Gene description for RB1
Gene name retinoblastoma 1
Gene symbol RB1
Other names/aliases OSRC
PPP1R130
RB
p105-Rb
pRb
pp110
Species Homo sapiens
 Database cross references - RB1
ExoCarta ExoCarta_5925
Vesiclepedia VP_5925
Entrez Gene 5925
HGNC 9884
MIM 614041
UniProt P06400  
 RB1 identified in sEVs derived from the following tissue/cell type
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Colorectal cancer cells 34887515    
Endothelial cells 26027894    
Mesenchymal stem cells 36408942    
 Gene ontology annotations for RB1
Molecular Function
    RNA polymerase II transcription regulatory region sequence-specific DNA binding GO:0000977 IBA
    transcription corepressor activity GO:0003714 TAS
    protein binding GO:0005515 IPI
    kinase binding GO:0019900 IDA
    ubiquitin protein ligase binding GO:0031625 IPI
    identical protein binding GO:0042802 IPI
    phosphoprotein binding GO:0051219 IPI
    molecular adaptor activity GO:0060090 EXP
    RNA polymerase II-specific DNA-binding transcription factor binding GO:0061629 IEA
    importin-alpha family protein binding GO:0061676 IPI
    disordered domain specific binding GO:0097718 IPI
    DNA-binding transcription factor binding GO:0140297 IPI
Biological Process
    G1/S transition of mitotic cell cycle GO:0000082 IEA
    negative regulation of transcription by RNA polymerase II GO:0000122 TAS
    tissue homeostasis GO:0001894 IEA
    chondrocyte differentiation GO:0002062 IEA
    aortic valve morphogenesis GO:0003180 ISS
    chromatin remodeling GO:0006338 TAS
    regulation of DNA-templated transcription GO:0006355 IDA
    regulation of DNA-templated transcription GO:0006355 ISS
    regulation of DNA-templated transcription GO:0006355 NAS
    transcription by RNA polymerase II GO:0006366 IEA
    negative regulation of protein kinase activity GO:0006469 IPI
    smoothened signaling pathway GO:0007224 IEA
    Ras protein signal transduction GO:0007265 IEP
    spermatogenesis GO:0007283 IEA
    regulation of mitotic cell cycle GO:0007346 IMP
    negative regulation of gene expression GO:0010629 IMP
    glial cell proliferation GO:0014009 IEA
    cell differentiation GO:0030154 IBA
    negative regulation of cell growth GO:0030308 ISS
    sister chromatid biorientation GO:0031134 IMP
    neuron projection development GO:0031175 IBA
    heterochromatin formation GO:0031507 IDA
    cellular response to insulin stimulus GO:0032869 IEA
    maintenance of mitotic sister chromatid cohesion GO:0034088 IMP
    glial cell apoptotic process GO:0034349 IEA
    skeletal muscle cell differentiation GO:0035914 IEA
    neuron maturation GO:0042551 IEA
    enucleate erythrocyte differentiation GO:0043353 IEA
    negative regulation of DNA-binding transcription factor activity GO:0043433 TAS
    regulation of lipid kinase activity GO:0043550 IDA
    myoblast differentiation GO:0045445 IMP
    positive regulation of macrophage differentiation GO:0045651 IEA
    negative regulation of cell cycle GO:0045786 ISS
    positive regulation of mitotic metaphase/anaphase transition GO:0045842 IMP
    negative regulation of smoothened signaling pathway GO:0045879 IEA
    negative regulation of DNA-templated transcription GO:0045892 IDA
    negative regulation of DNA-templated transcription GO:0045892 IMP
    negative regulation of DNA-templated transcription GO:0045892 TAS
    positive regulation of transcription by RNA polymerase II GO:0045944 IEA
    digestive tract development GO:0048565 IEA
    cell morphogenesis involved in neuron differentiation GO:0048667 IBA
    epithelial cell proliferation GO:0050673 IEA
    negative regulation of epithelial cell proliferation GO:0050680 IEA
    negative regulation of inflammatory response GO:0050728 ISS
    striated muscle cell differentiation GO:0051146 IEA
    chromosome organization GO:0051276 IMP
    cell division GO:0051301 IEA
    neuron apoptotic process GO:0051402 IEA
    regulation of cell cycle GO:0051726 TAS
    negative regulation of glial cell proliferation GO:0060253 IEA
    protein localization to chromosome, centromeric region GO:0071459 IMP
    cellular response to xenobiotic stimulus GO:0071466 IEA
    negative regulation of protein serine/threonine kinase activity GO:0071901 ISS
    regulation of centromere complex assembly GO:0090230 TAS
    hepatocyte apoptotic process GO:0097284 IEA
