Gene description for MTA2
Gene name metastasis associated 1 family, member 2
Gene symbol MTA2
Other names/aliases MTA1L1
PID
Species Homo sapiens
 Database cross references - MTA2
ExoCarta ExoCarta_9219
Vesiclepedia VP_9219
Entrez Gene 9219
HGNC 7411
MIM 603947
UniProt O94776  
 MTA2 identified in sEVs derived from the following tissue/cell type
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Breast cancer cells 34108659    
Breast cancer cells 34108659    
Chondrocytes 35931686    
Chondrocytes 35931686    
Colorectal cancer cells 23161513    
Colorectal cancer cells 23161513    
Colorectal cancer cells 23161513    
Colorectal cancer cells 34887515    
Embryonic kidney cells 34108659    
Embryonic kidney cells 34108659    
Embryonic kidney cells 36706192    
Embryonic kidney cells 36706192    
Hepatocytes 26054723    
Mesenchymal stem cells 36408942    
Ovarian cancer cells 23333927    
Ovarian cancer cells 23333927    
Pancreatic cancer cells 34108659    
Pancreatic cancer cells 34108659    
Squamous carcinoma cells 20124223    
Thymus 23844026    
 Gene ontology annotations for MTA2
Molecular Function
    transcription coactivator activity GO:0003713 IBA
    transcription corepressor activity GO:0003714 IBA
    histone deacetylase activity GO:0004407 IEA
    protein binding GO:0005515 IPI
    nucleosomal DNA binding GO:0031492 HDA
    histone deacetylase binding GO:0042826 IBA
    sequence-specific DNA binding GO:0043565 IEA
    metal ion binding GO:0046872 IEA
    RNA polymerase II-specific DNA-binding transcription factor binding GO:0061629 IPI
Biological Process
    negative regulation of transcription by RNA polymerase II GO:0000122 IBA
    chromatin organization GO:0006325 TAS
    chromatin remodeling GO:0006338 HDA
    chromatin remodeling GO:0006338 IDA
    regulation of fibroblast migration GO:0010762 IEA
    regulation of cell fate specification GO:0042659 NAS
    negative regulation of DNA-templated transcription GO:0045892 NAS
    positive regulation of DNA-templated transcription GO:0045893 NAS
    positive regulation of transcription by RNA polymerase II GO:0045944 IEA
    genomic imprinting GO:0071514 IEA
    regulation of stem cell differentiation GO:2000736 NAS
Subcellular Localization
    histone deacetylase complex GO:0000118 TAS
    chromosome, telomeric region GO:0000781 IDA
    chromatin GO:0000785 HDA
    nucleus GO:0005634 IDA
    nucleoplasm GO:0005654 IBA
    nucleoplasm GO:0005654 IDA
    nucleoplasm GO:0005654 TAS
    transcription regulator complex GO:0005667 IDA
    membrane GO:0016020 HDA
    NuRD complex GO:0016581 IBA
    NuRD complex GO:0016581 IDA
    NuRD complex GO:0016581 NAS
    protein-containing complex GO:0032991 HDA
 Experiment description of studies that identified MTA2 in sEVs
1
Experiment ID 489
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 6
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
2
Experiment ID 490
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 7
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
3
Experiment ID 491
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 8
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
4
Experiment ID 492
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 9
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
5
Experiment ID 426
MISEV standards
✘ Biophysical techniques
✔
SDCBP|FLOT1|CD81|CD9|CD151|FLOT2|TSG101|LAMP1|TFRC|RAB5A|RAB35|GAPDH|UCHL1|ICAM1
Enriched markers
✔
CANX
Negative markers
✘ Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 34108659    
Organism Homo sapiens
Experiment description Quantitative Proteomics Identifies the Core Proteome of Exosomes with Syntenin-1 as the highest abundant protein and a Putative Universal Biomarker
Authors "Kugeratski FG, Hodge K, Lilla S, McAndrews KM, Zhou X, Hwang RF, Zanivan S, Kalluri R."
Journal name Nat Cell Biol
Publication year 2021
Sample Breast cancer cells
Sample name MDA-MB-231 - Exo-rich fractions 7-10 pooled
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Size exclusion chromatography
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
6
Experiment ID 427
MISEV standards
✘ Biophysical techniques
✔
CD81|SDCBP|FLOT1|CD9|CD151|FLOT2|TSG101|LAMP1|TFRC|RAB5A|RAB35|GAPDH|UCHL1|ICAM1
Enriched markers
✔
CANX
Negative markers
✘ Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 34108659    
Organism Homo sapiens
Experiment description Quantitative Proteomics Identifies the Core Proteome of Exosomes with Syntenin-1 as the highest abundant protein and a Putative Universal Biomarker
Authors "Kugeratski FG, Hodge K, Lilla S, McAndrews KM, Zhou X, Hwang RF, Zanivan S, Kalluri R."
Journal name Nat Cell Biol
Publication year 2021
Sample Breast cancer cells
Sample name MDA-MB-231 - Exo-rich fractions 1-6 pooled
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
OptiPrep density gradient centrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
7
Experiment ID 497
MISEV standards
✘ Biophysical techniques
✔
CD9|CD151|CD63|CD81|CD82|FLOT1|FLOT2|GAPDH|LAMP1|LAMP2|RAB5A|SDCBP|TFRC|TSG101|UCHL1
Enriched markers
✘ Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 35931686    
Organism Homo sapiens
Experiment description Extracellular vesicles enriched in connexin 43 promote a senescent phenotype in bone and synovial cells contributing to osteoarthritis progression
Authors "Varela-Eirín M, Carpintero-Fernández P, Guitián-Caamaño A, Varela-Vázquez A, García-Yuste A, Sánchez-Temprano A, Bravo-López SB, Yañez-Cabanas J, Fonseca E, Largo R, Mobasheri A, Caeiro JR, Mayán MD."
