Gene description for POR
Gene name P450 (cytochrome) oxidoreductase
Gene symbol POR
Other names/aliases CPR
CYPOR
P450R
Species Homo sapiens
 Database cross references - POR
ExoCarta ExoCarta_5447
Vesiclepedia VP_5447
Entrez Gene 5447
HGNC 9208
MIM 124015
UniProt P16435  
 POR identified in sEVs derived from the following tissue/cell type
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Breast cancer cells 34108659    
Breast cancer cells 34108659    
Colorectal cancer cells 34887515    
Embryonic kidney cells 34108659    
Embryonic kidney cells 34108659    
Gastric cancer cells 33991177    
Gastric cancer cells 33991177    
Gastric cancer cells 33991177    
Mesenchymal stem cells 36408942    
Ovarian cancer cells 23333927    
Ovarian cancer cells 23333927    
Pancreatic cancer cells 34108659    
Pancreatic cancer cells 34108659    
Retinal pigment epithelial cells 35333565    
Retinal pigment epithelial cells 35333565    
 Gene ontology annotations for POR
Molecular Function
    NADPH-hemoprotein reductase activity GO:0003958 IBA
    NADPH-hemoprotein reductase activity GO:0003958 IDA
    NADPH-hemoprotein reductase activity GO:0003958 TAS
    protein binding GO:0005515 IPI
    FMN binding GO:0010181 IBA
    flavin adenine dinucleotide binding GO:0050660 IBA
    NADP binding GO:0050661 IEA
Biological Process
    xenobiotic metabolic process GO:0006805 TAS
    nitric oxide biosynthetic process GO:0006809 IBA
    response to hormone GO:0009725 IBA
    electron transport chain GO:0022900 IDA
    positive regulation of monooxygenase activity GO:0032770 IDA
    organofluorine metabolic process GO:0090346 IDA
Subcellular Localization
    endoplasmic reticulum membrane GO:0005789 TAS
    cytosol GO:0005829 IBA
    membrane GO:0016020 HDA
    intracellular membrane-bounded organelle GO:0043231 IDA
 Experiment description of studies that identified POR in sEVs
1
Experiment ID 489
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 6
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
2
Experiment ID 490
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 7
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
3
Experiment ID 491
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 8
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
4
Experiment ID 492
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 9
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
5
Experiment ID 426
MISEV standards
✘ Biophysical techniques
✔
SDCBP|FLOT1|CD81|CD9|CD151|FLOT2|TSG101|LAMP1|TFRC|RAB5A|RAB35|GAPDH|UCHL1|ICAM1
Enriched markers
✔
CANX
Negative markers
✘ Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 34108659    
Organism Homo sapiens
Experiment description Quantitative Proteomics Identifies the Core Proteome of Exosomes with Syntenin-1 as the highest abundant protein and a Putative Universal Biomarker
Authors "Kugeratski FG, Hodge K, Lilla S, McAndrews KM, Zhou X, Hwang RF, Zanivan S, Kalluri R."
Journal name Nat Cell Biol
Publication year 2021
Sample Breast cancer cells
Sample name MDA-MB-231 - Exo-rich fractions 7-10 pooled
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Size exclusion chromatography
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
6
Experiment ID 427
MISEV standards
✘ Biophysical techniques
✔
CD81|SDCBP|FLOT1|CD9|CD151|FLOT2|TSG101|LAMP1|TFRC|RAB5A|RAB35|GAPDH|UCHL1|ICAM1
Enriched markers
✔
CANX
Negative markers
✘ Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 34108659    
Organism Homo sapiens
Experiment description Quantitative Proteomics Identifies the Core Proteome of Exosomes with Syntenin-1 as the highest abundant protein and a Putative Universal Biomarker
Authors "Kugeratski FG, Hodge K, Lilla S, McAndrews KM, Zhou X, Hwang RF, Zanivan S, Kalluri R."
