Gene description for CAV1
Gene name caveolin 1, caveolae protein, 22kDa
Gene symbol CAV1
Other names/aliases BSCL3
CGL3
LCCNS
MSTP085
PPH3
VIP21
Species Homo sapiens
 Database cross references - CAV1
ExoCarta ExoCarta_857
Entrez Gene 857
HGNC 1527
MIM 601047
UniProt Q03135  
 CAV1 identified in exosomes derived from the following tissue/cell type
Hepatocellular carcinoma cells 26054723    
Hepatocellular carcinoma cells 26054723    
Melanoma cells 19801663    
Melanoma cells 19381331    
Melanoma cells 25950383    
Melanoma cells 25950383    
Melanoma cells 25950383    
Mesenchymal stem cells Unpublished / Not applicable
Ovarian cancer cells 23333927    
Ovarian cancer cells 23333927    
Plasma 19381331    
Prostate cancer cells 25519911    
Prostate cancer cells 25519911    
Prostate cancer cells 25519911    
Prostate cancer cells 25844599    
Squamous carcinoma cells 20124223    
 Gene ontology annotations for CAV1
Molecular Function
    patched binding GO:0005113 NAS
    nitric-oxide synthase binding GO:0050998 IPI
    enzyme binding GO:0019899 IPI
    peptidase activator activity GO:0016504 ISS
    protein complex scaffold GO:0032947 TAS
    protein binding GO:0005515 IPI
    inward rectifier potassium channel inhibitor activity GO:0070320 IDA
    cholesterol binding GO:0015485 TAS
    protein kinase binding GO:0019901 IPI
    ion channel binding GO:0044325 IPI
    ATPase binding GO:0051117 IPI
    receptor binding GO:0005102 IPI
    structural molecule activity GO:0005198 IDA
    identical protein binding GO:0042802 IPI
Biological Process
    regulation of blood coagulation GO:0030193 IMP
    regulation of heart rate by cardiac conduction GO:0086091 ISS
    protein localization to plasma membrane raft GO:0044860 ISS
    regulation of nitric-oxide synthase activity GO:0050999 TAS
    regulation of membrane repolarization during action potential GO:0098903 IMP
    negative regulation of transcription from RNA polymerase II promoter GO:0000122 ISS
    positive regulation of extrinsic apoptotic signaling pathway GO:2001238 IMP
    regulation of cell communication by electrical coupling involved in cardiac conduction GO:1901844 ISS
    positive regulation of ER-associated ubiquitin-dependent protein catabolic process GO:1903071 IC
    mammary gland development GO:0030879 ISS
    vasoconstriction GO:0042310 IEA
    calcium ion homeostasis GO:0055074 ISS
    negative regulation of BMP signaling pathway GO:0030514 IDA
    cellular response to hyperoxia GO:0071455 IMP
    protein homooligomerization GO:0051260 ISS
    membrane depolarization GO:0051899 ISS
    positive regulation of cell adhesion molecule production GO:0060355 IMP
    positive regulation of protein ubiquitination GO:0031398 IMP
    positive regulation of metalloenzyme activity GO:0048554 ISS
    negative regulation of pinocytosis GO:0048550 IMP
    response to hypoxia GO:0001666 ISS
    caveola assembly GO:0070836 ISS
    lipid storage GO:0019915 ISS
    response to ischemia GO:0002931 IEA
    positive regulation of toll-like receptor 3 signaling pathway GO:0034141 IMP
    regulation of fatty acid metabolic process GO:0019217 ISS
    receptor-mediated endocytosis of virus by host cell GO:0019065 IGI
    negative regulation of potassium ion transmembrane transport GO:1901380 IMP
    positive regulation of peptidase activity GO:0010952 IEA
    negative regulation of tyrosine phosphorylation of Stat5 protein GO:0042524 IEA
    cellular calcium ion homeostasis GO:0006874 ISS
    vascular endothelial growth factor receptor signaling pathway GO:0048010 TAS
    negative regulation of peptidyl-tyrosine autophosphorylation GO:1900085 IMP
