Gene description for FOS
Gene name FBJ murine osteosarcoma viral oncogene homolog
Gene symbol FOS
Other names/aliases AP-1
C-FOS
p55
Species Homo sapiens
 Database cross references - FOS
ExoCarta ExoCarta_2353
Entrez Gene 2353
HGNC 3796
MIM 164810
UniProt P01100  
 FOS identified in exosomes derived from the following tissue/cell type
Hepatocytes 26054723    
 Gene ontology annotations for FOS
Molecular Function
    transcription factor binding GO:0008134 IPI
    sequence-specific DNA binding transcription factor activity GO:0003700 IDA
    protein binding GO:0005515 IPI
    transcription regulatory region DNA binding GO:0044212 IDA
    R-SMAD binding GO:0070412 IPI
    RNA polymerase II core promoter sequence-specific DNA binding GO:0000979 IEA
    double-stranded DNA binding GO:0003690 IEA
Biological Process
    response to corticosterone GO:0051412 IEA
    response to progesterone GO:0032570 IEA
    innate immune response GO:0045087 TAS
    SMAD protein signal transduction GO:0060395 IDA
    response to immobilization stress GO:0035902 IEA
    positive regulation of osteoclast differentiation GO:0045672 IEA
    transcription from RNA polymerase II promoter GO:0006366 IEA
    stress-activated MAPK cascade GO:0051403 TAS
    conditioned taste aversion GO:0001661 IEA
    regulation of sequence-specific DNA binding transcription factor activity GO:0051090 TAS
    response to lipopolysaccharide GO:0032496 IEA
    cellular response to extracellular stimulus GO:0031668 IEA
    response to cytokine GO:0034097 IEA
    cellular response to hormone stimulus GO:0032870 IEA
    regulation of transcription from RNA polymerase II promoter GO:0006357 TAS
    cellular response to reactive oxygen species GO:0034614 IDA
    transforming growth factor beta receptor signaling pathway GO:0007179 IDA
    toll-like receptor 9 signaling pathway GO:0034162 TAS
    cellular response to calcium ion GO:0071277 IEA
    sleep GO:0030431 IEA
    toll-like receptor 10 signaling pathway GO:0034166 TAS
    response to cold GO:0009409 IEA
    positive regulation of transcription from RNA polymerase II promoter GO:0045944 IGI
    DNA methylation GO:0006306 TAS
    TRIF-dependent toll-like receptor signaling pathway GO:0035666 TAS
    inflammatory response GO:0006954 TAS
    MyD88-dependent toll-like receptor signaling pathway GO:0002755 TAS
    response to mechanical stimulus GO:0009612 IEA
    toll-like receptor 5 signaling pathway GO:0034146 TAS
    response to cAMP GO:0051591 IEA
    toll-like receptor TLR6:TLR2 signaling pathway GO:0038124 TAS
    aging GO:0007568 IEA
    Fc-epsilon receptor signaling pathway GO:0038095 TAS
    toll-like receptor signaling pathway GO:0002224 TAS
    female pregnancy GO:0007565 IEA
    nervous system development GO:0007399 IEA
    skeletal muscle cell differentiation GO:0035914 IEA
    toll-like receptor 2 signaling pathway GO:0034134 TAS
    response to light stimulus GO:0009416 IEA
    toll-like receptor TLR1:TLR2 signaling pathway GO:0038123 TAS
    toll-like receptor 4 signaling pathway GO:0034142 TAS
    MyD88-independent toll-like receptor signaling pathway GO:0002756 TAS
    response to gravity GO:0009629 IEA
    positive regulation of transcription, DNA-templated GO:0045893 IDA
    response to toxic substance GO:0009636 IEA
    response to drug GO:0042493 IEA
    toll-like receptor 3 signaling pathway GO:0034138 TAS
Subcellular Localization
    nucleoplasm GO:0005654 TAS
    membrane GO:0016020 IEA
    nucleus GO:0005634 TAS
    transcription factor complex GO:0005667 IEA
    neuron projection GO:0043005 IEA
    endoplasmic reticulum GO:0005783 IEA
