Gene description for FGG
Gene name fibrinogen gamma chain
Gene symbol FGG
Other names/aliases -
Species Homo sapiens
 Database cross references - FGG
ExoCarta ExoCarta_2266
Vesiclepedia VP_2266
Entrez Gene 2266
HGNC 3694
MIM 134850
UniProt P02679  
 FGG identified in exosomes derived from the following tissue/cell type
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Chondrocytes 35931686    
Chondrocytes 35931686    
Hepatocellular carcinoma cells 26054723    
Hepatocytes 26054723    
Malignant pleural effusions 14975938    
Mesenchymal stem cells Unpublished / Not applicable
Mesenchymal stem cells 36408942    
Plasma 19028452    
Platelets 25332113    
Platelets 25332113    
Platelets 25332113    
Prostate cancer cells 25844599    
Synovial fluid 17133577    
Synovial fluid 17133577    
Thymus 23844026    
Urine 19056867    
 Gene ontology annotations for FGG
Molecular Function
    signaling receptor binding GO:0005102 IBA
    signaling receptor binding GO:0005102 IPI
    structural molecule activity GO:0005198 IDA
    extracellular matrix structural constituent GO:0005201 HDA
    extracellular matrix structural constituent GO:0005201 RCA
    protein binding GO:0005515 IPI
    identical protein binding GO:0042802 IEA
    metal ion binding GO:0046872 IEA
    cell adhesion molecule binding GO:0050839 IPI
Biological Process
    cell-matrix adhesion GO:0007160 IBA
    cell-matrix adhesion GO:0007160 IDA
    protein secretion GO:0009306 IMP
    plasminogen activation GO:0031639 IDA
    positive regulation of heterotypic cell-cell adhesion GO:0034116 IDA
    platelet maturation GO:0036345 IEA
    fibrinolysis GO:0042730 IDA
    positive regulation of vasoconstriction GO:0045907 IDA
    positive regulation of exocytosis GO:0045921 IDA
    positive regulation of protein secretion GO:0050714 IDA
    protein polymerization GO:0051258 IMP
    response to calcium ion GO:0051592 IDA
    protein-containing complex assembly GO:0065003 IDA
    positive regulation of ERK1 and ERK2 cascade GO:0070374 IDA
    platelet aggregation GO:0070527 IBA
    platelet aggregation GO:0070527 IDA
    cellular response to interleukin-1 GO:0071347 IEA
    cellular response to interleukin-6 GO:0071354 IEA
    blood coagulation, fibrin clot formation GO:0072378 IDA
    blood coagulation, fibrin clot formation GO:0072378 IMP
    positive regulation of peptide hormone secretion GO:0090277 IDA
    positive regulation of substrate adhesion-dependent cell spreading GO:1900026 NAS
    negative regulation of extrinsic apoptotic signaling pathway via death domain receptors GO:1902042 IDA
    negative regulation of endothelial cell apoptotic process GO:2000352 IDA
Subcellular Localization
    extracellular region GO:0005576 TAS
    fibrinogen complex GO:0005577 IDA
    extracellular space GO:0005615 HDA
    extracellular space GO:0005615 IBA
    extracellular space GO:0005615 IDA
    endoplasmic reticulum lumen GO:0005788 TAS
    plasma membrane GO:0005886 TAS
    external side of plasma membrane GO:0009897 IDA
    cell surface GO:0009986 IDA
    platelet alpha granule GO:0031091 IDA
    platelet alpha granule lumen GO:0031093 TAS
    collagen-containing extracellular matrix GO:0062023 HDA
    collagen-containing extracellular matrix GO:0062023 IBA
    extracellular exosome GO:0070062 HDA
    blood microparticle GO:0072562 HDA
 Experiment description of studies that identified FGG in exosomes
1
Experiment ID 489
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 6
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
2
Experiment ID 490
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 7
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
3
Experiment ID 491
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 8
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
4
Experiment ID 492
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 9
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
5
Experiment ID 494
MISEV standards
✔
EM
Biophysical techniques
✔
CD9|CD81|CD151|CD63|CD82|FLOT1|FLOT2|GAPDH|LAMP1|LAMP2|SDCBP|TFRC|TSG101
Enriched markers
✘ Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 35931686    
Organism Homo sapiens
Experiment description Extracellular vesicles enriched in connexin 43 promote a senescent phenotype in bone and synovial cells contributing to osteoarthritis progression
Authors "Varela-Eirín M, Carpintero-Fernández P, Guitián-Caamaño A, Varela-Vázquez A, García-Yuste A, Sánchez-Temprano A, Bravo-López SB, Yañez-Cabanas J, Fonseca E, Largo R, Mobasheri A, Caeiro JR, Mayán MD."
