Gene description for RING1
Gene name ring finger protein 1
Gene symbol RING1
Other names/aliases RING1A
RNF1
Species Homo sapiens
 Database cross references - RING1
ExoCarta ExoCarta_6015
Vesiclepedia VP_6015
Entrez Gene 6015
HGNC 10018
MIM 602045
UniProt Q06587  
 RING1 identified in exosomes derived from the following tissue/cell type
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
 Gene ontology annotations for RING1
Molecular Function
    chromatin binding GO:0003682 IBA
    protein binding GO:0005515 IPI
    metal ion binding GO:0046872 IEA
    ubiquitin protein ligase activity GO:0061630 IBA
    ubiquitin-protein transferase activator activity GO:0097027 IEA
Biological Process
    chromatin remodeling GO:0006338 IDA
    anterior/posterior pattern specification GO:0009952 IEA
    protein ubiquitination GO:0016567 IEA
    negative regulation of DNA-templated transcription GO:0045892 IBA
    negative regulation of DNA-templated transcription GO:0045892 IDA
    camera-type eye morphogenesis GO:0048593 IEA
Subcellular Localization
    ubiquitin ligase complex GO:0000151 IBA
    sex chromatin GO:0001739 IEA
    nucleus GO:0005634 IDA
    nucleoplasm GO:0005654 IDA
    nucleoplasm GO:0005654 TAS
    cytosol GO:0005829 IDA
    nuclear speck GO:0016607 IEA
    PcG protein complex GO:0031519 IBA
    PcG protein complex GO:0031519 IDA
    PRC1 complex GO:0035102 IDA
 Experiment description of studies that identified RING1 in exosomes
1
Experiment ID 489
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 6
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
2
Experiment ID 490
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 7
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
3
Experiment ID 491
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 8
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
4
Experiment ID 492
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 9
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
 Protein-protein interactions for RING1
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 HNRNPH1 3187
Affinity Capture-RNA Homo sapiens
2 GATA1  
Proximity Label-MS Homo sapiens
3 Cbx2  
Co-purification Mus musculus
Affinity Capture-MS Mus musculus
4 CBX1 10951
Affinity Capture-MS Homo sapiens
5 FEV  
Proximity Label-MS Homo sapiens
6 LHX2  
Proximity Label-MS Homo sapiens
7 HIST1H2BG 8339
Proximity Label-MS Homo sapiens
8 GATA2  
Proximity Label-MS Homo sapiens
9 EN1  
Proximity Label-MS Homo sapiens
10 Cbx7  
Affinity Capture-MS Mus musculus
11 CSNK2A1 1457
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
12 TRIM55  
Two-hybrid Homo sapiens
13 FBRS 64319
Affinity Capture-MS Homo sapiens
14 APP 351
Reconstituted Complex Homo sapiens
15 CENPA  
Co-purification Homo sapiens
16 PCGF2 7703
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Two-hybrid Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
Affinity Capture-MS Homo sapiens
17 KIF13B 23303
Cross-Linking-MS (XL-MS) Homo sapiens
18 TOP2A 7153
Affinity Capture-Western Homo sapiens
19 BRD4 23476
Affinity Capture-MS Homo sapiens
20 UBE2E2  
Two-hybrid Homo sapiens
21 KLF8  
Proximity Label-MS Homo sapiens
22 HSPA5 3309
Co-fractionation Homo sapiens
23 UBE2K 3093
Two-hybrid Homo sapiens
24 PHC3  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
25 E2F6 1876
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-MS Homo sapiens
26 Ddx39 68278
Two-hybrid Mus musculus
27 ZFP42  
Affinity Capture-Western Homo sapiens
28 AUTS2  
Affinity Capture-MS Homo sapiens
29 TEAD1  
Proximity Label-MS Homo sapiens
30 BCORL1  
Affinity Capture-MS Homo sapiens
31 TULP3 7289
Affinity Capture-MS Homo sapiens
32 EED  
Affinity Capture-MS Homo sapiens
Co-localization Homo sapiens
Affinity Capture-Western Homo sapiens
33 BCOR  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
34 LAMTOR4 389541
Affinity Capture-MS Homo sapiens
35 RAB6B 51560
Affinity Capture-MS Homo sapiens
36 USP7 7874
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-MS Homo sapiens
37 CSNK2B 1460
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
38 YAF2  
Affinity Capture-MS Homo sapiens
Two-hybrid Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Two-hybrid Homo sapiens
Affinity Capture-MS Homo sapiens
39 HSPA8 3312
Co-fractionation Homo sapiens
40 ACADS 35
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