    negative regulation of endothelial cell proliferation GO:0001937 ISS
    cellular response to peptide hormone stimulus GO:0071375 ISS
    MAPK cascade GO:0000165 IEA
    vesicle organization GO:0016050 ISS
    negative regulation of protein ubiquitination GO:0031397 IMP
    T cell costimulation GO:0031295 IDA
    response to calcium ion GO:0051592 ISS
    positive regulation of calcium ion transport into cytosol GO:0010524 ISS
    negative regulation of JAK-STAT cascade GO:0046426 ISS
    cholesterol transport GO:0030301 TAS
    nitric oxide metabolic process GO:0046209 TAS
    cholesterol homeostasis GO:0042632 TAS
    positive regulation of intrinsic apoptotic signaling pathway GO:2001244 IMP
    negative regulation of protein binding GO:0032091 IDA
    triglyceride metabolic process GO:0006641 ISS
    caveolin-mediated endocytosis GO:0072584 IDA
    mammary gland involution GO:0060056 ISS
    cytosolic calcium ion homeostasis GO:0051480 IDA
    negative regulation of MAPK cascade GO:0043409 ISS
    regulation of smooth muscle contraction GO:0006940 ISS
    angiogenesis GO:0001525 IEA
    response to estrogen GO:0043627 IDA
    regulation of cardiac muscle cell action potential involved in regulation of contraction GO:0098909 IC
    positive regulation of peptidyl-serine phosphorylation GO:0033138 IDA
    receptor internalization involved in canonical Wnt signaling pathway GO:2000286 IMP
    nitric oxide homeostasis GO:0033484 ISS
    regulation of ventricular cardiac muscle cell action potential GO:0098911 ISS
    skeletal muscle tissue development GO:0007519 ISS
    response to progesterone GO:0032570 IDA
    negative regulation of protein tyrosine kinase activity GO:0061099 IMP
    regulation of inward rectifier potassium channel activity GO:1901979 IMP
    apoptotic signaling pathway GO:0097190 IMP
    lactation GO:0007595 IEA
    cellular response to starvation GO:0009267 IEP
    maintenance of protein location in cell GO:0032507 ISS
    leukocyte migration GO:0050900 TAS
    negative regulation of epithelial cell differentiation GO:0030857 ISS
    negative regulation of nitric oxide biosynthetic process GO:0045019 ISS
    negative regulation of cytokine-mediated signaling pathway GO:0001960 IEA
    cellular response to exogenous dsRNA GO:0071360 IMP
    angiotensin-activated signaling pathway involved in heart process GO:0086098 ISS
    negative regulation of peptidyl-serine phosphorylation GO:0033137 IDA
    vasculogenesis GO:0001570 ISS
    positive regulation of vasoconstriction GO:0045907 ISS
    negative regulation of canonical Wnt signaling pathway GO:0090090 ISS
    protein localization to basolateral plasma membrane GO:1903361 ISS
    negative regulation of anoikis GO:2000811 IMP
    blood coagulation GO:0007596 TAS
    protein localization GO:0008104 ISS
    small molecule metabolic process GO:0044281 TAS
    negative regulation of nitric-oxide synthase activity GO:0051001 IEA
    regulation of peptidase activity GO:0052547 ISS
    positive regulation of canonical Wnt signaling pathway GO:0090263 TAS
    inactivation of MAPK activity GO:0000188 ISS
    positive regulation of gap junction assembly GO:1903598 ISS
    regulation of the force of heart contraction by chemical signal GO:0003057 IEA
    positive regulation of protein binding GO:0032092 IMP
    calcium ion transport GO:0006816 ISS
Subcellular Localization
    cell cortex GO:0005938 IEA
    endocytic vesicle membrane GO:0030666 TAS
    endoplasmic reticulum GO:0005783 IDA
    VCP-NPL4-UFD1 AAA ATPase complex GO:0034098 IPI
    endoplasmic reticulum membrane GO:0005789 TAS