Journal name Cell Death Dis
Publication year 2022
Sample Chondrocytes
Sample name Osteoarthritic cartilage
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
6
Experiment ID 496
MISEV standards
✘ Biophysical techniques
✔
CD9|CD151|CD63|CD81|CD82|FLOT1|FLOT2|GAPDH|LAMP1|LAMP2|SDCBP|TFRC|TSG101
Enriched markers
✘ Negative markers
✘ Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 35931686    
Organism Homo sapiens
Experiment description Extracellular vesicles enriched in connexin 43 promote a senescent phenotype in bone and synovial cells contributing to osteoarthritis progression
Authors "Varela-Eirín M, Carpintero-Fernández P, Guitián-Caamaño A, Varela-Vázquez A, García-Yuste A, Sánchez-Temprano A, Bravo-López SB, Yañez-Cabanas J, Fonseca E, Largo R, Mobasheri A, Caeiro JR, Mayán MD."
Journal name Cell Death Dis
Publication year 2022
Sample Chondrocytes
Sample name Healthy cartilage
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
7
Experiment ID 234
MISEV standards
✔
EM
Biophysical techniques
✔
TSG101|Alix|HSC70|GAPDH
Enriched markers
✔
HSP90B1
Negative markers
✔
qNano
Particle analysis
Identified molecule mRNA
Identification method RNA Sequencing
PubMed ID 26054723    
Organism Homo sapiens
Experiment description Hepatocellular carcinoma-derived exosomes promote motility of immortalized hepatocyte through transfer of oncogenic proteins and RNAs
Authors "He M, Qin H, Poon TC, Sze SC, Ding X, Co NN, Ngai SM, Chan TF, Wong N"
Journal name Carcinogenesis
Publication year 2015
Sample Hepatocellular carcinoma cells
Sample name HKCI-C3
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.13-1.19 g/mL
Molecules identified in the study Protein
RNA
Methods used in the study Western blotting
Mass spectrometry
RT-PCR
RNA Sequencing
8
Experiment ID 237
MISEV standards
✔
EM
Biophysical techniques
✔
TSG101|Alix|HSC70|GAPDH
Enriched markers
✔
HSP90B1
Negative markers
✔
qNano
Particle analysis
Identified molecule mRNA
Identification method RNA Sequencing
PubMed ID 26054723    
Organism Homo sapiens
Experiment description Hepatocellular carcinoma-derived exosomes promote motility of immortalized hepatocyte through transfer of oncogenic proteins and RNAs
Authors "He M, Qin H, Poon TC, Sze SC, Ding X, Co NN, Ngai SM, Chan TF, Wong N"
Journal name Carcinogenesis
Publication year 2015
Sample Hepatocytes
Sample name MIHA
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.13-1.19 g/mL
Molecules identified in the study Protein
RNA
Methods used in the study Western blotting
Mass spectrometry
RNA Sequencing
9
Experiment ID 51
MISEV standards
✔
EM
Biophysical techniques
✔
HSP90|MHCII
Enriched markers
✘ Negative markers
✘ Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 14975938    
Organism Homo sapiens
Experiment description Proteomic analysis of exosomes isolated from human malignant pleural effusions.
