Gene description for ZBTB2
Gene name zinc finger and BTB domain containing 2
Gene symbol ZBTB2
Other names/aliases ZNF437
Species Homo sapiens
 Database cross references - ZBTB2
ExoCarta ExoCarta_57621
Vesiclepedia VP_57621
Entrez Gene 57621
HGNC 20868
UniProt Q8N680  
 ZBTB2 identified in exosomes derived from the following tissue/cell type
Hepatocellular carcinoma cells 26054723    
Hepatocellular carcinoma cells 26054723    
 Gene ontology annotations for ZBTB2
Molecular Function
    RNA polymerase II cis-regulatory region sequence-specific DNA binding GO:0000978 IBA
    RNA polymerase II cis-regulatory region sequence-specific DNA binding GO:0000978 IDA
    DNA-binding transcription repressor activity, RNA polymerase II-specific GO:0001227 IBA
    DNA-binding transcription repressor activity, RNA polymerase II-specific GO:0001227 IDA
    protein binding GO:0005515 IPI
    identical protein binding GO:0042802 IPI
    metal ion binding GO:0046872 IEA
    sequence-specific double-stranded DNA binding GO:1990837 IDA
Biological Process
    negative regulation of transcription by RNA polymerase II GO:0000122 IBA
    negative regulation of transcription by RNA polymerase II GO:0000122 IDA
    regulation of cytokine production GO:0001817 IBA
    regulation of immune system process GO:0002682 IBA
Subcellular Localization
    nucleoplasm GO:0005654 IBA
 Experiment description of studies that identified ZBTB2 in exosomes
1
Experiment ID 234
MISEV standards
EM
Biophysical techniques
TSG101|Alix|HSC70|GAPDH
Enriched markers
HSP90B1
Negative markers
qNano
Particle analysis
Identified molecule mRNA
Identification method RNA Sequencing
PubMed ID 26054723    
Organism Homo sapiens
Experiment description Hepatocellular carcinoma-derived exosomes promote motility of immortalized hepatocyte through transfer of oncogenic proteins and RNAs
Authors "He M, Qin H, Poon TC, Sze SC, Ding X, Co NN, Ngai SM, Chan TF, Wong N"
Journal name Carcinogenesis
Publication year 2015
Sample Hepatocellular carcinoma cells
Sample name HKCI-C3
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.13-1.19 g/mL
Molecules identified in the study Protein
RNA
Methods used in the study Western blotting
Mass spectrometry
RT-PCR
RNA Sequencing
2
Experiment ID 235
MISEV standards
EM
Biophysical techniques
TSG101|Alix|HSC70|GAPDH
Enriched markers
HSP90B1
Negative markers
qNano
Particle analysis
Identified molecule mRNA
Identification method RNA Sequencing
PubMed ID 26054723    
Organism Homo sapiens
Experiment description Hepatocellular carcinoma-derived exosomes promote motility of immortalized hepatocyte through transfer of oncogenic proteins and RNAs
Authors "He M, Qin H, Poon TC, Sze SC, Ding X, Co NN, Ngai SM, Chan TF, Wong N"
Journal name Carcinogenesis
Publication year 2015
Sample Hepatocellular carcinoma cells
Sample name HKCI-8
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.13-1.19 g/mL
Molecules identified in the study Protein
RNA
Methods used in the study Western blotting
Mass spectrometry
RT-PCR
RNA Sequencing
 Protein-protein interactions for ZBTB2
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 CHMP2A 27243