    negative regulation of cold-induced thermogenesis GO:0120163 ISS
    negative regulation of tau-protein kinase activity GO:1902948 ISS
    positive regulation of extracellular matrix organization GO:1903055 ISS
    negative regulation of hepatocyte apoptotic process GO:1903944 IEA
    positive regulation of collagen fibril organization GO:1904028 ISS
    negative regulation of myofibroblast differentiation GO:1904761 ISS
    negative regulation of G1/S transition of mitotic cell cycle GO:2000134 IBA
    negative regulation of G1/S transition of mitotic cell cycle GO:2000134 TAS
    positive regulation of transcription regulatory region DNA binding GO:2000679 IDA
    negative regulation of apoptotic signaling pathway GO:2001234 ISS
Subcellular Localization
    chromatin GO:0000785 IBA
    nucleus GO:0005634 IDA
    nucleus GO:0005634 NAS
    nucleus GO:0005634 TAS
    nucleoplasm GO:0005654 IDA
    nucleoplasm GO:0005654 TAS
    cytoplasm GO:0005737 ISS
    spindle GO:0005819 IEA
    cytosol GO:0005829 TAS
    cyclin/CDK positive transcription elongation factor complex GO:0008024 IDA
    SWI/SNF complex GO:0016514 TAS
    PML body GO:0016605 IDA
    Rb-E2F complex GO:0035189 IBA
    Rb-E2F complex GO:0035189 IDA
    Rb-E2F complex GO:0035189 IPI
    Rb-E2F complex GO:0035189 ISS
    Rb-E2F complex GO:0035189 TAS
    chromatin lock complex GO:0061793 IPI
 Experiment description of studies that identified RB1 in sEVs
1
Experiment ID 489
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 6
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
2
Experiment ID 490
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 7
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
3
Experiment ID 491
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 8
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
4
Experiment ID 492
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 9
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
5
Experiment ID 1203
MISEV standards
✔
EM
Biophysical techniques
✔
SDCBP|FLOT1|CD9|CD81|CD63|EPCAM|GAPDH|LAMP1|TFRC|CD151|CD82|LAMP2|RAB35|TSG101|FLOT2|RAB5B|ICAM1|RAB5A
Enriched markers
✘ Negative markers
✘ Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 34887515    
Organism Homo sapiens
Experiment description Supermeres are functional extracellular nanoparticles replete with disease biomarkers and therapeutic targets
Authors "Zhang Q, Jeppesen DK, Higginbotham JN, Graves-Deal R, Trinh VQ, Ramirez MA, Sohn Y, Neininger AC, Taneja N, McKinley ET, Niitsu H, Cao Z, Evans R, Glass SE, Ray KC, Fissell WH, Hill S, Rose KL, Huh WJ, Washington MK, Ayers GD, Burnette DT, Sharma S, Rome LH, Franklin JL, Lee YA, Liu Q, Coffey RJ."
Journal name Nat Cell Biol
Publication year 2021
Sample Colorectal cancer cells
Sample name DiFi
Isolation/purification methods Differential centrifugation
Filtration
Centrifugal ultrafiltration
Ultracentrifugation
OptiPrep density gradient centrifugation
Flotation density -
Molecules identified in the study Protein
miRNA
Methods used in the study Western blotting
Mass spectrometry
RNA sequencing
6
Experiment ID 226
MISEV standards
✔
EM
Biophysical techniques
✔
GAPDH|CD9|FLOT1
Enriched markers
✔
LMNA|H2AFX|ATP5A1|TOMM20
Negative markers
✘ Particle analysis
Identified molecule mRNA
Identification method Small RNA sequencing (Illumina HiSeq 2000 (Solexa)
PubMed ID 26027894    
Organism Homo sapiens
Experiment description "Quantitative and qualitative analysis of small RNAs in human endothelial cells and exosomes provides insights into localized RNA processing, degradation and sorting"
Authors "Bas W. M. van Balkom, Almut S. Eisele, D. Michiel Pegtel, Sander Bervoets, Marianne C. Verhaar"
Journal name Journal of Extracellular Vesicles
Publication year 2015
Sample Endothelial cells
Sample name HMEC-1
Isolation/purification methods Differential ultracentrifugation
Sucrose density gradient
Flotation density 1.10 g/mL
Molecules identified in the study miRNA
Protein
snoRNA
lncRNA
yRNA
snRNA
mRNA
ncRNA
mtRNA
vtRNA
scaRNA
lincRNA
Methods used in the study Small RNA sequencing (Illumina HiSeq 2000 (Solexa)
Western blotting
7
Experiment ID 488
MISEV standards
✔
EM
Biophysical techniques
✔
CD9|CD81|CD63|GAPDH|SDCBP|LAMP1|TFRC|UCHL1|FLOT2|LAMP2|FLOT1|ICAM1|RAB5B|CD151|RAB35|TSG101|RAB5A|CD82
Enriched markers
