Gene description for CBX1
Gene name chromobox homolog 1
Gene symbol CBX1
Other names/aliases CBX
HP1-BETA
HP1Hs-beta
HP1Hsbeta
M31
MOD1
p25beta
Species Homo sapiens
 Database cross references - CBX1
ExoCarta ExoCarta_10951
Entrez Gene 10951
HGNC 1551
MIM 604511
UniProt P83916  
 CBX1 identified in exosomes derived from the following tissue/cell type
Thymus 23844026    
 Gene ontology annotations for CBX1
Molecular Function
    histone methyltransferase binding GO:1990226 IPI
    enzyme binding GO:0019899 IPI
    chromatin binding GO:0003682 TAS
    protein binding GO:0005515 IPI
    protein homodimerization activity GO:0042803 IEA
Biological Process
    negative regulation of transcription, DNA-templated GO:0045892 IEA
Subcellular Localization
    chromocenter GO:0010369 IEA
    chromatin GO:0000785 IDA
    spindle GO:0005819 IDA
    nucleoplasm GO:0005654 TAS
    chromosome, centromeric region GO:0000775 IDA
    male pronucleus GO:0001940 IEA
    female pronucleus GO:0001939 IEA
    nuclear heterochromatin GO:0005720 TAS
    pericentric heterochromatin GO:0005721 IEA
 Experiment description of studies that identified CBX1 in exosomes
1
Experiment ID 217
ISEV standards
EM
EV Biophysical techniques
TSG101
EV Cytosolic markers
CD81|CD9|CD63
EV Membrane markers
EV Negative markers
NTA
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23844026    
Organism Homo sapiens
Experiment description Characterization of human thymic exosomes.
Authors Skogberg G, Gudmundsdottir J, van der Post S, Sandstrom K, Bruhn S, Benson M, Mincheva-Nilsson L, Baranov V, Telemo E, Ekwall O.
Journal name PLoS One
Publication year 2013
Sample Thymus
Sample name Normal-Thymus
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for CBX1
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 RB1 5925
Reconstituted Complex Homo sapiens
2 DNMT3A 1788
Reconstituted Complex Homo sapiens
3 Suv39h1  
Affinity Capture-Western Mus musculus
4 DNMT1 1786
Reconstituted Complex Homo sapiens
5 CBX3 11335
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
6 UCHL1 7345
Two-hybrid Homo sapiens
7 SUV39H1  
Affinity Capture-Western Homo sapiens
Co-fractionation Homo sapiens
Affinity Capture-Western Homo sapiens
8 CBX1 10951
Invivo Homo sapiens
Invitro Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Invivo Homo sapiens
Invitro Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
9 DNMT3B  
Invivo Homo sapiens
10 TRIM28 10155
Invivo Homo sapiens
Invitro Homo sapiens
Two-hybrid Homo sapiens
Affinity Capture-Western Homo sapiens
11 PIM1  
Invitro Homo sapiens
Invivo Homo sapiens
12 C11orf30  
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Two-hybrid Homo sapiens
Reconstituted Complex Homo sapiens
13 TIF1  
Invitro Homo sapiens
14 ARL5  
Two-hybrid Homo sapiens
15 CHAF1A  
Invitro Homo sapiens
Invivo Homo sapiens
Two-hybrid Homo sapiens
16 CBX5 23468
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
17 HIST1H3C 8352
Invitro Homo sapiens
18 RPL12 6136
Two-hybrid Homo sapiens
19 RIF1  
Two-hybrid Homo sapiens
View the network image/svg+xml
 Pathways in which CBX1 is involved
No pathways found





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