    cytosol GO:0005829 IEA
 Experiment description of studies that identified FOS in exosomes
1
Experiment ID 237
ISEV standards
EM
EV Biophysical techniques
TSG101|Alix|HSC70|GAPDH
EV Cytosolic markers
EV Membrane markers
HSP90B1
EV Negative markers
qNano
EV Particle analysis
Identified molecule mRNA
Identification method RNA Sequencing
PubMed ID 26054723    
Organism Homo sapiens
Experiment description Hepatocellular carcinoma-derived exosomes promote motility of immortalized hepatocyte through transfer of oncogenic proteins and RNAs
Authors He M, Qin H, Poon TC, Sze SC, Ding X, Co NN, Ngai SM, Chan TF, Wong N
Journal name Carcinogenesis
Publication year 2015
Sample Hepatocytes
Sample name MIHA
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.13-1.19 g/mL
Molecules identified in the study Protein
RNA
Methods used in the study Western blotting
Mass spectrometry
RNA Sequencing
 Protein-protein interactions for FOS
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 GTF2F1 2962
Reconstituted Complex Homo sapiens
2 NCOA6  
Reconstituted Complex Homo sapiens
3 VDR  
Reconstituted Complex Homo sapiens
4 SPI1  
Reconstituted Complex Homo sapiens
5 MITF  
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
6 TCF1  
Invivo Homo sapiens
Invitro Homo sapiens
7 NCOA1  
Invivo Homo sapiens
Two-hybrid Homo sapiens
Reconstituted Complex Homo sapiens
8 ELK4 2005
Invivo Homo sapiens
9 TBP  
Invivo Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
10 RUNX1  
Invivo Homo sapiens
11 RB1 5925
Affinity Capture-MS Homo sapiens
12 NACA 4666
Reconstituted Complex Homo sapiens
13 SMARCD1 6602
Affinity Capture-MS Homo sapiens
14 GTF2F2  
Affinity Capture-MS Homo sapiens
Reconstituted Complex Homo sapiens
15 JUND 3727
Invitro Homo sapiens
16 BATF  
Invitro Homo sapiens
Two-hybrid Homo sapiens
Affinity Capture-MS Homo sapiens
17 RPS6KA4 8986
Biochemical Activity Homo sapiens
18 RELA  
Two-hybrid Homo sapiens
Phenotypic Enhancement Homo sapiens
Affinity Capture-MS Homo sapiens
19 CSNK2A1 1457
Reconstituted Complex Homo sapiens
Far Western Homo sapiens
20 CEBPG  
Affinity Capture-MS Homo sapiens
21 CREBBP  
Reconstituted Complex Homo sapiens
22 BCL3  
Two-hybrid Homo sapiens
Reconstituted Complex Homo sapiens
23 NCOR2  
Invitro Homo sapiens
Two-hybrid Homo sapiens
24 MAP3K7  
Invivo Homo sapiens
25 FOSL2  
Affinity Capture-MS Homo sapiens
26 XBP1  
Invitro Homo sapiens
Affinity Capture-MS Homo sapiens
27 ATF4  
Affinity Capture-MS Homo sapiens
28 ATF2  
Invitro Homo sapiens
29 JUN 3725
Invivo Homo sapiens
Invitro Homo sapiens
Reconstituted Complex Homo sapiens
Co-crystal Structure Homo sapiens
Two-hybrid Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Two-hybrid Homo sapiens
30 ELK1  
Invivo Homo sapiens
31 DDIT3 1649
Affinity Capture-MS Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
32 SMAD3  
Two-hybrid Homo sapiens
Reconstituted Complex Homo sapiens
33 ETS2  
Reconstituted Complex Homo sapiens
34 PML  
Invivo Homo sapiens
Affinity Capture-MS Homo sapiens
35 CSNK2A2 1459
Affinity Capture-MS Homo sapiens
Reconstituted Complex Homo sapiens
Far Western Homo sapiens
36 RUNX2  
Invivo Homo sapiens
37 ETS1  
Invitro Homo sapiens
Affinity Capture-MS Homo sapiens
38 JUNB  
Affinity Capture-MS Homo sapiens
39 MAF  
Invivo Homo sapiens
Invitro Homo sapiens
40 TAF1  
Reconstituted Complex Homo sapiens
41 NELFB 25920
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
42 TSC22D3  
Affinity Capture-MS Homo sapiens
Reconstituted Complex Homo sapiens
43 GTF2E2  
Reconstituted Complex Homo sapiens
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