✔
CANX
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Homo sapiens
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Mesenchymal stem cells
Sample name UCMSC
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
 Protein-protein interactions for RB1
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 ACD  
Negative Genetic Homo sapiens
2 FRK 2444
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
3 TADA1  
Negative Genetic Homo sapiens
4 MCM7 4176
Two-hybrid Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Two-hybrid Homo sapiens
5 DDX19A 55308
Negative Genetic Homo sapiens
6 NCOA6  
Two-hybrid Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
7 CITED1 4435
Affinity Capture-MS Homo sapiens
8 FOXA3  
Affinity Capture-MS Homo sapiens
9 HDAC2 3066
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
10 RINT1 60561
Reconstituted Complex Homo sapiens
11 CDK3 1018
Biochemical Activity Homo sapiens
12 AATF  
Two-hybrid Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
13 GART 2618
Negative Genetic Homo sapiens
14 NPEPL1 79716
Co-fractionation Homo sapiens
15 SKI 6497
Affinity Capture-Western Homo sapiens
16 CTBP2 1488
Negative Genetic Homo sapiens
17 TARDBP 23435
Co-fractionation Homo sapiens
18 SP1  
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
19 FAM208A  
Two-hybrid Homo sapiens
20 E2F1 1869
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Co-fractionation Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Proximity Label-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Two-hybrid Homo sapiens
Reconstituted Complex Homo sapiens
Two-hybrid Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Luminescence Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Two-hybrid Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Co-localization Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Co-crystal Structure Homo sapiens
Reconstituted Complex Homo sapiens
Two-hybrid Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
21 NHLRC2 374354
Co-fractionation Homo sapiens
22 RUNX2  
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
23 BRCA1 672
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Co-localization Homo sapiens
Reconstituted Complex Homo sapiens
Negative Genetic Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
24 PAX2  
Affinity Capture-Western Homo sapiens
25 CSNK2A1 1457
Affinity Capture-MS Homo sapiens
26 CHEK2  
Biochemical Activity Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
27 PSMD10 5716
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Protein-peptide Homo sapiens
28 FKBP4 2288
Co-fractionation Homo sapiens
29 KDM4A  
Affinity Capture-Western Homo sapiens
Two-hybrid Homo sapiens
30 TAF1  
Phenotypic Suppression Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
31 MYOD1  
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
32 RBM26 64062
Affinity Capture-MS Homo sapiens
33 E2F6 1876
Affinity Capture-MS Homo sapiens
34 LMO2  
Affinity Capture-Western Homo sapiens
35 E2F2 1870
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Co-crystal Structure Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
36 MED13 9969
Negative Genetic Homo sapiens
37 HDAC3 8841
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
38 B3GAT1  
Affinity Capture-MS Homo sapiens
39 CBX1 10951
Reconstituted Complex Homo sapiens
40 BRD4 23476
Negative Genetic Homo sapiens
41 CDK14 5218
Biochemical Activity Homo sapiens
Biochemical Activity Homo sapiens
42 DYRK1A 1859
Affinity Capture-Western Homo sapiens
FRET Homo sapiens
Affinity Capture-MS Homo sapiens
43 PAX6  
Reconstituted Complex Homo sapiens
44 HELZ 9931
Affinity Capture-MS Homo sapiens
45 KDM2A  
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
46 FZR1  
Affinity Capture-Western Homo sapiens
Co-fractionation Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
47 CCL19  
Affinity Capture-MS Homo sapiens
48 CUX1 1523
Two-hybrid Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
49 SUV39H1  
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
50 STAT3 6774
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Co-localization Homo sapiens
51 NPM1 4869
Affinity Capture-Western Homo sapiens
52 MAPK14 1432
Biochemical Activity Homo sapiens
53 KLF15  
Proximity Label-MS Homo sapiens
54 PCGF3  
Affinity Capture-MS Homo sapiens
55 STAT1 6772
