Gene description for BCKDHA
Gene name branched chain keto acid dehydrogenase E1, alpha polypeptide
Gene symbol BCKDHA
Other names/aliases BCKDE1A
MSU
MSUD1
OVD1A
Species Homo sapiens
 Database cross references - BCKDHA
ExoCarta ExoCarta_593
Vesiclepedia VP_593
Entrez Gene 593
HGNC 986
MIM 608348
UniProt P12694  
 BCKDHA identified in exosomes derived from the following tissue/cell type
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
 Gene ontology annotations for BCKDHA
Molecular Function
    3-methyl-2-oxobutanoate dehydrogenase (2-methylpropanoyl-transferring) activity GO:0003863 IDA
    3-methyl-2-oxobutanoate dehydrogenase (2-methylpropanoyl-transferring) activity GO:0003863 IDA
    protein binding GO:0005515 IPI
    carboxy-lyase activity GO:0016831 TAS
    metal ion binding GO:0046872 IEA
    branched-chain alpha-keto acid dehydrogenase activity GO:0047101 IDA
Biological Process
    branched-chain amino acid catabolic process GO:0009083 IBA
    branched-chain amino acid catabolic process GO:0009083 IDA
    branched-chain amino acid catabolic process GO:0009083 IMP
Subcellular Localization
    mitochondrion GO:0005739 HDA
    mitochondrion GO:0005739 HTP
    mitochondrion GO:0005739 TAS
    mitochondrial matrix GO:0005759 NAS
    mitochondrial matrix GO:0005759 TAS
    oxoglutarate dehydrogenase complex GO:0045252 IBA
    branched-chain alpha-ketoacid dehydrogenase complex GO:0160157 IDA
    branched-chain alpha-ketoacid dehydrogenase complex GO:0160157 IPI
 Experiment description of studies that identified BCKDHA in exosomes
1
Experiment ID 489
MISEV standards
EM
Biophysical techniques
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
Canx
Negative markers
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 6
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
2
Experiment ID 490
MISEV standards
EM
Biophysical techniques
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
Canx
Negative markers
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 7
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
3
Experiment ID 491
MISEV standards
EM
Biophysical techniques
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
Canx
Negative markers
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 8
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
4
Experiment ID 492
MISEV standards
EM
Biophysical techniques
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
Canx
Negative markers
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 9
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
 Protein-protein interactions for BCKDHA
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 EMC4 51234
Co-fractionation Homo sapiens
2 ATP6V1B2 526
Co-fractionation Homo sapiens
3 UQCRFS1 7386
Affinity Capture-MS Homo sapiens
4 POR 5447
Co-fractionation Homo sapiens
5 SPRTN  
Affinity Capture-MS Homo sapiens
6 BCKDK 10295
Affinity Capture-MS Homo sapiens
7 NDUFS1 4719
Co-fractionation Homo sapiens
8 SPRYD4 283377
Affinity Capture-MS Homo sapiens
9 APOE 348
Co-fractionation Homo sapiens
10 GRPEL1 80273
Co-fractionation Homo sapiens
11 ASPH 444
Co-fractionation Homo sapiens
12 NDUFS2 4720
Co-fractionation Homo sapiens
13 PPM1K  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
14 CCDC90B  
Proximity Label-MS Homo sapiens