41 NFKBID  
Two-hybrid Homo sapiens
42 SOX6  
Proximity Label-MS Homo sapiens
43 UBE2E3 10477
Two-hybrid Homo sapiens
44 MSLN 10232
Affinity Capture-MS Homo sapiens
45 HIST1H4A 8359
Affinity Capture-MS Homo sapiens
46 TLX3  
Proximity Label-MS Homo sapiens
47 USP11 8237
Affinity Capture-Western Homo sapiens
48 UBE2D4  
Two-hybrid Homo sapiens
49 NFIX 4784
Proximity Label-MS Homo sapiens
50 CBX3 11335
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
51 TFDP1  
Affinity Capture-MS Homo sapiens
52 Fhl1  
Affinity Capture-Western Mus musculus
53 UBR5 51366
Co-localization Homo sapiens
54 FGG 2266
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
55 GATA3  
Proximity Label-MS Homo sapiens
56 OGT 8473
Reconstituted Complex Homo sapiens
57 AIM2  
Affinity Capture-MS Homo sapiens
58 DCAF7 10238
Affinity Capture-MS Homo sapiens
59 LHX3  
Proximity Label-MS Homo sapiens
60 CBX6  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
61 Cbx4  
Affinity Capture-MS Mus musculus
62 E2F1 1869
Affinity Capture-Western Homo sapiens
63 UBE2D3 7323
Two-hybrid Homo sapiens
Reconstituted Complex Homo sapiens
Co-crystal Structure Homo sapiens
64 T  
Proximity Label-MS Homo sapiens
65 L3MBTL2  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
66 FLOT2 2319
Affinity Capture-MS Homo sapiens
67 UBE2D1 7321
Two-hybrid Homo sapiens
Reconstituted Complex Homo sapiens
68 RYBP  
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
Affinity Capture-MS Homo sapiens
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Two-hybrid Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
69 TRIM63  
Two-hybrid Homo sapiens
70 RING1 6015
Two-hybrid Homo sapiens
Reconstituted Complex Homo sapiens
Biochemical Activity Homo sapiens
Two-hybrid Homo sapiens
Reconstituted Complex Homo sapiens
Biochemical Activity Homo sapiens
71 PAX6  
Proximity Label-MS Homo sapiens
72 PPP1R9B 84687
Cross-Linking-MS (XL-MS) Homo sapiens
73 YY2  
Affinity Capture-Western Homo sapiens
74 SMARCAD1  
Affinity Capture-MS Homo sapiens
75 ZIM3  
Two-hybrid Homo sapiens
76 XPO1 7514
Affinity Capture-MS Homo sapiens
77 PIP 5304
Affinity Capture-MS Homo sapiens
78 ZG16B 124220
Affinity Capture-MS Homo sapiens
79 SMARCA5 8467
Co-fractionation Homo sapiens
80 MGA  
Affinity Capture-MS Homo sapiens
81 PCGF1 84759
Affinity Capture-MS Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-MS Homo sapiens
Two-hybrid Homo sapiens
Affinity Capture-MS Homo sapiens
Co-purification Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
82 FOXI1  
Proximity Label-MS Homo sapiens
83 CST1  
Affinity Capture-MS Homo sapiens
84 UBE2E1  
Two-hybrid Homo sapiens
85 YY1 7528
Co-fractionation Homo sapiens
86 FOXL1  
Proximity Label-MS Homo sapiens
87 CBX2  
Reconstituted Complex Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
88 HIST3H3 8290
Protein-peptide Homo sapiens
89 AMY1C 278
Affinity Capture-MS Homo sapiens
90 HNF4A  
Proximity Label-MS Homo sapiens
91 UBE2D2 7322
Two-hybrid Homo sapiens
Reconstituted Complex Homo sapiens
Two-hybrid Homo sapiens
92 WDR5 11091
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
93 NOS2  
Affinity Capture-Western Homo sapiens
94 CST4 1472
Affinity Capture-MS Homo sapiens
95 HECW2  
Affinity Capture-MS Homo sapiens
96 CSNK2A2 1459
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Co-fractionation Homo sapiens
Affinity Capture-MS Homo sapiens
97 PHC1  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
98 ZDHHC18 84243
Affinity Capture-MS Homo sapiens
99 KLF15  
Proximity Label-MS Homo sapiens
100 Bmi1  
Co-purification Mus musculus
Affinity Capture-MS Mus musculus
101 Mllt1  
Affinity Capture-MS Mus musculus
102 ACTL6B  
Affinity Capture-MS Homo sapiens
103 RNF2  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Cross-Linking-MS (XL-MS) Homo sapiens
104 BMI1  
Affinity Capture-Western Homo sapiens
Co-purification Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Two-hybrid Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Two-hybrid Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Two-hybrid Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Two-hybrid Homo sapiens
Affinity Capture-MS Homo sapiens
Two-hybrid Homo sapiens
105 FOXQ1  
Proximity Label-MS Homo sapiens
106 SCMH1  
Affinity Capture-MS Homo sapiens
107 FLOT1 10211
Affinity Capture-MS Homo sapiens
108 PIGR 5284
Affinity Capture-MS Homo sapiens