Co-fractionation Homo sapiens
56 HERC4 26091
Affinity Capture-MS Homo sapiens
57 GAK 2580
Negative Genetic Homo sapiens
58 C3orf62  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
59 HNRNPU 3192
Co-fractionation Homo sapiens
60 HMGA2 8091
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Far Western Homo sapiens
61 PLA2G12A  
Two-hybrid Homo sapiens
62 CDC27 996
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Co-fractionation Homo sapiens
Two-hybrid Homo sapiens
63 PHB 5245
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
64 E4F1  
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Two-hybrid Homo sapiens
65 C2CD4B  
Affinity Capture-MS Homo sapiens
66 MCM6 4175
Co-fractionation Homo sapiens
67 VDR  
Reconstituted Complex Homo sapiens
68 USP7 7874
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Biochemical Activity Homo sapiens
Affinity Capture-Western Homo sapiens
69 THOC1 9984
Reconstituted Complex Homo sapiens
Two-hybrid Homo sapiens
70 STAT6 6778
Negative Genetic Homo sapiens
71 CCAR1 55749
Negative Genetic Homo sapiens
72 FOXM1  
Affinity Capture-Western Homo sapiens
73 RIN1 9610
Negative Genetic Homo sapiens
74 BAG6 7917
Affinity Capture-MS Homo sapiens
75 HSPA8 3312
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
76 DYRK1B  
Affinity Capture-Western Homo sapiens
FRET Homo sapiens
Affinity Capture-MS Homo sapiens
77 ANAPC2 29882
Affinity Capture-Western Homo sapiens
Co-fractionation Homo sapiens
Affinity Capture-Western Homo sapiens
78 UNC13D 201294
Negative Genetic Homo sapiens
79 RB1 5925
Affinity Capture-Western Homo sapiens
Protein-peptide Homo sapiens
Affinity Capture-Western Homo sapiens
Protein-peptide Homo sapiens
80 E2F4  
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Two-hybrid Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
81 UBR4 23352
Affinity Capture-MS Homo sapiens
Co-localization Homo sapiens
82 PPP1CA 5499
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
83 EBNA1BP2 10969
Negative Genetic Homo sapiens
84 DLD 1738
Co-fractionation Homo sapiens
85 EID1  
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Two-hybrid Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
86 RBBP7 5931
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Negative Genetic Homo sapiens
87 P4HA1 5033
Negative Genetic Homo sapiens
88 SAP130  
Negative Genetic Homo sapiens
89 RFC5 5985
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
90 TGM2 7052
Affinity Capture-Western Homo sapiens
91 CDK5 1020
Biochemical Activity Homo sapiens
92 CTBP1 1487
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
93 STAC2  
Negative Genetic Homo sapiens
94 TUBA1A 7846
Synthetic Lethality Homo sapiens
95 DNMT3A 1788
Reconstituted Complex Homo sapiens
96 NFIX 4784
Affinity Capture-Western Homo sapiens
97 ATF2  
Reconstituted Complex Homo sapiens
98 PNO1 56902
Co-fractionation Homo sapiens
99 GTF2H1 2965
Co-fractionation Homo sapiens
100 PRDM2  
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Protein-peptide Homo sapiens
101 RPS6KB1 6198
Negative Genetic Homo sapiens
102 SMARCA4 6597
Co-fractionation Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Two-hybrid Homo sapiens
103 MAPT  
Co-fractionation Homo sapiens
104 CCNB1 891
Biochemical Activity Homo sapiens
105 MKRN2 23609
Affinity Capture-RNA Homo sapiens
106 MDM2  
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Biochemical Activity Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
107 MNAT1  
Reconstituted Complex Homo sapiens
108 RPA2 6118
Proximity Label-MS Homo sapiens
109 NTRK1 4914
Affinity Capture-MS Homo sapiens
110 FOXK2  
Affinity Capture-MS Homo sapiens
111 KDM5B  
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
112 CBX5 23468
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
113 ARNT 405
Affinity Capture-Western Homo sapiens
114 CHEK1  
Biochemical Activity Homo sapiens
Reconstituted Complex Homo sapiens
115 PAX8  
Affinity Capture-Western Homo sapiens
116 RBBP9 10741
Two-hybrid Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
117 HIST1H2BG 8339
Proximity Label-MS Homo sapiens
118 UBTF 7343
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
119 PML 5371
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
120 SNAPC1  
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
121 L3MBTL2  
Affinity Capture-Western Homo sapiens
122 PELP1 27043
