Gene description for SLA2
Gene name Src-like-adaptor 2
Gene symbol SLA2
Other names/aliases C20orf156
MARS
SLAP-2
SLAP2
Species Homo sapiens
 Database cross references - SLA2
ExoCarta ExoCarta_84174
Entrez Gene 84174
HGNC 17329
MIM 606577
UniProt Q9H6Q3  
 SLA2 identified in exosomes derived from the following tissue/cell type
Platelets 25332113    
Platelets 25332113    
Platelets 25332113    
 Gene ontology annotations for SLA2
Molecular Function
    protein N-terminus binding GO:0047485 IPI
    SH3/SH2 adaptor activity GO:0005070 IDA
    protein binding GO:0005515 IPI
Biological Process
    regulation of immune response GO:0050776 NAS
    antigen receptor-mediated signaling pathway GO:0050851 TAS
    negative regulation of transcription from RNA polymerase II promoter GO:0000122 IDA
    B cell mediated immunity GO:0019724 TAS
    T cell activation GO:0042110 TAS
    intracellular receptor signaling pathway GO:0030522 TAS
    positive regulation of signal transduction GO:0009967 IDA
    negative regulation of B cell activation GO:0050869 TAS
    negative regulation of calcium-mediated signaling GO:0050849 IDA
Subcellular Localization
    endosome membrane GO:0010008 NAS
    cytoplasm GO:0005737 TAS
    late endosome GO:0005770 IEA
    cytoplasmic membrane-bounded vesicle GO:0016023 IEA
    plasma membrane GO:0005886 TAS
 Experiment description of studies that identified SLA2 in exosomes
1
Experiment ID 231
ISEV standards
EV Biophysical techniques
Alix
EV Cytosolic markers
CD63|CD9
EV Membrane markers
EV Negative markers
NTA
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25332113    
Organism Homo sapiens
Experiment description Lipidomic and proteomic characterization of platelet extracellular vesicle subfractions from senescent platelets
Authors Pienimaeki-Roemer A, Kuhlmann K, Bottcher A, Konovalova T, Black A, Orso E, Liebisch G, Ahrens M, Eisenacher M, Meyer HE, Schmitz G.
Journal name Transfusion
Publication year 2015
Sample Platelets
Sample name PL-Exs - Rep 1
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Optiprep density gradient
Flotation density 1.12-1.15 g/mL
Molecules identified in the study Protein
Lipids
Methods used in the study Western blotting
Mass spectrometry
2
Experiment ID 232
ISEV standards
EV Biophysical techniques
EV Cytosolic markers
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25332113    
Organism Homo sapiens
Experiment description Lipidomic and proteomic characterization of platelet extracellular vesicle subfractions from senescent platelets
Authors Pienimaeki-Roemer A, Kuhlmann K, Bottcher A, Konovalova T, Black A, Orso E, Liebisch G, Ahrens M, Eisenacher M, Meyer HE, Schmitz G.
Journal name Transfusion
Publication year 2015
Sample Platelets
Sample name PL-Exs - Rep 2
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Optiprep density gradient
Flotation density 1.12-1.15 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
3
Experiment ID 233
ISEV standards
EV Biophysical techniques
EV Cytosolic markers
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25332113    
Organism Homo sapiens
Experiment description Lipidomic and proteomic characterization of platelet extracellular vesicle subfractions from senescent platelets
Authors Pienimaeki-Roemer A, Kuhlmann K, Bottcher A, Konovalova T, Black A, Orso E, Liebisch G, Ahrens M, Eisenacher M, Meyer HE, Schmitz G.
Journal name Transfusion
Publication year 2015
Sample Platelets
Sample name PL-Exs - Rep 3
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Optiprep density gradient
Flotation density 1.12-1.15 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for SLA2
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 CD247 919
Invivo Homo sapiens
2 CBL 867
Invivo Homo sapiens
Invitro Homo sapiens
3 ZAP70 7535
Invivo Homo sapiens
View the network image/svg+xml
 Pathways in which SLA2 is involved
No pathways found





Perform bioinformatics analysis of your extracellular vesicle data set using FunRich, a open access standalone tool. NEW UPDATED VERSION OF FunRich available for download (12/09/2016) from here