Gene description for HDAC2
Gene name	histone deacetylase 2
Gene symbol	HDAC2
Other names/aliases	HD2 RPD3 YAF1
Species	Homo sapiens
Database cross references - HDAC2
ExoCarta	ExoCarta_3066
Entrez Gene	3066
HGNC	4853
MIM	605164
UniProt	Q92769
HDAC2 identified in exosomes derived from the following tissue/cell type
Ovarian cancer cells	23333927
Ovarian cancer cells	23333927
Thymus	23844026

Gene ontology annotations for HDAC2

Molecular Function     deacetylase activity GO:0019213 ISS     sequence-specific DNA binding transcription factor activity GO:0003700 IEA     chromatin binding GO:0003682 ISS     protein deacetylase activity GO:0033558 IMP     enzyme binding GO:0019899 IPI     transcription factor binding GO:0008134 IPI     Krueppel-associated box domain binding GO:0035851 IEA     RNA polymerase II distal enhancer sequence-specific DNA binding GO:0000980 IDA     nucleosomal DNA binding GO:0031492 IDA     RNA polymerase II repressing transcription factor binding GO:0001103 IPI     protein binding GO:0005515 IPI     poly(A) RNA binding GO:0044822 IDA     NAD-dependent histone deacetylase activity (H3-K9 specific) GO:0046969 IEA     NAD-dependent histone deacetylase activity (H4-K16 specific) GO:0046970 IEA     histone deacetylase activity GO:0004407 IDA     core promoter binding GO:0001047 IEA     RNA polymerase II core promoter proximal region sequence-specific DNA binding GO:0000978 IDA     NAD-dependent histone deacetylase activity (H3-K14 specific) GO:0032041 IEA     NAD-dependent histone deacetylase activity (H3-K18 specific) GO:0097372 IEA     sequence-specific DNA binding GO:0043565 IDA     NF-kappaB binding GO:0051059 IPI     heat shock protein binding GO:0031072 IEA Biological Process     negative regulation of transcription from RNA polymerase II promoter GO:0000122 IMP     regulation of protein kinase B signaling GO:0051896 IEA     negative regulation of intrinsic apoptotic signaling pathway GO:2001243 IEA     negative regulation of MHC class II biosynthetic process GO:0045347 IC     neurotrophin TRK receptor signaling pathway GO:0048011 TAS     chromatin remodeling GO:0006338 IC     ATP-dependent chromatin remodeling GO:0043044 IDA     positive regulation of transcription, DNA-templated GO:0045893 IC     positive regulation of receptor biosynthetic process GO:0010870 IMP     negative regulation of gene expression, epigenetic GO:0045814 TAS     histone H3-K9 modification GO:0061647 IEA     negative regulation of apoptotic process GO:0043066 ISS     positive regulation of oligodendrocyte differentiation GO:0048714 IEA     dendrite development GO:0016358 ISS     negative regulation of cardiac muscle cell proliferation GO:0060044 IEA     eyelid development in camera-type eye GO:0061029 ISS     blood coagulation GO:0007596 TAS     histone H3-K9 deacetylation GO:1990619 IEA     positive regulation of cell proliferation GO:0008284 IMP     negative regulation of canonical Wnt signaling pathway GO:0090090 IEA     regulation of protein deacetylation GO:0090311 IEA     gene expression GO:0010467 TAS     positive regulation of transcription from RNA polymerase II promoter GO:0045944 IMP     maintenance of chromatin silencing GO:0006344 IMP     positive regulation of sequence-specific DNA binding transcription factor activity GO:0051091 IEA     histone deacetylation GO:0016575 IMP     negative regulation of cell cycle GO:0045786 TAS     positive regulation of collagen biosynthetic process GO:0032967 IC     response to cocaine GO:0042220 IEA     histone H3 deacetylation GO:0070932 ISS     circadian regulation of gene expression GO:0032922 ISS     negative regulation of sequence-specific DNA binding transcription factor activity GO:0043433 IMP     fungiform papilla formation GO:0061198 ISS     odontogenesis of dentin-containing tooth GO:0042475 ISS     regulation of gene expression, epigenetic GO:0040029 TAS     epidermal cell differentiation GO:0009913 ISS     hippocampus development GO:0021766 IEA     hair follicle placode formation GO:0060789 ISS     cellular response to heat GO:0034605 IEA     negative regulation of neuron projection development GO:0010977 ISS     positive regulation of proteolysis GO:0045862 IMP     transcription, DNA-templated GO:0006351 IEA     chromatin organization GO:0006325 TAS     cardiac muscle cell development GO:0055013 IEA     embryonic digit morphogenesis GO:0042733 ISS     response to drug GO:0042493 IEA     regulation of sarcomere organization GO:0060297 IEA     histone H4 deacetylation GO:0070933 ISS     negative regulation of transcription, DNA-templated GO:0045892 IMP Subcellular Localization     nuclear chromatin GO:0000790 IDA     protein complex GO:0043234 IDA     ESC/E(Z) complex GO:0035098 IDA     nucleus GO:0005634 IDA     transcription factor complex GO:0005667 IEA     Sin3 complex GO:0016580 IDA     NuRD complex GO:0016581 IDA     cytoplasm GO:0005737 TAS     nucleoplasm GO:0005654 TAS     heterochromatin GO:0000792 IEA     replication fork GO:0005657 IEA