Gene description for TNKS2
Gene name	tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase 2
Gene symbol	TNKS2
Other names/aliases	ARTD6 PARP-5b PARP-5c PARP5B PARP5C TANK2 TNKL pART6
Species	Homo sapiens
Database cross references - TNKS2
ExoCarta	ExoCarta_80351
Vesiclepedia	VP_80351
Entrez Gene	80351
HGNC	15677
MIM	607128
UniProt	Q9H2K2
TNKS2 identified in sEVs derived from the following tissue/cell type
Endothelial cells	26027894

Gene ontology annotations for TNKS2

Molecular Function     NAD+-protein poly-ADP-ribosyltransferase activity GO:0003950 IBA     NAD+-protein poly-ADP-ribosyltransferase activity GO:0003950 IDA     NAD+-protein poly-ADP-ribosyltransferase activity GO:0003950 TAS     protein binding GO:0005515 IPI     nucleotidyltransferase activity GO:0016779 IEA     enzyme binding GO:0019899 IPI     metal ion binding GO:0046872 IEA     NAD+-protein-aspartate ADP-ribosyltransferase activity GO:0140806 IEA     NAD+-histone H2BE35 glutamate ADP-ribosyltransferase activity GO:0140822 IEA     NAD+-histone H2BE2 glutamate ADP-ribosyltransferase activity GO:0140844 IEA     NAD+-histone H2BE18 glutamate ADP-ribosyltransferase activity GO:0140867 IEA     NAD+-protein ADP-ribosyltransferase activity GO:1990404 IDA Biological Process     protein polyubiquitination GO:0000209 IDA     Wnt signaling pathway GO:0016055 IEA     positive regulation of telomere maintenance via telomerase GO:0032212 TAS     protein localization to chromosome, telomeric region GO:0070198 IBA     protein localization to chromosome, telomeric region GO:0070198 IMP     protein poly-ADP-ribosylation GO:0070212 IDA     protein auto-ADP-ribosylation GO:0070213 IDA     positive regulation of canonical Wnt signaling pathway GO:0090263 IBA     positive regulation of canonical Wnt signaling pathway GO:0090263 IMP     positive regulation of canonical Wnt signaling pathway GO:0090263 TAS     positive regulation of telomere capping GO:1904355 IBA     positive regulation of telomere capping GO:1904355 IMP     negative regulation of telomere maintenance via telomere lengthening GO:1904357 IMP Subcellular Localization     Golgi membrane GO:0000139 IEA     pericentriolar material GO:0000242 IDA     chromosome, telomeric region GO:0000781 TAS     nucleus GO:0005634 IBA     nucleus GO:0005634 IDA     nuclear envelope GO:0005635 IDA     cytoplasm GO:0005737 IBA     cytoplasm GO:0005737 IDA     cytosol GO:0005829 TAS     perinuclear region of cytoplasm GO:0048471 IDA