Gene description for LAMC2
Gene name laminin, gamma 2
Gene symbol LAMC2
Other names/aliases B2T
BM600
CSF
EBR2
EBR2A
LAMB2T
LAMNB2
Species Homo sapiens
 Database cross references - LAMC2
ExoCarta ExoCarta_3918
Entrez Gene 3918
HGNC 6493
MIM 150292
UniProt Q13753  
 LAMC2 identified in exosomes derived from the following tissue/cell type
Bladder cancer cells 20224111    
Prostate cancer cells 22723089    
 Gene ontology annotations for LAMC2
Molecular Function
    heparin binding GO:0008201 IEA
Biological Process
    hemidesmosome assembly GO:0031581 TAS
    epidermis development GO:0008544 TAS
    cell junction assembly GO:0034329 TAS
    extracellular matrix organization GO:0030198 TAS
    cell adhesion GO:0007155 IEA
    extracellular matrix disassembly GO:0022617 TAS
Subcellular Localization
    cell cortex GO:0005938 IEA
    laminin-5 complex GO:0005610 IEA
    laminin-2 complex GO:0005607 IEA
    extracellular space GO:0005615 IEA
    perinuclear region of cytoplasm GO:0048471 IEA
    membrane GO:0016020 IEA
    extracellular region GO:0005576 TAS
 Experiment description of studies that identified LAMC2 in exosomes
1
Experiment ID 76
ISEV standards
✔
EM
EV Biophysical techniques
✔
TSG101|GAPDH|HSP90
EV Cytosolic markers
✔
CD81|CD9|CD63|LAMP1|MHCI
EV Membrane markers
✔
HSP90B1
EV Negative markers
✘ EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 20224111    
Organism Homo sapiens
Experiment description Proteomics analysis of bladder cancer exosomes.
Authors Welton JL, Khanna S, Giles PJ, Brennan P, Brewis IA, Staffurth J, Mason MD, Clayton A.
Journal name MCP
Publication year 2010
Sample Bladder cancer cells
Sample name HT1376
Isolation/purification methods Differential centrifugation
Sucrose density gradient
Flotation density 1.10-1.19 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry [MALDI TOF/TOF]
Western blotting
FACS
2
Experiment ID 146
ISEV standards
✔
EM
EV Biophysical techniques
✔
HSP70|HSP90
EV Cytosolic markers
✔
CD9
EV Membrane markers
✔
HSP90B1
EV Negative markers
✘ EV Particle analysis
Identified molecule protein
Identification method
Mass spectrometry [QTOF]   
PubMed ID 22723089    
Organism Homo sapiens
Experiment description Prostate cancer cell derived exosomes
Authors Hosseini-Beheshti E, Guns ES.
Journal name MCP
Publication year 2012
Sample Prostate cancer cells
Sample name RWPE - Rep 2
Isolation/purification methods Sucrose density gradient
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry [QTOF]
 Protein-protein interactions for LAMC2
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 COL7A1 1294
Reconstituted Complex Homo sapiens
2 LAMB3 3914
Invivo Homo sapiens
3 BMP1  
Invivo Homo sapiens
Invitro Homo sapiens
View the network image/svg+xml



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