Journal name Nat Cell Biol
Publication year 2021
Sample Breast cancer cells
Sample name MDA-MB-231 - Exo-rich fractions 1-6 pooled
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
OptiPrep density gradient centrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
7
Experiment ID 1203
MISEV standards
✔
EM
Biophysical techniques
✔
SDCBP|FLOT1|CD9|CD81|CD63|EPCAM|GAPDH|LAMP1|TFRC|CD151|CD82|LAMP2|RAB35|TSG101|FLOT2|RAB5B|ICAM1|RAB5A
Enriched markers
✘ Negative markers
✘ Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 34887515    
Organism Homo sapiens
Experiment description Supermeres are functional extracellular nanoparticles replete with disease biomarkers and therapeutic targets
Authors "Zhang Q, Jeppesen DK, Higginbotham JN, Graves-Deal R, Trinh VQ, Ramirez MA, Sohn Y, Neininger AC, Taneja N, McKinley ET, Niitsu H, Cao Z, Evans R, Glass SE, Ray KC, Fissell WH, Hill S, Rose KL, Huh WJ, Washington MK, Ayers GD, Burnette DT, Sharma S, Rome LH, Franklin JL, Lee YA, Liu Q, Coffey RJ."
Journal name Nat Cell Biol
Publication year 2021
Sample Colorectal cancer cells
Sample name DiFi
Isolation/purification methods Differential centrifugation
Filtration
Centrifugal ultrafiltration
Ultracentrifugation
OptiPrep density gradient centrifugation
Flotation density -
Molecules identified in the study Protein
miRNA
Methods used in the study Western blotting
Mass spectrometry
RNA sequencing
8
Experiment ID 419
MISEV standards
✘ Biophysical techniques
✔
SDCBP|FLOT1|CD81|CD9|CD151|FLOT2|TSG101|LAMP1|TFRC|RAB5A|RAB35|GAPDH|UCHL1|ICAM1
Enriched markers
✔
CANX
Negative markers
✘ Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 34108659    
Organism Homo sapiens
Experiment description Quantitative Proteomics Identifies the Core Proteome of Exosomes with Syntenin-1 as the highest abundant protein and a Putative Universal Biomarker
Authors "Kugeratski FG, Hodge K, Lilla S, McAndrews KM, Zhou X, Hwang RF, Zanivan S, Kalluri R."
Journal name Nat Cell Biol
Publication year 2021
Sample Embryonic kidney cells
Sample name HEK293T - Exo-rich fractions 7-10 pooled
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Size exclusion chromatography
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
9
Experiment ID 419
MISEV standards
✘ Biophysical techniques
✔
SDCBP|FLOT1|CD81|CD9|CD151|FLOT2|TSG101|LAMP1|TFRC|RAB5A|RAB35|GAPDH|UCHL1|ICAM1
Enriched markers
✔
CANX
Negative markers
✘ Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 34108659    
Organism Homo sapiens
Experiment description Quantitative Proteomics Identifies the Core Proteome of Exosomes with Syntenin-1 as the highest abundant protein and a Putative Universal Biomarker
Authors "Kugeratski FG, Hodge K, Lilla S, McAndrews KM, Zhou X, Hwang RF, Zanivan S, Kalluri R."
Journal name Nat Cell Biol
Publication year 2021
Sample Embryonic kidney cells
Sample name HEK293T - Exo-rich fractions 7-10 pooled
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Size exclusion chromatography
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
10
Experiment ID 420
MISEV standards
✘ Biophysical techniques
✔
CD81|SDCBP|FLOT1|CD9|CD151|FLOT2|TSG101|LAMP1|TFRC|RAB5A|RAB35|GAPDH|UCHL1|ICAM1
Enriched markers
✔
CANX
Negative markers
✘ Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 34108659    
Organism Homo sapiens
Experiment description Quantitative Proteomics Identifies the Core Proteome of Exosomes with Syntenin-1 as the highest abundant protein and a Putative Universal Biomarker
Authors "Kugeratski FG, Hodge K, Lilla S, McAndrews KM, Zhou X, Hwang RF, Zanivan S, Kalluri R."