Affinity Capture-MS Homo sapiens
2 RASSF8 11228
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Two-hybrid Homo sapiens
Affinity Capture-MS Homo sapiens
3 HDAC2 3066
Affinity Capture-MS Homo sapiens
4 UBL4A 8266
Affinity Capture-MS Homo sapiens
5 ZNF346  
Affinity Capture-MS Homo sapiens
6 ELP6 54859
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
7 TOP2B 7155
Affinity Capture-MS Homo sapiens
8 SUCO  
Affinity Capture-MS Homo sapiens
9 DDX17 10521
Affinity Capture-MS Homo sapiens
10 NMNAT1  
Affinity Capture-MS Homo sapiens
11 KPNA2 3838
Affinity Capture-MS Homo sapiens
12 PRPF40A 55660
Affinity Capture-MS Homo sapiens
13 PARK7 11315
Affinity Capture-MS Homo sapiens
14 AKAP8L  
Affinity Capture-MS Homo sapiens
15 PCBP3 54039
Affinity Capture-MS Homo sapiens
16 CCDC43 124808
Affinity Capture-MS Homo sapiens
17 DPPA4  
Affinity Capture-MS Homo sapiens
18 GPATCH4 54865
Affinity Capture-MS Homo sapiens
19 SNRNP70 6625
Affinity Capture-MS Homo sapiens
20 CBX1 10951
Affinity Capture-MS Homo sapiens
21 WHSC1 7468
Affinity Capture-MS Homo sapiens
22 MTF2  
Affinity Capture-MS Homo sapiens
23 UBE2O 63893
Affinity Capture-MS Homo sapiens
24 SF3B1 23451
Affinity Capture-MS Homo sapiens
25 CDK2AP1  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
26 DDX24 57062
Affinity Capture-MS Homo sapiens
27 POU5F1  
Affinity Capture-MS Homo sapiens
28 CHMP2B 25978
Affinity Capture-MS Homo sapiens
29 ZBTB18  
Two-hybrid Homo sapiens
30 DYNLL1 8655
Affinity Capture-MS Homo sapiens
31 MARCKSL1 65108
Affinity Capture-MS Homo sapiens
32 MECP2 4204
Affinity Capture-MS Homo sapiens
33 ANAPC16  
Affinity Capture-MS Homo sapiens
34 WDR5 11091
Affinity Capture-MS Homo sapiens
35 KIF21A 55605
Affinity Capture-MS Homo sapiens
36 MTA2 9219
Affinity Capture-MS Homo sapiens
37 SLC25A3 5250
Affinity Capture-MS Homo sapiens
38 KIF14 9928
Affinity Capture-MS Homo sapiens
39 BAG6 7917
Affinity Capture-MS Homo sapiens
40 XRCC4  
Affinity Capture-MS Homo sapiens
41 ANGPTL2 23452
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
42 WBP4  
Affinity Capture-MS Homo sapiens
43 TCP1 6950
Affinity Capture-MS Homo sapiens
44 ENSA 2029
Affinity Capture-MS Homo sapiens
45 TXNL4B  
Affinity Capture-MS Homo sapiens
46 LIN28B  
Affinity Capture-RNA Homo sapiens
47 SBNO1 55206
Affinity Capture-MS Homo sapiens
48 SRPK2 6733
Affinity Capture-MS Homo sapiens
49 PGAM5 192111
Affinity Capture-MS Homo sapiens
50 ZMYM3  
Affinity Capture-MS Homo sapiens
51 CBX5 23468
Affinity Capture-MS Homo sapiens
52 GMEB1  
Affinity Capture-MS Homo sapiens
53 DTX2 113878
Proximity Label-MS Homo sapiens
54 MEOX2  
Two-hybrid Homo sapiens
55 BICD2 23299
Affinity Capture-MS Homo sapiens
56 P4HB 5034
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
57 ZFP91 80829
Affinity Capture-MS Homo sapiens
58 NGDN  
Affinity Capture-MS Homo sapiens
59 RRP1B 23076
Affinity Capture-MS Homo sapiens
60 SON 6651
Affinity Capture-MS Homo sapiens
61 DDX39B 7919
Affinity Capture-MS Homo sapiens
62 PICALM 8301
Affinity Capture-MS Homo sapiens
63 VDAC2 7417
Affinity Capture-MS Homo sapiens
64 GTPBP4 23560