Journal name Cell Death Dis
Publication year 2022
Sample Chondrocytes
Sample name T/C-28a2
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
8
Experiment ID 498
MISEV standards
✔
EM
Biophysical techniques
✔
CD9|CD151|CD63|CD81|CD82|FLOT1|FLOT2|GAPDH|LAMP1|LAMP2|RAB5A|SDCBP|TFRC|TSG101|UCHL1
Enriched markers
✘ Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 35931686    
Organism Homo sapiens
Experiment description Extracellular vesicles enriched in connexin 43 promote a senescent phenotype in bone and synovial cells contributing to osteoarthritis progression
Authors "Varela-Eirín M, Carpintero-Fernández P, Guitián-Caamaño A, Varela-Vázquez A, García-Yuste A, Sánchez-Temprano A, Bravo-López SB, Yañez-Cabanas J, Fonseca E, Largo R, Mobasheri A, Caeiro JR, Mayán MD."
Journal name Cell Death Dis
Publication year 2022
Sample Chondrocytes
Sample name T/C-28a2
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
9
Experiment ID 207
MISEV standards
✔
EM
Biophysical techniques
✔
TSG101|HSP70|FLOT1
Enriched markers
✔
VDAC
Negative markers
✔
NTA
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23161513    
Organism Homo sapiens
Experiment description Proteomic analysis of exosomes from mutant KRAS colon cancer cells identifies intercellular transfer of mutant KRAS.
Authors "Demory Beckler M, Higginbotham JN, Franklin JL, Ham AJ, Halvey PJ, Imasuen IE, Whitwell C, Li M, Liebler DC, Coffey RJ."
Journal name Mol Cell Proteomics
Publication year 2012
Sample Colorectal cancer cells
Sample name DKO-1
Isolation/purification methods Differential centrifugation
Filtration
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
10
Experiment ID 208
MISEV standards
✔
EM
Biophysical techniques
✔
TSG101|HSP70|FLOT1
Enriched markers
✔
VDAC
Negative markers
✔
NTA
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23161513    
Organism Homo sapiens
Experiment description Proteomic analysis of exosomes from mutant KRAS colon cancer cells identifies intercellular transfer of mutant KRAS.
Authors "Demory Beckler M, Higginbotham JN, Franklin JL, Ham AJ, Halvey PJ, Imasuen IE, Whitwell C, Li M, Liebler DC, Coffey RJ."
Journal name Mol Cell Proteomics
Publication year 2012
Sample Colorectal cancer cells
Sample name Dks-8
Isolation/purification methods Differential centrifugation
Filtration
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
11
Experiment ID 209
MISEV standards
✘ Biophysical techniques
✔
TSG101|HSP70|FLOT1
Enriched markers
✔
VDAC
Negative markers
✔
NTA
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23161513    
Organism Homo sapiens
Experiment description Proteomic analysis of exosomes from mutant KRAS colon cancer cells identifies intercellular transfer of mutant KRAS.
Authors "Demory Beckler M, Higginbotham JN, Franklin JL, Ham AJ, Halvey PJ, Imasuen IE, Whitwell C, Li M, Liebler DC, Coffey RJ."
Journal name Mol Cell Proteomics
Publication year 2012
Sample Colorectal cancer cells
Sample name DLD-1
Isolation/purification methods Differential centrifugation
Filtration
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
12
Experiment ID 1203
MISEV standards
✔
EM
Biophysical techniques
✔
SDCBP|FLOT1|CD9|CD81|CD63|EPCAM|GAPDH|LAMP1|TFRC|CD151|CD82|LAMP2|RAB35|TSG101|FLOT2|RAB5B|ICAM1|RAB5A
Enriched markers
✘ Negative markers
✘ Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 34887515    
Organism Homo sapiens
Experiment description Supermeres are functional extracellular nanoparticles replete with disease biomarkers and therapeutic targets
Authors "Zhang Q, Jeppesen DK, Higginbotham JN, Graves-Deal R, Trinh VQ, Ramirez MA, Sohn Y, Neininger AC, Taneja N, McKinley ET, Niitsu H, Cao Z, Evans R, Glass SE, Ray KC, Fissell WH, Hill S, Rose KL, Huh WJ, Washington MK, Ayers GD, Burnette DT, Sharma S, Rome LH, Franklin JL, Lee YA, Liu Q, Coffey RJ."
Journal name Nat Cell Biol
Publication year 2021
Sample Colorectal cancer cells
Sample name DiFi
Isolation/purification methods Differential centrifugation
Filtration
Centrifugal ultrafiltration
Ultracentrifugation
OptiPrep density gradient centrifugation
Flotation density -
Molecules identified in the study Protein
miRNA
Methods used in the study Western blotting
Mass spectrometry
RNA sequencing
13
Experiment ID 419
MISEV standards
✘ Biophysical techniques
✔
SDCBP|FLOT1|CD81|CD9|CD151|FLOT2|TSG101|LAMP1|TFRC|RAB5A|RAB35|GAPDH|UCHL1|ICAM1
Enriched markers
✔
CANX
Negative markers
✘ Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 34108659    
Organism Homo sapiens
Experiment description Quantitative Proteomics Identifies the Core Proteome of Exosomes with Syntenin-1 as the highest abundant protein and a Putative Universal Biomarker
Authors "Kugeratski FG, Hodge K, Lilla S, McAndrews KM, Zhou X, Hwang RF, Zanivan S, Kalluri R."