Journal name Nat Cell Biol
Publication year 2021
Sample Embryonic kidney cells
Sample name HEK293T - Exo-rich fractions 1-6 pooled
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
OptiPrep density gradient centrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
11
Experiment ID 420
MISEV standards
✘ Biophysical techniques
✔
CD81|SDCBP|FLOT1|CD9|CD151|FLOT2|TSG101|LAMP1|TFRC|RAB5A|RAB35|GAPDH|UCHL1|ICAM1
Enriched markers
✔
CANX
Negative markers
✘ Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 34108659    
Organism Homo sapiens
Experiment description Quantitative Proteomics Identifies the Core Proteome of Exosomes with Syntenin-1 as the highest abundant protein and a Putative Universal Biomarker
Authors "Kugeratski FG, Hodge K, Lilla S, McAndrews KM, Zhou X, Hwang RF, Zanivan S, Kalluri R."
Journal name Nat Cell Biol
Publication year 2021
Sample Embryonic kidney cells
Sample name HEK293T - Exo-rich fractions 1-6 pooled
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
OptiPrep density gradient centrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
12
Experiment ID 363
MISEV standards
✘ Biophysical techniques
✔
TSG101|GAPDH|AQP1|CD151|CD81|CD82|CD9|EPCAM|FLOT1|FLOT2|ICAM1|ITGA2B|LAMP2|RAB35|RAB5A|RAB5B|SDCBP|TFRC|UCHL1
Enriched markers
✔
DCLK1
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 33991177    
Organism Homo sapiens
Experiment description Cancer stem cell marker DCLK1 reprograms small extracellular vesicles toward migratory phenotype in gastric cancer cells
Authors "Carli ALE, Afshar-Sterle S, Rai A, Fang H, O'Keefe R, Tse J, Ferguson FM, Gray NS, Ernst M, Greening DW, Buchert M."
Journal name Proteomics
Publication year 2021
Sample Gastric cancer cells
Sample name MKN1 - 100K pellet
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
13
Experiment ID 364
MISEV standards
✘ Biophysical techniques
✔
TSG101|GAPDH|AQP1|CD151|CD81|CD82|CD9|EPCAM|FLOT1|FLOT2|ICAM1|ITGA2B|LAMP2|RAB35|RAB5A|RAB5B|SDCBP|TFRC|UCHL1
Enriched markers
✔
DCLK1
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 33991177    
Organism Homo sapiens
Experiment description Cancer stem cell marker DCLK1 reprograms small extracellular vesicles toward migratory phenotype in gastric cancer cells
Authors "Carli ALE, Afshar-Sterle S, Rai A, Fang H, O'Keefe R, Tse J, Ferguson FM, Gray NS, Ernst M, Greening DW, Buchert M."
Journal name Proteomics
Publication year 2021
Sample Gastric cancer cells
Sample name MKN1 - 100K pellet
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
14
Experiment ID 365
MISEV standards
✘ Biophysical techniques
✔
TSG101|GAPDH|AQP1|CD151|CD81|CD82|CD9|EPCAM|FLOT1|FLOT2|ICAM1|ITGA2B|LAMP2|RAB35|RAB5A|RAB5B|SDCBP|TFRC|UCHL1
Enriched markers
✔
DCLK1
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 33991177    
Organism Homo sapiens
Experiment description Cancer stem cell marker DCLK1 reprograms small extracellular vesicles toward migratory phenotype in gastric cancer cells
Authors "Carli ALE, Afshar-Sterle S, Rai A, Fang H, O'Keefe R, Tse J, Ferguson FM, Gray NS, Ernst M, Greening DW, Buchert M."
