Gene description for SUCLG2
Gene name succinate-CoA ligase, GDP-forming, beta subunit
Gene symbol SUCLG2
Other names/aliases GBETA
Species Homo sapiens
 Database cross references - SUCLG2
ExoCarta ExoCarta_8801
Entrez Gene 8801
HGNC 11450
MIM 603922
UniProt Q96I99  
 SUCLG2 identified in exosomes derived from the following tissue/cell type
Ovarian cancer cells 23333927    
Ovarian cancer cells 23333927    
 Gene ontology annotations for SUCLG2
Molecular Function
    succinate-CoA ligase (GDP-forming) activity GO:0004776 NAS
    GDP binding GO:0019003 IEA
    GTP binding GO:0005525 IEA
    protein heterodimerization activity GO:0046982 IEA
    ATP binding GO:0005524 IEA
Biological Process
    succinyl-CoA metabolic process GO:0006104 NAS
    cellular metabolic process GO:0044237 TAS
    succinate metabolic process GO:0006105 IEA
    tricarboxylic acid cycle GO:0006099 TAS
    small molecule metabolic process GO:0044281 TAS
Subcellular Localization
    succinate-CoA ligase complex (GDP-forming) GO:0045244 IEA
    mitochondrion GO:0005739 IDA
    mitochondrial matrix GO:0005759 TAS
    plasma membrane GO:0005886 IDA
 Experiment description of studies that identified SUCLG2 in exosomes
1
Experiment ID 211
ISEV standards
EM
EV Biophysical techniques
TSG101|Alix
EV Cytosolic markers
EpCAM|TFRC
EV Membrane markers
cytochrome c|GOLGA2
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23333927    
Organism Homo sapiens
Experiment description Characterization and proteomic analysis of ovarian cancer-derived exosomes.
Authors Liang B, Peng P, Chen S, Li L, Zhang M, Cao D, Yang J, Li H, Gui T, Li X, Shen K.
Journal name J Proteomics
Publication year 2013
Sample Ovarian cancer cells
Sample name IGROV1
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient
Flotation density 1.09-1.15 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
2
Experiment ID 212
ISEV standards
CEM
EV Biophysical techniques
TSG101|Alix
EV Cytosolic markers
EpCAM|TFRC
EV Membrane markers
Cytochrome C|GOLGA2
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23333927    
Organism Homo sapiens
Experiment description Characterization and proteomic analysis of ovarian cancer-derived exosomes.
Authors Liang B, Peng P, Chen S, Li L, Zhang M, Cao D, Yang J, Li H, Gui T, Li X, Shen K.
Journal name J Proteomics
Publication year 2013
Sample Ovarian cancer cells
Sample name OVCAR-3
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient
Flotation density 1.09-1.15 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for SUCLG2
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 GPR143 4935
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
View the network image/svg+xml
 Pathways in which SUCLG2 is involved
PathwayEvidenceSource
Citric acid cycle (TCA cycle) TAS Reactome





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