Gene description for GMPS
Gene name guanine monphosphate synthase
Gene symbol GMPS
Other names/aliases -
Species Homo sapiens
 Database cross references - GMPS
ExoCarta ExoCarta_8833
Entrez Gene 8833
HGNC 4378
MIM 600358
UniProt P49915  
 GMPS identified in exosomes derived from the following tissue/cell type
Ovarian cancer cells 23333927    
Ovarian cancer cells 23333927    
Thymus 23844026    
 Gene ontology annotations for GMPS
Molecular Function
    pyrophosphatase activity GO:0016462 IEA
    GMP synthase (glutamine-hydrolyzing) activity GO:0003922 IEA
    GMP synthase activity GO:0003921 IEA
    enzyme binding GO:0019899 IEA
    ATP binding GO:0005524 IEA
Biological Process
    glutamine metabolic process GO:0006541 IEA
    purine ribonucleoside monophosphate biosynthetic process GO:0009168 TAS
    response to drug GO:0042493 IEA
    purine nucleobase biosynthetic process GO:0009113 TAS
    purine nucleobase metabolic process GO:0006144 TAS
    GMP biosynthetic process GO:0006177 IEA
    small molecule metabolic process GO:0044281 TAS
    nucleobase-containing small molecule metabolic process GO:0055086 TAS
Subcellular Localization
    cytosol GO:0005829 TAS
    cytoplasm GO:0005737 IDA
 Experiment description of studies that identified GMPS in exosomes
1
Experiment ID 211
ISEV standards
EM
EV Biophysical techniques
TSG101|Alix
EV Cytosolic markers
EpCAM|TFRC
EV Membrane markers
cytochrome c|GOLGA2
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23333927    
Organism Homo sapiens
Experiment description Characterization and proteomic analysis of ovarian cancer-derived exosomes.
Authors Liang B, Peng P, Chen S, Li L, Zhang M, Cao D, Yang J, Li H, Gui T, Li X, Shen K.
Journal name J Proteomics
Publication year 2013
Sample Ovarian cancer cells
Sample name IGROV1
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient
Flotation density 1.09-1.15 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
2
Experiment ID 212
ISEV standards
CEM
EV Biophysical techniques
TSG101|Alix
EV Cytosolic markers
EpCAM|TFRC
EV Membrane markers
Cytochrome C|GOLGA2
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23333927    
Organism Homo sapiens
Experiment description Characterization and proteomic analysis of ovarian cancer-derived exosomes.
Authors Liang B, Peng P, Chen S, Li L, Zhang M, Cao D, Yang J, Li H, Gui T, Li X, Shen K.
Journal name J Proteomics
Publication year 2013
Sample Ovarian cancer cells
Sample name OVCAR-3
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient
Flotation density 1.09-1.15 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
3
Experiment ID 217
ISEV standards
EM
EV Biophysical techniques
TSG101
EV Cytosolic markers
CD81|CD9|CD63
EV Membrane markers
EV Negative markers
NTA
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23844026    
Organism Homo sapiens
Experiment description Characterization of human thymic exosomes.
Authors Skogberg G, Gudmundsdottir J, van der Post S, Sandstrom K, Bruhn S, Benson M, Mincheva-Nilsson L, Baranov V, Telemo E, Ekwall O.
Journal name PLoS One
Publication year 2013
Sample Thymus
Sample name Normal-Thymus
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for GMPS
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which GMPS is involved
PathwayEvidenceSource
Purine ribonucleoside monophosphate biosynthesis TAS Reactome





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