Gene description for SMARCA2
Gene name SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2
Gene symbol SMARCA2
Other names/aliases BAF190
BRM
NCBRS
SNF2
SNF2L2
SNF2LA
SWI2
Sth1p
hBRM
hSNF2a
Species Homo sapiens
 Database cross references - SMARCA2
ExoCarta ExoCarta_6595
Vesiclepedia VP_6595
Entrez Gene 6595
HGNC 11098
MIM 600014
UniProt P51531  
 SMARCA2 identified in exosomes derived from the following tissue/cell type
Chondrocytes 35931686    
Chondrocytes 35931686    
 Gene ontology annotations for SMARCA2
Molecular Function
    transcription cis-regulatory region binding GO:0000976 IDA
    DNA binding GO:0003677 IBA
    chromatin binding GO:0003682 IBA
    transcription coactivator activity GO:0003713 IDA
    helicase activity GO:0004386 IEA
    protein binding GO:0005515 IPI
    ATP binding GO:0005524 IEA
    ATP-dependent activity, acting on DNA GO:0008094 TAS
    hydrolase activity GO:0016787 IEA
    histone binding GO:0042393 IEA
    nucleosome array spacer activity GO:0140750 IBA
Biological Process
    negative regulation of transcription by RNA polymerase II GO:0000122 TAS
    chromatin remodeling GO:0006338 NAS
    chromatin remodeling GO:0006338 TAS
    regulation of DNA-templated transcription GO:0006355 TAS
    regulation of transcription by RNA polymerase II GO:0006357 NAS
    spermatid development GO:0007286 IEA
    nervous system development GO:0007399 IEA
    positive regulation of cell population proliferation GO:0008284 NAS
    negative regulation of cell population proliferation GO:0008285 IDA
    regulation of mitotic metaphase/anaphase transition GO:0030071 NAS
    negative regulation of cell growth GO:0030308 IMP
    heterochromatin formation GO:0031507 IBA
    positive regulation of T cell differentiation GO:0045582 NAS
    negative regulation of cell differentiation GO:0045596 NAS
    positive regulation of cell differentiation GO:0045597 NAS
    positive regulation of myoblast differentiation GO:0045663 NAS
    negative regulation of DNA-templated transcription GO:0045892 IDA
    positive regulation of DNA-templated transcription GO:0045893 IDA
    positive regulation of DNA-templated transcription GO:0045893 IMP
    positive regulation of transcription by RNA polymerase II GO:0045944 IBA
    positive regulation of transcription by RNA polymerase II GO:0045944 IDA
    positive regulation of transcription by RNA polymerase II GO:0045944 TAS
    regulation of G0 to G1 transition GO:0070316 NAS
    positive regulation of stem cell population maintenance GO:1902459 NAS
    regulation of G1/S transition of mitotic cell cycle GO:2000045 NAS
    positive regulation of double-strand break repair GO:2000781 NAS
    regulation of nucleotide-excision repair GO:2000819 NAS
Subcellular Localization
    chromatin GO:0000785 IBA
    chromatin GO:0000785 IDA
    chromatin GO:0000785 NAS
    nucleus GO:0005634 IBA
    nucleus GO:0005634 IDA
    nucleoplasm GO:0005654 IDA
    nucleoplasm GO:0005654 TAS
    SWI/SNF complex GO:0016514 IDA
    brahma complex GO:0035060 NAS
    intracellular membrane-bounded organelle GO:0043231 IDA
    intermediate filament cytoskeleton GO:0045111 IDA
    npBAF complex GO:0071564 ISS
    npBAF complex GO:0071564 NAS
    nBAF complex GO:0071565 ISS
    nBAF complex GO:0071565 NAS
    bBAF complex GO:0140092 NAS
    GBAF complex GO:0140288 NAS
 Experiment description of studies that identified SMARCA2 in exosomes
1
Experiment ID 497
MISEV standards
✘ Biophysical techniques
✔
CD9|CD151|CD63|CD81|CD82|FLOT1|FLOT2|GAPDH|LAMP1|LAMP2|RAB5A|SDCBP|TFRC|TSG101|UCHL1
Enriched markers
✘ Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 35931686    
Organism Homo sapiens
Experiment description Extracellular vesicles enriched in connexin 43 promote a senescent phenotype in bone and synovial cells contributing to osteoarthritis progression
Authors "Varela-Eirín M, Carpintero-Fernández P, Guitián-Caamaño A, Varela-Vázquez A, García-Yuste A, Sánchez-Temprano A, Bravo-López SB, Yañez-Cabanas J, Fonseca E, Largo R, Mobasheri A, Caeiro JR, Mayán MD."
