Gene description for SETD1A
Gene name SET domain containing 1A
Gene symbol SETD1A
Other names/aliases KMT2F
Set1
Set1A
Species Homo sapiens
 Database cross references - SETD1A
ExoCarta ExoCarta_9739
Entrez Gene 9739
HGNC 29010
MIM 611052
UniProt O15047  
 SETD1A identified in exosomes derived from the following tissue/cell type
Hepatocytes 26054723    
 Gene ontology annotations for SETD1A
Molecular Function
    RNA binding GO:0003723 IEA
    nucleotide binding GO:0000166 IEA
    protein binding GO:0005515 IPI
    histone methyltransferase activity (H3-K4 specific) GO:0042800 IDA
Biological Process
    positive regulation of stem cell proliferation GO:2000648 IEA
    regulation of transcription, DNA-templated GO:0006355 IEA
    stem cell maintenance GO:0019827 IEA
    histone H3-K4 methylation GO:0051568 IEA
    positive regulation of neural precursor cell proliferation GO:2000179 IEA
    chromatin organization GO:0006325 TAS
    transcription, DNA-templated GO:0006351 IEA
Subcellular Localization
    nucleus GO:0005634 IMP
    histone methyltransferase complex GO:0035097 IDA
    Set1C/COMPASS complex GO:0048188 IDA
    nuclear speck GO:0016607 IEA
    nucleoplasm GO:0005654 TAS
    chromosome GO:0005694 IEA
 Experiment description of studies that identified SETD1A in exosomes
1
Experiment ID 237
ISEV standards
EM
EV Biophysical techniques
TSG101|Alix|HSC70|GAPDH
EV Cytosolic markers
EV Membrane markers
HSP90B1
EV Negative markers
qNano
EV Particle analysis
Identified molecule mRNA
Identification method RNA Sequencing
PubMed ID 26054723    
Organism Homo sapiens
Experiment description Hepatocellular carcinoma-derived exosomes promote motility of immortalized hepatocyte through transfer of oncogenic proteins and RNAs
Authors He M, Qin H, Poon TC, Sze SC, Ding X, Co NN, Ngai SM, Chan TF, Wong N
Journal name Carcinogenesis
Publication year 2015
Sample Hepatocytes
Sample name MIHA
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.13-1.19 g/mL
Molecules identified in the study Protein
RNA
Methods used in the study Western blotting
Mass spectrometry
RNA Sequencing
 Protein-protein interactions for SETD1A
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 HCFC1 3054
Affinity Capture-MS Homo sapiens
View the network image/svg+xml
 Pathways in which SETD1A is involved
PathwayEvidenceSource
PKMTs methylate histone lysines TAS Reactome





Perform bioinformatics analysis of your extracellular vesicle data set using FunRich, a open access standalone tool. NEW UPDATED VERSION OF FunRich available for download (12/09/2016) from here