Tse J, Ferguson FM, Gray NS, Ernst M, Greening DW, Buchert M."

Journal name

Proteomics

Publication year

2021

Sample

Gastric cancer cells

Sample name

MKN1 - 100K pellet

Isolation/purification methods

Differential centrifugation
Ultracentrifugation

Flotation density

Molecules identified in the study

Protein

Methods used in the study

Western blotting
Mass spectrometry

Experiment ID

365

MISEV standards
✘	Biophysical techniques
✔ TSG101\|GAPDH\|AQP1\|CD151\|CD81\|CD82\|CD9\|EPCAM\|FLOT1\|FLOT2\|ICAM1\|ITGA2B\|LAMP2\|RAB35\|RAB5A\|RAB5B\|SDCBP\|TFRC\|UCHL1	Enriched markers
✔ DCLK1	Negative markers
✔ NTA	Particle analysis

Identified molecule

Protein

Identification method

Mass spectrometry

PubMed ID

33991177

Organism

Homo sapiens

Experiment description

Cancer stem cell marker DCLK1 reprograms small extracellular vesicles toward migratory phenotype in gastric cancer cells

Authors

"Carli ALE, Afshar-Sterle S, Rai A, Fang H, O'Keefe R, Tse J, Ferguson FM, Gray NS, Ernst M, Greening DW, Buchert M."

Journal name

Proteomics

Publication year

2021

Sample

Gastric cancer cells

Sample name

MKN1 - 100K pellet

Isolation/purification methods

Differential centrifugation
Ultracentrifugation

Flotation density

Molecules identified in the study

Protein

Methods used in the study

Western blotting
Mass spectrometry

Experiment ID

237

MISEV standards
✔ EM	Biophysical techniques
✔ TSG101\|Alix\|HSC70\|GAPDH	Enriched markers
✔ HSP90B1	Negative markers
✔ qNano	Particle analysis

Identified molecule

mRNA

Identification method

RNA Sequencing

PubMed ID

26054723

Organism

Homo sapiens

Experiment description

Hepatocellular carcinoma-derived exosomes promote motility of immortalized hepatocyte through transfer of oncogenic proteins and RNAs

Authors

"He M, Qin H, Poon TC, Sze SC, Ding X, Co NN, Ngai SM, Chan TF, Wong N"

Journal name

Carcinogenesis

Publication year

2015

Sample

Hepatocytes

Sample name

MIHA

Isolation/purification methods

Differential centrifugation
Filtration
Ultracentrifugation
Sucrose density gradient

Flotation density

1.13-1.19 g/mL

Molecules identified in the study

Protein
RNA

Methods used in the study

Western blotting
Mass spectrometry
RNA Sequencing

Experiment ID

217

MISEV standards
✔ EM	Biophysical techniques
✔ TSG101\|CD81\|CD9\|CD63	Enriched markers
✘	Negative markers
✔ NTA	Particle analysis

Identified molecule

protein

Identification method

Mass spectrometry

PubMed ID

23844026

Organism

Homo sapiens

Experiment description

Characterization of human thymic exosomes.

Authors

"Skogberg G, Gudmundsdottir J, van der Post S, Sandstrom K, Bruhn S, Benson M, Mincheva-Nilsson L, Baranov V, Telemo E, Ekwall O."

Journal name

PLoS One

Publication year

2013

Sample

Thymus

Sample name

Normal-Thymus

Isolation/purification methods

Differential centrifugation
Filtration
Ultracentrifugation

Flotation density

Molecules identified in the study

Protein

Methods used in the study

Mass spectrometry

Protein-protein interactions for FBXO2

Protein Interactor

ExoCarta ID

Identification method

PubMed

Species

ITGB1

3688

Affinity Capture-Western		Homo sapiens
Biochemical Activity		Homo sapiens
Affinity Capture-Western		Homo sapiens
Affinity Capture-MS		Homo sapiens