Journal name Proteomics
Publication year 2021
Sample Gastric cancer cells
Sample name MKN1 - 100K pellet
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
15
Experiment ID 488
MISEV standards
✔
EM
Biophysical techniques
✔
CD9|CD81|CD63|GAPDH|SDCBP|LAMP1|TFRC|UCHL1|FLOT2|LAMP2|FLOT1|ICAM1|RAB5B|CD151|RAB35|TSG101|RAB5A|CD82
Enriched markers
✔
CANX
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Homo sapiens
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Mesenchymal stem cells
Sample name UCMSC
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
16
Experiment ID 211
MISEV standards
✔
EM
Biophysical techniques
✔
TSG101|Alix|EpCAM|TFRC
Enriched markers
✔
cytochrome c|GOLGA2
Negative markers
✘ Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23333927    
Organism Homo sapiens
Experiment description Characterization and proteomic analysis of ovarian cancer-derived exosomes.
Authors "Liang B, Peng P, Chen S, Li L, Zhang M, Cao D, Yang J, Li H, Gui T, Li X, Shen K."
Journal name J Proteomics
Publication year 2013
Sample Ovarian cancer cells
Sample name IGROV1
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient
Flotation density 1.09-1.15 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
17
Experiment ID 212
MISEV standards
✔
CEM
Biophysical techniques
✔
TSG101|Alix|EpCAM|TFRC
Enriched markers
✔
Cytochrome C|GOLGA2
Negative markers
✘ Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23333927    
Organism Homo sapiens
Experiment description Characterization and proteomic analysis of ovarian cancer-derived exosomes.
Authors "Liang B, Peng P, Chen S, Li L, Zhang M, Cao D, Yang J, Li H, Gui T, Li X, Shen K."
Journal name J Proteomics
Publication year 2013
Sample Ovarian cancer cells
Sample name OVCAR-3
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient
Flotation density 1.09-1.15 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
18
Experiment ID 434
MISEV standards
✘ Biophysical techniques
✔
SDCBP|FLOT1|CD81|CD9|CD151|FLOT2|TSG101|LAMP1|TFRC|RAB5A|RAB35|GAPDH|UCHL1|ICAM1
Enriched markers
✔
CANX
Negative markers
✘ Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 34108659    
Organism Homo sapiens
Experiment description Quantitative Proteomics Identifies the Core Proteome of Exosomes with Syntenin-1 as the highest abundant protein and a Putative Universal Biomarker
Authors "Kugeratski FG, Hodge K, Lilla S, McAndrews KM, Zhou X, Hwang RF, Zanivan S, Kalluri R."
Journal name Nat Cell Biol
Publication year 2021
Sample Pancreatic cancer cells
Sample name PANC-1 - Exo-rich fractions 7-10 pooled
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Size exclusion chromatography
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
19
Experiment ID 435
MISEV standards
✘ Biophysical techniques
✔
CD81|SDCBP|FLOT1|CD9|CD151|FLOT2|TSG101|LAMP1|TFRC|RAB5A|RAB35|GAPDH|UCHL1|ICAM1
Enriched markers
✔
CANX
Negative markers
✘ Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 34108659    
Organism Homo sapiens
Experiment description Quantitative Proteomics Identifies the Core Proteome of Exosomes with Syntenin-1 as the highest abundant protein and a Putative Universal Biomarker
Authors "Kugeratski FG, Hodge K, Lilla S, McAndrews KM, Zhou X, Hwang RF, Zanivan S, Kalluri R."
