Gene description for CCBL2
Gene name cysteine conjugate-beta lyase 2
Gene symbol CCBL2
Other names/aliases KAT3
KATIII
Species Homo sapiens
 Database cross references - CCBL2
ExoCarta ExoCarta_56267
Entrez Gene 56267
HGNC 33238
MIM 610656
UniProt Q6YP21  
 CCBL2 identified in exosomes derived from the following tissue/cell type
Ovarian cancer cells 23333927    
Ovarian cancer cells 23333927    
 Gene ontology annotations for CCBL2
Molecular Function
    poly(A) RNA binding GO:0044822 IDA
    pyridoxal phosphate binding GO:0030170 IEA
    protein homodimerization activity GO:0042803 IEA
    kynurenine-glyoxylate transaminase activity GO:0047315 ISS
    cysteine-S-conjugate beta-lyase activity GO:0047804 IEA
    kynurenine-oxoglutarate transaminase activity GO:0016212 ISS
Biological Process
    biosynthetic process GO:0009058 IEA
    L-kynurenine metabolic process GO:0097052 ISS
    cellular amino acid metabolic process GO:0006520 ISS
    2-oxoglutarate metabolic process GO:0006103 IEA
    small molecule metabolic process GO:0044281 TAS
    cellular nitrogen compound metabolic process GO:0034641 TAS
    tryptophan catabolic process GO:0006569 TAS
    kynurenine metabolic process GO:0070189 ISS
Subcellular Localization
    mitochondrion GO:0005739 IEA
 Experiment description of studies that identified CCBL2 in exosomes
1
Experiment ID 211
ISEV standards
✔
EM
EV Biophysical techniques
✔
TSG101|Alix
EV Cytosolic markers
✔
EpCAM|TFRC
EV Membrane markers
✔
cytochrome c|GOLGA2
EV Negative markers
✘ EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23333927    
Organism Homo sapiens
Experiment description Characterization and proteomic analysis of ovarian cancer-derived exosomes.
Authors Liang B, Peng P, Chen S, Li L, Zhang M, Cao D, Yang J, Li H, Gui T, Li X, Shen K.
Journal name J Proteomics
Publication year 2013
Sample Ovarian cancer cells
Sample name IGROV1
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient
Flotation density 1.09-1.15 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
2
Experiment ID 212
ISEV standards
✔
CEM
EV Biophysical techniques
✔
TSG101|Alix
EV Cytosolic markers
✔
EpCAM|TFRC
EV Membrane markers
✔
Cytochrome C|GOLGA2
EV Negative markers
✘ EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23333927    
Organism Homo sapiens
Experiment description Characterization and proteomic analysis of ovarian cancer-derived exosomes.
Authors Liang B, Peng P, Chen S, Li L, Zhang M, Cao D, Yang J, Li H, Gui T, Li X, Shen K.
Journal name J Proteomics
Publication year 2013
Sample Ovarian cancer cells
Sample name OVCAR-3
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient
Flotation density 1.09-1.15 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for CCBL2
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 RABIF  
Two-hybrid Homo sapiens
View the network image/svg+xml
 Pathways in which CCBL2 is involved
PathwayEvidenceSource
Tryptophan catabolism TAS Reactome





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