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
123 HIST4H4 121504
Co-localization Homo sapiens
124 CEBPA  
Affinity Capture-MS Homo sapiens
125 ENC1  
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
126 CREG1 8804
Reconstituted Complex Homo sapiens
127 ARID4A  
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
128 CCNT1  
Co-fractionation Homo sapiens
129 ID2  
Affinity Capture-Western Homo sapiens
130 ENO3 2027
Negative Genetic Homo sapiens
131 PPP1R26  
Affinity Capture-Western Homo sapiens
Biochemical Activity Homo sapiens
Reconstituted Complex Homo sapiens
132 RING1 6015
Affinity Capture-Western Homo sapiens
133 PA2G4 5036
Reconstituted Complex Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
134 PPAN 56342
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
135 TMPO 7112
Affinity Capture-Western Homo sapiens
136 BRF1  
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
137 CCNA2 890
Biochemical Activity Homo sapiens
Biochemical Activity Homo sapiens
Biochemical Activity Homo sapiens
Biochemical Activity Homo sapiens
Biochemical Activity Homo sapiens
Biochemical Activity Homo sapiens
Affinity Capture-Western Homo sapiens
138 FRS2 10818
Negative Genetic Homo sapiens
139 USP4 7375
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Co-fractionation Homo sapiens
140 CUL3 8452
Affinity Capture-MS Homo sapiens
141 DCAF7 10238
Affinity Capture-MS Homo sapiens
142 MSH2 4436
Co-fractionation Homo sapiens
143 LMNB1 4001
Co-fractionation Homo sapiens
144 MAGEA11  
Affinity Capture-Western Homo sapiens
145 SIRT7  
Negative Genetic Homo sapiens
146 KLK11 11012
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
147 PPARG 5468
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
148 TAL1  
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
149 LIN54  
Reconstituted Complex Homo sapiens
150 FOXO1  
Affinity Capture-MS Homo sapiens
151 NFATC2  
Affinity Capture-MS Homo sapiens
152 E2F5  
Affinity Capture-MS Homo sapiens
153 SKP2  
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Negative Genetic Homo sapiens
154 CCNE1  
Biochemical Activity Homo sapiens
Biochemical Activity Homo sapiens
Biochemical Activity Homo sapiens
Biochemical Activity Homo sapiens
Biochemical Activity Homo sapiens
Biochemical Activity Homo sapiens
Biochemical Activity Homo sapiens
155 UHRF2  
Far Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
156 RPRD1B 58490
Affinity Capture-MS Homo sapiens
157 HES1 3280
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
158 YY1 7528
Affinity Capture-Western Homo sapiens
159 MCM4 4173
Co-fractionation Homo sapiens
160 PPIA 5478
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
161 MORF4L1  
Reconstituted Complex Homo sapiens
Co-purification Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
162 MDM4  
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
163 TP73  
Affinity Capture-Western Homo sapiens
164 RBBP4 5928
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
165 WEE1 7465
Synthetic Lethality Homo sapiens
166 INS 3630
Co-purification Homo sapiens
167 KIAA0430  
Affinity Capture-MS Homo sapiens
168 RFC1 5981
Affinity Capture-Western Homo sapiens
169 UBL4A 8266
Affinity Capture-MS Homo sapiens
170 TBP  
Reconstituted Complex Homo sapiens
171 AURKB 9212
Reconstituted Complex Homo sapiens
Biochemical Activity Homo sapiens
Affinity Capture-Western Homo sapiens
172 JUN 3725
Affinity Capture-Western Homo sapiens
Two-hybrid Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
173 CDK2 1017
Biochemical Activity Homo sapiens
Biochemical Activity Homo sapiens
Biochemical Activity Homo sapiens
Biochemical Activity Homo sapiens
Biochemical Activity Homo sapiens
Biochemical Activity Homo sapiens
Biochemical Activity Homo sapiens
Biochemical Activity Homo sapiens
Biochemical Activity Homo sapiens
Biochemical Activity Homo sapiens
Biochemical Activity Homo sapiens
Biochemical Activity Homo sapiens
Biochemical Activity Homo sapiens
Biochemical Activity Homo sapiens
Biochemical Activity Homo sapiens
Biochemical Activity Homo sapiens
Biochemical Activity Homo sapiens
Biochemical Activity Homo sapiens
Biochemical Activity Homo sapiens
Biochemical Activity Homo sapiens
Biochemical Activity Homo sapiens
Biochemical Activity Homo sapiens
Biochemical Activity Homo sapiens
Biochemical Activity Homo sapiens