109 CBX7  
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
110 CBX4  
Two-hybrid Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Two-hybrid Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-MS Homo sapiens
111 TLX1  
Proximity Label-MS Homo sapiens
112 H2AFX 3014
Affinity Capture-MS Homo sapiens
113 FHL1 2273
Two-hybrid Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
114 PLEKHA4 57664
Affinity Capture-MS Homo sapiens
115 TERF2  
Affinity Capture-MS Homo sapiens
116 MAX  
Affinity Capture-MS Homo sapiens
117 MYOD1  
Proximity Label-MS Homo sapiens
118 SNAI1  
Affinity Capture-MS Homo sapiens
Co-localization Homo sapiens
Affinity Capture-Western Homo sapiens
Co-localization Homo sapiens
119 TP53 7157
Affinity Capture-Western Homo sapiens
120 Pcgf1  
Affinity Capture-MS Mus musculus
121 KLF3  
Proximity Label-MS Homo sapiens
122 SKP1 6500
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
123 FGB 2244
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
124 LAMTOR2 28956
Affinity Capture-MS Homo sapiens
125 HDAC1 3065
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
126 ZDHHC23  
Affinity Capture-MS Homo sapiens
127 FGA 2243
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
128 PCGF3  
Affinity Capture-MS Homo sapiens
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
Affinity Capture-MS Homo sapiens
129 COMMD3-BMI1 100532731
Affinity Capture-MS Homo sapiens
130 RB1 5925
Affinity Capture-Western Homo sapiens
131 TERF1 7013
Affinity Capture-MS Homo sapiens
132 ME1 4199
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
133 PCGF6  
Affinity Capture-MS Homo sapiens
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
Affinity Capture-MS Homo sapiens
Two-hybrid Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
134 CBX8 57332
Affinity Capture-MS Homo sapiens
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
Affinity Capture-Western Homo sapiens
Two-hybrid Homo sapiens
Affinity Capture-MS Homo sapiens
135 HIST1H2AB 8335
Co-crystal Structure Homo sapiens
136 GRSF1 2926
Two-hybrid Homo sapiens
137 ERG  
Reconstituted Complex Homo sapiens
Proximity Label-MS Homo sapiens
138 HNF1B  
Proximity Label-MS Homo sapiens
139 KDM2B 84678
Affinity Capture-MS Homo sapiens
140 PHC2  
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
141 PCGF5  
Affinity Capture-MS Homo sapiens
Two-hybrid Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Two-hybrid Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
142 FBXO38 81545
Two-hybrid Homo sapiens
143 SP7  
Proximity Label-MS Homo sapiens
144 NOTCH1 4851
Affinity Capture-MS Homo sapiens
145 KDM5C  
Affinity Capture-MS Homo sapiens
146 PIK3R3 8503
Two-hybrid Homo sapiens
View the network image/svg+xml
 Pathways in which RING1 is involved
PathwayEvidenceSource
Cellular responses to stimuli TAS Reactome
Cellular responses to stress TAS Reactome
Cellular Senescence TAS Reactome
Gene expression (Transcription) TAS Reactome
Generic Transcription Pathway TAS Reactome
Intracellular signaling by second messengers IEA Reactome
Intracellular signaling by second messengers TAS Reactome
Metabolism of proteins TAS Reactome
Metabolism of proteins IEA Reactome
Oxidative Stress Induced Senescence TAS Reactome
PIP3 activates AKT signaling IEA Reactome
PIP3 activates AKT signaling TAS Reactome
Post-translational protein modification TAS Reactome
Post-translational protein modification IEA Reactome
PTEN Regulation IEA Reactome
PTEN Regulation TAS Reactome
Regulation of PTEN gene transcription IEA Reactome
Regulation of PTEN gene transcription TAS Reactome
RNA Polymerase II Transcription TAS Reactome
RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known TAS Reactome
Signal Transduction IEA Reactome
Signal Transduction TAS Reactome
SUMO E3 ligases SUMOylate target proteins TAS Reactome
SUMO E3 ligases SUMOylate target proteins IEA Reactome
SUMOylation TAS Reactome
SUMOylation IEA Reactome
SUMOylation of chromatin organization proteins TAS Reactome
SUMOylation of DNA damage response and repair proteins TAS Reactome
SUMOylation of DNA methylation proteins IEA Reactome
SUMOylation of RNA binding proteins TAS Reactome
SUMOylation of transcription cofactors TAS Reactome
Transcriptional Regulation by E2F6 TAS Reactome
Transcriptional regulation by RUNX1 TAS Reactome





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