    focal adhesion GO:0005925 IDA
    protein complex GO:0043234 IDA
    apical plasma membrane GO:0016324 IDA
    membrane raft GO:0045121 IDA
    endosome GO:0005768 IDA
    cilium GO:0005929 IEA
    acrosomal membrane GO:0002080 IEA
    cytosol GO:0005829 IDA
    Golgi membrane GO:0000139 TAS
    lipid particle GO:0005811 TAS
    integral component of plasma membrane GO:0005887 IEA
    intracellular GO:0005622 IDA
    basolateral plasma membrane GO:0016323 IDA
    caveola GO:0005901 NAS
    perinuclear region of cytoplasm GO:0048471 ISS
    plasma membrane GO:0005886 TAS
    early endosome membrane GO:0031901 TAS
    cytoplasmic vesicle GO:0031410 IDA
 Experiment description of studies that identified CAV1 in exosomes
1
Experiment ID 235
ISEV standards
✔
EM
EV Biophysical techniques
✔
TSG101|Alix|HSC70|GAPDH
EV Cytosolic markers
✘ EV Membrane markers
✔
HSP90B1
EV Negative markers
✔
qNano
EV Particle analysis
Identified molecule mRNA
Identification method RNA Sequencing
RT-PCR
PubMed ID 26054723    
Organism Homo sapiens
Experiment description Hepatocellular carcinoma-derived exosomes promote motility of immortalized hepatocyte through transfer of oncogenic proteins and RNAs
Authors He M, Qin H, Poon TC, Sze SC, Ding X, Co NN, Ngai SM, Chan TF, Wong N
Journal name Carcinogenesis
Publication year 2015
Sample Hepatocellular carcinoma cells
Sample name HKCI-8
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.13-1.19 g/mL
Molecules identified in the study Protein
RNA
Methods used in the study Western blotting
Mass spectrometry
RT-PCR
RNA Sequencing
2
Experiment ID 236
ISEV standards
✔
EM
EV Biophysical techniques
✔
TSG101|Alix|HSC70|GAPDH
EV Cytosolic markers
✘ EV Membrane markers
✔
HSP90B1
EV Negative markers
✔
qNano
EV Particle analysis
Identified molecule mRNA
Identification method RNA Sequencing
RT-PCR
PubMed ID 26054723    
Organism Homo sapiens
Experiment description Hepatocellular carcinoma-derived exosomes promote motility of immortalized hepatocyte through transfer of oncogenic proteins and RNAs
Authors He M, Qin H, Poon TC, Sze SC, Ding X, Co NN, Ngai SM, Chan TF, Wong N
Journal name Carcinogenesis
Publication year 2015
Sample Hepatocellular carcinoma cells
Sample name MHCC97L
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.13-1.19 g/mL
Molecules identified in the study Protein
RNA
Methods used in the study Western blotting
Mass spectrometry
RT-PCR
RNA Sequencing
3
Experiment ID 236
ISEV standards
✔
EM
EV Biophysical techniques
✔
TSG101|Alix|HSC70|GAPDH
EV Cytosolic markers
✘ EV Membrane markers
✔
HSP90B1
EV Negative markers
✔
qNano
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
Western blotting
PubMed ID 26054723    
Organism Homo sapiens
Experiment description Hepatocellular carcinoma-derived exosomes promote motility of immortalized hepatocyte through transfer of oncogenic proteins and RNAs
Authors He M, Qin H, Poon TC, Sze SC, Ding X, Co NN, Ngai SM, Chan TF, Wong N
Journal name Carcinogenesis
Publication year 2015
Sample Hepatocellular carcinoma cells
Sample name MHCC97L
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.13-1.19 g/mL
Molecules identified in the study Protein
RNA
Methods used in the study Western blotting
Mass spectrometry
RT-PCR
RNA Sequencing
4
Experiment ID 72
ISEV standards
✘ EV Biophysical techniques
✘ EV Cytosolic markers
✔
LAMP2
EV Membrane markers
✘ EV Negative markers
✘ EV Particle analysis
Identified molecule protein
Identification method Western blotting
PubMed ID 19801663    
Organism Homo sapiens
Experiment description Microenvironmental pH is a key factor for exosome traffic in tumor cells.
