Gene description for BABAM1
Gene name BRISC and BRCA1 A complex member 1
Gene symbol BABAM1
Other names/aliases C19orf62
HSPC142
MERIT40
NBA1
Species Homo sapiens
 Database cross references - BABAM1
ExoCarta ExoCarta_29086
Vesiclepedia VP_29086
Entrez Gene 29086
HGNC 25008
MIM 612766
UniProt Q9NWV8  
 BABAM1 identified in exosomes derived from the following tissue/cell type
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Ovarian cancer cells 23333927    
Ovarian cancer cells 23333927    
Thymus 23844026    
 Gene ontology annotations for BABAM1
Molecular Function
    protein binding GO:0005515 IPI
    identical protein binding GO:0042802 IPI
Biological Process
    regulation of DNA repair GO:0006282 NAS
    double-strand break repair GO:0006302 IBA
    double-strand break repair GO:0006302 IMP
    mitotic G2 DNA damage checkpoint signaling GO:0007095 IBA
    mitotic G2 DNA damage checkpoint signaling GO:0007095 IMP
    response to ionizing radiation GO:0010212 IMP
    mitotic G2/M transition checkpoint GO:0044818 NAS
    positive regulation of DNA repair GO:0045739 IMP
    cell division GO:0051301 IEA
    hematopoietic stem cell proliferation GO:0071425 IEA
    DNA repair-dependent chromatin remodeling GO:0140861 IMP
Subcellular Localization
    nucleus GO:0005634 IDA
    nucleus GO:0005634 NAS
    nucleoplasm GO:0005654 IDA
    nucleoplasm GO:0005654 TAS
    cytoplasm GO:0005737 IDA
    cytosol GO:0005829 IDA
    cytosol GO:0005829 TAS
    nuclear body GO:0016604 IBA
    nuclear body GO:0016604 IDA
    BRCA1-A complex GO:0070531 IBA
    BRCA1-A complex GO:0070531 IDA
    BRCA1-A complex GO:0070531 NAS
    BRISC complex GO:0070552 IBA
    BRISC complex GO:0070552 IDA
 Experiment description of studies that identified BABAM1 in exosomes
1
Experiment ID 489
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 6
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
2
Experiment ID 490
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 7
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
3
Experiment ID 491
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 8
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
4
Experiment ID 492
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 9
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
5
Experiment ID 211
MISEV standards
✔
EM
Biophysical techniques
✔
TSG101|Alix|EpCAM|TFRC
Enriched markers
✔
cytochrome c|GOLGA2
Negative markers
✘ Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23333927    
Organism Homo sapiens
Experiment description Characterization and proteomic analysis of ovarian cancer-derived exosomes.
Authors "Liang B, Peng P, Chen S, Li L, Zhang M, Cao D, Yang J, Li H, Gui T, Li X, Shen K."
Journal name J Proteomics
Publication year 2013
Sample Ovarian cancer cells
Sample name IGROV1
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient
Flotation density 1.09-1.15 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
6
Experiment ID 212
MISEV standards
✔
CEM
Biophysical techniques
✔
TSG101|Alix|EpCAM|TFRC
Enriched markers
✔
Cytochrome C|GOLGA2
Negative markers
✘ Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23333927    
Organism Homo sapiens
Experiment description Characterization and proteomic analysis of ovarian cancer-derived exosomes.
Authors "Liang B, Peng P, Chen S, Li L, Zhang M, Cao D, Yang J, Li H, Gui T, Li X, Shen K."
Journal name J Proteomics
Publication year 2013
Sample Ovarian cancer cells
Sample name OVCAR-3
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient
Flotation density 1.09-1.15 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
7
Experiment ID 217
MISEV standards
✔
EM
Biophysical techniques
✔
TSG101|CD81|CD9|CD63
Enriched markers
✘ Negative markers
✔
NTA
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23844026    
Organism Homo sapiens
Experiment description Characterization of human thymic exosomes.
Authors "Skogberg G, Gudmundsdottir J, van der Post S, Sandstrom K, Bruhn S, Benson M, Mincheva-Nilsson L, Baranov V, Telemo E, Ekwall O."