Journal name Cell Death Dis
Publication year 2022
Sample Chondrocytes
Sample name T/C-28a2
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
2
Experiment ID 498
MISEV standards
✔
EM
Biophysical techniques
✔
CD9|CD151|CD63|CD81|CD82|FLOT1|FLOT2|GAPDH|LAMP1|LAMP2|RAB5A|SDCBP|TFRC|TSG101|UCHL1
Enriched markers
✘ Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 35931686    
Organism Homo sapiens
Experiment description Extracellular vesicles enriched in connexin 43 promote a senescent phenotype in bone and synovial cells contributing to osteoarthritis progression
Authors "Varela-Eirín M, Carpintero-Fernández P, Guitián-Caamaño A, Varela-Vázquez A, García-Yuste A, Sánchez-Temprano A, Bravo-López SB, Yañez-Cabanas J, Fonseca E, Largo R, Mobasheri A, Caeiro JR, Mayán MD."
Journal name Cell Death Dis
Publication year 2022
Sample Chondrocytes
Sample name T/C-28a2
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
 Protein-protein interactions for SMARCA2
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 SEC22B 9554
Co-fractionation Homo sapiens
2 GATA1  
Proximity Label-MS Homo sapiens
3 KIF9 64147
Cross-Linking-MS (XL-MS) Homo sapiens
4 SLFN11 91607
Affinity Capture-MS Homo sapiens
5 GTF2F1 2962
Co-fractionation Homo sapiens
6 SMC3 9126
Co-fractionation Homo sapiens
7 MCM8 84515
Affinity Capture-MS Homo sapiens
8 CBX1 10951
Affinity Capture-MS Homo sapiens
9 GMNN  
Affinity Capture-Western Homo sapiens
10 TAF1  
Affinity Capture-Western Homo sapiens
11 HDAC2 3066
Co-purification Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
12 ELF1 1997
Proximity Label-MS Homo sapiens
13 IRF4  
Proximity Label-MS Homo sapiens
14 GLTSCR1L  
Affinity Capture-MS Homo sapiens
15 ADCK3  
Affinity Capture-MS Homo sapiens
16 KPNA1 3836
Affinity Capture-MS Homo sapiens
17 MYL6 4637
Affinity Capture-MS Homo sapiens
18 TOP2B 7155
Co-fractionation Homo sapiens
19 Bcl7b  
Affinity Capture-MS Mus musculus
20 LHX2  
Proximity Label-MS Homo sapiens
21 GATA2  
Proximity Label-MS Homo sapiens
22 ACTC1 70
Affinity Capture-MS Homo sapiens
23 NOP56 10528
Co-fractionation Homo sapiens
24 TEKT1  
Affinity Capture-MS Homo sapiens
25 SMARCE1 6605
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Co-fractionation Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Co-purification Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Co-fractionation Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
26 KIF20A 10112
Affinity Capture-MS Homo sapiens
27 BRD2  
Affinity Capture-MS Homo sapiens
28 PPIA 5478
Affinity Capture-MS Homo sapiens
29 KPNA2 3838
Affinity Capture-MS Homo sapiens
30 SAP30 8819
Co-fractionation Homo sapiens
Affinity Capture-Western Homo sapiens
31 SMARCD2 6603
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Co-fractionation Homo sapiens
Co-fractionation Homo sapiens
Affinity Capture-MS Homo sapiens
32 SOX10  
Proximity Label-MS Homo sapiens
33 ELF4 2000
Proximity Label-MS Homo sapiens
34 CMBL 134147
Affinity Capture-MS Homo sapiens
35 CENPA  
Proximity Label-MS Homo sapiens
36 IL21R  
Affinity Capture-MS Homo sapiens
37 DPF1  
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
38 HSPA4 3308
Cross-Linking-MS (XL-MS) Homo sapiens
39 RUVBL1 8607
Co-fractionation Homo sapiens
40 NCOR1  
Co-fractionation Homo sapiens
41 TAF9 6880
Affinity Capture-Western Homo sapiens
42 BCL7B  
Co-fractionation Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
43 Actl6a  
Affinity Capture-Western Mus musculus
44 NONO 4841
Affinity Capture-Western Homo sapiens
45 ACTR3 10096
Proximity Label-MS Homo sapiens
46 ACTL6B  
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
47 NUP35 129401
Proximity Label-MS Homo sapiens
48 CHMP2A 27243
Affinity Capture-MS Homo sapiens
49 KHDRBS1 10657
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
50 REV3L  
Affinity Capture-MS Homo sapiens
51 GCM1  
Proximity Label-MS Homo sapiens
52 KHSRP 8570
Co-fractionation Homo sapiens
53 TEAD1  
Proximity Label-MS Homo sapiens
54 BMI1  
Affinity Capture-MS Homo sapiens
55 SCN5A 6331