Authors Parolini I, Federici C, Raggi C, Lugini L, Palleschi S, de Milito A, Coscia C, Iessi E, Logozzi MA, Molinari A, Colone M, Tatti M, Sargiacomo M, Fais S
Journal name JBC
Publication year 2009
Sample Melanoma cells
Sample name Me665/1
Isolation/purification methods Differential centrifugation
Flotation density -
Molecules identified in the study Protein
Lipids
Methods used in the study Western blotting
Thin layer chromatography
5
Experiment ID 74
ISEV standards
✘ EV Biophysical techniques
✔
RAB5B
EV Cytosolic markers
✔
LAMP1|CD63
EV Membrane markers
✘ EV Negative markers
✘ EV Particle analysis
Identified molecule protein
Identification method Western blotting
PubMed ID 19381331    
Organism Homo sapiens
Experiment description High levels of exosomes expressing CD63 and caveolin-1 in plasma of melanoma patients.
Authors Logozzi M, De Milito A, Lugini L, Borghi M, Calabrò L, Spada M, Perdicchio M, Marino ML, Federici C, Iessi E, Brambilla D, Venturi G, Lozupone F, Santinami M, Huber V, Maio M, Rivoltini L, Fais S
Journal name PLoS One
Publication year 2009
Sample Melanoma cells
Sample name Me501
Isolation/purification methods Differential centrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
ELISA
FACS
6
Experiment ID 257
ISEV standards
✔
EM
EV Biophysical techniques
✔
TSG101
EV Cytosolic markers
✔
FLOT1
EV Membrane markers
✘ EV Negative markers
✔
NTA
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25950383    
Organism Homo sapiens
Experiment description Proteome characterization of melanoma exosomes reveals a specific signature for metastatic cell lines
Authors Lazar I, Clement E, Ducoux-Petit M, Denat L, Soldan V, Dauvillier S, Balor S4, Burlet-Schiltz O1, Larue L, Muller C Nieto L
Journal name Pigment Cell Melanoma Res
Publication year 2015
Sample Melanoma cells
Sample name Daju
Isolation/purification methods Differential centrifugation
Unltracentrifugation
Sucrose density gradient
Flotation density 1.13 - 1.19 g/mL
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
7
Experiment ID 259
ISEV standards
✔
EM
EV Biophysical techniques
✔
TSG101
EV Cytosolic markers
✔
FLOT1
EV Membrane markers
✘ EV Negative markers
✔
NTA
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25950383    
Organism Homo sapiens
Experiment description Proteome characterization of melanoma exosomes reveals a specific signature for metastatic cell lines
Authors Lazar I, Clement E, Ducoux-Petit M, Denat L, Soldan V, Dauvillier S, Balor S4, Burlet-Schiltz O1, Larue L, Muller C Nieto L
Journal name Pigment Cell Melanoma Res
Publication year 2015
Sample Melanoma cells
Sample name A375M
Isolation/purification methods Differential centrifugation
Unltracentrifugation
Sucrose density gradient
Flotation density 1.13 - 1.19 g/mL
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
8
Experiment ID 260
ISEV standards
✔
EM
EV Biophysical techniques
✔
TSG101
EV Cytosolic markers
✔
FLOT1|CD81
EV Membrane markers
✘ EV Negative markers
✔
NTA
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25950383    
Organism Homo sapiens
Experiment description Proteome characterization of melanoma exosomes reveals a specific signature for metastatic cell lines
Authors Lazar I, Clement E, Ducoux-Petit M, Denat L, Soldan V, Dauvillier S, Balor S4, Burlet-Schiltz O1, Larue L, Muller C Nieto L
Journal name Pigment Cell Melanoma Res
Publication year 2015
Sample Melanoma cells
Sample name 1205Lu
Isolation/purification methods Differential centrifugation
Unltracentrifugation
Sucrose density gradient
Flotation density 1.13 - 1.19 g/mL
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
9
Experiment ID 126
ISEV standards
✘ EV Biophysical techniques
✔
GAPDH
EV Cytosolic markers
✘ EV Membrane markers
✘ EV Negative markers
✘ EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry [LTQ-FT Ultra]
PubMed ID Unpublished / Not applicable
Organism Homo sapiens
Experiment description Mesenchymal Stem Cell Exosomes: The Future MSC-based Therapy?