Biochemical Activity Homo sapiens
Biochemical Activity Homo sapiens
Biochemical Activity Homo sapiens
Biochemical Activity Homo sapiens
174 ANKRD52 283373
Negative Genetic Homo sapiens
175 DGKZ  
Affinity Capture-Western Homo sapiens
176 VGLL3  
Negative Genetic Homo sapiens
177 LIN9  
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
178 FOS 2353
Reconstituted Complex Homo sapiens
179 MYC  
Two-hybrid Homo sapiens
180 BAG1 573
Affinity Capture-Western Homo sapiens
181 TFDP2  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
182 AHR 196
Two-hybrid Homo sapiens
Reconstituted Complex Homo sapiens
Two-hybrid Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Two-hybrid Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
183 CSNK2A2 1459
Affinity Capture-MS Homo sapiens
184 MRFAP1  
Affinity Capture-Western Homo sapiens
Co-purification Homo sapiens
Affinity Capture-Western Homo sapiens
185 TRIM27  
Two-hybrid Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Luminescence Homo sapiens
Two-hybrid Homo sapiens
Affinity Capture-Western Homo sapiens
186 KAT5  
Biochemical Activity Homo sapiens
Affinity Capture-Luminescence Homo sapiens
Affinity Capture-Western Homo sapiens
187 RAF1 5894
Two-hybrid Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Biochemical Activity Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
188 CCNA1  
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
189 PARP1 142
Proximity Label-MS Homo sapiens
Affinity Capture-MS Homo sapiens
190 EBNA3B  
Affinity Capture-Western
Affinity Capture-Western
191 PPP1CA  
Two-hybrid Bos taurus
192 SEPT11 55752
Co-fractionation Homo sapiens
193 CCND1 595
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Biochemical Activity Homo sapiens
Biochemical Activity Homo sapiens
Biochemical Activity Homo sapiens
Biochemical Activity Homo sapiens
Biochemical Activity Homo sapiens
Biochemical Activity Homo sapiens
Biochemical Activity Homo sapiens
Biochemical Activity Homo sapiens
Biochemical Activity Homo sapiens
Biochemical Activity Homo sapiens
Phenotypic Suppression Homo sapiens
Affinity Capture-Western Homo sapiens
194 RBBP5 5929
Reconstituted Complex Homo sapiens
195 LMNA 4000
Reconstituted Complex Homo sapiens
Co-fractionation Homo sapiens
196 FLT3LG  
Negative Genetic Homo sapiens
197 FOXK1 221937
Affinity Capture-MS Homo sapiens
198 HMGB1 3146
Reconstituted Complex Homo sapiens
199 UMPS 7372
Negative Genetic Homo sapiens
200 IRF3 3661
Affinity Capture-MS Homo sapiens
Reconstituted Complex Homo sapiens
201 RBBP8  
Two-hybrid Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
202 CBX4  
Phenotypic Enhancement Homo sapiens
Affinity Capture-Western Homo sapiens
203 DZIP3  
Affinity Capture-MS Homo sapiens
204 GYPA  
Affinity Capture-MS Homo sapiens
205 PLEKHA4 57664
Affinity Capture-MS Homo sapiens
206 FOXO3  
Affinity Capture-MS Homo sapiens
207 HNRNPDL 9987
Negative Genetic Homo sapiens
208 TFDP3  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
209 CCND2  
Biochemical Activity Homo sapiens
Biochemical Activity Homo sapiens
Biochemical Activity Homo sapiens
Biochemical Activity Homo sapiens
210 TP53 7157
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
211 SKIL  
Affinity Capture-Western Homo sapiens
212 ELMO2 63916
Negative Genetic Homo sapiens
213 ATP5J 522
Negative Genetic Homo sapiens
214 RNF40 9810
Reconstituted Complex Homo sapiens
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
215 SNAPC3  
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
216 NMI  
Co-fractionation Homo sapiens
217 TAF5L  
Negative Genetic Homo sapiens
218 DNAJA2 10294
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
219 PIN1 5300
Negative Genetic Homo sapiens
220 FAS 355
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
221 KAT2B  
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
222 TFDP1  
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
223 PURA 5813
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
224 GOLPH3 64083
Co-fractionation Homo sapiens
225 ABL1 25
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
226 MORF4L2  
Reconstituted Complex Homo sapiens
227 PPP1R9B 84687
Affinity Capture-Western Homo sapiens
Biochemical Activity Homo sapiens
228 HBP1  
Two-hybrid Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
229 RBAK  
Reconstituted Complex Homo sapiens
230 HDAC1 3065