AXL

558

Affinity Capture-MS

Homo sapiens

SEMA4D

Affinity Capture-MS

Homo sapiens

NOTCH3

4854

Affinity Capture-MS

Homo sapiens

DAG1

1605

Affinity Capture-MS

Homo sapiens

ENPP4

22875

Affinity Capture-MS

Homo sapiens

POMGNT2

Affinity Capture-MS

Homo sapiens

AMOTL1

154810

Affinity Capture-MS

Homo sapiens

FGFR3

2261

Affinity Capture-MS

Homo sapiens

LAMC1

3915

Affinity Capture-MS

Homo sapiens

HPSE

10855

Affinity Capture-MS		Homo sapiens
Affinity Capture-MS		Homo sapiens

SCARA3

Affinity Capture-MS

Homo sapiens

ADGRG1

9289

Affinity Capture-MS

Homo sapiens

GNS

2799

Affinity Capture-MS

Homo sapiens

UNC5B

219699

Affinity Capture-MS

Homo sapiens

NID1

4811

Affinity Capture-MS

Homo sapiens

HEXB

3074

Affinity Capture-MS

Homo sapiens

PLBD2

196463

Affinity Capture-MS

Homo sapiens

ST14

6768

Affinity Capture-MS

Homo sapiens

LAMA4

3910

Affinity Capture-MS

Homo sapiens

SCARB1

949

Affinity Capture-MS

Homo sapiens

CD14

929

Affinity Capture-MS

Homo sapiens

IL17RA

23765

Affinity Capture-MS

Homo sapiens

KPTN

Affinity Capture-MS

Homo sapiens

POMT1

10585

Affinity Capture-MS

Homo sapiens

PFDN6

10471

Two-hybrid

Homo sapiens

SLC12A7

10723

Affinity Capture-MS

Homo sapiens

MEST

4232

Affinity Capture-MS

Homo sapiens

EMC1

23065

Affinity Capture-MS

Homo sapiens

TMEM25

Affinity Capture-MS

Homo sapiens

AMOTL2

51421

Affinity Capture-MS

Homo sapiens

NOMO1

23420

Affinity Capture-MS

Homo sapiens

SHMT1

6470

Affinity Capture-MS

Homo sapiens

PCSK5

5125

Affinity Capture-MS

Homo sapiens

UGT8

Affinity Capture-MS

Homo sapiens

KIAA1161

57462

Affinity Capture-MS

Homo sapiens

MCAM

4162

Affinity Capture-MS

Homo sapiens

TMTC3

160418

Affinity Capture-MS

Homo sapiens

ACP2

Affinity Capture-MS

Homo sapiens

CDHR2

54825

Affinity Capture-MS

Homo sapiens

KDELC2

143888

Affinity Capture-MS

Homo sapiens

PIGT

51604

Affinity Capture-MS		Homo sapiens
Affinity Capture-MS		Homo sapiens

CNTN1

1272

Affinity Capture-MS

Homo sapiens

FRAS1

80144

Affinity Capture-MS

Homo sapiens

GRIN1

2902

Affinity Capture-MS

Homo sapiens

B4GALT3

8703

Affinity Capture-MS

Homo sapiens

PLA2G15

23659

Affinity Capture-MS

Homo sapiens

BRAP

Two-hybrid

Homo sapiens

LRP1B

53353

Affinity Capture-MS

Homo sapiens

ADGRV1

84059

Affinity Capture-MS

Homo sapiens

CCDC28A

Affinity Capture-MS

Homo sapiens

EPHB4

2050

Affinity Capture-MS

Homo sapiens

MGMT

4255

Affinity Capture-MS

Homo sapiens

LRIG3

Affinity Capture-MS

Homo sapiens

GJB2

Reconstituted Complex		Homo sapiens
Affinity Capture-Western		Homo sapiens

ANO6

196527

Affinity Capture-MS

Homo sapiens

EPDR1

54749

Affinity Capture-MS

Homo sapiens

QSOX1

5768

Affinity Capture-MS

Homo sapiens

CTU1

90353

Affinity Capture-MS

Homo sapiens

IL25

Affinity Capture-MS

Homo sapiens

CHST8

64377

Affinity Capture-MS

Homo sapiens

IQCB1

Affinity Capture-MS

Homo sapiens

ATRN

8455

Affinity Capture-MS

Homo sapiens

SERPINA9

327657

