Gene description for AURKB
Gene name aurora kinase B
Gene symbol AURKB
Other names/aliases AIK2
AIM-1
AIM1
ARK2
AurB
IPL1
PPP1R48
STK12
STK5
aurkb-sv1
aurkb-sv2
Species Homo sapiens
 Database cross references - AURKB
ExoCarta ExoCarta_9212
Vesiclepedia VP_9212
Entrez Gene 9212
HGNC 11390
MIM 604970
UniProt Q96GD4  
 AURKB identified in exosomes derived from the following tissue/cell type
Gastric cancer cells 33991177    
Gastric cancer cells 33991177    
Gastric cancer cells 33991177    
 Gene ontology annotations for AURKB
Molecular Function
    protein serine/threonine/tyrosine kinase activity GO:0004712 TAS
    protein serine/threonine kinase activity GO:0004674 IDA
    ATP binding GO:0005524 IEA
    histone serine kinase activity GO:0035174 ISS
    protein binding GO:0005515 IPI
    metal ion binding GO:0046872 IEA
Biological Process
    positive regulation of cytokinesis GO:0032467 TAS
    cellular response to UV GO:0034644 IDA
    protein autophosphorylation GO:0046777 TAS
    mitotic spindle midzone assembly GO:0051256 TAS
    protein phosphorylation GO:0006468 IDA
    negative regulation of B cell apoptotic process GO:0002903 IDA
    regulation of chromosome segregation GO:0051983 TAS
    aging GO:0007568 IEA
    mitotic spindle organization GO:0007052 IBA
    negative regulation of cytokinesis GO:0032466 ISS
    spindle stabilization GO:0043146 IMP
    protein localization to kinetochore GO:0034501 IMP
    histone H3-S28 phosphorylation GO:0043988 ISS
    attachment of spindle microtubules to kinetochore GO:0008608 TAS
    spindle checkpoint GO:0031577 IEA
    cleavage furrow formation GO:0036089 IDA
    cell proliferation GO:0008283 IEA
    anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process GO:0031145 TAS
    histone modification GO:0016570 TAS
    small GTPase mediated signal transduction GO:0007264 TAS
    negative regulation of transcription from RNA polymerase II promoter GO:0000122 IDA
    mitotic cell cycle GO:0000278 TAS
    negative regulation of protein binding GO:0032091 IDA
    abscission GO:0009838 ISS
Subcellular Localization
    condensed nuclear chromosome, centromeric region GO:0000780 IDA
    chromocenter GO:0010369 IEA
    spindle GO:0005819 TAS
    cytosol GO:0005829 TAS
    chromosome passenger complex GO:0032133 TAS
    spindle microtubule GO:0005876 IBA
    nucleus GO:0005634 IDA
    spindle pole centrosome GO:0031616 IBA
    condensed chromosome, centromeric region GO:0000779 IDA
    midbody GO:0030496 TAS
    spindle midzone GO:0051233 IBA
 Experiment description of studies that identified AURKB in exosomes
1
Experiment ID 363
MISEV standards
✘ EV Biophysical techniques
✔
TSG101|GAPDH|AQP1|CD151|CD81|CD82|CD9|EPCAM|FLOT1|FLOT2|ICAM1|ITGA2B|LAMP2|RAB35|RAB5A|RAB5B|SDCBP|TFRC|UCHL1
EV Enriched markers
✔
DCLK1
EV Negative markers
✔
NTA
EV Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 33991177    
Organism Homo sapiens
Experiment description Cancer stem cell marker DCLK1 reprograms small extracellular vesicles toward migratory phenotype in gastric cancer cells
Authors Carli ALE, Afshar-Sterle S, Rai A, Fang H, O'Keefe R, Tse J, Ferguson FM, Gray NS, Ernst M, Greening DW, Buchert M.
Journal name Proteomics
Publication year 2021
Sample Gastric cancer cells
Sample name MKN1 - 100K pellet
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
2
Experiment ID 364
MISEV standards
✘ EV Biophysical techniques
✔
TSG101|GAPDH|AQP1|CD151|CD81|CD82|CD9|EPCAM|FLOT1|FLOT2|ICAM1|ITGA2B|LAMP2|RAB35|RAB5A|RAB5B|SDCBP|TFRC|UCHL1
EV Enriched markers
✔
DCLK1
EV Negative markers
✔
NTA
EV Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 33991177    
Organism Homo sapiens
Experiment description Cancer stem cell marker DCLK1 reprograms small extracellular vesicles toward migratory phenotype in gastric cancer cells
Authors Carli ALE, Afshar-Sterle S, Rai A, Fang H, O'Keefe R, Tse J, Ferguson FM, Gray NS, Ernst M, Greening DW, Buchert M.
Journal name Proteomics
Publication year 2021
Sample Gastric cancer cells
Sample name MKN1 - 100K pellet
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
3
Experiment ID 365
MISEV standards
✘ EV Biophysical techniques
✔
TSG101|GAPDH|AQP1|CD151|CD81|CD82|CD9|EPCAM|FLOT1|FLOT2|ICAM1|ITGA2B|LAMP2|RAB35|RAB5A|RAB5B|SDCBP|TFRC|UCHL1
EV Enriched markers
✔
DCLK1
EV Negative markers
✔
NTA
EV Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 33991177    
Organism Homo sapiens
Experiment description Cancer stem cell marker DCLK1 reprograms small extracellular vesicles toward migratory phenotype in gastric cancer cells
Authors Carli ALE, Afshar-Sterle S, Rai A, Fang H, O'Keefe R, Tse J, Ferguson FM, Gray NS, Ernst M, Greening DW, Buchert M.
Journal name Proteomics
Publication year 2021
Sample Gastric cancer cells
Sample name MKN1 - 100K pellet
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
 Protein-protein interactions for AURKB
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 RACGAP1 29127
Biochemical Activity Homo sapiens
2 TACC1 6867
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
3 CDCA8 55143
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Biochemical Activity Homo sapiens
4 RCC2 55920
Affinity Capture-Western Homo sapiens
5 AURKB 9212
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
6 INCENP 3619
Affinity Capture-Western Homo sapiens
7 BIRC5  
Two-hybrid Homo sapiens
Reconstituted Complex Homo sapiens
Phenotypic Enhancement Homo sapiens
Reconstituted Complex Homo sapiens
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