15 LRPPRC 10128
Co-fractionation Homo sapiens
16 NNT 23530
Co-fractionation Homo sapiens
17 QPRT 23475
Co-fractionation Homo sapiens
18 S100A4 6275
Affinity Capture-MS Homo sapiens
19 NDUFS3 4722
Affinity Capture-MS Homo sapiens
Co-fractionation Homo sapiens
20 TRMU  
Affinity Capture-MS Homo sapiens
21 NDUFB8 4714
Co-fractionation Homo sapiens
22 POLL  
Affinity Capture-MS Homo sapiens
23 MRPL23 6150
Affinity Capture-MS Homo sapiens
24 HEY1  
Affinity Capture-MS Homo sapiens
25 YARS2  
Affinity Capture-MS Homo sapiens
26 HINT2 84681
Proximity Label-MS Homo sapiens
27 MRPS24 64951
Affinity Capture-MS Homo sapiens
28 GCAT  
Affinity Capture-MS Homo sapiens
29 BRPF3  
Affinity Capture-MS Homo sapiens
30 ADCYAP1  
Affinity Capture-MS Homo sapiens
31 ARMCX3 51566
Co-fractionation Homo sapiens
32 Hdac6  
Affinity Capture-MS Mus musculus
33 Pdlim5 56376
Affinity Capture-MS Mus musculus
34 ATP5C1 509
Co-fractionation Homo sapiens
35 FAM136A 84908
Affinity Capture-MS Homo sapiens
36 SPATA20  
Affinity Capture-MS Homo sapiens
37 C20orf24  
Co-fractionation Homo sapiens
38 LACTB 114294
Co-fractionation Homo sapiens
39 NDUFV1 4723
Co-fractionation Homo sapiens
40 PHB 5245
Co-fractionation Homo sapiens
41 TOMM40 10452
Co-fractionation Homo sapiens
42 PREX1  
Co-fractionation Homo sapiens
43 CGA  
Affinity Capture-MS Homo sapiens
44 PMPCB 9512
Proximity Label-MS Homo sapiens
45 SMARCA2 6595
Affinity Capture-MS Homo sapiens
46 NDUFS5 4725
Co-fractionation Homo sapiens
47 KIF14 9928
Affinity Capture-MS Homo sapiens
48 MRPS30 10884
Affinity Capture-MS Homo sapiens
49 TMEM25  
Affinity Capture-MS Homo sapiens
50 LRRC59 55379
Co-fractionation Homo sapiens
51 DLD 1738
Co-fractionation Homo sapiens
52 S100A2 6273
Affinity Capture-MS Homo sapiens
53 SLC25A10 1468
Affinity Capture-MS Homo sapiens
54 P4HA1 5033
Co-fractionation Homo sapiens
55 ZNF444  
Affinity Capture-MS Homo sapiens
56 PARK2  
Affinity Capture-MS Homo sapiens
57 NDUFA8 4702
Co-fractionation Homo sapiens
58 AMACR 23600
Affinity Capture-MS Homo sapiens
59 TUFM 7284
Co-fractionation Homo sapiens
60 ATP2A2 488
Co-fractionation Homo sapiens
61 VCP 7415
Co-fractionation Homo sapiens
62 CYC1 1537
Co-fractionation Homo sapiens
63 UQCRC1 7384
Co-fractionation Homo sapiens
64 LYRM4 57128
Affinity Capture-MS Homo sapiens
65 HECTD1 25831
Affinity Capture-MS Homo sapiens
66 COQ10B  
Affinity Capture-MS Homo sapiens
67 MTRF1L  
Proximity Label-MS Homo sapiens
68 UQCRH 7388
Co-fractionation Homo sapiens
69 AGPS 8540
Co-fractionation Homo sapiens
70 HSD17B8  
Affinity Capture-MS Homo sapiens
71 NIPSNAP1 8508
Co-fractionation Homo sapiens
72 ATP5B 506
Co-fractionation Homo sapiens
73 SP100 6672
Affinity Capture-MS Homo sapiens
74 COX4I1 1327
Co-fractionation Homo sapiens
75 SQRDL 58472
Co-fractionation Homo sapiens
76 CISD3 284106
Affinity Capture-MS Homo sapiens
77 IMMT 10989
Co-fractionation Homo sapiens
78 CYB5B 80777
Co-fractionation Homo sapiens
79 WBSCR16  
Affinity Capture-MS Homo sapiens
80 HADHB 3032
Co-fractionation Homo sapiens
81 AK4 205
Affinity Capture-MS Homo sapiens
82 MINOS1  
Co-fractionation Homo sapiens
83 CANX 821
Co-fractionation Homo sapiens
84 BCKDHB 594
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
85 EMC8 10328
Co-fractionation Homo sapiens
86 TRIM33 51592