Authors Ruenn Chai Lai, Ronne Wee Yeh Yeo, Soon Sim Tan, Bin Zhang, Yijun Yin, Newman Siu Kwan Sze, Andre Choo, and Sai Kiang Lim
Journal name Mesenchymal Stem Cell Therapy
Publication year 2011
Sample Mesenchymal stem cells
Sample name huES9.E1
Isolation/purification methods HPLC
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Antobody array
Mass spectrometry
10
Experiment ID 211
ISEV standards
✔
EM
EV Biophysical techniques
✔
TSG101|Alix
EV Cytosolic markers
✔
EpCAM|TFRC
EV Membrane markers
✔
cytochrome c|GOLGA2
EV Negative markers
✘ EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23333927    
Organism Homo sapiens
Experiment description Characterization and proteomic analysis of ovarian cancer-derived exosomes.
Authors Liang B, Peng P, Chen S, Li L, Zhang M, Cao D, Yang J, Li H, Gui T, Li X, Shen K.
Journal name J Proteomics
Publication year 2013
Sample Ovarian cancer cells
Sample name IGROV1
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient
Flotation density 1.09-1.15 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
11
Experiment ID 212
ISEV standards
✔
CEM
EV Biophysical techniques
✔
TSG101|Alix
EV Cytosolic markers
✔
EpCAM|TFRC
EV Membrane markers
✔
Cytochrome C|GOLGA2
EV Negative markers
✘ EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23333927    
Organism Homo sapiens
Experiment description Characterization and proteomic analysis of ovarian cancer-derived exosomes.
Authors Liang B, Peng P, Chen S, Li L, Zhang M, Cao D, Yang J, Li H, Gui T, Li X, Shen K.
Journal name J Proteomics
Publication year 2013
Sample Ovarian cancer cells
Sample name OVCAR-3
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient
Flotation density 1.09-1.15 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
12
Experiment ID 75
ISEV standards
✘ EV Biophysical techniques
✔
RAB5B
EV Cytosolic markers
✔
CD63
EV Membrane markers
✘ EV Negative markers
✘ EV Particle analysis
Identified molecule protein
Identification method Western blotting
PubMed ID 19381331    
Organism Homo sapiens
Experiment description High levels of exosomes expressing CD63 and caveolin-1 in plasma of melanoma patients.
Authors Logozzi M, De Milito A, Lugini L, Borghi M, Calabrò L, Spada M, Perdicchio M, Marino ML, Federici C, Iessi E, Brambilla D, Venturi G, Lozupone F, Santinami M, Huber V, Maio M, Rivoltini L, Fais S
Journal name PLoS One
Publication year 2009
Sample Plasma
Sample name Plasma - Melanoma
Isolation/purification methods Differential centrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
ELISA
FACS
13
Experiment ID 245
ISEV standards
✔
EM
EV Biophysical techniques
✔
TSG101|Alix
EV Cytosolic markers
✔
CD9|CD63|FLOT1
EV Membrane markers
✘ EV Negative markers
✔
NTA
EV Particle analysis
Identified molecule protein
Identification method Western blotting
PubMed ID 25519911    
Organism Homo sapiens
Experiment description The ether lipid precursor hexadecylglycerol stimulates the release and changes the composition of exosomes derived from PC-3 cells
Authors Phuyal S, Skotland T, Hessvik NP, Simolin H, Overbye A, Brech A, Parton RG, Ekroos K, Sandvig K, Llorente A.