Affinity Capture-MS

Homo sapiens

CLN5

Affinity Capture-MS

Homo sapiens

NAGLU

4669

Affinity Capture-MS

Homo sapiens

FN1

2335

Affinity Capture-MS

Homo sapiens

ITGA1

3672

Affinity Capture-MS

Homo sapiens

PLTP

5360

Affinity Capture-MS

Homo sapiens

JAG2

Affinity Capture-MS

Homo sapiens

PLXNC1

10154

Affinity Capture-MS

Homo sapiens

IGSF3

3321

Affinity Capture-MS

Homo sapiens

NCLN

56926

Affinity Capture-MS

Homo sapiens

GXYLT1

283464

Affinity Capture-MS

Homo sapiens

OPCML

Affinity Capture-MS		Homo sapiens
Affinity Capture-MS		Homo sapiens

PVR

5817

Affinity Capture-MS

Homo sapiens

CTSF

8722

Affinity Capture-MS

Homo sapiens

LYRM4

57128

Affinity Capture-MS

Homo sapiens

STUB1

10273

Affinity Capture-Western		Homo sapiens
Reconstituted Complex		Homo sapiens
Biochemical Activity		Homo sapiens

HK2

3099

Affinity Capture-MS

Homo sapiens

TTC13

Affinity Capture-MS

Homo sapiens

NAAA

Affinity Capture-MS		Homo sapiens
Affinity Capture-MS		Homo sapiens

ENPP5

Affinity Capture-MS

Homo sapiens

PIEZO1

9780

Affinity Capture-MS

Homo sapiens

CTHRC1

115908

Affinity Capture-MS

Homo sapiens

ASIC5

Affinity Capture-MS

Homo sapiens

EMC7

56851

Affinity Capture-MS

Homo sapiens

ASIC4

Affinity Capture-MS		Homo sapiens
Affinity Capture-MS		Homo sapiens

CLPTM1

1209

Affinity Capture-MS

Homo sapiens

EMC4

51234

Affinity Capture-MS

Homo sapiens

SKP1

6500

Co-crystal Structure		Homo sapiens
Two-hybrid		Homo sapiens
Affinity Capture-Western		Homo sapiens
Reconstituted Complex		Homo sapiens
Reconstituted Complex		Homo sapiens
Two-hybrid		Homo sapiens
Two-hybrid		Homo sapiens
Affinity Capture-MS		Homo sapiens
Affinity Capture-Western		Homo sapiens
Reconstituted Complex		Homo sapiens
Affinity Capture-Western		Homo sapiens
Reconstituted Complex		Homo sapiens
Affinity Capture-Western		Homo sapiens

BOC

Affinity Capture-MS		Homo sapiens
Affinity Capture-MS		Homo sapiens

AGRN

375790

Affinity Capture-MS

Homo sapiens

ITGA2

3673

Affinity Capture-MS

Homo sapiens

ATF6B

Affinity Capture-MS

Homo sapiens

DUOX1

Affinity Capture-MS

Homo sapiens

EMILIN2

84034

Affinity Capture-MS

Homo sapiens

TM2D3

Affinity Capture-MS

Homo sapiens

POMK

Affinity Capture-MS

Homo sapiens

100

OLFM2

Affinity Capture-MS

Homo sapiens

101

LAMA5

3911

Affinity Capture-MS

Homo sapiens

102

CUL7

9820

Affinity Capture-Western

Homo sapiens

103

WFS1

7466

Affinity Capture-MS

Homo sapiens

104

RNF157

114804

Affinity Capture-MS

Homo sapiens

105

CTF1

Affinity Capture-MS

Homo sapiens

106

PTGFRN

5738

Affinity Capture-MS

Homo sapiens

107

PIGS

94005

Affinity Capture-MS

Homo sapiens

108

ADAM23

8745

Affinity Capture-MS

Homo sapiens

109

TOR1A

1861

Affinity Capture-Western

Homo sapiens

110

CNTNAP3

Affinity Capture-MS		Homo sapiens
Affinity Capture-MS		Homo sapiens

111

CD48

962

Affinity Capture-MS

Homo sapiens

112

ST6GALNAC5

Affinity Capture-MS		Homo sapiens
Affinity Capture-MS		Homo sapiens
Affinity Capture-MS		Homo sapiens

