Gene description for MBNL1
Gene name muscleblind-like splicing regulator 1
Gene symbol MBNL1
Other names/aliases EXP
EXP35
EXP40
EXP42
MBNL
Species Homo sapiens
 Database cross references - MBNL1
ExoCarta ExoCarta_4154
Entrez Gene 4154
HGNC 6923
MIM 606516
UniProt Q9NR56  
 MBNL1 identified in exosomes derived from the following tissue/cell type
Ovarian cancer cells 23333927    
Ovarian cancer cells 23333927    
Thymus 23844026    
 Gene ontology annotations for MBNL1
Molecular Function
    double-stranded RNA binding GO:0003725 IDA
    poly(A) RNA binding GO:0044822 IDA
    metal ion binding GO:0046872 IEA
    RNA binding GO:0003723 IDA
    protein binding GO:0005515 IPI
Biological Process
    in utero embryonic development GO:0001701 ISS
    regulation of alternative mRNA splicing, via spliceosome GO:0000381 IEA
    regulation of RNA splicing GO:0043484 IDA
    nervous system development GO:0007399 ISS
    skeletal muscle tissue development GO:0007519 IEA
    myoblast differentiation GO:0045445 ISS
    alternative mRNA splicing, via spliceosome GO:0000380 IEA
    mRNA splice site selection GO:0006376 IEA
    embryonic limb morphogenesis GO:0030326 ISS
    RNA splicing GO:0008380 IDA
Subcellular Localization
    centrosome GO:0005813 IDA
    cytoplasm GO:0005737 IDA
    nucleus GO:0005634 IDA
    cytoplasmic stress granule GO:0010494 IDA
    nucleoplasm GO:0005654 IDA
 Experiment description of studies that identified MBNL1 in exosomes
1
Experiment ID 211
ISEV standards
EM
EV Biophysical techniques
TSG101|Alix
EV Cytosolic markers
EpCAM|TFRC
EV Membrane markers
cytochrome c|GOLGA2
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23333927    
Organism Homo sapiens
Experiment description Characterization and proteomic analysis of ovarian cancer-derived exosomes.
Authors Liang B, Peng P, Chen S, Li L, Zhang M, Cao D, Yang J, Li H, Gui T, Li X, Shen K.
Journal name J Proteomics
Publication year 2013
Sample Ovarian cancer cells
Sample name IGROV1
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient
Flotation density 1.09-1.15 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
2
Experiment ID 212
ISEV standards
CEM
EV Biophysical techniques
TSG101|Alix
EV Cytosolic markers
EpCAM|TFRC
EV Membrane markers
Cytochrome C|GOLGA2
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23333927    
Organism Homo sapiens
Experiment description Characterization and proteomic analysis of ovarian cancer-derived exosomes.
Authors Liang B, Peng P, Chen S, Li L, Zhang M, Cao D, Yang J, Li H, Gui T, Li X, Shen K.
Journal name J Proteomics
Publication year 2013
Sample Ovarian cancer cells
Sample name OVCAR-3
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient
Flotation density 1.09-1.15 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
3
Experiment ID 217
ISEV standards
EM
EV Biophysical techniques
TSG101
EV Cytosolic markers
CD81|CD9|CD63
EV Membrane markers
EV Negative markers
NTA
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23844026    
Organism Homo sapiens
Experiment description Characterization of human thymic exosomes.
Authors Skogberg G, Gudmundsdottir J, van der Post S, Sandstrom K, Bruhn S, Benson M, Mincheva-Nilsson L, Baranov V, Telemo E, Ekwall O.
Journal name PLoS One
Publication year 2013
Sample Thymus
Sample name Normal-Thymus
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for MBNL1
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which MBNL1 is involved
No pathways found





Perform bioinformatics analysis of your extracellular vesicle data set using FunRich, a open access standalone tool. NEW UPDATED VERSION OF FunRich available for download (12/09/2016) from here