Journal name J Biol Chem
Publication year 2015
Sample Prostate cancer cells
Sample name PC-3 - Ethanol treated (control)
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Lipids
Protein
Methods used in the study Western blotting
Mass spectrometry
14
Experiment ID 246
ISEV standards
✔
EM
EV Biophysical techniques
✔
TSG101|Alix
EV Cytosolic markers
✔
CD9|CD63|FLOT1
EV Membrane markers
✘ EV Negative markers
✔
NTA
EV Particle analysis
Identified molecule protein
Identification method Western blotting
PubMed ID 25519911    
Organism Homo sapiens
Experiment description The ether lipid precursor hexadecylglycerol stimulates the release and changes the composition of exosomes derived from PC-3 cells
Authors Phuyal S, Skotland T, Hessvik NP, Simolin H, Overbye A, Brech A, Parton RG, Ekroos K, Sandvig K, Llorente A.
Journal name J Biol Chem
Publication year 2015
Sample Prostate cancer cells
Sample name PC-3 - sn-1-O-hexadecylglycerol treated
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Lipids
Methods used in the study Western blotting
Mass spectrometry
15
Experiment ID 247
ISEV standards
✘ EV Biophysical techniques
✔
TSG101|Alix
EV Cytosolic markers
✔
FLOT1
EV Membrane markers
✘ EV Negative markers
✔
NTA
EV Particle analysis
Identified molecule protein
Identification method Western blotting
PubMed ID 25519911    
Organism Homo sapiens
Experiment description The ether lipid precursor hexadecylglycerol stimulates the release and changes the composition of exosomes derived from PC-3 cells
Authors Phuyal S, Skotland T, Hessvik NP, Simolin H, Overbye A, Brech A, Parton RG, Ekroos K, Sandvig K, Llorente A.
Journal name J Biol Chem
Publication year 2015
Sample Prostate cancer cells
Sample name PC-3 - DL- palmitin treated
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Lipids
Methods used in the study Western blotting
Mass spectrometry
16
Experiment ID 275
ISEV standards
✔
EM
EV Biophysical techniques
✔
TSG101|Alix|RAB5A
EV Cytosolic markers
✔
CD9|CD82|CD63|CD81
EV Membrane markers
✔
AIF
EV Negative markers
✔
NTA
EV Particle analysis
Identified molecule protein
Identification method Western blotting
Mass spectrometry
PubMed ID 25844599    
Organism Homo sapiens
Experiment description Molecular profiling of prostate cancer derived exosomes may reveal a predictive signature for response to docetaxel.
Authors Kharaziha P, Chioureas D, Rutishauser D, Baltatzis G, Lennartsson L, Fonseca P, Azimi A, Hultenby K, Zubarev R, Ullen A, Yachnin J, Nilsson S, Panaretakis T.
Journal name Oncotarget
Publication year 2015
Sample Prostate cancer cells
Sample name DU145 - Docetaxel sensitive
Isolation/purification methods Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.12-1.19 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry/Flow cytometry/Western blotting
17
Experiment ID 191
ISEV standards
✘ EV Biophysical techniques
✔
Alix
EV Cytosolic markers
✔
CD81|CD9
EV Membrane markers
✘ EV Negative markers
✘ EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 20124223    
Organism Homo sapiens
Experiment description Hypoxic tumor cell modulates its microenvironment to enhance angiogenic and metastatic potential by secretion of proteins and exosomes.