Journal name Nat Cell Biol
Publication year 2021
Sample Embryonic kidney cells
Sample name HEK293T - Exo-rich fractions 7-10 pooled
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Size exclusion chromatography
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
14
Experiment ID 419
MISEV standards
✘ Biophysical techniques
✔
SDCBP|FLOT1|CD81|CD9|CD151|FLOT2|TSG101|LAMP1|TFRC|RAB5A|RAB35|GAPDH|UCHL1|ICAM1
Enriched markers
✔
CANX
Negative markers
✘ Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 34108659    
Organism Homo sapiens
Experiment description Quantitative Proteomics Identifies the Core Proteome of Exosomes with Syntenin-1 as the highest abundant protein and a Putative Universal Biomarker
Authors "Kugeratski FG, Hodge K, Lilla S, McAndrews KM, Zhou X, Hwang RF, Zanivan S, Kalluri R."
Journal name Nat Cell Biol
Publication year 2021
Sample Embryonic kidney cells
Sample name HEK293T - Exo-rich fractions 7-10 pooled
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Size exclusion chromatography
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
15
Experiment ID 420
MISEV standards
✘ Biophysical techniques
✔
CD81|SDCBP|FLOT1|CD9|CD151|FLOT2|TSG101|LAMP1|TFRC|RAB5A|RAB35|GAPDH|UCHL1|ICAM1
Enriched markers
✔
CANX
Negative markers
✘ Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 34108659    
Organism Homo sapiens
Experiment description Quantitative Proteomics Identifies the Core Proteome of Exosomes with Syntenin-1 as the highest abundant protein and a Putative Universal Biomarker
Authors "Kugeratski FG, Hodge K, Lilla S, McAndrews KM, Zhou X, Hwang RF, Zanivan S, Kalluri R."
Journal name Nat Cell Biol
Publication year 2021
Sample Embryonic kidney cells
Sample name HEK293T - Exo-rich fractions 1-6 pooled
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
OptiPrep density gradient centrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
16
Experiment ID 420
MISEV standards
✘ Biophysical techniques
✔
CD81|SDCBP|FLOT1|CD9|CD151|FLOT2|TSG101|LAMP1|TFRC|RAB5A|RAB35|GAPDH|UCHL1|ICAM1
Enriched markers
✔
CANX
Negative markers
✘ Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 34108659    
Organism Homo sapiens
Experiment description Quantitative Proteomics Identifies the Core Proteome of Exosomes with Syntenin-1 as the highest abundant protein and a Putative Universal Biomarker
Authors "Kugeratski FG, Hodge K, Lilla S, McAndrews KM, Zhou X, Hwang RF, Zanivan S, Kalluri R."
Journal name Nat Cell Biol
Publication year 2021
Sample Embryonic kidney cells
Sample name HEK293T - Exo-rich fractions 1-6 pooled
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
OptiPrep density gradient centrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
17
Experiment ID 1275
MISEV standards
Biophysical techniques
✔
CD9|TSG101|FLOT1|FLOT2|RAB35|RAB5A|GAPDH|TFRC|CD63|Alix
Enriched markers
✔
PCNA|CANX|GAPDH|HSP90AA1|HSP90B1
Negative markers
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36706192    
Organism Homo sapiens
Experiment description Displaying and delivering viral membrane antigens via WW domain-activated extracellular vesicles
Authors "Choi S, Yang Z, Wang Q, Qiao Z, Sun M, Wiggins J, Xiang SH, Lu Q."
Journal name Sci Adv
Publication year 2023
Sample Embryonic kidney cells
Sample name HEK293T
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
18
Experiment ID 1280
MISEV standards
Biophysical techniques
✔
TSG101|CD9|FLOT1|FLOT2|RAB35|RAB5A|GAPDH|TFRC|CD63|Alix
Enriched markers
✔
PCNA|CANX|GAPDH|HSP90AA1|HSP90B1
Negative markers
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36706192    
Organism Homo sapiens
Experiment description Displaying and delivering viral membrane antigens via WW domain-activated extracellular vesicles
Authors "Choi S, Yang Z, Wang Q, Qiao Z, Sun M, Wiggins J, Xiang SH, Lu Q."
Journal name Sci Adv
Publication year 2023
Sample Embryonic kidney cells
Sample name HEK293T - Fraction 5
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
OptiPrep density gradient centrifugation
Flotation density 1.151 g/mL
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
19
Experiment ID 237
MISEV standards
✔
EM
Biophysical techniques
✔
TSG101|Alix|HSC70|GAPDH
Enriched markers
✔
HSP90B1
Negative markers
✔
qNano
Particle analysis
Identified molecule mRNA
Identification method RNA Sequencing
PubMed ID 26054723    
Organism Homo sapiens
Experiment description Hepatocellular carcinoma-derived exosomes promote motility of immortalized hepatocyte through transfer of oncogenic proteins and RNAs
Authors "He M, Qin H, Poon TC, Sze SC, Ding X, Co NN, Ngai SM, Chan TF, Wong N"
Journal name Carcinogenesis
Publication year 2015
Sample Hepatocytes
Sample name MIHA
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.13-1.19 g/mL
Molecules identified in the study Protein
RNA
Methods used in the study Western blotting
Mass spectrometry
RNA Sequencing
20
Experiment ID 488
MISEV standards
✔
EM
Biophysical techniques
✔
CD9|CD81|CD63|GAPDH|SDCBP|LAMP1|TFRC|UCHL1|FLOT2|LAMP2|FLOT1|ICAM1|RAB5B|CD151|RAB35|TSG101|RAB5A|CD82
Enriched markers
✔
CANX
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Homo sapiens
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Mesenchymal stem cells
Sample name UCMSC
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
21
Experiment ID 211
MISEV standards
✔
EM
Biophysical techniques
✔
TSG101|Alix|EpCAM|TFRC
Enriched markers
✔
cytochrome c|GOLGA2
Negative markers
✘ Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23333927    
Organism Homo sapiens
Experiment description Characterization and proteomic analysis of ovarian cancer-derived exosomes.
