Gene description for SERPINB13
Gene name serpin peptidase inhibitor, clade B (ovalbumin), member 13
Gene symbol SERPINB13
Other names/aliases HSHUR7SEQ
HUR7
PI13
headpin
Species Homo sapiens
 Database cross references - SERPINB13
ExoCarta ExoCarta_5275
Vesiclepedia VP_5275
Entrez Gene 5275
HGNC 8944
MIM 604445
UniProt Q9UIV8  
 SERPINB13 identified in exosomes derived from the following tissue/cell type
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Urine 19056867    
 Gene ontology annotations for SERPINB13
Molecular Function
    protease binding GO:0002020 IPI
    serine-type endopeptidase inhibitor activity GO:0004867 IDA
    serine-type endopeptidase inhibitor activity GO:0004867 NAS
    cysteine-type endopeptidase inhibitor activity GO:0004869 IDA
    cysteine-type endopeptidase inhibitor activity GO:0004869 IMP
    protein binding GO:0005515 IPI
Biological Process
    response to UV GO:0009411 TAS
    negative regulation of endopeptidase activity GO:0010951 IDA
    regulation of proteolysis GO:0030162 NAS
    negative regulation of keratinocyte apoptotic process GO:1902173 IMP
Subcellular Localization
    extracellular space GO:0005615 IBA
    nucleoplasm GO:0005654 IDA
    nucleolus GO:0005730 IDA
    cytoplasm GO:0005737 IDA
    cytosol GO:0005829 IDA
    nuclear speck GO:0016607 IDA
    lysosomal lumen GO:0043202 TAS
    extracellular exosome GO:0070062 HDA
 Experiment description of studies that identified SERPINB13 in exosomes
1
Experiment ID 489
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 6
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
2
Experiment ID 490
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 7
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
3
Experiment ID 491
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 8
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
4
Experiment ID 492
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 9
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
5
Experiment ID 63
MISEV standards
✘ Biophysical techniques
✔
AQP2
Enriched markers
✘ Negative markers
✘ Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 19056867    
Organism Homo sapiens
Experiment description Large-scale proteomics and phosphoproteomics of urinary exosomes.
Authors "Gonzales PA, Pisitkun T, Hoffert JD, Tchapyjnikov D, Star RA, Kleta R, Wang NS, Knepper MA"
Journal name JASN
Publication year 2009
Sample Urine
Sample name Urine - Normal
Isolation/purification methods Differential centrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry [LTQ]
Western blotting
 Protein-protein interactions for SERPINB13
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 FNDC5  
Affinity Capture-MS Homo sapiens
2 SNCA 6622
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
3 C1orf198 84886
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
4 BRAP  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
5 KIAA0907  
Affinity Capture-MS Homo sapiens
6 PPP2R2B 5521
Affinity Capture-MS Homo sapiens
7 AGPAT1 10554
Affinity Capture-MS Homo sapiens
8 SLC25A6 293
Affinity Capture-MS Homo sapiens
9 SGOL2 151246
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
10 CSGALNACT1 55790
Affinity Capture-MS Homo sapiens
11 SSUH2  
Affinity Capture-MS Homo sapiens
12 CCNC  
Affinity Capture-MS Homo sapiens
13 FCF1  
Affinity Capture-MS Homo sapiens
14 RBM24 221662
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
15 TTC4  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
16 HIGD1A 25994
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
17 POLR2L 5441
Affinity Capture-MS Homo sapiens
18 TBC1D22B  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
19 BSDC1 55108
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
20 MOGAT3  
Affinity Capture-MS Homo sapiens
21 C18orf21  
Affinity Capture-MS Homo sapiens
22 CHST10  
Affinity Capture-MS Homo sapiens
23 WNK1 65125
Affinity Capture-MS Homo sapiens
24 PCP4  
Affinity Capture-MS Homo sapiens
25 ATP6AP2 10159
Affinity Capture-MS Homo sapiens
26 C9orf78 51759
Affinity Capture-MS Homo sapiens
27 C1orf35  
Affinity Capture-MS Homo sapiens
28 ERP27  
Affinity Capture-MS Homo sapiens
29 ZC3HC1  
Affinity Capture-MS Homo sapiens
30 ZIC1  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
31 ZDHHC19  
Affinity Capture-MS Homo sapiens
32 FTH1 2495
Affinity Capture-MS Homo sapiens
33 ADH1C 126
Affinity Capture-MS Homo sapiens
34 NPSR1  
Affinity Capture-MS Homo sapiens
35 SOX2  
Affinity Capture-MS Homo sapiens
36 CERS3  
Affinity Capture-MS Homo sapiens
37 PI4KA 5297
Affinity Capture-MS Homo sapiens
38 KLHL11  
Affinity Capture-MS Homo sapiens
39 PEMT  
Affinity Capture-MS Homo sapiens
40 RNF115  
Affinity Capture-MS Homo sapiens
41 GOLGA2 2801
Affinity Capture-MS Homo sapiens
42 SH3GLB1 51100
Affinity Capture-MS Homo sapiens
43 SRRT 51593
Affinity Capture-MS Homo sapiens
44 ANXA9  
Affinity Capture-MS Homo sapiens
45 MBNL1 4154
Affinity Capture-MS Homo sapiens
46 FRMD1  
Affinity Capture-MS Homo sapiens
47 PI4KAP1  
Affinity Capture-MS Homo sapiens
48 FOS 2353
Affinity Capture-MS Homo sapiens
49 GDF5 8200
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
50 ADD2 119
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
51 SARAF  
Affinity Capture-MS Homo sapiens
52 RBM14-RBM4 100526737
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
53 PIGT 51604
Affinity Capture-MS Homo sapiens
54 PINK1  
Affinity Capture-MS Homo sapiens
55 SLC25A32 81034
Affinity Capture-MS Homo sapiens
56 FOXN3 1112
Affinity Capture-MS Homo sapiens
57 IQUB  
Affinity Capture-MS Homo sapiens
58 STK11 6794
Affinity Capture-MS Homo sapiens
59 ACAD9 28976
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
60 NUDT3 11165
Affinity Capture-MS Homo sapiens
61 GLMP 112770
Affinity Capture-MS Homo sapiens
62 ROR1 4919
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
63 PLD5  
Affinity Capture-MS Homo sapiens
64 OR2A4 79541
Affinity Capture-MS Homo sapiens
65 EIF2B1 1967
Co-fractionation Homo sapiens
66 RNF34  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
67 GMCL1  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
68 GABPA 2551
Affinity Capture-MS Homo sapiens
69 PHF8  
Affinity Capture-MS Homo sapiens
70 ONECUT1  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
71 SCN3B  
Affinity Capture-MS Homo sapiens
72 STX17 55014
Affinity Capture-MS Homo sapiens
73 RIPPLY3  
Affinity Capture-MS Homo sapiens
74 CCR1  
Affinity Capture-MS Homo sapiens
75 DLG2 1740
Two-hybrid Homo sapiens
76 FSTL1 11167
Affinity Capture-MS Homo sapiens
77 PHF11 51131
Affinity Capture-MS Homo sapiens
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