Gene description for HDAC1
Gene name	histone deacetylase 1
Gene symbol	HDAC1
Other names/aliases	GON-10 HD1 RPD3 RPD3L1
Species	Homo sapiens
Database cross references - HDAC1
ExoCarta	ExoCarta_3065
Entrez Gene	3065
HGNC	4852
MIM	601241
UniProt	Q13547
HDAC1 identified in exosomes derived from the following tissue/cell type
Colorectal cancer cells	23161513
Colorectal cancer cells	23161513
Colorectal cancer cells	23161513
Hepatocellular carcinoma cells	26054723
Hepatocellular carcinoma cells	26054723
Thymus	23844026

Gene ontology annotations for HDAC1

Molecular Function     enzyme binding GO:0019899 IPI     repressing transcription factor binding GO:0070491 IPI     RNA polymerase II transcription corepressor activity GO:0001106 IDA     NAD-dependent histone deacetylase activity (H3-K9 specific) GO:0046969 IEA     NAD-dependent histone deacetylase activity (H3-K18 specific) GO:0097372 IEA     histone deacetylase binding GO:0042826 IPI     activating transcription factor binding GO:0033613 IPI     sequence-specific DNA binding transcription factor activity GO:0003700 TAS     protein deacetylase activity GO:0033558 IMP     histone deacetylase activity GO:0004407 TAS     NAD-dependent histone deacetylase activity (H4-K16 specific) GO:0046970 IEA     NF-kappaB binding GO:0051059 IPI     core promoter binding GO:0001047 IDA     transcription regulatory region sequence-specific DNA binding GO:0000976 ISS     nucleosomal DNA binding GO:0031492 IDA     RNA polymerase II repressing transcription factor binding GO:0001103 IPI     transcription factor binding GO:0008134 TAS     transcription regulatory region DNA binding GO:0044212 IDA     RNA polymerase II core promoter proximal region sequence-specific DNA binding GO:0000978 IDA     deacetylase activity GO:0019213 ISS     NAD-dependent histone deacetylase activity (H3-K14 specific) GO:0032041 IEA     protein N-terminus binding GO:0047485 IDA     protein binding GO:0005515 IPI     RNA polymerase II distal enhancer sequence-specific DNA binding GO:0000980 IDA Biological Process     transcription, DNA-templated GO:0006351 TAS     viral process GO:0016032 IEA     negative regulation of cell cycle GO:0045786 TAS     negative regulation by host of viral transcription GO:0043922 IMP     embryonic digit morphogenesis GO:0042733 ISS     positive regulation of transcription from RNA polymerase II promoter GO:0045944 IDA     mitotic cell cycle GO:0000278 TAS     negative regulation of androgen receptor signaling pathway GO:0060766 IDA     odontogenesis of dentin-containing tooth GO:0042475 ISS     fungiform papilla formation GO:0061198 ISS     hair follicle placode formation GO:0060789 ISS     negative regulation of gene expression, epigenetic GO:0045814 TAS     histone deacetylation GO:0016575 IMP     positive regulation of receptor biosynthetic process GO:0010870 IMP     protein deacetylation GO:0006476 IDA     histone H3-K9 modification GO:0061647 IEA     regulation of gene expression, epigenetic GO:0040029 TAS     positive regulation of cell proliferation GO:0008284 IMP     chromatin remodeling GO:0006338 IC     negative regulation of myotube differentiation GO:0010832 IMP     eyelid development in camera-type eye GO:0061029 ISS     circadian regulation of gene expression GO:0032922 ISS     negative regulation of gene expression GO:0010629 IMP     Notch signaling pathway GO:0007219 TAS     histone H3 deacetylation GO:0070932 IDA     negative regulation of apoptotic process GO:0043066 ISS     positive regulation of transcription, DNA-templated GO:0045893 IDA     epidermal cell differentiation GO:0009913 ISS     gene expression GO:0010467 TAS     neurotrophin TRK receptor signaling pathway GO:0048011 TAS     ATP-dependent chromatin remodeling GO:0043044 IDA     transforming growth factor beta receptor signaling pathway GO:0007179 TAS     transcription initiation from RNA polymerase II promoter GO:0006367 TAS     histone H4 deacetylation GO:0070933 IDA     histone H3-K9 deacetylation GO:1990619 IEA     chromatin organization GO:0006325 TAS     negative regulation of transcription from RNA polymerase II promoter GO:0000122 TAS     blood coagulation GO:0007596 TAS     chromatin modification GO:0016568 TAS     negative regulation of transcription, DNA-templated GO:0045892 ISS Subcellular Localization     chromatin GO:0000785 IDA     histone deacetylase complex GO:0000118 TAS     nuclear chromatin GO:0000790 IDA     nucleus GO:0005634 IDA     cytosol GO:0005829 IDA     Sin3 complex GO:0016580 IDA     protein complex GO:0043234 IDA     nucleoplasm GO:0005654 TAS     NuRD complex GO:0016581 IDA     cytoplasm GO:0005737 TAS