113

KLK5

25818

Affinity Capture-MS

Homo sapiens

114

IDUA

3425

Affinity Capture-MS

Homo sapiens

115

ROCK2

9475

Affinity Capture-MS

Homo sapiens

116

IFNGR1

3459

Affinity Capture-MS

Homo sapiens

117

GPR110

Affinity Capture-MS

Homo sapiens

118

FFAR1

Affinity Capture-MS

Homo sapiens

119

LRP10

26020

Affinity Capture-MS

Homo sapiens

120

CHST10

Affinity Capture-MS

Homo sapiens

121

IL6ST

3572

Affinity Capture-Western		Homo sapiens
Reconstituted Complex		Homo sapiens
Affinity Capture-MS		Homo sapiens

122

B3GNT2

10678

Affinity Capture-MS		Homo sapiens
Affinity Capture-MS		Homo sapiens

123

ADAM9

8754

Affinity Capture-MS

Homo sapiens

124

TMEM231

79583

Affinity Capture-MS

Homo sapiens

125

FGFR4

2264

Affinity Capture-MS

Homo sapiens

126

AMIGO3

Affinity Capture-MS		Homo sapiens
Affinity Capture-MS		Homo sapiens

127

TINAGL1

64129

Affinity Capture-MS

Homo sapiens

128

L1CAM

3897

Affinity Capture-MS

Homo sapiens

129

NID2

22795

Affinity Capture-MS

Homo sapiens

130

EMB

133418

Affinity Capture-MS

Homo sapiens

131

CUL1

8454

Affinity Capture-MS		Homo sapiens
Affinity Capture-Western		Homo sapiens
Affinity Capture-Western		Homo sapiens
Affinity Capture-Western		Homo sapiens
Affinity Capture-Western		Homo sapiens

132

GNPTAB

79158

Affinity Capture-MS

Homo sapiens

133

PXDN

7837

Affinity Capture-MS

Homo sapiens

134

PCYOX1

51449

Affinity Capture-MS

Homo sapiens

135

SLAMF7

Affinity Capture-MS		Homo sapiens
Affinity Capture-MS		Homo sapiens
Affinity Capture-MS		Homo sapiens