Affinity Capture-MS Homo sapiens
87 IL25  
Affinity Capture-MS Homo sapiens
88 CPT1A 1374
Co-fractionation Homo sapiens
89 UQCRC2 7385
Co-fractionation Homo sapiens
90 HMOX2 3163
Co-fractionation Homo sapiens
91 EEF2 1938
Co-fractionation Homo sapiens
92 PHIP 55023
Affinity Capture-MS Homo sapiens
93 CUL3 8452
Affinity Capture-MS Homo sapiens
94 COX7A2 1347
Co-fractionation Homo sapiens
95 FAHD1 81889
Affinity Capture-MS Homo sapiens
96 BOLA1 51027
Affinity Capture-MS Homo sapiens
97 CORO1C 23603
Co-fractionation Homo sapiens
98 ZNF782  
Co-fractionation Homo sapiens
99 HADHA 3030
Co-fractionation Homo sapiens
100 PHB2 11331
Co-fractionation Homo sapiens
101 ZSCAN5A  
Affinity Capture-MS Homo sapiens
102 TOMM5  
Co-fractionation Homo sapiens
103 COX6C 1345
Co-fractionation Homo sapiens
104 EMC2 9694
Co-fractionation Homo sapiens
105 POLB 5423
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
106 TNS2 23371
Affinity Capture-MS Homo sapiens
107 PPP6C 5537
Affinity Capture-MS Homo sapiens
108 RCN2 5955
Co-fractionation Homo sapiens
109 DNAJB13  
Affinity Capture-MS Homo sapiens
110 SUGCT  
Affinity Capture-MS Homo sapiens
111 COX2 4513
Co-fractionation Homo sapiens
112 NDUFV2 4729
Co-fractionation Homo sapiens
113 MTCH2 23788
Co-fractionation Homo sapiens
114 MTRF1  
Proximity Label-MS Homo sapiens
115 TCF25 22980
Affinity Capture-MS Homo sapiens
116 ZRANB1 54764
Affinity Capture-MS Homo sapiens
117 NIPSNAP3A  
Affinity Capture-MS Homo sapiens
118 CLPP 8192
Proximity Label-MS Homo sapiens
119 CS 1431
Proximity Label-MS Homo sapiens
120 PLEKHA4 57664
Affinity Capture-MS Homo sapiens
121 CA6 765
Affinity Capture-MS Homo sapiens
122 BMP2  
Affinity Capture-MS Homo sapiens
123 ZNF785  
Affinity Capture-MS Homo sapiens
124 AUH 549
Proximity Label-MS Homo sapiens
Co-fractionation Homo sapiens
125 COQ5  
Affinity Capture-MS Homo sapiens
126 COQ6 51004
Affinity Capture-MS Homo sapiens
127 LONP1 9361
Co-fractionation Homo sapiens
128 HDAC6 10013
Affinity Capture-MS Homo sapiens
129 ACAA2 10449
Affinity Capture-MS Homo sapiens
130 PDHA1 5160
Co-fractionation Homo sapiens
Proximity Label-MS Homo sapiens
131 NDUFS7 374291
Co-fractionation Homo sapiens
Affinity Capture-MS Homo sapiens
132 PDHB 5162
Co-fractionation Homo sapiens
133 C21orf33  
Proximity Label-MS Homo sapiens
134 NIPSNAP3B 55335
Affinity Capture-MS Homo sapiens
135 VDAC2 7417
Co-fractionation Homo sapiens
136 TAZ  
Affinity Capture-MS Homo sapiens
137 HOXB1  
Affinity Capture-MS Homo sapiens
138 NDUFS8 4728
Co-fractionation Homo sapiens
139 AARS2  
Proximity Label-MS Homo sapiens
140 ATP6V1E1 529
Co-fractionation Homo sapiens
141 COX5A 9377
Co-fractionation Homo sapiens
142 DHRS4 10901
Affinity Capture-MS Homo sapiens
143 BRD1 23774
Affinity Capture-MS Homo sapiens
144 NDUFAF4 29078
Affinity Capture-MS Homo sapiens
145 OXCT2  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
146 COX7C 1350
Co-fractionation Homo sapiens
147 C9orf72  
Affinity Capture-MS Homo sapiens
148 METTL17  
Proximity Label-MS Homo sapiens
149 ATOH1  
Affinity Capture-MS Homo sapiens
150 TRIM43  
Affinity Capture-MS Homo sapiens
151 MGST3 4259
Co-fractionation Homo sapiens
152 VDAC3 7419
Co-fractionation Homo sapiens
153 ATP5A1 498
Affinity Capture-MS Homo sapiens
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