Authors "Bard MP, Hegmans JP, Hemmes A, Luider TM, Willemsen R, Severijnen LA, van Meerbeeck JP, Burgers SA, Hoogsteden HC, Lambrecht BN"
Journal name AJRCMB
Publication year 2004
Sample Malignant pleural effusions
Sample name Pleural Fluid - Breast cancer
Isolation/purification methods Differential centrifugation
Sucrose density gradient
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry [MALDI TOF]
Western blotting
10
Experiment ID 126
MISEV standards
✘ Biophysical techniques
✔
GAPDH
Enriched markers
✘ Negative markers
✘ Particle analysis
Identified molecule protein
Identification method Mass spectrometry [LTQ-FT Ultra]
PubMed ID Unpublished / Not applicable
Organism Homo sapiens
Experiment description Mesenchymal Stem Cell Exosomes: The Future MSC-based Therapy?
Authors "Ruenn Chai Lai, Ronne Wee Yeh Yeo, Soon Sim Tan, Bin Zhang, Yijun Yin, Newman Siu Kwan Sze, Andre Choo, and Sai Kiang Lim"
Journal name Mesenchymal Stem Cell Therapy
Publication year 2011
Sample Mesenchymal stem cells
Sample name huES9.E1
Isolation/purification methods HPLC
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Antobody array
Mass spectrometry
11
Experiment ID 488
MISEV standards
✔
EM
Biophysical techniques
✔
CD9|CD81|CD63|GAPDH|SDCBP|LAMP1|TFRC|UCHL1|FLOT2|LAMP2|FLOT1|ICAM1|RAB5B|CD151|RAB35|TSG101|RAB5A|CD82
Enriched markers
✔
CANX
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Homo sapiens
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Mesenchymal stem cells
Sample name UCMSC
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
12
Experiment ID 44
MISEV standards
✔
IEM
Biophysical techniques
✘ Enriched markers
✘ Negative markers
✘ Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 19028452    
Organism Homo sapiens
Experiment description Proteomic profiling of human plasma exosomes identifies PPARgamma as an exosome-associated protein.
Authors "Looze C, Yui D, Leung L, Ingham M, Kaler M, Yao X, Wu WW, Shen RF, Daniels MP, Levine SJ"
Journal name BBRC
Publication year 2009
Sample Plasma
Sample name Plasma
Isolation/purification methods Filtration
Size exclusion
Sucrose density gradient
Flotation density 1.15-1.16 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry [LTQ]
Western blotting
Immunoelectron Microscopy
13
Experiment ID 231
MISEV standards
✘ Biophysical techniques
✔
Alix|CD63|CD9
Enriched markers
✘ Negative markers
✔
NTA
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25332113    
Organism Homo sapiens
Experiment description Lipidomic and proteomic characterization of platelet extracellular vesicle subfractions from senescent platelets
Authors "Pienimaeki-Roemer A, Kuhlmann K, Bottcher A, Konovalova T, Black A, Orso E, Liebisch G, Ahrens M, Eisenacher M, Meyer HE, Schmitz G."
Journal name Transfusion
Publication year 2015
Sample Platelets
Sample name PL-Exs - Rep 1
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Optiprep density gradient
Flotation density 1.12-1.15 g/mL
Molecules identified in the study Protein
Lipids
Methods used in the study Western blotting
Mass spectrometry
14
Experiment ID 232
MISEV standards
✘ Biophysical techniques
✘ Enriched markers
✘ Negative markers
✘ Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25332113    
Organism Homo sapiens
Experiment description Lipidomic and proteomic characterization of platelet extracellular vesicle subfractions from senescent platelets
Authors "Pienimaeki-Roemer A, Kuhlmann K, Bottcher A, Konovalova T, Black A, Orso E, Liebisch G, Ahrens M, Eisenacher M, Meyer HE, Schmitz G."
Journal name Transfusion
Publication year 2015
Sample Platelets
Sample name PL-Exs - Rep 2
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Optiprep density gradient
Flotation density 1.12-1.15 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
15
Experiment ID 233
MISEV standards
✘ Biophysical techniques
✘ Enriched markers
✘ Negative markers
✘ Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25332113    
Organism Homo sapiens
Experiment description Lipidomic and proteomic characterization of platelet extracellular vesicle subfractions from senescent platelets
Authors "Pienimaeki-Roemer A, Kuhlmann K, Bottcher A, Konovalova T, Black A, Orso E, Liebisch G, Ahrens M, Eisenacher M, Meyer HE, Schmitz G."