Authors "Liang B, Peng P, Chen S, Li L, Zhang M, Cao D, Yang J, Li H, Gui T, Li X, Shen K."
Journal name J Proteomics
Publication year 2013
Sample Ovarian cancer cells
Sample name IGROV1
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient
Flotation density 1.09-1.15 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
22
Experiment ID 212
MISEV standards
✔
CEM
Biophysical techniques
✔
TSG101|Alix|EpCAM|TFRC
Enriched markers
✔
Cytochrome C|GOLGA2
Negative markers
✘ Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23333927    
Organism Homo sapiens
Experiment description Characterization and proteomic analysis of ovarian cancer-derived exosomes.
Authors "Liang B, Peng P, Chen S, Li L, Zhang M, Cao D, Yang J, Li H, Gui T, Li X, Shen K."
Journal name J Proteomics
Publication year 2013
Sample Ovarian cancer cells
Sample name OVCAR-3
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient
Flotation density 1.09-1.15 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
23
Experiment ID 434
MISEV standards
✘ Biophysical techniques
✔
SDCBP|FLOT1|CD81|CD9|CD151|FLOT2|TSG101|LAMP1|TFRC|RAB5A|RAB35|GAPDH|UCHL1|ICAM1
Enriched markers
✔
CANX
Negative markers
✘ Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 34108659    
Organism Homo sapiens
Experiment description Quantitative Proteomics Identifies the Core Proteome of Exosomes with Syntenin-1 as the highest abundant protein and a Putative Universal Biomarker
Authors "Kugeratski FG, Hodge K, Lilla S, McAndrews KM, Zhou X, Hwang RF, Zanivan S, Kalluri R."
Journal name Nat Cell Biol
Publication year 2021
Sample Pancreatic cancer cells
Sample name PANC-1 - Exo-rich fractions 7-10 pooled
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Size exclusion chromatography
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
24
Experiment ID 435
MISEV standards
✘ Biophysical techniques
✔
CD81|SDCBP|FLOT1|CD9|CD151|FLOT2|TSG101|LAMP1|TFRC|RAB5A|RAB35|GAPDH|UCHL1|ICAM1
Enriched markers
✔
CANX
Negative markers
✘ Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 34108659    
Organism Homo sapiens
Experiment description Quantitative Proteomics Identifies the Core Proteome of Exosomes with Syntenin-1 as the highest abundant protein and a Putative Universal Biomarker
Authors "Kugeratski FG, Hodge K, Lilla S, McAndrews KM, Zhou X, Hwang RF, Zanivan S, Kalluri R."
Journal name Nat Cell Biol
Publication year 2021
Sample Pancreatic cancer cells
Sample name PANC-1 - Exo-rich fractions 1-6 pooled
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
OptiPrep density gradient centrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
25
Experiment ID 191
MISEV standards
✘ Biophysical techniques
✔
Alix|CD81|CD9
Enriched markers
✘ Negative markers
✘ Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 20124223    
Organism Homo sapiens
Experiment description Hypoxic tumor cell modulates its microenvironment to enhance angiogenic and metastatic potential by secretion of proteins and exosomes.
Authors "Park JE, Tan HS, Datta A, Lai RC, Zhang H, Meng W, Lim SK, Sze SK."
Journal name Mol Cell Proteomics
Publication year 2010
Sample Squamous carcinoma cells
Sample name Squamous carcinoma cell (A431)
Isolation/purification methods Differential centrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
26
Experiment ID 217
MISEV standards
✔
EM
Biophysical techniques
✔
TSG101|CD81|CD9|CD63
Enriched markers
✘ Negative markers
✔
NTA
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23844026    
Organism Homo sapiens
Experiment description Characterization of human thymic exosomes.
Authors "Skogberg G, Gudmundsdottir J, van der Post S, Sandstrom K, Bruhn S, Benson M, Mincheva-Nilsson L, Baranov V, Telemo E, Ekwall O."