Affinity Capture-MS Homo sapiens
65 SRPK1 6732
Affinity Capture-MS Homo sapiens
66 NRF1 4899
Affinity Capture-MS Homo sapiens
67 ZNF326 284695
Affinity Capture-MS Homo sapiens
68 BCLAF1 9774
Affinity Capture-MS Homo sapiens
69 TMPO 7112
Affinity Capture-MS Homo sapiens
70 NOC3L 64318
Affinity Capture-MS Homo sapiens
71 MRPS12  
Affinity Capture-MS Homo sapiens
72 MRTO4 51154
Affinity Capture-MS Homo sapiens
73 LRRC59 55379
Affinity Capture-MS Homo sapiens
74 IGHA1 3493
Affinity Capture-MS Homo sapiens
75 SRSF4 6429
Affinity Capture-MS Homo sapiens
76 EBNA1BP2 10969
Affinity Capture-MS Homo sapiens
77 NOM1  
Affinity Capture-MS Homo sapiens
78 RPL7L1 285855
Affinity Capture-MS Homo sapiens
79 DHX37  
Affinity Capture-MS Homo sapiens
80 RBBP4 5928
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
81 NIP7 51388
Affinity Capture-MS Homo sapiens
82 YTHDC1  
Affinity Capture-MS Homo sapiens
83 ZNF512  
Affinity Capture-MS Homo sapiens
84 BAZ2A  
Affinity Capture-MS Homo sapiens
85 PCBP1 5093
Affinity Capture-MS Homo sapiens
86 CMSS1  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
87 LTV1  
Affinity Capture-MS Homo sapiens
88 ZMYND8 23613
Affinity Capture-MS Homo sapiens
89 PHF5A 84844
Affinity Capture-MS Homo sapiens
90 UQCRC1 7384
Affinity Capture-MS Homo sapiens
91 ZNF687  
Affinity Capture-MS Homo sapiens
92 SUPT16H 11198
Affinity Capture-MS Homo sapiens
93 GNL3 26354
Affinity Capture-MS Homo sapiens
94 BIRC5  
Affinity Capture-MS Homo sapiens
95 SBDS 51119
Affinity Capture-MS Homo sapiens
96 FASN 2194
Positive Genetic Homo sapiens
97 RRS1 23212
Affinity Capture-MS Homo sapiens
98 RWDD4 201965
Affinity Capture-MS Homo sapiens
99 MTA1 9112
Affinity Capture-MS Homo sapiens
100 SRSF12  
Affinity Capture-MS Homo sapiens
101 COX5A 9377
Affinity Capture-MS Homo sapiens
102 TRA2B 6434
Affinity Capture-MS Homo sapiens
103 PDCD2 5134
Affinity Capture-MS Homo sapiens
104 PWP1 11137
Affinity Capture-MS Homo sapiens
105 KRR1 11103
Affinity Capture-MS Homo sapiens
106 LARP7 51574
Affinity Capture-MS Homo sapiens
107 ALYREF 10189
Affinity Capture-MS Homo sapiens
108 ZNF768 79724
Affinity Capture-MS Homo sapiens
109 FAM50A 9130
Affinity Capture-MS Homo sapiens
110 EHMT1  
Affinity Capture-MS Homo sapiens
111 CAMK2D 817
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
112 LUC7L 55692
Affinity Capture-MS Homo sapiens
113 CENPB 1059
Affinity Capture-MS Homo sapiens
114 RPS17 6218
Affinity Capture-MS Homo sapiens
115 SH3GL1 6455
Affinity Capture-MS Homo sapiens
116 FMR1 2332
Affinity Capture-MS Homo sapiens
117 POGZ 23126
Affinity Capture-MS Homo sapiens
118 PRPF38A 84950
Affinity Capture-MS Homo sapiens
119 PBRM1 55193
Affinity Capture-MS Homo sapiens
120 NOP56 10528
Affinity Capture-MS Homo sapiens
121 ARL6IP4  
Affinity Capture-MS Homo sapiens
122 SMARCA1 6594
Affinity Capture-MS Homo sapiens
123 ROCK2 9475
Affinity Capture-MS Homo sapiens
124 TERF2IP 54386
Affinity Capture-MS Homo sapiens
125 SRSF2 6427
Affinity Capture-MS Homo sapiens
126 COPA 1314
Affinity Capture-MS Homo sapiens
127 SNRPF 6636
Affinity Capture-MS Homo sapiens
128 KIAA1598 57698
Affinity Capture-MS Homo sapiens