136

PRNP

5621

Affinity Capture-MS

Homo sapiens

137

SDK2

54549

Affinity Capture-MS

Homo sapiens

138

NPC1

4864

Affinity Capture-MS

Homo sapiens

139

RBX1

9978

Affinity Capture-Western		Homo sapiens
Affinity Capture-Western		Homo sapiens

140

PPT2

Affinity Capture-MS

Homo sapiens

141

HS6ST1

Affinity Capture-MS

Homo sapiens

142

C12orf49

Affinity Capture-MS

Homo sapiens

143

LAG3

Affinity Capture-MS

Homo sapiens

144

EMILIN3

Affinity Capture-MS

Homo sapiens

145

TCTN2

Affinity Capture-MS

Homo sapiens

146

NOMO3

408050

Affinity Capture-MS

Homo sapiens

147

C4BPB

725

Affinity Capture-MS

Homo sapiens

148

TGFBR3

7049

Affinity Capture-MS

Homo sapiens

149

TMEM131

Affinity Capture-MS

Homo sapiens

150

ICAM5

7087

Affinity Capture-MS

Homo sapiens

151

SUSD1

64420

Affinity Capture-MS

Homo sapiens

152

TMED9

54732

Affinity Capture-MS

Homo sapiens

153

MAN2B2

23324

Affinity Capture-MS

Homo sapiens

154

EMC8

10328

Affinity Capture-MS

Homo sapiens

155

TMPRSS11B

132724

Affinity Capture-MS		Homo sapiens
Affinity Capture-MS		Homo sapiens

156

LAMB2

3913

Affinity Capture-MS

Homo sapiens

157

UBE2L3

7332

Reconstituted Complex

Homo sapiens

158

GALNT5

11227

Affinity Capture-MS

Homo sapiens

159

PRCP

5547

Affinity Capture-MS

Homo sapiens

160

LRFN3

Affinity Capture-MS

Homo sapiens

161

LTBP4

8425

Affinity Capture-MS

Homo sapiens

162

EGFR

1956

Affinity Capture-MS

Homo sapiens

163

LEPR

3953

Affinity Capture-MS

Homo sapiens

164

FGFR2

2263

Affinity Capture-MS

Homo sapiens

165

PLXND1

23129

Affinity Capture-MS

Homo sapiens

166

IL12RB1

Affinity Capture-MS

Homo sapiens

167

GIF

Affinity Capture-MS		Homo sapiens
Affinity Capture-MS		Homo sapiens

168

UBE2E1

Reconstituted Complex

Homo sapiens

169

MET

4233

Affinity Capture-MS

Homo sapiens

170

PKD2

5311

Affinity Capture-MS

Homo sapiens

171

ABCA2

Affinity Capture-MS

Homo sapiens

172

PCYOX1L

78991

Affinity Capture-MS

Homo sapiens

173

OSBPL8

114882

Affinity Capture-MS

Homo sapiens

174

IL6R

Affinity Capture-Western

Homo sapiens

175

FBN1

2200

Affinity Capture-Western		Homo sapiens
Affinity Capture-Western		Homo sapiens
Affinity Capture-MS		Homo sapiens

176

EDIL3

10085

Affinity Capture-MS

Homo sapiens

177

SUN1

23353

Affinity Capture-MS

Homo sapiens

178

PLXNB2

23654

Affinity Capture-MS

Homo sapiens

179

GRN

2896

Affinity Capture-MS

Homo sapiens

180

TIMP1

7076

Affinity Capture-MS

Homo sapiens

181

BTD

686

Affinity Capture-MS

Homo sapiens

182

CRLF1

9244

Affinity Capture-MS		Homo sapiens
Affinity Capture-MS		Homo sapiens

183

NOTCH2

4853

Affinity Capture-MS

Homo sapiens

184

WNT10B

7480

Affinity Capture-MS

Homo sapiens

185

SEC11A

23478

Affinity Capture-MS

Homo sapiens

186

ADAM33

80332

Affinity Capture-MS		Homo sapiens
Affinity Capture-MS		Homo sapiens

187

SEMA3C

10512

Affinity Capture-MS

Homo sapiens

188

SPINT1

6692

Affinity Capture-MS

Homo sapiens

189

CD47

961

Affinity Capture-MS

Homo sapiens

190

GPR125

Affinity Capture-MS

Homo sapiens

191

PIGU

128869

Affinity Capture-MS

Homo sapiens

192

TOR1AIP1

26092

Affinity Capture-MS

Homo sapiens

193

EDEM2

Affinity Capture-MS

Homo sapiens

194

FOLR3

Affinity Capture-MS

Homo sapiens

195

MINPP1

9562

Affinity Capture-MS

Homo sapiens

196

IGF2R

3482

Affinity Capture-MS

Homo sapiens

197

HSPG2

3339

Affinity Capture-MS

Homo sapiens

198

VASN

114990

Affinity Capture-MS		Homo sapiens
Affinity Capture-MS		Homo sapiens

199

ANKRD46

157567

Affinity Capture-MS

Homo sapiens

200

HS6ST2

90161

Affinity Capture-MS

Homo sapiens

201

LRIG1

26018

Affinity Capture-MS

Homo sapiens

202

POMT2

Affinity Capture-MS

Homo sapiens

203

COL6A1

1291

Affinity Capture-MS

Homo sapiens

204

PTPRG

5793

Affinity Capture-MS

Homo sapiens

205

SUCO

Affinity Capture-MS

Homo sapiens

206

CSTL1

Affinity Capture-MS

Homo sapiens

207

PAX4

Two-hybrid

Homo sapiens

208

C8A

731

Affinity Capture-MS

Homo sapiens

209

MAN2B1

4125

Affinity Capture-MS

Homo sapiens

210

AZU1

566

Affinity Capture-MS		Homo sapiens
Affinity Capture-MS		Homo sapiens
Affinity Capture-MS		Homo sapiens

211

SORL1

6653

Affinity Capture-MS

Homo sapiens

212

SGSH

6448

Affinity Capture-MS

Homo sapiens

213

TMED4

222068

Affinity Capture-MS

Homo sapiens

214

GDF9

2661

Affinity Capture-MS		Homo sapiens
Affinity Capture-MS		Homo sapiens

215

IGHM

3507

Affinity Capture-MS

Homo sapiens

216

ROBO1

6091

Affinity Capture-MS

Homo sapiens

217

SYNE2

23224

Affinity Capture-MS

Homo sapiens

218

ERO1LB

56605