Affinity Capture-MS Homo sapiens
56 EED  
Affinity Capture-MS Homo sapiens
57 KLF4  
Proximity Label-MS Homo sapiens
58 TPRN 286262
Affinity Capture-MS Homo sapiens
59 PHB 5245
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
60 SLC35G1  
Affinity Capture-MS Homo sapiens
61 LHX4  
Proximity Label-MS Homo sapiens
62 MECP2 4204
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
63 TLX3  
Proximity Label-MS Homo sapiens
64 UBE2H 7328
Affinity Capture-MS Homo sapiens
65 MYCN  
Affinity Capture-MS Homo sapiens
66 SDCBP 6386
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
67 CHD3 1107
Affinity Capture-Western Homo sapiens
68 SMARCB1 6598
Co-purification Homo sapiens
Co-purification Homo sapiens
Co-purification Homo sapiens
Affinity Capture-MS Homo sapiens
Co-purification Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Co-fractionation Homo sapiens
Co-fractionation Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Cross-Linking-MS (XL-MS) Homo sapiens
69 NFIB  
Proximity Label-MS Homo sapiens
70 MTA2 9219
Co-fractionation Homo sapiens
71 KIF14 9928
Affinity Capture-MS Homo sapiens
72 Cebpb  
Affinity Capture-Western Rattus norvegicus
73 FOXP1 27086
Protein-RNA Homo sapiens
74 Actl6b  
Affinity Capture-Western Mus musculus
75 RAN 5901
Affinity Capture-Western Homo sapiens
76 PRPF6 24148
Affinity Capture-Western Homo sapiens
77 PHF10  
Affinity Capture-Western Homo sapiens
Co-fractionation Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
78 ZIC2  
Affinity Capture-MS Homo sapiens
79 RBBP7 5931
Affinity Capture-Western Homo sapiens
80 FOXC1  
Affinity Capture-MS Homo sapiens
81 SPTA1  
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
82 SOX17  
Proximity Label-MS Homo sapiens
83 RAD51AP1  
Affinity Capture-MS Homo sapiens
84 PARK2  
Affinity Capture-MS Homo sapiens
85 IRF1  
Proximity Label-MS Homo sapiens
86 TMEM59L  
Affinity Capture-MS Homo sapiens
87 TBR1  
Proximity Label-MS Homo sapiens
88 XYLB 9942
Affinity Capture-MS Homo sapiens
89 SIRT7  
Affinity Capture-MS Homo sapiens
90 SYT7  
Affinity Capture-MS Homo sapiens
91 NFIX 4784
Proximity Label-MS Homo sapiens
92 SSX2  
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
93 GLTSCR1 29998
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
94 Smarcc1  
Affinity Capture-MS Mus musculus
95 SMARCA4 6597
Co-fractionation Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Co-fractionation Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Negative Genetic Homo sapiens
Cross-Linking-MS (XL-MS) Homo sapiens
96 LHX1  
Proximity Label-MS Homo sapiens
97 SP7  
Proximity Label-MS Homo sapiens
98 NFIA 4774
Proximity Label-MS Homo sapiens
99 YAP1 10413
Affinity Capture-MS Homo sapiens
100 WDR72  
Affinity Capture-MS Homo sapiens
101 BCL7C  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Co-fractionation Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
102 GJD4  
Affinity Capture-MS Homo sapiens
103 DPF2  
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Co-fractionation Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
104 ACTL6A 86
Co-fractionation Homo sapiens
Affinity Capture-MS Homo sapiens
Co-fractionation Homo sapiens
Cross-Linking-MS (XL-MS) Homo sapiens
Co-purification Homo sapiens
Co-fractionation Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Co-fractionation Homo sapiens
Affinity Capture-MS Homo sapiens
105 CBX5 23468
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Reconstituted Complex Homo sapiens
106 LHX3  
Proximity Label-MS Homo sapiens
107 LHX8  
Proximity Label-MS Homo sapiens
108 RAP1A 5906
Reconstituted Complex Homo sapiens
109 BEND7 222389
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
110 SIN3A  
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Co-purification Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Co-fractionation Homo sapiens
111 CLSTN2 64084
Affinity Capture-MS Homo sapiens
112 PAX8  
Proximity Label-MS Homo sapiens
113 BANF1 8815
Affinity Capture-MS Homo sapiens
114 RCN2 5955
Affinity Capture-MS Homo sapiens