Authors Park JE, Tan HS, Datta A, Lai RC, Zhang H, Meng W, Lim SK, Sze SK.
Journal name Mol Cell Proteomics
Publication year 2010
Sample Squamous carcinoma cells
Sample name Squamous carcinoma cell (A431)
Isolation/purification methods Differential centrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for CAV1
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 ADRBK1 156
Affinity Capture-MS Homo sapiens
Reconstituted Complex Homo sapiens
2 EDG1  
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
3 NEU3  
Affinity Capture-Western Homo sapiens
4 NOS2A  
Co-fractionation Homo sapiens
Reconstituted Complex Homo sapiens
5 FLOT2 2319
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
6 GJB2  
Invivo Homo sapiens
Invitro Homo sapiens
Affinity Capture-MS Homo sapiens
7 PTPRF 5792
Affinity Capture-Western Homo sapiens
8 ERBB2 2064
Invivo Homo sapiens
Invitro Homo sapiens
9 TNFRSF1B  
Affinity Capture-Western Homo sapiens
10 PDGFRA  
Invitro Homo sapiens
Affinity Capture-MS Homo sapiens
11 CSK 1445
Two-hybrid Homo sapiens
12 Clic4 83718
Co-fractionation Rattus norvegicus
13 PTPN6 5777
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
14 SCP2  
Affinity Capture-Western Homo sapiens
FRET Homo sapiens
Two-hybrid Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
15 GJA1 2697
Invitro Homo sapiens
Affinity Capture-MS Homo sapiens
16 NOS3  
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
17 CAV2 858
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
18 GRK5 2869
Reconstituted Complex Homo sapiens
19 PRNP 5621
Affinity Capture-MS Homo sapiens
20 DAG1 1605
Reconstituted Complex Homo sapiens
21 TRAF2  
Invivo Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
22 INSR 3643
Affinity Capture-Western Homo sapiens
23 EGFR 1956
Invivo Homo sapiens
Invitro Homo sapiens
24 EDNRB 1910
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
25 RCV1  
Invivo Homo sapiens
Affinity Capture-MS Homo sapiens
26 GJA3  
Invivo Homo sapiens
Invitro Homo sapiens
27 AQP3  
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
28 APP 351
Affinity Capture-MS Homo sapiens
Co-fractionation Homo sapiens
Protein-RNA Homo sapiens
29 PTGS2  
Invivo Homo sapiens
Invitro Homo sapiens
Affinity Capture-MS Homo sapiens
30 PTPN11 5781
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
31 ESR1  
Invitro Homo sapiens
32 PRKACA 5566
Affinity Capture-Western Homo sapiens
33 TRPC1  
Affinity Capture-Western Homo sapiens
34 NTRK1  
Affinity Capture-Western Homo sapiens
35 FLOT1  
Affinity Capture-Western Homo sapiens
36 NGFR 4804
Reconstituted Complex Homo sapiens
37 PTPN1 5770
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
38 PTEN  
Affinity Capture-Western Homo sapiens
39 GRK1  
Reconstituted Complex Homo sapiens
40 TGFBR1  
Invivo Homo sapiens
Invitro Homo sapiens
41 PPP1CA 5499
Affinity Capture-MS Homo sapiens
42 SRC 6714
Invitro Homo sapiens
43 TRADD 8717
Affinity Capture-Western Homo sapiens
44 AR 367
Affinity Capture-Western Homo sapiens
Two-hybrid Homo sapiens
Reconstituted Complex Homo sapiens
45 BTK 695
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
46 BMX  
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
47 TSC2 7249
Co-purification Homo sapiens
48 PLD2 5338
Affinity Capture-Western Homo sapiens
Co-fractionation Homo sapiens
Affinity Capture-Western Homo sapiens
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Perform bioinformatics analysis of your extracellular vesicle data set using FunRich, a open access standalone tool. NEW UPDATED VERSION OF FunRich available for download (12/09/2016) from here