Gene description for TNKS1BP1
Gene name tankyrase 1 binding protein 1, 182kDa
Gene symbol TNKS1BP1
Other names/aliases TAB182
Species Homo sapiens
 Database cross references - TNKS1BP1
ExoCarta ExoCarta_85456
Entrez Gene 85456
HGNC 19081
MIM 607104
UniProt Q9C0C2  
 TNKS1BP1 identified in exosomes derived from the following tissue/cell type
Colorectal cancer cells 17956143    
 Gene ontology annotations for TNKS1BP1
Molecular Function
    enzyme binding GO:0019899 NAS
    ankyrin binding GO:0030506 NAS
Biological Process
    nuclear-transcribed mRNA poly(A) tail shortening GO:0000289 TAS
    nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay GO:0000288 TAS
    telomere maintenance via telomerase GO:0007004 NAS
    gene expression GO:0010467 TAS
Subcellular Localization
    CCR4-NOT complex GO:0030014 IDA
    cytoskeleton GO:0005856 IEA
    cytosol GO:0005829 TAS
    nucleoplasm GO:0005654 IDA
    cytoplasm GO:0005737 NAS
    nuclear telomeric heterochromatin GO:0005724 NAS
    plasma membrane GO:0005886 IDA
    nucleus GO:0005634 NAS
 Experiment description of studies that identified TNKS1BP1 in exosomes
1
Experiment ID 20
ISEV standards
✔
EM
EV Biophysical techniques
✔
HSP90
EV Cytosolic markers
✔
CD63|CD81|LAMP1
EV Membrane markers
✔
GOLGA2|cytochrome c
EV Negative markers
✘ EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 17956143    
Organism Homo sapiens
Experiment description Proteomic analysis of microvesicles derived from human colorectal cancer cells.
Authors Choi DS, Lee JM, Park GW, Lim HW, Bang JY, Kim YK, Kwon KH, Kwon HJ, Kim KP, Gho YS
Journal name JPR
Publication year 2007
Sample Colorectal cancer cells
Sample name HT29
Isolation/purification methods Differential centrifugation
Sucrose density gradient
Diafiltration
Flotation density 1.16 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry [LTQ]
Western blotting
 Protein-protein interactions for TNKS1BP1
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 TNKS 8658
Two-hybrid Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
2 TNKS2 80351
Two-hybrid Homo sapiens
View the network image/svg+xml
 Pathways in which TNKS1BP1 is involved
PathwayEvidenceSource
Deadenylation of mRNA TAS Reactome





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