129 ATP5L 10632
Affinity Capture-MS Homo sapiens
130 SAFB 6294
Affinity Capture-MS Homo sapiens
131 PDCD10 11235
Affinity Capture-MS Homo sapiens
132 RNPS1 10921
Affinity Capture-MS Homo sapiens
133 CDK11B 984
Affinity Capture-MS Homo sapiens
134 H1FX 8971
Affinity Capture-MS Homo sapiens
135 TOMM34 10953
Affinity Capture-MS Homo sapiens
136 TLN1 7094
Affinity Capture-MS Homo sapiens
137 RRP12 23223
Affinity Capture-MS Homo sapiens
138 MAGOHB 55110
Affinity Capture-MS Homo sapiens
139 PARVA 55742
Affinity Capture-MS Homo sapiens
140 KRI1  
Affinity Capture-MS Homo sapiens
141 GRWD1 83743
Affinity Capture-MS Homo sapiens
142 ABCD3 5825
Affinity Capture-MS Homo sapiens
143 PHB 5245
Affinity Capture-MS Homo sapiens
144 MRPS7 51081
Affinity Capture-MS Homo sapiens
145 LHX4  
Two-hybrid Homo sapiens
146 GAR1 54433
Affinity Capture-MS Homo sapiens
147 XPO1 7514
Affinity Capture-MS Homo sapiens
148 PRPF8 10594
Affinity Capture-MS Homo sapiens
149 TRIM26 7726
Affinity Capture-MS Homo sapiens
150 RTFDC1  
Affinity Capture-MS Homo sapiens
151 RBM28 55131
Affinity Capture-MS Homo sapiens
152 TRA2A 29896
Affinity Capture-MS Homo sapiens
153 RPF2 84154
Affinity Capture-MS Homo sapiens
154 ACIN1 22985
Affinity Capture-MS Homo sapiens
155 SNRNP200 23020
Affinity Capture-MS Homo sapiens
156 RAP1B 5908
Affinity Capture-MS Homo sapiens
157 DDX10  
Affinity Capture-MS Homo sapiens
158 NKRF 55922
Affinity Capture-MS Homo sapiens
159 TAPT1 202018
Affinity Capture-MS Homo sapiens
160 RBMX2  
Affinity Capture-MS Homo sapiens
161 MBD2 8932
Affinity Capture-MS Homo sapiens
162 UBTF 7343
Affinity Capture-MS Homo sapiens
163 LYAR 55646
Affinity Capture-MS Homo sapiens
164 SNRPD3 6634
Affinity Capture-MS Homo sapiens
165 C7orf50 84310
Affinity Capture-MS Homo sapiens
166 RSL1D1 26156
Affinity Capture-MS Homo sapiens
167 CHMP3 51652
Affinity Capture-MS Homo sapiens
168 RPN2 6185
Affinity Capture-MS Homo sapiens
169 POP1 10940
Affinity Capture-MS Homo sapiens
170 EIF6 3692
Affinity Capture-MS Homo sapiens
171 MGME1  
Affinity Capture-MS Homo sapiens
172 MRPS11  
Affinity Capture-MS Homo sapiens
173 PHIP 55023
Affinity Capture-MS Homo sapiens
174 SRSF5 6430
Affinity Capture-MS Homo sapiens
175 SLK 9748
Affinity Capture-MS Homo sapiens
176 Paxip1  
Affinity Capture-MS Mus musculus
177 EFTUD2 9343
Affinity Capture-MS Homo sapiens
178 RPS27 6232
Affinity Capture-MS Homo sapiens
179 UBLCP1  
Affinity Capture-MS Homo sapiens
180 CEBPZ  
Affinity Capture-MS Homo sapiens
181 FOCAD 54914
Affinity Capture-MS Homo sapiens
182 DDB1 1642
Affinity Capture-MS Homo sapiens
183 FKBP3 2287
Affinity Capture-MS Homo sapiens
184 MRPS17 51373
Affinity Capture-MS Homo sapiens
185 HMG20A  
Affinity Capture-MS Homo sapiens
186 RPL26 6154
Affinity Capture-MS Homo sapiens
187 GATAD2A 54815
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
188 SURF6  
Affinity Capture-MS Homo sapiens
189 NKTR  
Affinity Capture-MS Homo sapiens
190 STK24 8428
Affinity Capture-MS Homo sapiens
191 RSF1  
Affinity Capture-MS Homo sapiens
192 ILF3 3609
Affinity Capture-MS Homo sapiens
193 TP53 7157
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-MS Homo sapiens
