Gene description for NTRK1
Gene name neurotrophic tyrosine kinase, receptor, type 1
Gene symbol NTRK1
Other names/aliases MTC
TRK
TRK1
TRKA
Trk-A
p140-TrkA
Species Homo sapiens
 Database cross references - NTRK1
ExoCarta ExoCarta_4914
Vesiclepedia VP_4914
Entrez Gene 4914
HGNC 8031
MIM 191315
UniProt P04629  
 NTRK1 identified in exosomes derived from the following tissue/cell type
Mesenchymal stem cells 36408942    
 Gene ontology annotations for NTRK1
Molecular Function
    neurotrophin binding GO:0043121 TAS
    nerve growth factor receptor activity GO:0010465 IDA
    neurotrophin p75 receptor binding GO:0005166 IEA
    transmembrane receptor protein tyrosine kinase activity GO:0004714 IDA
    ATP binding GO:0005524 IEA
    protein homodimerization activity GO:0042803 IDA
    nerve growth factor binding GO:0048406 IDA
    protein binding GO:0005515 IPI
    ephrin receptor binding GO:0046875 IEA
Biological Process
    positive regulation of Ras protein signal transduction GO:0046579 IDA
    Sertoli cell development GO:0060009 IEA
    learning or memory GO:0007611 IEA
    positive regulation of programmed cell death GO:0043068 ISS
    negative regulation of neuron apoptotic process GO:0043524 ISS
    sympathetic nervous system development GO:0048485 ISS
    positive regulation of ERK1 and ERK2 cascade GO:0070374 IDA
    positive regulation of angiogenesis GO:0045766 IDA
    mechanoreceptor differentiation GO:0042490 IEA
    small GTPase mediated signal transduction GO:0007264 TAS
    activation of adenylate cyclase activity GO:0007190 TAS
    positive regulation of NF-kappaB transcription factor activity GO:0051092 IDA
    response to activity GO:0014823 IEA
    neurotrophin TRK receptor signaling pathway GO:0048011 TAS
    peptidyl-tyrosine phosphorylation GO:0018108 IEA
    cellular response to nicotine GO:0071316 IEA
    developmental programmed cell death GO:0010623 ISS
    response to hydrostatic pressure GO:0051599 IEA
    positive regulation of GTPase activity GO:0043547 IDA
    activation of MAPKK activity GO:0000186 TAS
    transmembrane receptor protein tyrosine kinase signaling pathway GO:0007169 TAS
    nerve growth factor signaling pathway GO:0038180 IEA
    response to axon injury GO:0048678 IEA
    positive regulation of neuron projection development GO:0010976 IDA
    response to ethanol GO:0045471 IEA
    phosphatidylinositol-mediated signaling GO:0048015 TAS
    aging GO:0007568 IEA
    response to radiation GO:0009314 IEA
    axon guidance GO:0007411 IEA
    detection of mechanical stimulus involved in sensory perception of pain GO:0050966 IEA
    detection of temperature stimulus involved in sensory perception of pain GO:0050965 IEA
    response to electrical stimulus GO:0051602 IEA
    protein phosphorylation GO:0006468 IDA
    axonogenesis involved in innervation GO:0060385 ISS
    activation of phospholipase C activity GO:0007202 TAS
    circadian rhythm GO:0007623 IEA
    positive regulation of synaptic transmission, glutamatergic GO:0051968 IEA
    negative regulation of cell proliferation GO:0008285 IDA
    Ras protein signal transduction GO:0007265 TAS
    olfactory nerve development GO:0021553 IEA
    cellular response to nerve growth factor stimulus GO:1990090 ISS
    B cell differentiation GO:0030183 IEA
    protein autophosphorylation GO:0046777 IDA
    response to drug GO:0042493 IEA
    response to nutrient levels GO:0031667 IEA
Subcellular Localization
    receptor complex GO:0043235 IDA
    dendrite GO:0030425 IEA
    protein complex GO:0043234 ISS
    late endosome GO:0005770 ISS
    early endosome GO:0005769 ISS
    late endosome membrane GO:0031902 IEA
    axon GO:0030424 IEA
    plasma membrane GO:0005886 TAS
    early endosome membrane GO:0031901 IEA
    cytoplasmic vesicle GO:0031410 IEA
    endosome GO:0005768 TAS
    neuronal cell body GO:0043025 IEA
    integral component of plasma membrane GO:0005887 IDA
    cell surface GO:0009986 IEA
 Experiment description of studies that identified NTRK1 in exosomes
1
Experiment ID 488
MISEV standards
✔
EM
EV Biophysical techniques
✔
CD9|CD81|CD63|GAPDH|SDCBP|LAMP1|TFRC|UCHL1|FLOT2|LAMP2|FLOT1|ICAM1|RAB5B|CD151|RAB35|TSG101|RAB5A|CD82
EV Enriched markers
✔
CANX
EV Negative markers
✔
NTA
EV Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Homo sapiens
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ.
Journal name Proteomics
Publication year 2023
Sample Mesenchymal stem cells
Sample name UCMSC
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
 Protein-protein interactions for NTRK1
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 RAP1A 5906
Invivo Homo sapiens
2 NTF3  
Reconstituted Complex Homo sapiens
3 SHC3  
Invivo Homo sapiens
4 CAV1 857
Affinity Capture-Western Homo sapiens
5 GIPC1 10755
Invitro Homo sapiens
Invivo Homo sapiens
Two-hybrid Homo sapiens
6 SQSTM1 8878
Affinity Capture-Western Homo sapiens
7 ABL1 25
Invivo Homo sapiens
Invivo Homo sapiens
Invitro Homo sapiens
Invitro Homo sapiens
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
8 PLCG1 5335
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Two-hybrid Homo sapiens
9 GRB2 2885
Affinity Capture-Western Homo sapiens
Invivo Homo sapiens
10 NGFR 4804
Invivo Homo sapiens
11 MATK  
Affinity Capture-Western Homo sapiens
Far Western Homo sapiens
12 NGFB  
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Co-crystal Structure Homo sapiens
13 FRS2 10818
Reconstituted Complex Homo sapiens
Two-hybrid Homo sapiens
14 PTPN1 5770
Invitro Homo sapiens
15 RICS  
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Two-hybrid Homo sapiens
16 SHC1 6464
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
17 APS  
Affinity Capture-Western Homo sapiens
Two-hybrid Homo sapiens
18 NTRK1 4914
Invitro Homo sapiens
Invitro Homo sapiens
19 SH2B1 25970
Affinity Capture-Western Homo sapiens
Two-hybrid Homo sapiens
View the network image/svg+xml



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