Gene description for SMARCA2
Gene name SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2
Gene symbol SMARCA2
Other names/aliases BAF190
BRM
NCBRS
SNF2
SNF2L2
SNF2LA
SWI2
Sth1p
hBRM
hSNF2a
Species Homo sapiens
 Database cross references - SMARCA2
ExoCarta ExoCarta_6595
Vesiclepedia VP_6595
Entrez Gene 6595
HGNC 11098
MIM 600014
UniProt P51531  
 SMARCA2 identified in exosomes derived from the following tissue/cell type
Chondrocytes 35931686    
Chondrocytes 35931686    
 Gene ontology annotations for SMARCA2
Molecular Function
    histone binding GO:0042393 IEA
    helicase activity GO:0004386 IEA
    RNA polymerase II transcription coactivator activity GO:0001105 IDA
    transcription regulatory region DNA binding GO:0044212 IDA
    ATP binding GO:0005524 IEA
    DNA-dependent ATPase activity GO:0008094 TAS
    transcription coactivator activity GO:0003713 TAS
    protein binding GO:0005515 IPI
Biological Process
    chromatin remodeling GO:0006338 TAS
    nervous system development GO:0007399 IEA
    negative regulation of transcription from RNA polymerase II promoter GO:0000122 TAS
    positive regulation of transcription from RNA polymerase II promoter GO:0045944 TAS
    aortic smooth muscle cell differentiation GO:0035887 IEA
    positive regulation of transcription, DNA-templated GO:0045893 IMP
    negative regulation of cell growth GO:0030308 IMP
    regulation of transcription, DNA-templated GO:0006355 TAS
    regulation of transcription from RNA polymerase II promoter GO:0006357 TAS
    negative regulation of transcription, DNA-templated GO:0045892 IDA
    chromatin organization GO:0006325 TAS
    transcription, DNA-templated GO:0006351 IEA
    negative regulation of cell proliferation GO:0008285 IDA
Subcellular Localization
    nucleus GO:0005634 IDA
    SWI/SNF complex GO:0016514 IDA
    intermediate filament cytoskeleton GO:0045111 IDA
    nBAF complex GO:0071565 ISS
    intracellular membrane-bounded organelle GO:0043231 IDA
    npBAF complex GO:0071564 ISS
    nuclear chromatin GO:0000790 IDA
    nucleoplasm GO:0005654 TAS
 Experiment description of studies that identified SMARCA2 in exosomes
1
Experiment ID 497
MISEV standards
✘ EV Biophysical techniques
✔
CD9|CD151|CD63|CD81|CD82|FLOT1|FLOT2|GAPDH|LAMP1|LAMP2|RAB5A|SDCBP|TFRC|TSG101|UCHL1
EV Enriched markers
✘ EV Negative markers
✔
NTA
EV Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 35931686    
Organism Homo sapiens
Experiment description Extracellular vesicles enriched in connexin 43 promote a senescent phenotype in bone and synovial cells contributing to osteoarthritis progression
Authors Varela-Eirín M, Carpintero-Fernández P, Guitián-Caamaño A, Varela-Vázquez A, García-Yuste A, Sánchez-Temprano A, Bravo-López SB, Yañez-Cabanas J, Fonseca E, Largo R, Mobasheri A, Caeiro JR, Mayán MD.
Journal name Cell Death Dis
Publication year 2022
Sample Chondrocytes
Sample name T/C-28a2
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
2
Experiment ID 498
MISEV standards
✔
EM
EV Biophysical techniques
✔
CD9|CD151|CD63|CD81|CD82|FLOT1|FLOT2|GAPDH|LAMP1|LAMP2|RAB5A|SDCBP|TFRC|TSG101|UCHL1
EV Enriched markers
✘ EV Negative markers
✔
NTA
EV Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 35931686    
Organism Homo sapiens
Experiment description Extracellular vesicles enriched in connexin 43 promote a senescent phenotype in bone and synovial cells contributing to osteoarthritis progression
Authors Varela-Eirín M, Carpintero-Fernández P, Guitián-Caamaño A, Varela-Vázquez A, García-Yuste A, Sánchez-Temprano A, Bravo-López SB, Yañez-Cabanas J, Fonseca E, Largo R, Mobasheri A, Caeiro JR, Mayán MD.
Journal name Cell Death Dis
Publication year 2022
Sample Chondrocytes
Sample name T/C-28a2
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
 Protein-protein interactions for SMARCA2
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 PHB 5245
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
2 HDAC2 3066
Co-purification Homo sapiens
3 SIN3A  
Reconstituted Complex Homo sapiens
Co-purification Homo sapiens
4 CDK8 1024
Co-fractionation Homo sapiens
5 SMARCC1 6599
Co-purification Homo sapiens
Co-purification Homo sapiens
6 BRCA1 672
Affinity Capture-Western Homo sapiens
7 SMARCE1 6605
Co-purification Homo sapiens
8 NR3C1 2908
Invivo Homo sapiens
9 CCNE1  
Affinity Capture-Western Homo sapiens
10 HDAC1 3065
Co-purification Homo sapiens
11 POLR2A 5430
Co-fractionation Homo sapiens
Co-purification Homo sapiens
Co-purification Homo sapiens
12 RBBP4 5928
Co-purification Homo sapiens
13 SS18  
Two-hybrid Homo sapiens
Reconstituted Complex Homo sapiens
14 ESR1  
Two-hybrid Homo sapiens
15 ARID1B 57492
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
16 RUVBL1 8607
Co-fractionation Homo sapiens
17 Actl6a  
Affinity Capture-Western Mus musculus
18 ACTL6A 86
Co-purification Homo sapiens
Co-fractionation Homo sapiens
Affinity Capture-Western Homo sapiens
19 SMARCB1 6598
Co-purification Homo sapiens
Co-purification Homo sapiens
Co-purification Homo sapiens
20 CEBPB  
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
21 ACTL6B  
Affinity Capture-Western Homo sapiens
22 ARID1A 8289
Co-purification Homo sapiens
23 MYB  
Reconstituted Complex Homo sapiens
24 Actl6b  
Affinity Capture-Western Mus musculus
25 SMARCC2 6601
Co-purification Homo sapiens
View the network image/svg+xml
 Pathways in which SMARCA2 is involved
PathwayEvidenceSource
RMTs methylate histone arginines TAS Reactome





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