Gene description for IRF3
Gene name	interferon regulatory factor 3
Gene symbol	IRF3
Other names/aliases	-
Species	Homo sapiens
Database cross references - IRF3
ExoCarta	ExoCarta_3661
Vesiclepedia	VP_3661
Entrez Gene	3661
HGNC	6118
MIM	603734
UniProt	Q14653
IRF3 identified in exosomes derived from the following tissue/cell type
Hepatocellular carcinoma cells	26054723

Gene ontology annotations for IRF3

Molecular Function     RNA polymerase II cis-regulatory region sequence-specific DNA binding GO:0000978 IBA     RNA polymerase II cis-regulatory region sequence-specific DNA binding GO:0000978 IDA     RNA polymerase II cis-regulatory region sequence-specific DNA binding GO:0000978 IMP     DNA-binding transcription factor activity, RNA polymerase II-specific GO:0000981 IBA     DNA-binding transcription factor activity, RNA polymerase II-specific GO:0000981 IDA     DNA-binding transcription factor activity, RNA polymerase II-specific GO:0000981 ISA     DNA-binding transcription activator activity GO:0001216 IDA     DNA-binding transcription repressor activity, RNA polymerase II-specific GO:0001227 IEA     DNA-binding transcription activator activity, RNA polymerase II-specific GO:0001228 IMP     DNA-binding transcription activator activity, RNA polymerase II-specific GO:0001228 TAS     DNA binding GO:0003677 NAS     DNA-binding transcription factor activity GO:0003700 IC     DNA-binding transcription factor activity GO:0003700 IDA     protein binding GO:0005515 IDA     protein binding GO:0005515 IPI     protein domain specific binding GO:0019904 IPI     identical protein binding GO:0042802 IPI     protein homodimerization activity GO:0042803 IDA     protein homodimerization activity GO:0042803 IPI     sequence-specific DNA binding GO:0043565 IDA     sequence-specific double-stranded DNA binding GO:1990837 IDA     promoter-specific chromatin binding GO:1990841 IEA Biological Process     negative regulation of transcription by RNA polymerase II GO:0000122 IEA     immune system process GO:0002376 IBA     cytoplasmic pattern recognition receptor signaling pathway GO:0002753 IDA     regulation of transcription by RNA polymerase II GO:0006357 IBA     apoptotic process GO:0006915 TAS     DNA damage response GO:0006974 TAS     mRNA transcription GO:0009299 IDA     signal transduction involved in regulation of gene expression GO:0023019 TAS     lipopolysaccharide-mediated signaling pathway GO:0031663 IEA     positive regulation of type I interferon production GO:0032481 IDA     positive regulation of interferon-alpha production GO:0032727 ISS     positive regulation of interferon-beta production GO:0032728 ISS     positive regulation of interferon-beta production GO:0032728 TAS     toll-like receptor 4 signaling pathway GO:0034142 IDA     TRIF-dependent toll-like receptor signaling pathway GO:0035666 IDA     MDA-5 signaling pathway GO:0039530 TAS     regulation of apoptotic process GO:0042981 IDA     positive regulation of canonical NF-kappaB signal transduction GO:0043123 IEA     innate immune response GO:0045087 TAS     positive regulation of DNA-templated transcription GO:0045893 IEA     positive regulation of transcription by RNA polymerase II GO:0045944 IDA     positive regulation of transcription by RNA polymerase II GO:0045944 IMP     regulation of inflammatory response GO:0050727 IEA     defense response to virus GO:0051607 ISS     type I interferon-mediated signaling pathway GO:0060337 IEA     positive regulation of type I interferon-mediated signaling pathway GO:0060340 IEA     cellular response to exogenous dsRNA GO:0071360 IEA     macrophage apoptotic process GO:0071888 TAS     programmed necrotic cell death GO:0097300 IEA     cellular response to virus GO:0098586 IDA     antiviral innate immune response GO:0140374 IDA     cGAS/STING signaling pathway GO:0140896 TAS     positive regulation of cytokine production involved in inflammatory response GO:1900017 TAS Subcellular Localization     chromatin GO:0000785 IDA     chromatin GO:0000785 ISA     nucleus GO:0005634 IBA     nucleus GO:0005634 IDA     nucleus GO:0005634 IDA     nucleoplasm GO:0005654 TAS     cytoplasm GO:0005737 IDA     cytoplasm GO:0005737 IDA     cytoplasm GO:0005737 IGI     mitochondrion GO:0005739 IDA     cytosol GO:0005829 IDA     cytosol GO:0005829 TAS