Journal name PLoS One
Publication year 2013
Sample Thymus
Sample name Normal-Thymus
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for BABAM1
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 ATAD1 84896
Affinity Capture-MS Homo sapiens
2 AASDHPPT 60496
Affinity Capture-MS Homo sapiens
3 PDHA1 5160
Affinity Capture-MS Homo sapiens
4 UGGT2 55757
Affinity Capture-MS Homo sapiens
5 PNOC  
Affinity Capture-MS Homo sapiens
6 SLC25A13 10165
Affinity Capture-MS Homo sapiens
7 TFG 10342
Co-fractionation Homo sapiens
8 FAM189B  
Affinity Capture-MS Homo sapiens
9 SNX27 81609
Affinity Capture-MS Homo sapiens
10 PLEKHA4 57664
Affinity Capture-MS Homo sapiens
11 SLC25A11 8402
Affinity Capture-MS Homo sapiens
12 FAM175B 23172
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
13 USP7 7874
Affinity Capture-MS Homo sapiens
14 CLPX 10845
Affinity Capture-MS Homo sapiens
15 GRB2 2885
Affinity Capture-MS Homo sapiens
16 DEF6 50619
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
17 NSF 4905
Affinity Capture-MS Homo sapiens
18 UIMC1  
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
19 MELK  
Affinity Capture-MS Homo sapiens
20 TNKS 8658
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Co-localization Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
21 WWOX 51741
Two-hybrid Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
22 FAM210A  
Affinity Capture-MS Homo sapiens
23 LRRC47 57470
Affinity Capture-MS Homo sapiens
24 MICU1 10367
Affinity Capture-MS Homo sapiens
25 MRPL53  
Affinity Capture-MS Homo sapiens
26 BRCA1 672
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
27 TNS1 7145
Affinity Capture-MS Homo sapiens
28 PRDX5 25824
Affinity Capture-MS Homo sapiens
29 GPT2  
Affinity Capture-MS Homo sapiens
30 CUL3 8452
Affinity Capture-MS Homo sapiens
31 HIST1H4A 8359
Affinity Capture-MS Homo sapiens
32 SLIRP 81892
Affinity Capture-MS Homo sapiens
33 UBC 7316
Affinity Capture-MS Homo sapiens
Reconstituted Complex Homo sapiens
34 FAM168A  
Affinity Capture-MS Homo sapiens
35 DNAJC25 548645
Affinity Capture-MS Homo sapiens
36 PSMA4 5685
Affinity Capture-MS Homo sapiens
37 TERF2IP 54386
Two-hybrid Homo sapiens
38 TNKS2 80351
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Co-localization Homo sapiens
Affinity Capture-MS Homo sapiens
39 FAM175A  
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
40 FAM35A  
Proximity Label-MS Homo sapiens
41 SHMT2 6472
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-MS Homo sapiens
42 PARK7 11315
Affinity Capture-MS Homo sapiens
43 CSTF2 1478
Co-fractionation Homo sapiens
44 BRE 9577
Two-hybrid Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Co-fractionation Homo sapiens
Affinity Capture-MS Homo sapiens
Co-fractionation Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
45 PRKAR2B 5577
Affinity Capture-MS Homo sapiens
46 ZNF653  
Affinity Capture-MS Homo sapiens
47 PRKAG1 5571
Affinity Capture-MS Homo sapiens
48 NXF1 10482
Affinity Capture-RNA Homo sapiens
49 PCNA 5111
Co-fractionation Homo sapiens
50 Mta1  
Affinity Capture-MS Mus musculus
51 DDX39A 10212
Affinity Capture-MS Homo sapiens
52 WWP2 11060
Affinity Capture-MS Homo sapiens
53 GNAL 2774
Affinity Capture-MS Homo sapiens
54 C2orf73  
Affinity Capture-MS Homo sapiens
55 PBDC1 51260
Affinity Capture-MS Homo sapiens
56 MOV10 4343
Affinity Capture-RNA Homo sapiens
57 UBXN1 51035
Affinity Capture-MS Homo sapiens
58 C9orf85  
Affinity Capture-MS Homo sapiens
59 DIS3 22894
Affinity Capture-MS Homo sapiens
60 TRIM27  
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
61 SPATA2  
Affinity Capture-MS Homo sapiens
62 PLK1 5347
Affinity Capture-MS Homo sapiens
63 TNS2 23371
Affinity Capture-MS Homo sapiens
64 STK11 6794
Affinity Capture-MS Homo sapiens
65 PYCRL 65263
Affinity Capture-MS Homo sapiens
66 LDLR 3949
Negative Genetic Homo sapiens
67 BRCC3 79184
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Co-fractionation Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
68 NDUFA5 4698
Affinity Capture-MS Homo sapiens
69 SNW1 22938
Affinity Capture-MS Homo sapiens
70 MDC1  
Affinity Capture-MS Homo sapiens
71 AKAP2 11217
Co-fractionation Homo sapiens
72 Tnks2  
Affinity Capture-MS Mus musculus
73 Vps41  
Affinity Capture-MS Mus musculus
74 GMPS 8833
Affinity Capture-MS Homo sapiens
75 SFXN4  
Affinity Capture-MS Homo sapiens
76 VPS4B 9525
Affinity Capture-MS Homo sapiens
77 ARF4 378
Affinity Capture-MS Homo sapiens
78 RANGAP1 5905
Affinity Capture-MS Homo sapiens
79 EXD2  
Proximity Label-MS Homo sapiens
80 VPS4A 27183
Affinity Capture-MS Homo sapiens
81 PAXIP1  
Affinity Capture-MS Homo sapiens
View the network image/svg+xml



Perform bioinformatics analysis of your extracellular vesicle data set using FunRich, a open access standalone tool. NEW UPDATED VERSION OF FunRich available for download (12/09/2016) from here