Journal name Transfusion
Publication year 2015
Sample Platelets
Sample name PL-Exs - Rep 3
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Optiprep density gradient
Flotation density 1.12-1.15 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
16
Experiment ID 275
MISEV standards
✔
EM
Biophysical techniques
✔
TSG101|Alix|RAB5A|CD9|CD82|CD63|CD81
Enriched markers
✔
AIF
Negative markers
✔
NTA
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25844599    
Organism Homo sapiens
Experiment description Molecular profiling of prostate cancer derived exosomes may reveal a predictive signature for response to docetaxel.
Authors "Kharaziha P, Chioureas D, Rutishauser D, Baltatzis G, Lennartsson L, Fonseca P, Azimi A, Hultenby K, Zubarev R, Ullen A, Yachnin J, Nilsson S, Panaretakis T."
Journal name Oncotarget
Publication year 2015
Sample Prostate cancer cells
Sample name DU145 - Docetaxel sensitive
Isolation/purification methods Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.12-1.19 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry/Flow cytometry/Western blotting
17
Experiment ID 62
MISEV standards
✔
EM
Biophysical techniques
✘ Enriched markers
✘ Negative markers
✘ Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 17133577    
Organism Mus musculus
Experiment description Association of citrullinated proteins with synovial exosomes.
Authors "Skriner K, Adolph K, Jungblut PR, Burmester GR"
Journal name AR
Publication year 2006
Sample Synovial fluid
Sample name Synovial fluid - Rheumatoid arthritis
Isolation/purification methods Differential centrifugation
Sucrose density gradient
Flotation density -
Molecules identified in the study Protein
Methods used in the study Immunoelectron Microscopy
Mass spectrometry [MALDI TOF]
Western blotting
18
Experiment ID 61
MISEV standards
✔
EM
Biophysical techniques
✘ Enriched markers
✘ Negative markers
✘ Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 17133577    
Organism Mus musculus
Experiment description Association of citrullinated proteins with synovial exosomes.
Authors "Skriner K, Adolph K, Jungblut PR, Burmester GR"
Journal name AR
Publication year 2006
Sample Synovial fluid
Sample name Synovial fluid - Osteoarthritis and reactive arthritis
Isolation/purification methods Differential centrifugation
Sucrose density gradient
Flotation density -
Molecules identified in the study Protein
Methods used in the study Immunoelectron Microscopy
Mass spectrometry [MALDI TOF]
Western blotting
19
Experiment ID 217
MISEV standards
✔
EM
Biophysical techniques
✔
TSG101|CD81|CD9|CD63
Enriched markers
✘ Negative markers
✔
NTA
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23844026    
Organism Homo sapiens
Experiment description Characterization of human thymic exosomes.
Authors "Skogberg G, Gudmundsdottir J, van der Post S, Sandstrom K, Bruhn S, Benson M, Mincheva-Nilsson L, Baranov V, Telemo E, Ekwall O."
Journal name PLoS One
Publication year 2013
Sample Thymus
Sample name Normal-Thymus
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
20
Experiment ID 63
MISEV standards
✘ Biophysical techniques
✔
AQP2
Enriched markers
✘ Negative markers
✘ Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 19056867    
Organism Homo sapiens
Experiment description Large-scale proteomics and phosphoproteomics of urinary exosomes.