Journal name Nat Cell Biol
Publication year 2021
Sample Pancreatic cancer cells
Sample name PANC-1 - Exo-rich fractions 1-6 pooled
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
OptiPrep density gradient centrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
20
Experiment ID 834
MISEV standards
✔
EM
Biophysical techniques
✔
LAMP2|CD63|FLOT1|ITGA2B|ICAM1|CD9|CD151|TFRC|RAB5A|GAPDH|AQP1|TSG101
Enriched markers
✔
CANX
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 35333565    
Organism Homo sapiens
Experiment description LAMP2A regulates the loading of proteins into exosomes
Authors "Ferreira JV, da Rosa Soares A, Ramalho J, Máximo Carvalho C, Cardoso MH, Pintado P, Carvalho AS, Beck HC, Matthiesen R, Zuzarte M, Girão H, van Niel G, Pereira P"
Journal name Sci Adv
Publication year 2022
Sample Retinal pigment epithelial cells
Sample name ARPE-19
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
21
Experiment ID 835
MISEV standards
✔
EM
Biophysical techniques
✔
CD63|FLOT1|ITGA2B|ICAM1|CD9|CD151|TFRC|RAB5A|GAPDH|AQP1|TSG101
Enriched markers
✔
CANX
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 35333565    
Organism Homo sapiens
Experiment description LAMP2A regulates the loading of proteins into exosomes
Authors "Ferreira JV, da Rosa Soares A, Ramalho J, Máximo Carvalho C, Cardoso MH, Pintado P, Carvalho AS, Beck HC, Matthiesen R, Zuzarte M, Girão H, van Niel G, Pereira P"
Journal name Sci Adv
Publication year 2022
Sample Retinal pigment epithelial cells
Sample name ARPE-19
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
 Protein-protein interactions for POR
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 INSIG1  
Affinity Capture-Western Homo sapiens
2 EMC4 51234
Affinity Capture-MS Homo sapiens
Co-fractionation Homo sapiens
3 ATP6V1B2 526
Co-fractionation Homo sapiens
4 SLC25A13 10165
Co-fractionation Homo sapiens
5 GJD3  
Proximity Label-MS Homo sapiens
6 ISG15 9636
Affinity Capture-MS Homo sapiens
7 KIF23 9493
Affinity Capture-MS Homo sapiens
8 POR 5447
PCA Homo sapiens
PCA Homo sapiens
9 DERL2 51009
Affinity Capture-MS Homo sapiens
10 CYP1A2  
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
11 VAPA 9218
Co-fractionation Homo sapiens
Affinity Capture-MS Homo sapiens
12 METTL7A 25840
Proximity Label-MS Homo sapiens
13 SRPRB 58477
Affinity Capture-MS Homo sapiens
14 TPP1 1200
Co-fractionation Homo sapiens
15 CTDNEP1 23399
Proximity Label-MS Homo sapiens
16 SRPR 6734
Affinity Capture-MS Homo sapiens
17 APOE 348
Co-fractionation Homo sapiens
18 NTNG1  
Affinity Capture-MS Homo sapiens
19 HSD17B11 51170
Proximity Label-MS Homo sapiens
20 LAMTOR2 28956
Co-fractionation Homo sapiens
21 DNAJC25 548645
Affinity Capture-MS Homo sapiens
Proximity Label-MS Homo sapiens
22 PTPN1 5770
Proximity Label-MS Homo sapiens
23 SYVN1 84447
Affinity Capture-MS Homo sapiens
24 STX4 6810
Proximity Label-MS Homo sapiens
25 RTN4 57142
Affinity Capture-MS Homo sapiens
26 APP 351
Co-fractionation Homo sapiens
27 MATN1  
Affinity Capture-MS Homo sapiens
28 PTGES2 80142
Co-fractionation Homo sapiens
29 APEX1 328
Affinity Capture-RNA Homo sapiens
30 KIAA1429 25962
Affinity Capture-MS Homo sapiens
31 NDUFB9 4715
Co-fractionation Homo sapiens
32 PLOD3 8985
Co-fractionation Homo sapiens
33 B3GAT1  
Proximity Label-MS Homo sapiens
