Gene description for KIT
Gene name	v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog
Gene symbol	KIT
Other names/aliases	C-Kit CD117 PBT SCFR
Species	Homo sapiens
Database cross references - KIT
ExoCarta	ExoCarta_3815
Entrez Gene	3815
HGNC	6342
MIM	164920
UniProt	P10721
KIT identified in exosomes derived from the following tissue/cell type
Melanoma cells	25950383
Melanoma cells	25950383
Melanoma cells	25950383

Gene ontology annotations for KIT

Molecular Function     metal ion binding GO:0046872 IEA     protease binding GO:0002020 IEA     protein homodimerization activity GO:0042803 IPI     transmembrane receptor protein tyrosine kinase activity GO:0004714 IDA     stem cell factor receptor activity GO:0005020 IEA     ATP binding GO:0005524 IEA     receptor signaling protein tyrosine kinase activity GO:0004716 IEA     cytokine binding GO:0019955 IDA     protein tyrosine kinase activity GO:0004713 TAS     protein binding GO:0005515 IPI Biological Process     Kit signaling pathway GO:0038109 IDA     detection of mechanical stimulus involved in sensory perception of sound GO:0050910 ISS     embryonic hemopoiesis GO:0035162 ISS     visual learning GO:0008542 IEA     activation of MAPK activity GO:0000187 IDA     cytokine-mediated signaling pathway GO:0019221 IDA     male gonad development GO:0008584 IEP     cellular response to thyroid hormone stimulus GO:0097067 IEA     hemopoiesis GO:0030097 TAS     phosphatidylinositol-mediated signaling GO:0048015 TAS     actin cytoskeleton reorganization GO:0031532 IDA     myeloid progenitor cell differentiation GO:0002318 IEA     positive regulation of tyrosine phosphorylation of Stat5 protein GO:0042523 IMP     regulation of developmental pigmentation GO:0048070 IEA     melanocyte differentiation GO:0030318 TAS     signal transduction by protein phosphorylation GO:0023014 TAS     epidermal growth factor receptor signaling pathway GO:0007173 TAS     Fc-epsilon receptor signaling pathway GO:0038095 TAS     lamellipodium assembly GO:0030032 ISS     positive regulation of tyrosine phosphorylation of Stat1 protein GO:0042511 IMP     positive regulation of tyrosine phosphorylation of Stat3 protein GO:0042517 IMP     regulation of cell shape GO:0008360 ISS     peptidyl-tyrosine phosphorylation GO:0018108 IDA     positive regulation of long-term neuronal synaptic plasticity GO:0048170 IEA     mast cell degranulation GO:0043303 IMP     spermatid development GO:0007286 IEA     epithelial cell proliferation GO:0050673 IEA     T cell differentiation GO:0030217 ISS     melanocyte migration GO:0097324 ISS     positive regulation of Notch signaling pathway GO:0045747 IEA     positive regulation of cell migration GO:0030335 IEA     lymphoid progenitor cell differentiation GO:0002320 IEA     mast cell cytokine production GO:0032762 IDA     negative regulation of programmed cell death GO:0043069 IEA     positive regulation of phosphatidylinositol 3-kinase signaling GO:0014068 TAS     signal transduction GO:0007165 TAS     positive regulation of sequence-specific DNA binding transcription factor activity GO:0051091 IMP     ovarian follicle development GO:0001541 ISS     mast cell chemotaxis GO:0002551 IDA     positive regulation of phospholipase C activity GO:0010863 TAS     positive regulation of pseudopodium assembly GO:0031274 IEA     spermatogenesis GO:0007283 TAS     ectopic germ cell programmed cell death GO:0035234 IEA     protein autophosphorylation GO:0046777 IDA     glycosphingolipid metabolic process GO:0006687 IEA     positive regulation of gene expression GO:0010628 IEA     digestive tract development GO:0048565 ISS     somatic stem cell maintenance GO:0035019 IEA     positive regulation of cell proliferation GO:0008284 IEA     fibroblast growth factor receptor signaling pathway GO:0008543 TAS     positive regulation of JAK-STAT cascade GO:0046427 IMP     immature B cell differentiation GO:0002327 ISS     dendritic cell cytokine production GO:0002371 ISS     positive regulation of MAPK cascade GO:0043410 IMP     mast cell proliferation GO:0070662 TAS     neurotrophin TRK receptor signaling pathway GO:0048011 TAS     cell chemotaxis GO:0060326 IDA     megakaryocyte development GO:0035855 ISS     innate immune response GO:0045087 TAS     erythrocyte differentiation GO:0030218 ISS     regulation of cell proliferation GO:0042127 TAS     Fc receptor signaling pathway GO:0038093 IDA     pigmentation GO:0043473 ISS     somatic stem cell division GO:0048103 IEA     stem cell maintenance GO:0019827 TAS     mast cell differentiation GO:0060374 TAS     stem cell differentiation GO:0048863 ISS     erythropoietin-mediated signaling pathway GO:0038162 ISS     inflammatory response GO:0006954 ISS     germ cell migration GO:0008354 IEA     melanocyte adhesion GO:0097326 ISS     positive regulation of phosphatidylinositol 3-kinase activity GO:0043552 TAS Subcellular Localization     plasma membrane GO:0005886 TAS     integral component of membrane GO:0016021 IEA     cytoplasmic side of plasma membrane GO:0009898 IEA     mast cell granule GO:0042629 IMP     acrosomal vesicle GO:0001669 IEA     extracellular space GO:0005615 IDA     cell-cell junction GO:0005911 IEA     external side of plasma membrane GO:0009897 IEA