194 HOMEZ  
Affinity Capture-MS Homo sapiens
195 GMEB2  
Affinity Capture-MS Homo sapiens
196 SSRP1 6749
Affinity Capture-MS Homo sapiens
197 FXR1 8087
Affinity Capture-MS Homo sapiens
198 SRP19 6728
Affinity Capture-MS Homo sapiens
199 C1orf35  
Affinity Capture-MS Homo sapiens
200 STK26 51765
Affinity Capture-MS Homo sapiens
201 NIFK 84365
Affinity Capture-MS Homo sapiens
202 ESR1  
Affinity Capture-MS Homo sapiens
203 EIF3J 8669
Affinity Capture-MS Homo sapiens
204 YBX3 8531
Affinity Capture-MS Homo sapiens
205 ATP1A1 476
Affinity Capture-MS Homo sapiens
206 BRD1 23774
Affinity Capture-MS Homo sapiens
207 GLYR1 84656
Affinity Capture-MS Homo sapiens
208 MTA3 57504
Affinity Capture-MS Homo sapiens
209 KAT6A  
Affinity Capture-MS Homo sapiens
210 QRSL1  
Affinity Capture-MS Homo sapiens
211 SNTB2 6645
Affinity Capture-MS Homo sapiens
212 TEX10 54881
Affinity Capture-MS Homo sapiens
213 MYL12B 103910
Affinity Capture-MS Homo sapiens
214 MTCH2 23788
Affinity Capture-MS Homo sapiens
215 ATAD1 84896
Affinity Capture-MS Homo sapiens
216 RALY 22913
Affinity Capture-MS Homo sapiens
217 NOP14 8602
Affinity Capture-MS Homo sapiens
218 MCM7 4176
Affinity Capture-MS Homo sapiens
219 SENP3 26168
Affinity Capture-MS Homo sapiens
220 RPL26L1 51121
Affinity Capture-MS Homo sapiens
221 GATAD2B 57459
Affinity Capture-MS Homo sapiens
222 NOP58 51602
Affinity Capture-MS Homo sapiens
223 PRKCD 5580
Affinity Capture-MS Homo sapiens
224 MARCKS 4082
Affinity Capture-MS Homo sapiens
225 SP1  
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
226 TBL2 26608
Affinity Capture-MS Homo sapiens
227 BYSL 705
Affinity Capture-MS Homo sapiens
228 MANF 7873
Affinity Capture-MS Homo sapiens
229 HNRNPR 10236
Affinity Capture-MS Homo sapiens
230 SRSF8 10929
Affinity Capture-MS Homo sapiens
231 FAU 2197
Affinity Capture-MS Homo sapiens
232 KAT7  
Affinity Capture-MS Homo sapiens
233 DIMT1 27292
Affinity Capture-MS Homo sapiens
234 WDR48 57599
Affinity Capture-MS Homo sapiens
235 ARFGAP2 84364
Affinity Capture-MS Homo sapiens
236 COPB2 9276
Affinity Capture-MS Homo sapiens
237 LIG1 3978
Affinity Capture-MS Homo sapiens
238 SUV39H1  
Two-hybrid Homo sapiens
239 MCTS1 28985
Affinity Capture-MS Homo sapiens
240 BRPF3  
Affinity Capture-MS Homo sapiens
241 CALCOCO2  
Affinity Capture-MS Homo sapiens
242 DDX18 8886
Affinity Capture-MS Homo sapiens
243 HIST1H1C 3006
Affinity Capture-MS Homo sapiens
244 NHP2 55651
Affinity Capture-MS Homo sapiens
245 PKN2 5586
Affinity Capture-MS Homo sapiens
246 STAT6 6778
Two-hybrid Homo sapiens
247 EHD1 10938
Affinity Capture-MS Homo sapiens
248 RBM8A 9939
Affinity Capture-MS Homo sapiens
249 CHD1 1105
Affinity Capture-MS Homo sapiens
250 BRIX1 55299
Affinity Capture-MS Homo sapiens
251 BSG 682
Affinity Capture-MS Homo sapiens
252 COPB1 1315
Affinity Capture-MS Homo sapiens
253 ATAD3B 83858
Affinity Capture-MS Homo sapiens
254 MRPS25 64432
Affinity Capture-MS Homo sapiens
255 IRS4 8471
Affinity Capture-MS Homo sapiens
256 CHMP1A 5119
Affinity Capture-MS Homo sapiens
257 SCAF1  
Affinity Capture-MS Homo sapiens
258 PHF14 9678
Affinity Capture-MS