34 NDUFS3 4722
Co-fractionation Homo sapiens
35 BTN2A1 11120
Affinity Capture-MS Homo sapiens
36 NDUFB8 4714
Co-fractionation Homo sapiens
37 RCN2 5955
Co-fractionation Homo sapiens
38 RAB3B 5865
Proximity Label-MS Homo sapiens
39 PRC1 9055
Affinity Capture-MS Homo sapiens
40 SSR1 6745
Proximity Label-MS Homo sapiens
41 ARMCX3 51566
Co-fractionation Homo sapiens
42 EWSR1 2130
Co-fractionation Homo sapiens
43 PIGH  
Affinity Capture-MS Homo sapiens
44 PGRMC2 10424
Affinity Capture-MS Homo sapiens
45 CYP2D6 1565
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
46 LACTB 114294
Co-fractionation Homo sapiens
47 CCDC47 57003
Affinity Capture-MS Homo sapiens
48 NDUFV1 4723
Co-fractionation Homo sapiens
Co-fractionation Homo sapiens
49 PHB 5245
Co-fractionation Homo sapiens
50 TOMM40 10452
Co-fractionation Homo sapiens
51 KRTCAP2 200185
Affinity Capture-MS Homo sapiens
52 FAM20C 56975
Affinity Capture-MS Homo sapiens
53 KIF14 9928
Affinity Capture-MS Homo sapiens
54 CLASP2 23122
Affinity Capture-MS Homo sapiens
55 LMAN1 3998
Proximity Label-MS Homo sapiens
56 TUFM 7284
Co-fractionation Homo sapiens
57 KIAA1715 80856
Proximity Label-MS Homo sapiens
58 PXMP2  
Proximity Label-MS Homo sapiens
59 CHMP4C 92421
Affinity Capture-MS Homo sapiens
60 RAB5A 5868
Proximity Label-MS Homo sapiens
61 DDOST 1650
Affinity Capture-MS Homo sapiens
62 ATP2A2 488
Co-fractionation Homo sapiens
63 P4HA1 5033
Co-fractionation Homo sapiens
64 EMD 2010
Proximity Label-MS Homo sapiens
65 PARK2  
Affinity Capture-MS Homo sapiens
66 NDUFA8 4702
Co-fractionation Homo sapiens
67 RAB4A 5867
Proximity Label-MS Homo sapiens
68 VCP 7415
Affinity Capture-MS Homo sapiens
Co-fractionation Homo sapiens
69 NTRK1 4914
Affinity Capture-MS Homo sapiens
70 HMOX2 3163
Co-fractionation Homo sapiens
71 PON2 5445
Co-fractionation Homo sapiens
72 SSUH2  
Affinity Capture-MS Homo sapiens
73 CYC1 1537
Co-fractionation Homo sapiens
74 UQCRC1 7384
Co-fractionation Homo sapiens
75 RPN1 6184
Proximity Label-MS Homo sapiens
Affinity Capture-MS Homo sapiens
76 COMT 1312
Co-fractionation Homo sapiens
77 CD63 967
Affinity Capture-MS Homo sapiens
78 UQCRH 7388
Co-fractionation Homo sapiens
79 AGPS 8540
Co-fractionation Homo sapiens
80 ELOVL5 60481
Proximity Label-MS Homo sapiens
81 SEC61B 10952
Proximity Label-MS Homo sapiens
Affinity Capture-MS Homo sapiens
82 ATP5B 506
Co-fractionation Homo sapiens
83 UBXN6 80700
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
84 SQRDL 58472
Co-fractionation Homo sapiens
85 REEP5 7905
Proximity Label-MS Homo sapiens
86 ANLN 54443
Affinity Capture-MS Homo sapiens
87 CYP2A6  
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
88 C4orf32  
Affinity Capture-MS Homo sapiens
89 CYP3A4  
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
90 RPN2 6185
Proximity Label-MS Homo sapiens
Affinity Capture-MS Homo sapiens
91 CUL3 8452
Affinity Capture-MS Homo sapiens
92 CANX 821
Affinity Capture-MS Homo sapiens
Co-fractionation Homo sapiens
93 ATL3 25923
Co-fractionation Homo sapiens
94 BCKDHB 594
Co-fractionation Homo sapiens
95 EMC8 10328
Co-fractionation Homo sapiens
96 LRRC59 55379
Proximity Label-MS Homo sapiens
Co-fractionation Homo sapiens
97 NDUFA9 4704
Co-fractionation Homo sapiens
98 NR3C1 2908
Affinity Capture-MS Homo sapiens