Journal name PLoS One
Publication year 2013
Sample Thymus
Sample name Normal-Thymus
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for MTA2
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 PHF12  
Affinity Capture-MS Homo sapiens
2 ATR  
Affinity Capture-Western Homo sapiens
3 HIST2H2BE 8349
Affinity Capture-MS Homo sapiens
4 UBE2H 7328
Affinity Capture-MS Homo sapiens
5 HNRNPC 3183
Co-fractionation Homo sapiens
6 APPL2 55198
Reconstituted Complex Homo sapiens
7 SMARCA2 6595
Co-fractionation Homo sapiens
8 GATAD2B 57459
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Co-fractionation Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Co-fractionation Homo sapiens
Co-fractionation Homo sapiens
9 ARID1A 8289
Co-fractionation Homo sapiens
10 HDAC2 3066
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Co-fractionation Homo sapiens
Affinity Capture-MS Homo sapiens
Co-fractionation Homo sapiens
Affinity Capture-MS Homo sapiens
Cross-Linking-MS (XL-MS) Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Co-purification Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-MS Homo sapiens
Co-fractionation Homo sapiens
11 RPS3A 6189
Co-fractionation Homo sapiens
12 KPNA1 3836
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
13 EML4 27436
Co-fractionation Homo sapiens
14 RABEP2 79874
Co-fractionation Homo sapiens
15 DLST 1743
Affinity Capture-MS Homo sapiens
16 TOP2B 7155
Affinity Capture-Western Homo sapiens
17 PFKP 5214
Co-fractionation Homo sapiens
18 RBM14 10432
Co-fractionation Homo sapiens
19 YWHAE 7531
Affinity Capture-MS Homo sapiens
20 MYPN 84665
Co-fractionation Homo sapiens
21 ACTR1A 10121
Co-fractionation Homo sapiens
22 SUB1 10923
Co-fractionation Homo sapiens
23 ACTC1 70
Proximity Label-MS Homo sapiens
24 BRCA1 672
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
25 ZDHHC1 29800
Affinity Capture-MS Homo sapiens
26 RBX1 9978
Affinity Capture-Western Homo sapiens
27 MAP4 4134
Co-fractionation Homo sapiens
28 C9orf78 51759
Affinity Capture-MS Homo sapiens
29 SMC3 9126
Co-fractionation Homo sapiens
30 CSNK2A1 1457
Affinity Capture-MS Homo sapiens
31 KPNA2 3838
Affinity Capture-MS Homo sapiens
Co-fractionation Homo sapiens
32 SAP30 8819
Co-purification Homo sapiens
Affinity Capture-MS Homo sapiens
Co-fractionation Homo sapiens
33 HNRNPR 10236
Co-fractionation Homo sapiens
34 STAG1  
Co-fractionation Homo sapiens
35 ZBTB1  
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
36 PARK7 11315
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
37 SOX2  
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
38 OTUD3 23252
Affinity Capture-MS Homo sapiens
39 SATB2  
Reconstituted Complex Homo sapiens
40 CAPRIN1 4076
Co-fractionation Homo sapiens
41 ATG13 9776
Affinity Capture-MS Homo sapiens
42 KIAA1429 25962
Affinity Capture-MS Homo sapiens
43 ALKBH7 84266
Affinity Capture-MS Homo sapiens
44 MARCH5  
Proximity Label-MS Homo sapiens
45 TCF19  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
46 RUVBL1 8607
Co-fractionation Homo sapiens
47 SNRNP70 6625
Co-fractionation Homo sapiens
48 TRIM28 10155
Co-fractionation Homo sapiens
49 PINK1  
Affinity Capture-MS Homo sapiens
50 PCNT  
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
51 Cdk2ap1  
Affinity Capture-MS Mus musculus
52 GTF2E2  
Affinity Capture-MS Homo sapiens
53 CHAF1A  
Affinity Capture-MS Homo sapiens
54 DPF2  
Co-fractionation Homo sapiens
55 GPHN 10243
Co-fractionation Homo sapiens
56 TRIM35 23087
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
57 CD2AP 23607
Co-fractionation Homo sapiens
58 CDK2AP1  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
59 SPAG9 9043
Co-fractionation Homo sapiens
Co-fractionation Homo sapiens
60 BRD4 23476
Affinity Capture-Western Homo sapiens
61 RABL6 55684
Co-fractionation Homo sapiens
62 BRCC3 79184
Co-fractionation Homo sapiens
63 ARID4B  
Affinity Capture-MS Homo sapiens
64 SATB1 6304
Co-fractionation Homo sapiens
Affinity Capture-Western Homo sapiens
65 SRRM2 23524
Affinity Capture-MS Homo sapiens
66 ZGPAT  
Affinity Capture-Western Homo sapiens
67 BCL2L14  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
68 OBSL1 23363
Affinity Capture-MS Homo sapiens
69 SIRT1  
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
70 SIN3B  
Affinity Capture-MS Homo sapiens
71 SNF8 11267
Co-fractionation Homo sapiens
72 RPLP2 6181
Cross-Linking-MS (XL-MS) Homo sapiens
73 MBD3L2  
Reconstituted Complex Homo sapiens
Affinity Capture-MS Homo sapiens
74 ZNF512B  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
75 FANCD2  
Affinity Capture-MS Homo sapiens
76 EED  
Affinity Capture-MS Homo sapiens
77 ZNF219  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
78 NR2C1  
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
79 POLR2C 5432
Co-fractionation Homo sapiens
80 PHF1  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
81 GOLGA3 2802
Co-fractionation Homo sapiens
82 SETD1A 9739
Affinity Capture-MS Homo sapiens
83 SMARCA1 6594
Affinity Capture-MS Homo sapiens
84 CHD3 1107
Co-fractionation Homo sapiens
Co-fractionation Homo sapiens
Co-purification Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Co-fractionation Homo sapiens
