Gene description for ACADM
Gene name acyl-CoA dehydrogenase, C-4 to C-12 straight chain
Gene symbol ACADM
Other names/aliases ACAD1
MCAD
MCADH
Species Homo sapiens
 Database cross references - ACADM
ExoCarta ExoCarta_34
Entrez Gene 34
HGNC 89
MIM 607008
UniProt P11310  
 ACADM identified in exosomes derived from the following tissue/cell type
Squamous carcinoma cells 20124223    
 Gene ontology annotations for ACADM
Molecular Function
    identical protein binding GO:0042802 IDA
    flavin adenine dinucleotide binding GO:0050660 IEA
    acyl-CoA dehydrogenase activity GO:0003995 TAS
    medium-chain-acyl-CoA dehydrogenase activity GO:0070991 IDA
Biological Process
    medium-chain fatty acid catabolic process GO:0051793 IDA
    cellular lipid metabolic process GO:0044255 TAS
    carnitine biosynthetic process GO:0045329 IMP
    oxidation-reduction process GO:0055114 IDA
    small molecule metabolic process GO:0044281 TAS
    medium-chain fatty acid metabolic process GO:0051791 IDA
    fatty acid beta-oxidation GO:0006635 TAS
    fatty acid beta-oxidation using acyl-CoA dehydrogenase GO:0033539 IMP
    carnitine metabolic process, CoA-linked GO:0019254 IMP
Subcellular Localization
    mitochondrial matrix GO:0005759 TAS
    extracellular exosome GO:0070062 IDA
    nucleus GO:0005634 IDA
    mitochondrion GO:0005739 IDA
    axon GO:0030424 IDA
 Experiment description of studies that identified ACADM in exosomes
1
Experiment ID 191
ISEV standards
✘ EV Biophysical techniques
✔
Alix
EV Cytosolic markers
✔
CD81|CD9
EV Membrane markers
✘ EV Negative markers
✘ EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 20124223    
Organism Homo sapiens
Experiment description Hypoxic tumor cell modulates its microenvironment to enhance angiogenic and metastatic potential by secretion of proteins and exosomes.
Authors Park JE, Tan HS, Datta A, Lai RC, Zhang H, Meng W, Lim SK, Sze SK.
Journal name Mol Cell Proteomics
Publication year 2010
Sample Squamous carcinoma cells
Sample name Squamous carcinoma cell (A431)
Isolation/purification methods Differential centrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for ACADM
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 ACADM 34
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
View the network image/svg+xml



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