99 ECT2 1894
Affinity Capture-MS Homo sapiens
100 UQCRC2 7385
Co-fractionation Homo sapiens
101 FGF12  
Affinity Capture-MS Homo sapiens
102 EEF2 1938
Co-fractionation Homo sapiens
103 BCAP31 10134
Proximity Label-MS Homo sapiens
Affinity Capture-MS Homo sapiens
104 HSD3B7 80270
Proximity Label-MS Homo sapiens
105 DAD1 1603
Affinity Capture-MS Homo sapiens
106 CIT 11113
Affinity Capture-MS Homo sapiens
107 STIM1 6786
Proximity Label-MS Homo sapiens
108 FKBP8 23770
Affinity Capture-MS Homo sapiens
109 CORO1C 23603
Co-fractionation Homo sapiens
110 XPO1 7514
Co-fractionation Homo sapiens
111 STAT1 6772
Two-hybrid Homo sapiens
112 SNX8 29886
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
113 EMC2 9694
Co-fractionation Homo sapiens
114 ATP6V1A 523
Co-fractionation Homo sapiens
115 RAB9A 9367
Proximity Label-MS Homo sapiens
116 ASPH 444
Co-fractionation Homo sapiens
117 DHFRL1  
Proximity Label-MS Homo sapiens
118 HK1 3098
Co-fractionation Homo sapiens
119 CYP2C9  
Proximity Label-MS Homo sapiens
Reconstituted Complex Homo sapiens
120 COX2 4513
Co-fractionation Homo sapiens
121 NDUFV2 4729
Co-fractionation Homo sapiens
122 NDUFS1 4719
Co-fractionation Homo sapiens
123 TFRC 7037
Co-fractionation Homo sapiens
124 OST4  
Affinity Capture-MS Homo sapiens
125 CYP2C19  
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
126 RABEPK  
Two-hybrid Homo sapiens
127 PHB2 11331
Co-fractionation Homo sapiens
128 TMED10 10972
Affinity Capture-MS Homo sapiens
129 VDAC3 7419
Co-fractionation Homo sapiens
130 FANCC 2176
Affinity Capture-Western Homo sapiens
Co-purification Homo sapiens
Two-hybrid Homo sapiens
131 PGRMC1 10857
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
132 PTRF 284119
Co-fractionation Homo sapiens
133 LONP1 9361
Co-fractionation Homo sapiens
134 LRPPRC 10128
Co-fractionation Homo sapiens
135 BCKDHA 593
Co-fractionation Homo sapiens
136 PDHA1 5160
Co-fractionation Homo sapiens
137 NDUFS7 374291
Co-fractionation Homo sapiens
138 PDHB 5162
Co-fractionation Homo sapiens
139 PLOD1 5351
Co-fractionation Homo sapiens
140 DDX58 23586
Affinity Capture-RNA Homo sapiens
141 NNT 23530
Co-fractionation Homo sapiens
142 NDUFS8 4728
Co-fractionation Homo sapiens
143 BCL2L13 23786
Co-fractionation Homo sapiens
144 SEC62 7095
Proximity Label-MS Homo sapiens
145 ATP6V1E1 529
Co-fractionation Homo sapiens
146 RAB7A 7879
Proximity Label-MS Homo sapiens
147 PINK1  
Affinity Capture-MS Homo sapiens
148 CYP2E1  
Reconstituted Complex Homo sapiens
PCA Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
149 CYB5R3 1727
Co-fractionation Homo sapiens
150 STT3B 201595
Affinity Capture-MS Homo sapiens
151 RARS 5917
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
152 CD44 960
Co-fractionation Homo sapiens
153 ITGB5 3693
Co-fractionation Homo sapiens
154 CKAP4 10970
Proximity Label-MS Homo sapiens
155 DARS2 55157
Co-fractionation Homo sapiens
156 CCR1  
Affinity Capture-MS Homo sapiens
157 DERL1 79139
Affinity Capture-MS Homo sapiens
Proximity Label-MS Homo sapiens
158 ATP2A1 487
Proximity Label-MS Homo sapiens
View the network image/svg+xml



Perform bioinformatics analysis of your extracellular vesicle data set using FunRich, a open access standalone tool. NEW UPDATED VERSION OF FunRich available for download (12/09/2016) from here