Gene description for IRF3
Gene name	interferon regulatory factor 3
Gene symbol	IRF3
Other names/aliases	-
Species	Homo sapiens
Database cross references - IRF3
ExoCarta	ExoCarta_3661
Entrez Gene	3661
HGNC	6118
MIM	603734
UniProt	Q14653
IRF3 identified in exosomes derived from the following tissue/cell type
Hepatocellular carcinoma cells	26054723

Gene ontology annotations for IRF3

Molecular Function     transcription regulatory region DNA binding GO:0044212 IEA     sequence-specific DNA binding transcription factor activity GO:0003700 IEA     DNA binding GO:0003677 NAS     protein homodimerization activity GO:0042803 IPI     identical protein binding GO:0042802 IPI     protein binding GO:0005515 IPI     transcription cofactor activity GO:0003712 TAS Biological Process     MDA-5 signaling pathway GO:0039530 TAS     negative regulation of interferon-beta biosynthetic process GO:0045358 IEA     macrophage apoptotic process GO:0071888 TAS     negative regulation of type I interferon production GO:0032480 TAS     lipopolysaccharide-mediated signaling pathway GO:0031663 IEA     toll-like receptor signaling pathway GO:0002224 TAS     response to exogenous dsRNA GO:0043330 IEA     positive regulation of interferon-alpha production GO:0032727 ISS     cytokine-mediated signaling pathway GO:0019221 TAS     type I interferon biosynthetic process GO:0045351 IEA     viral process GO:0016032 IEA     toll-like receptor 3 signaling pathway GO:0034138 TAS     positive regulation of type I interferon production GO:0032481 TAS     apoptotic process GO:0006915 TAS     innate immune response GO:0045087 TAS     positive regulation of I-kappaB kinase/NF-kappaB signaling GO:0043123 IEA     positive regulation of cytokine secretion GO:0050715 IEA     MyD88-independent toll-like receptor signaling pathway GO:0002756 TAS     transcription from RNA polymerase II promoter GO:0006366 TAS     negative regulation of transcription from RNA polymerase II promoter GO:0000122 IEA     TRIF-dependent toll-like receptor signaling pathway GO:0035666 TAS     positive regulation of type I interferon-mediated signaling pathway GO:0060340 IEA     defense response to virus GO:0051607 ISS     positive regulation of interferon-beta production GO:0032728 TAS     programmed necrotic cell death GO:0097300 IEA     negative regulation of defense response to virus by host GO:0050689 IEA     type I interferon signaling pathway GO:0060337 TAS     cellular response to dsRNA GO:0071359 IEA     cellular response to DNA damage stimulus GO:0006974 TAS     interferon-gamma-mediated signaling pathway GO:0060333 TAS     toll-like receptor 4 signaling pathway GO:0034142 TAS Subcellular Localization     cytoplasm GO:0005737 IDA     nucleoplasm GO:0005654 TAS     nucleus GO:0005634 IDA     cytosol GO:0005829 TAS