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Luminescence Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Co-fractionation Homo sapiens
231 HSP90AA1 3320
Synthetic Lethality Homo sapiens
232 CDK6 1021
Biochemical Activity Homo sapiens
Biochemical Activity Homo sapiens
Biochemical Activity Homo sapiens
Biochemical Activity Homo sapiens
Biochemical Activity Homo sapiens
Biochemical Activity Homo sapiens
Biochemical Activity Homo sapiens
Affinity Capture-Western Homo sapiens
233 SIRT1  
Affinity Capture-Western Homo sapiens
234 TRIP11 9321
Reconstituted Complex Homo sapiens
Two-hybrid Homo sapiens
Affinity Capture-Western Homo sapiens
235 CDK1 983
Biochemical Activity Homo sapiens
Biochemical Activity Homo sapiens
Biochemical Activity Homo sapiens
Biochemical Activity Homo sapiens
Biochemical Activity Homo sapiens
Biochemical Activity Homo sapiens
236 TOP2A 7153
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
237 TRAP1 10131
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Two-hybrid Homo sapiens
Affinity Capture-Western Homo sapiens
238 RFPL2  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
239 Sin3a  
Reconstituted Complex Mus musculus
240 E2F3  
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
241 COQ2  
Negative Genetic Homo sapiens
242 KDM1A 23028
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
243 CDK13 8621
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
244 LDB1  
Affinity Capture-Western Homo sapiens
245 PPP2R3C  
Negative Genetic Homo sapiens
246 CEBPD  
Affinity Capture-Western Homo sapiens
247 SMYD2 56950
Biochemical Activity Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
248 COMMD5 28991
Negative Genetic Homo sapiens
249 CDK4 1019
Biochemical Activity Homo sapiens
Biochemical Activity Homo sapiens
Biochemical Activity Homo sapiens
Biochemical Activity Homo sapiens
Biochemical Activity Homo sapiens
Biochemical Activity Homo sapiens
Affinity Capture-Western Homo sapiens
Biochemical Activity Homo sapiens
Biochemical Activity Homo sapiens
Biochemical Activity Homo sapiens
Biochemical Activity Homo sapiens
Biochemical Activity Homo sapiens
Biochemical Activity Homo sapiens
Biochemical Activity Homo sapiens
Biochemical Activity Homo sapiens
Biochemical Activity Homo sapiens
Biochemical Activity Homo sapiens
Biochemical Activity Homo sapiens
Biochemical Activity Homo sapiens
Biochemical Activity Homo sapiens
Biochemical Activity Homo sapiens
Biochemical Activity Homo sapiens
Biochemical Activity Homo sapiens
Biochemical Activity Homo sapiens
Biochemical Activity Homo sapiens
Biochemical Activity Homo sapiens
Biochemical Activity Homo sapiens
Biochemical Activity Homo sapiens
Biochemical Activity Homo sapiens
Biochemical Activity Homo sapiens
Biochemical Activity Homo sapiens
Biochemical Activity Homo sapiens
Biochemical Activity Homo sapiens
Reconstituted Complex Homo sapiens
250 PSMA7 5688
Affinity Capture-Western Homo sapiens
251 KDM5A  
Affinity Capture-Western Homo sapiens
Two-hybrid Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
252 PCGF6  
Affinity Capture-MS Homo sapiens
253 CDK9 1025
Affinity Capture-Western Homo sapiens
Biochemical Activity Homo sapiens
Biochemical Activity Homo sapiens
Reconstituted Complex Homo sapiens
Co-fractionation Homo sapiens
254 CDC16 8881
Affinity Capture-Western Homo sapiens
Co-fractionation Homo sapiens
255 TCF3  
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
256 SERPINB2 5055
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
257 L3MBTL1  
Affinity Capture-Western Homo sapiens
258 CCNT2  
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
259 POLA1  
Affinity Capture-Western Homo sapiens
Co-purification Homo sapiens
260 CEBPB  
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Far Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
261 SNW1 22938
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Co-fractionation Homo sapiens
262 UHRF1 29128
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
263 GNB2L1 10399
Affinity Capture-Western Homo sapiens
264 AR 367
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Two-hybrid Homo sapiens
Affinity Capture-Western Homo sapiens
265 NEFM 4741
Reconstituted Complex Homo sapiens
266 GBE1 2632
Co-fractionation Homo sapiens
267 SPI1  
Reconstituted Complex Homo sapiens
268 DNMT1 1786