85 SALL4  
Affinity Capture-MS Homo sapiens
86 CPNE5 57699
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
87 MAD2L1 4085
Affinity Capture-MS Homo sapiens
88 UBE3C 9690
Two-hybrid Homo sapiens
89 CGB2  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
90 BCL11B  
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
91 Racgap1 26934
Affinity Capture-MS Mus musculus
92 APPL1 26060
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
93 ZFPM2  
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
94 SMARCD2 6603
Co-fractionation Homo sapiens
95 SMC2 10592
Co-fractionation Homo sapiens
96 EMC9  
Affinity Capture-MS Homo sapiens
97 FNBP1 23048
Co-fractionation Homo sapiens
98 MED30  
Two-hybrid Homo sapiens
99 UNK  
Affinity Capture-RNA Homo sapiens
100 E2F4  
Affinity Capture-MS Homo sapiens
101 H2AFZ 3015
Affinity Capture-MS Homo sapiens
102 UFL1 23376
Affinity Capture-MS Homo sapiens
103 HMGA1 3159
Affinity Capture-MS Homo sapiens
104 PHF20L1  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
105 RBBP7 5931
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Co-purification Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Reconstituted Complex Homo sapiens
Co-fractionation Homo sapiens
Co-fractionation Homo sapiens
106 SYMPK 8189
Co-fractionation Homo sapiens
107 FOXC1  
Affinity Capture-MS Homo sapiens
108 TSC22D3  
Two-hybrid Homo sapiens
109 SHPRH  
Affinity Capture-MS Homo sapiens
110 HIST1H4A 8359
Affinity Capture-MS Homo sapiens
111 KPNA4 3840
Affinity Capture-MS Homo sapiens
112 BCL2L11  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
113 TNPO1 3842
Co-fractionation Homo sapiens
114 CUL4B 8450
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
115 PARK2  
Affinity Capture-MS Homo sapiens
116 ZBTB16  
Affinity Capture-Western Homo sapiens
117 NCAPH 23397
Co-fractionation Homo sapiens
118 Zfp521  
Affinity Capture-Western Mus musculus
119 C17orf49 124944
Affinity Capture-MS Homo sapiens
120 SMEK1 55671
Co-fractionation Homo sapiens
Co-fractionation Homo sapiens
121 IKZF3  
Affinity Capture-MS Homo sapiens
122 ZMYM3  
Co-fractionation Homo sapiens
123 HIST1H3E 8353
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
124 LIN52  
Affinity Capture-MS Homo sapiens
125 SMARCA4 6597
Affinity Capture-MS Homo sapiens
Co-fractionation Homo sapiens
126 HIST1H3J 8356
Affinity Capture-MS Homo sapiens
127 ZEB2  
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
128 LRRFIP1 9208
Co-fractionation Homo sapiens
129 RFX3 5991
Affinity Capture-MS Homo sapiens
130 MYH9 4627
Co-fractionation Homo sapiens
131 BARD1 580
Affinity Capture-MS Homo sapiens
132 NTRK1 4914
Affinity Capture-MS Homo sapiens
133 AIM2  
Affinity Capture-MS Homo sapiens
134 KDM5B  
Affinity Capture-Western Homo sapiens
135 SMAD3 4088
Co-fractionation Homo sapiens
136 RAD18  
Affinity Capture-MS Homo sapiens
137 SUMO2 6613
Reconstituted Complex Homo sapiens
138 PARP1 142
Proximity Label-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Co-fractionation Homo sapiens
139 BRMS1L  
Affinity Capture-MS Homo sapiens
140 MYBL2 4605
Affinity Capture-MS Homo sapiens
141 BANF1 8815
Affinity Capture-MS Homo sapiens
142 MBD2 8932
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Co-fractionation Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Co-fractionation Homo sapiens
143 ACTB 60
Co-fractionation Homo sapiens
144 CSNK1E 1454
Affinity Capture-MS Homo sapiens
145 CHD5 26038
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Co-fractionation Homo sapiens
Affinity Capture-MS Homo sapiens
146 PRKDC 5591
Co-fractionation Homo sapiens
147 EHBP1L1 254102
Co-fractionation Homo sapiens
148 HECTD1 25831
Affinity Capture-MS Homo sapiens
149 CSNK2A2 1459
Affinity Capture-MS Homo sapiens
150 SUDS3  
Affinity Capture-MS Homo sapiens
151 MBD3 53615
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Co-fractionation Homo sapiens
Co-fractionation Homo sapiens
Affinity Capture-MS Homo sapiens
Co-purification Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Co-fractionation Homo sapiens
152 LSM8 51691
Co-fractionation Homo sapiens
153 XYLT2 64132
Affinity Capture-MS Homo sapiens
154 CPSF2 53981
Co-fractionation Homo sapiens
155 GET4 51608
Co-fractionation Homo sapiens
156 CEBPA  
Proximity Label-MS Homo sapiens
Protein-peptide Homo sapiens
157 RAD21 5885
Co-fractionation Homo sapiens
158 SMARCB1 6598
Co-fractionation Homo sapiens
159 BZW1 9689
Co-fractionation Homo sapiens
160 ZBED1  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
161 VCP 7415
Co-fractionation Homo sapiens
162 CD3EAP  
Proximity Label-MS Homo sapiens
163 FAM43A  
Affinity Capture-MS Homo sapiens
164 TWIST1  
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Co-localization Homo sapiens
165 BCL11A 53335
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
166 ATG16L1 55054
Affinity Capture-MS Homo sapiens
167 HNRNPD 3184
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
168 PTOV1  
Affinity Capture-MS Homo sapiens
169 ZBTB2 57621
Affinity Capture-MS Homo sapiens
170 HIST1H3F 8968
Affinity Capture-MS Homo sapiens
171 HIST1H3A 8350
Affinity Capture-MS Homo sapiens
172 NR4A1  
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
