Gene description for RB1
Gene name	retinoblastoma 1
Gene symbol	RB1
Other names/aliases	OSRC PPP1R130 RB p105-Rb pRb pp110
Species	Homo sapiens
Database cross references - RB1
ExoCarta	ExoCarta_5925
Entrez Gene	5925
HGNC	9884
MIM	614041
UniProt	P06400
RB1 identified in exosomes derived from the following tissue/cell type
Endothelial cells	26027894

Gene ontology annotations for RB1

Molecular Function     protein binding GO:0005515 IPI     phosphoprotein binding GO:0051219 IPI     sequence-specific DNA binding transcription factor activity GO:0003700 TAS     androgen receptor binding GO:0050681 NAS     kinase binding GO:0019900 IDA     core promoter binding GO:0001047 IDA     transcription coactivator activity GO:0003713 NAS     identical protein binding GO:0042802 IPI     RNA polymerase II activating transcription factor binding GO:0001102 IEA     DNA binding GO:0003677 TAS     ubiquitin protein ligase binding GO:0031625 IPI     transcription factor binding GO:0008134 IPI Biological Process     striated muscle cell differentiation GO:0051146 IEA     androgen receptor signaling pathway GO:0030521 NAS     neuron maturation GO:0042551 IEA     regulation of lipid kinase activity GO:0043550 IDA     mitotic cell cycle checkpoint GO:0007093 TAS     negative regulation of epithelial cell proliferation GO:0050680 IEA     sister chromatid biorientation GO:0031134 IMP     cell morphogenesis involved in neuron differentiation GO:0048667 IEA     glial cell apoptotic process GO:0034349 IEA     positive regulation of transcription, DNA-templated GO:0045893 NAS     regulation of mitotic cell cycle GO:0007346 IMP     neuron apoptotic process GO:0051402 IEA     regulation of transcription involved in G1/S transition of mitotic cell cycle GO:0000083 TAS     maintenance of mitotic sister chromatid cohesion GO:0034088 IMP     positive regulation of macrophage differentiation GO:0045651 IEA     G1/S transition of mitotic cell cycle GO:0000082 TAS     regulation of cohesin localization to chromatin GO:0071922 IMP     negative regulation of protein kinase activity GO:0006469 IPI     positive regulation of transcription from RNA polymerase II promoter GO:0045944 IEA     digestive tract development GO:0048565 IEA     negative regulation of transcription involved in G1/S transition of mitotic cell cycle GO:0071930 IEA     negative regulation of transcription from RNA polymerase II promoter during mitosis GO:0007070 TAS     hepatocyte apoptotic process GO:0097284 IEA     skeletal muscle cell differentiation GO:0035914 IEA     mitotic cell cycle GO:0000278 TAS     negative regulation of G1/S transition of mitotic cell cycle GO:2000134 TAS     cell cycle arrest GO:0007050 TAS     chromatin remodeling GO:0006338 TAS     cell division GO:0051301 IEA     regulation of centromere complex assembly GO:0090230 TAS     negative regulation of transcription, DNA-templated GO:0045892 TAS     transcription, DNA-templated GO:0006351 IEA     myoblast differentiation GO:0045445 IMP     enucleate erythrocyte differentiation GO:0043353 IEA     negative regulation of sequence-specific DNA binding transcription factor activity GO:0043433 TAS     neuron projection development GO:0031175 IEA     protein localization to chromosome, centromeric region GO:0071459 IMP     negative regulation of smoothened signaling pathway GO:0045879 IEA     Ras protein signal transduction GO:0007265 IEP     positive regulation of mitotic metaphase/anaphase transition GO:0045842 IMP     cell cycle checkpoint GO:0000075 TAS     viral process GO:0016032 IEA Subcellular Localization     SWI/SNF complex GO:0016514 TAS     spindle GO:0005819 IEA     chromatin GO:0000785 TAS     nucleus GO:0005634 IDA     nucleoplasm GO:0005654 TAS     PML body GO:0016605 IDA     Rb-E2F complex GO:0035189 TAS