Authors "Gonzales PA, Pisitkun T, Hoffert JD, Tchapyjnikov D, Star RA, Kleta R, Wang NS, Knepper MA"
Journal name JASN
Publication year 2009
Sample Urine
Sample name Urine - Normal
Isolation/purification methods Differential centrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry [LTQ]
Western blotting
 Protein-protein interactions for FGG
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 FNDC5  
Affinity Capture-MS Homo sapiens
2 FNDC1 84624
Affinity Capture-MS Homo sapiens
3 RING1 6015
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
4 PDE6D 5147
Affinity Capture-MS Homo sapiens
5 GNG8  
Affinity Capture-MS Homo sapiens
6 SNX27 81609
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
7 F13B  
Co-purification Homo sapiens
8 LRRC17 10234
Affinity Capture-MS Homo sapiens
9 GPR141  
Affinity Capture-MS Homo sapiens
10 PPP2R2B 5521
Affinity Capture-MS Homo sapiens
11 SLC25A6 293
Affinity Capture-MS Homo sapiens
12 C18orf21  
Affinity Capture-MS Homo sapiens
13 HMGCLL1  
Affinity Capture-MS Homo sapiens
14 PIGT 51604
Affinity Capture-MS Homo sapiens
15 AGPAT1 10554
Affinity Capture-MS Homo sapiens
16 ICAM1 3383
Co-localization Homo sapiens
17 BLOC1S1  
Affinity Capture-MS Homo sapiens
18 CCNYL1 151195
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
19 ASCC1 51008
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
20 DDX19B 11269
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
21 RABGEF1 27342
Affinity Capture-MS Homo sapiens
22 LGALS3 3958
Affinity Capture-MS Homo sapiens
23 ALDH2 217
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
24 HIST1H2BJ 8970
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
25 ASB6 140459
Affinity Capture-MS Homo sapiens
26 TRAF6 7189
Affinity Capture-MS Homo sapiens
27 GLRA3  
Affinity Capture-MS Homo sapiens
28 Pkm 18746
Affinity Capture-MS Mus musculus
29 CDK15  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
30 CIR1  
Affinity Capture-MS Homo sapiens
31 ST6GALNAC6 30815
Affinity Capture-MS Homo sapiens
32 ADAT2  
Affinity Capture-MS Homo sapiens
33 TFPT  
Affinity Capture-MS Homo sapiens
34 FGA 2243
Cross-Linking-MS (XL-MS) Homo sapiens
Co-crystal Structure Homo sapiens
35 SLC9A5  
Affinity Capture-MS Homo sapiens
36 CERS3  
Affinity Capture-MS Homo sapiens
37 GNG10 2790
Affinity Capture-MS Homo sapiens
38 MBNL1 4154
Affinity Capture-MS Homo sapiens
39 PRKAR2B 5577
Affinity Capture-MS Homo sapiens
40 APP 351
Reconstituted Complex Homo sapiens
41 SLC6A1  
Affinity Capture-MS Homo sapiens
42 TF 7018
Affinity Capture-MS Homo sapiens
43 CHRDL2 25884
Affinity Capture-MS Homo sapiens
44 EDEM2  
Affinity Capture-MS Homo sapiens
45 ASB12  
Affinity Capture-MS Homo sapiens
46 RHBDD1 84236
Affinity Capture-MS Homo sapiens
47 KHDRBS2  
Affinity Capture-MS Homo sapiens
48 PRKACA 5566
Affinity Capture-MS Homo sapiens
49 MAPK6  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
50 HP 3240
Affinity Capture-MS Homo sapiens
51 KDM1A 23028
Affinity Capture-MS Homo sapiens
52 TRIM31  
Affinity Capture-MS Homo sapiens
53 RIPPLY3  
Affinity Capture-MS Homo sapiens
54 FGG 2266
Co-crystal Structure Homo sapiens
Co-crystal Structure Homo sapiens
Co-crystal Structure Homo sapiens
Co-crystal Structure Homo sapiens
55 FGB 2244
Cross-Linking-MS (XL-MS) Homo sapiens
Co-crystal Structure Homo sapiens
56 SARAF  
Affinity Capture-MS Homo sapiens
57 YWHAQ 10971
Affinity Capture-MS Homo sapiens
58 PINK1  
Affinity Capture-MS Homo sapiens
59 CA8  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
60 GOT1 2805
Affinity Capture-MS Homo sapiens