115 OSMR 9180
Affinity Capture-MS Homo sapiens
116 WHSC1L1  
Affinity Capture-MS Homo sapiens
117 NOL4  
Affinity Capture-MS Homo sapiens
118 BARD1 580
Affinity Capture-Western Homo sapiens
119 CREBBP  
Affinity Capture-Western Homo sapiens
120 T  
Proximity Label-MS Homo sapiens
121 MBD3 53615
Co-fractionation Homo sapiens
Affinity Capture-Western Homo sapiens
122 SS18L1  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
123 FUBP1 8880
Co-fractionation Homo sapiens
124 ZMYND11 10771
Affinity Capture-Western Homo sapiens
125 DNTTIP2  
Affinity Capture-MS Homo sapiens
126 CEBPA  
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Proximity Label-MS Homo sapiens
127 BRCA1 672
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
128 SMARCC2 6601
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Co-purification Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Co-fractionation Homo sapiens
Co-fractionation Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
129 IYD  
Affinity Capture-MS Homo sapiens
130 SQRDL 58472
Affinity Capture-MS Homo sapiens
131 SOX7  
Proximity Label-MS Homo sapiens
132 BRD7  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
133 XIAP  
Affinity Capture-MS Homo sapiens
134 PAX6  
Proximity Label-MS Homo sapiens
135 HIST1H3A 8350
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
136 NR4A1  
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Co-localization Homo sapiens
137 ASS1 445
Affinity Capture-MS Homo sapiens
138 LBX1  
Affinity Capture-MS Homo sapiens
139 SLC9A3R2 9351
Co-fractionation Homo sapiens
140 SMARCD1 6602
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Co-fractionation Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Co-fractionation Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
141 SMARCA5 8467
Co-fractionation Homo sapiens
142 NR0B2  
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
143 EPAS1  
Affinity Capture-MS Homo sapiens
144 PPARG 5468
Proximity Label-MS Homo sapiens
145 AOX1 316
Affinity Capture-MS Homo sapiens
146 CPEB4  
Affinity Capture-MS Homo sapiens
147 SREBF1 6720
Affinity Capture-Western Homo sapiens
148 DPF3  
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Co-fractionation Homo sapiens
Affinity Capture-MS Homo sapiens
149 FOXI1  
Proximity Label-MS Homo sapiens
150 ACTBL2 345651
Affinity Capture-MS Homo sapiens
151 NR3C1 2908
Affinity Capture-Western Homo sapiens
Proximity Label-MS Homo sapiens
152 CCNE1  
Affinity Capture-Western Homo sapiens
153 GATA3  
Proximity Label-MS Homo sapiens
154 SEPT11 55752
Co-fractionation Homo sapiens
155 CCNB3  
Affinity Capture-MS Homo sapiens
156 MDM4  
Reconstituted Complex Homo sapiens
157 POLR2A 5430
Co-fractionation Homo sapiens
Co-fractionation Homo sapiens
Co-purification Homo sapiens
Co-purification Homo sapiens
Co-localization Homo sapiens
158 SIN3B  
Reconstituted Complex Homo sapiens
159 SS18  
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Two-hybrid Homo sapiens
Reconstituted Complex Homo sapiens
Co-fractionation Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
160 ZNF212  
Affinity Capture-MS Homo sapiens
161 ARID1B 57492
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Co-fractionation Homo sapiens
Co-fractionation Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
162 HNF4A  
Proximity Label-MS Homo sapiens
163 PRMT5 10419
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Co-fractionation Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
164 STAT1 6772
Affinity Capture-Western Homo sapiens
165 MYC  
Reconstituted Complex Homo sapiens
Proximity Label-MS Homo sapiens
Affinity Capture-MS Homo sapiens
166 ERG  
Proximity Label-MS Homo sapiens
167 ARHGAP4 393
Affinity Capture-MS Homo sapiens
168 MAPK4  
Affinity Capture-MS Homo sapiens
169 OR8H2  
Affinity Capture-MS Homo sapiens
170 TMOD3 29766
Affinity Capture-MS Homo sapiens
171 ARHGAP33 115703
Affinity Capture-MS Homo sapiens
172 ETS1  
Proximity Label-MS Homo sapiens
173 ETV4  
Proximity Label-MS Homo sapiens
174 BAZ1A 11177