173 NASP 4678
Co-fractionation Homo sapiens
174 SMARCAD1  
Affinity Capture-MS Homo sapiens
175 TP53BP1 7158
Affinity Capture-MS Homo sapiens
176 EMC8 10328
Affinity Capture-MS Homo sapiens
177 HIST2H3C 126961
Co-fractionation Homo sapiens
178 USP15 9958
Co-fractionation Homo sapiens
179 TCF20  
Affinity Capture-MS Homo sapiens
180 SMARCA5 8467
Co-fractionation Homo sapiens
Affinity Capture-MS Homo sapiens
181 SMARCC2 6601
Co-fractionation Homo sapiens
182 SIRT7  
Affinity Capture-MS Homo sapiens
183 FLII 2314
Co-fractionation Homo sapiens
184 SMC4 10051
Co-fractionation Homo sapiens
185 CTNNB1 1499
Co-fractionation Homo sapiens
186 NAA15 80155
Co-fractionation Homo sapiens
187 BAZ1A 11177
Co-fractionation Homo sapiens
188 CUL3 8452
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
189 NR3C1 2908
Co-fractionation Homo sapiens
190 BPTF 2186
Affinity Capture-MS Homo sapiens
191 BTF3 689
Affinity Capture-MS Homo sapiens
192 ROCK2 9475
Co-fractionation Homo sapiens
193 YY1 7528
Reconstituted Complex Homo sapiens
194 TSSC4  
Affinity Capture-MS Homo sapiens
195 IKZF1  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
196 PPP6R3 55291
Co-fractionation Homo sapiens
197 POLR2A 5430
Co-fractionation Homo sapiens
198 RBBP4 5928
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Co-fractionation Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Co-purification Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Co-fractionation Homo sapiens
Affinity Capture-MS Homo sapiens
Co-fractionation Homo sapiens
199 HIST3H3 8290
Protein-peptide Homo sapiens
200 DCTN1 1639
Co-fractionation Homo sapiens
201 HIST1H3H 8357
Affinity Capture-MS Homo sapiens
202 TROVE2 6738
Co-fractionation Homo sapiens
203 BUD13  
Affinity Capture-MS Homo sapiens
204 EFTUD2 9343
Co-fractionation Homo sapiens
205 PRMT5 10419
Co-fractionation Homo sapiens
206 HMG20B  
Co-fractionation Homo sapiens
207 WDR5 11091
Co-fractionation Homo sapiens
208 DNMT3B  
Affinity Capture-Western Homo sapiens
209 LIN9  
Affinity Capture-MS Homo sapiens
210 RPP25  
Co-fractionation Homo sapiens
211 RPA3 6119
Proximity Label-MS Homo sapiens
212 FAM64A 54478
Affinity Capture-MS Homo sapiens
213 ZMYND8 23613
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
214 MTOR 2475
Co-fractionation Homo sapiens
215 ASF1A 25842
Proximity Label-MS Homo sapiens
216 TOP1 7150
Affinity Capture-MS Homo sapiens
217 HJURP  
Affinity Capture-MS Homo sapiens
218 CSNK2B 1460
Affinity Capture-MS Homo sapiens
219 DDB1 1642
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
220 FKBP3 2287
Reconstituted Complex Homo sapiens
221 DDRGK1 65992
Affinity Capture-MS Homo sapiens
222 RNF2  
Affinity Capture-MS Homo sapiens
223 BEND3  
Affinity Capture-MS Homo sapiens
224 GSE1 23199
Co-fractionation Homo sapiens
225 THEG  
Affinity Capture-MS Homo sapiens
226 MECOM 2122
Affinity Capture-MS Homo sapiens
227 HAT1 8520
Affinity Capture-MS Homo sapiens
228 NANOG  
Affinity Capture-MS Homo sapiens
229 MYH10 4628
Co-fractionation Homo sapiens
230 HMG20A  
Affinity Capture-MS Homo sapiens
231 NFATC2  
Affinity Capture-MS Homo sapiens
232 ZMYM2  
Co-fractionation Homo sapiens
233 SNAI1  
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
234 SUZ12  
Affinity Capture-MS Homo sapiens
235 NCAPG 64151
Co-fractionation Homo sapiens
236 CHD7  
Affinity Capture-MS Homo sapiens
237 BACH2 60468
Affinity Capture-MS Homo sapiens
238 GBAS 2631
Affinity Capture-MS Homo sapiens
239 GATAD2A 54815
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Co-fractionation Homo sapiens
Co-fractionation Homo sapiens
Co-fractionation Homo sapiens
240 DZIP3  
Affinity Capture-MS Homo sapiens
241 Cbx1  
Affinity Capture-MS Mus musculus
242 RELA 5970
Co-fractionation Homo sapiens
243 TAF6 6878
Co-fractionation Homo sapiens
244 PLEKHA4 57664
Affinity Capture-MS Homo sapiens
245 GIGYF2 26058
Co-fractionation Homo sapiens
246 RARA 5914
Affinity Capture-Western Homo sapiens
247 SMC1A 8243
Co-fractionation Homo sapiens
248 SIRT6  
Affinity Capture-MS Homo sapiens
249 KIF14 9928
Affinity Capture-MS Homo sapiens
250 CENPA  
Proximity Label-MS Homo sapiens
251 TRPS1  
Affinity Capture-MS Homo sapiens
252 WDR77 79084
Affinity Capture-MS Homo sapiens
253 SAP130  
Affinity Capture-MS Homo sapiens
254 TP53 7157
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-MS Homo sapiens
255 SIN3A  
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Co-fractionation Homo sapiens
256 C21orf58  
Affinity Capture-MS Homo sapiens
257 L3MBTL2  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
258 MTA1 9112
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Cross-Linking-MS (XL-MS) Homo sapiens
Affinity Capture-MS Homo sapiens
Co-fractionation Homo sapiens
Affinity Capture-MS Homo sapiens
Co-fractionation Homo sapiens
259 XRCC6 2547
Co-fractionation Homo sapiens
260 SSRP1 6749
Affinity Capture-MS Homo sapiens
261 DDX3X 1654
Affinity Capture-MS Homo sapiens
262 SMARCE1 6605
Co-fractionation Homo sapiens
263 SMARCC1 6599
Co-fractionation Homo sapiens
264 USP36  
Affinity Capture-MS Homo sapiens
265 SAP18 10284
Co-fractionation Homo sapiens
266 DPY30 84661
Affinity Capture-MS Homo sapiens