61 PLIN3 10226
Affinity Capture-MS Homo sapiens
62 SSUH2  
Affinity Capture-MS Homo sapiens
63 VKORC1 79001
Two-hybrid Homo sapiens
64 DNAJC1 64215
Affinity Capture-MS Homo sapiens
65 P2RX6  
Affinity Capture-MS Homo sapiens
66 DDX1 1653
Affinity Capture-MS Homo sapiens
67 OR2A4 79541
Affinity Capture-MS Homo sapiens
68 NUP93 9688
Co-fractionation Homo sapiens
69 HCN1  
Affinity Capture-MS Homo sapiens
70 SCGB1D1  
Affinity Capture-MS Homo sapiens
71 MATN2 4147
Affinity Capture-MS Homo sapiens
72 CCR1  
Affinity Capture-MS Homo sapiens
73 KLK10 5655
Affinity Capture-MS Homo sapiens
74 GUCY1A3  
Affinity Capture-MS Homo sapiens
75 CYP3A43  
Affinity Capture-MS Homo sapiens
76 STX17 55014
Affinity Capture-MS Homo sapiens
77 AKAP1 8165
Affinity Capture-MS Homo sapiens
78 PRKACB 5567
Affinity Capture-MS Homo sapiens
79 ASB7  
Affinity Capture-MS Homo sapiens
80 UBE2U  
Affinity Capture-MS Homo sapiens
81 SOX2  
Affinity Capture-MS Homo sapiens
82 TXNDC11 51061
Affinity Capture-MS Homo sapiens
83 CHD9 80205
Co-fractionation Homo sapiens
84 PHF11 51131
Affinity Capture-MS Homo sapiens
View the network image/svg+xml
 Pathways in which FGG is involved
PathwayEvidenceSource
Adaptive Immune System TAS Reactome
Antigen processing-Cross presentation TAS Reactome
Class I MHC mediated antigen processing & presentation TAS Reactome
Common Pathway of Fibrin Clot Formation TAS Reactome
Disease TAS Reactome
Diseases associated with the TLR signaling cascade TAS Reactome
Diseases of Immune System TAS Reactome
Diseases of signal transduction by growth factor receptors and second messengers TAS Reactome
ER-Phagosome pathway TAS Reactome
Extracellular matrix organization TAS Reactome
Formation of Fibrin Clot (Clotting Cascade) TAS Reactome
GRB2:SOS provides linkage to MAPK signaling for Integrins TAS Reactome
Hemostasis TAS Reactome
Immune System TAS Reactome
Innate Immune System TAS Reactome
Integrin cell surface interactions TAS Reactome
Integrin signaling TAS Reactome
IRAK4 deficiency (TLR2/4) TAS Reactome
MAP2K and MAPK activation TAS Reactome
MAPK family signaling cascades TAS Reactome
MAPK1/MAPK3 signaling TAS Reactome
Metabolism of proteins TAS Reactome
MyD88 deficiency (TLR2/4) TAS Reactome
MyD88:MAL(TIRAP) cascade initiated on plasma membrane TAS Reactome
Oncogenic MAPK signaling TAS Reactome
p130Cas linkage to MAPK signaling for integrins TAS Reactome
Paradoxical activation of RAF signaling by kinase inactive BRAF TAS Reactome
Platelet activation, signaling and aggregation TAS Reactome
Platelet Aggregation (Plug Formation) TAS Reactome
Platelet degranulation TAS Reactome
Post-translational protein modification TAS Reactome
Post-translational protein phosphorylation TAS Reactome
RAF/MAP kinase cascade TAS Reactome
Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) TAS Reactome
Regulation of TLR by endogenous ligand TAS Reactome
Response to elevated platelet cytosolic Ca2+ TAS Reactome
Signal Transduction TAS Reactome
Signaling by BRAF and RAF1 fusions TAS Reactome
Signaling by high-kinase activity BRAF mutants TAS Reactome
Signaling by moderate kinase activity BRAF mutants TAS Reactome
Signaling by RAF1 mutants TAS Reactome
Signaling by RAS mutants TAS Reactome
Signaling downstream of RAS mutants TAS Reactome
Toll Like Receptor 2 (TLR2) Cascade TAS Reactome
Toll Like Receptor 4 (TLR4) Cascade TAS Reactome
Toll Like Receptor TLR1:TLR2 Cascade TAS Reactome
Toll Like Receptor TLR6:TLR2 Cascade TAS Reactome
Toll-like Receptor Cascades TAS Reactome





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