Co-fractionation Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Co-fractionation Homo sapiens
269 Smarca4  
Reconstituted Complex Mus musculus
Reconstituted Complex Mus musculus
270 ZBTB7A 51341
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
271 NOTCH1 4851
Affinity Capture-MS Homo sapiens
272 ARID3B  
Reconstituted Complex Homo sapiens
273 EP300 2033
Affinity Capture-Western Homo sapiens
Biochemical Activity Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
274 BCR 613
Affinity Capture-Western Homo sapiens
275 PIK3R3 8503
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
276 CCND3  
Affinity Capture-Western Homo sapiens
Two-hybrid Homo sapiens
View the network image/svg+xml
 Pathways in which RB1 is involved
PathwayEvidenceSource
Aberrant regulation of mitotic cell cycle due to RB1 defects TAS Reactome
Aberrant regulation of mitotic exit in cancer due to RB1 defects TAS Reactome
Aberrant regulation of mitotic G1/S transition in cancer due to RB1 defects TAS Reactome
APC/C-mediated degradation of cell cycle proteins TAS Reactome
APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 TAS Reactome
Cell Cycle TAS Reactome
Cell Cycle IEA Reactome
Cell Cycle, Mitotic TAS Reactome
Cell Cycle, Mitotic IEA Reactome
Cellular responses to stimuli TAS Reactome
Cellular responses to stress TAS Reactome
Cellular Senescence TAS Reactome
Condensation of Prophase Chromosomes TAS Reactome
Cyclin A:Cdk2-associated events at S phase entry TAS Reactome
Cyclin D associated events in G1 TAS Reactome
Cyclin E associated events during G1/S transition TAS Reactome
Defective binding of RB1 mutants to E2F1,(E2F2, E2F3) TAS Reactome
Defective translocation of RB1 mutants to the nucleus TAS Reactome
Disease TAS Reactome
Disease IEA Reactome
Diseases of mitotic cell cycle TAS Reactome
Diseases of signal transduction by growth factor receptors and second messengers TAS Reactome
DNA Damage/Telomere Stress Induced Senescence TAS Reactome
E2F mediated regulation of DNA replication TAS Reactome
E2F mediated regulation of DNA replication IEA Reactome
Early SARS-CoV-2 Infection Events IEA Reactome
Epigenetic regulation by WDR5-containing histone modifying complexes TAS Reactome
Epigenetic regulation of adipogenesis genes by MLL3 and MLL4 complexes TAS Reactome
Epigenetic regulation of gene expression TAS Reactome
Epigenetic regulation of gene expression by MLL3 and MLL4 complexes TAS Reactome
Formation of Senescence-Associated Heterochromatin Foci (SAHF) TAS Reactome
G1 Phase TAS Reactome
G1/S Transition TAS Reactome
G1/S Transition IEA Reactome
Gene expression (Transcription) TAS Reactome
Gene expression (Transcription) IEA Reactome
Generic Transcription Pathway IEA Reactome
Infectious disease TAS Reactome
Infectious disease IEA Reactome
Inhibition of replication initiation of damaged DNA by RB1/E2F1 TAS Reactome
Inhibition of replication initiation of damaged DNA by RB1/E2F1 IEA Reactome
M Phase TAS Reactome
Mitotic G1 phase and G1/S transition TAS Reactome
Mitotic G1 phase and G1/S transition IEA Reactome
Mitotic Prophase TAS Reactome
MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis TAS Reactome
Nuclear events stimulated by ALK signaling in cancer TAS Reactome
Oncogene Induced Senescence TAS Reactome
Phosphorylation of proteins involved in G1/S transition by active Cyclin E:Cdk2 complexes TAS Reactome
Regulation of mitotic cell cycle TAS Reactome
Replication of the SARS-CoV-1 genome TAS Reactome
Replication of the SARS-CoV-2 genome IEA Reactome
RNA Polymerase II Transcription IEA Reactome
RUNX2 regulates bone development IEA Reactome
RUNX2 regulates osteoblast differentiation IEA Reactome
S Phase TAS Reactome
SARS-CoV Infections TAS Reactome
SARS-CoV Infections IEA Reactome
SARS-CoV-1 Genome Replication and Transcription TAS Reactome
SARS-CoV-1 Infection TAS Reactome
SARS-CoV-2 Genome Replication and Transcription IEA Reactome
SARS-CoV-2 Infection IEA Reactome
Signaling by ALK fusions and activated point mutants TAS Reactome
Signaling by ALK in cancer TAS Reactome
Transcriptional regulation by RUNX2 IEA Reactome
Viral Infection Pathways TAS Reactome
Viral Infection Pathways IEA Reactome





Perform bioinformatics analysis of your extracellular vesicle data set using FunRich, a open access standalone tool. NEW UPDATED VERSION OF FunRich available for download (12/09/2016) from here