267 SMAD2 4087
Co-fractionation Homo sapiens
268 PDHA1 5160
Affinity Capture-MS Homo sapiens
269 CDK18 5129
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
270 HNRNPM 4670
Co-fractionation Homo sapiens
271 DCTN2 10540
Co-fractionation Homo sapiens
272 ELAVL1 1994
Affinity Capture-RNA Homo sapiens
273 HDAC1 3065
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Co-purification Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Co-fractionation Homo sapiens
Affinity Capture-MS Homo sapiens
Co-fractionation Homo sapiens
Co-fractionation Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Co-purification Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Co-fractionation Homo sapiens
274 CHD4 1108
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Co-fractionation Homo sapiens
Affinity Capture-Western Homo sapiens
Co-fractionation Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Co-fractionation Homo sapiens
275 SALL1 6299
Affinity Capture-MS Homo sapiens
276 GTF2I 2969
Co-fractionation Homo sapiens
277 STMN2  
Affinity Capture-MS Homo sapiens
278 DDX58 23586
Affinity Capture-RNA Homo sapiens
279 HDAC5 10014
Affinity Capture-MS Homo sapiens
280 PPP4R1 9989
Co-fractionation Homo sapiens
281 GATAD1  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
282 TOP2A 7153
Affinity Capture-MS Homo sapiens
283 ESR1  
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
284 Mta1  
Affinity Capture-MS Mus musculus
285 HMGXB4 10042
Affinity Capture-MS Homo sapiens
286 FAM219A 203259
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
287 LARP7 51574
Co-fractionation Homo sapiens
288 NCAPD2 9918
Co-fractionation Homo sapiens
289 KDM1A 23028
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Co-fractionation Homo sapiens
Affinity Capture-MS Homo sapiens
290 Mbd2  
Affinity Capture-MS Mus musculus
291 EZH2  
Affinity Capture-MS Homo sapiens
292 PSMA5 5686
Affinity Capture-MS Homo sapiens
293 RTCB 51493
Affinity Capture-MS Homo sapiens
294 STAG2 10735
Co-fractionation Homo sapiens
295 RBBP5 5929
Co-fractionation Homo sapiens
296 NACC2  
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
297 SSSCA1 10534
Affinity Capture-MS Homo sapiens
298 ZNF800  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
299 MTA3 57504
Affinity Capture-MS Homo sapiens
Co-fractionation Homo sapiens
Affinity Capture-MS Homo sapiens
300 ACTL6A 86
Co-fractionation Homo sapiens
301 CCDC69 26112
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
302 ADRM1 11047
Co-fractionation Homo sapiens
303 C9orf72  
Affinity Capture-MS Homo sapiens
304 MBD3L1  
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
305 SERBP1 26135
Affinity Capture-MS Homo sapiens
306 MTF2  
Affinity Capture-MS Homo sapiens
307 CHAF1B  
Affinity Capture-MS Homo sapiens
308 PWWP2A  
Affinity Capture-MS Homo sapiens
309 NUCKS1 64710
Affinity Capture-MS Homo sapiens
310 DNMT1 1786
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
311 USP47 55031
Co-fractionation Homo sapiens
312 RCOR1  
Co-fractionation Homo sapiens
313 LIN37  
Affinity Capture-MS Homo sapiens
314 MECP2 4204
Affinity Capture-MS Homo sapiens
315 EP300 2033
Affinity Capture-MS Homo sapiens
316 RAN 5901
Co-fractionation Homo sapiens
View the network image/svg+xml
 Pathways in which MTA2 is involved
PathwayEvidenceSource
Adipogenesis IEA Reactome
Chromatin modifying enzymes TAS Reactome
Chromatin organization TAS Reactome
Developmental Biology IEA Reactome
Disease TAS Reactome
Epigenetic regulation of gene expression IEA Reactome
ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression IEA Reactome
Gene expression (Transcription) IEA Reactome
Gene expression (Transcription) TAS Reactome
Generic Transcription Pathway TAS Reactome
HDACs deacetylate histones TAS Reactome
Infectious disease TAS Reactome
Intracellular signaling by second messengers IEA Reactome
Intracellular signaling by second messengers TAS Reactome
PIP3 activates AKT signaling IEA Reactome
PIP3 activates AKT signaling TAS Reactome
Positive epigenetic regulation of rRNA expression IEA Reactome
Potential therapeutics for SARS TAS Reactome
PTEN Regulation IEA Reactome
PTEN Regulation TAS Reactome
Regulation of endogenous retroelements IEA Reactome
Regulation of endogenous retroelements by KRAB-ZFP proteins IEA Reactome
Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs) IEA Reactome
Regulation of PTEN gene transcription IEA Reactome
Regulation of PTEN gene transcription TAS Reactome
Regulation of TP53 Activity TAS Reactome
Regulation of TP53 Activity through Acetylation TAS Reactome
RNA Polymerase I Promoter Clearance TAS Reactome
RNA Polymerase I Transcription TAS Reactome
RNA Polymerase I Transcription Initiation TAS Reactome
RNA Polymerase II Transcription TAS Reactome
SARS-CoV Infections TAS Reactome
Signal Transduction IEA Reactome
Signal Transduction TAS Reactome
Transcriptional Regulation by TP53 TAS Reactome
Transcriptional regulation of brown and beige adipocyte differentiation IEA Reactome
Transcriptional regulation of brown and beige adipocyte differentiation by EBF2 IEA Reactome
Viral Infection Pathways TAS Reactome





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