Gene description for POR
Gene name P450 (cytochrome) oxidoreductase
Gene symbol POR
Other names/aliases CPR
CYPOR
P450R
Species Homo sapiens
 Database cross references - POR
ExoCarta ExoCarta_5447
Entrez Gene 5447
HGNC 9208
MIM 124015
UniProt P16435  
 POR identified in exosomes derived from the following tissue/cell type
Ovarian cancer cells 23333927    
Ovarian cancer cells 23333927    
 Gene ontology annotations for POR
Molecular Function
    nitric oxide dioxygenase activity GO:0008941 IEA
    enzyme binding GO:0019899 IEA
    electron carrier activity GO:0009055 IEA
    oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen GO:0016709 IBA
    FMN binding GO:0010181 IEA
    iron-cytochrome-c reductase activity GO:0047726 IEA
    protein binding GO:0005515 IPI
    cytochrome-b5 reductase activity, acting on NAD(P)H GO:0004128 IEA
    flavin adenine dinucleotide binding GO:0050660 IEA
    NADPH-hemoprotein reductase activity GO:0003958 TAS
    hydrolase activity GO:0016787 IEA
    NADP binding GO:0050661 IEA
    iron ion binding GO:0005506 IEA
Biological Process
    nitrate catabolic process GO:0043602 IEA
    nitric oxide catabolic process GO:0046210 IEA
    internal peptidyl-lysine acetylation GO:0018393 IEA
    cellular response to follicle-stimulating hormone stimulus GO:0071372 IEA
    flavonoid metabolic process GO:0009812 IEA
    cellular organofluorine metabolic process GO:0090346 IDA
    response to drug GO:0042493 IEA
    positive regulation of steroid hormone biosynthetic process GO:0090031 IEA
    positive regulation of monooxygenase activity GO:0032770 IDA
    regulation of growth plate cartilage chondrocyte proliferation GO:0003420 IEA
    negative regulation of cysteine-type endopeptidase activity involved in apoptotic process GO:0043154 IEA
    oxidation-reduction process GO:0055114 TAS
    carnitine metabolic process GO:0009437 IEA
    response to nutrient GO:0007584 IEA
    negative regulation of lipase activity GO:0060192 IEA
    positive regulation of smoothened signaling pathway GO:0045880 IEA
    positive regulation of chondrocyte differentiation GO:0032332 IEA
    demethylation GO:0070988 IEA
    fatty acid oxidation GO:0019395 IEA
    positive regulation of cholesterol biosynthetic process GO:0045542 IEA
    cellular response to peptide hormone stimulus GO:0071375 IEA
Subcellular Localization
    endoplasmic reticulum membrane GO:0005789 IEA
    mitochondrion GO:0005739 IEA
    membrane GO:0016020 IDA
    cytosol GO:0005829 IBA
    intracellular membrane-bounded organelle GO:0043231 IDA
 Experiment description of studies that identified POR in exosomes
1
Experiment ID 211
ISEV standards
✔
EM
EV Biophysical techniques
✔
TSG101|Alix
EV Cytosolic markers
✔
EpCAM|TFRC
EV Membrane markers
✔
cytochrome c|GOLGA2
EV Negative markers
✘ EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23333927    
Organism Homo sapiens
Experiment description Characterization and proteomic analysis of ovarian cancer-derived exosomes.
Authors Liang B, Peng P, Chen S, Li L, Zhang M, Cao D, Yang J, Li H, Gui T, Li X, Shen K.
Journal name J Proteomics
Publication year 2013
Sample Ovarian cancer cells
Sample name IGROV1
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient
Flotation density 1.09-1.15 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
2
Experiment ID 212
ISEV standards
✔
CEM
EV Biophysical techniques
✔
TSG101|Alix
EV Cytosolic markers
✔
EpCAM|TFRC
EV Membrane markers
✔
Cytochrome C|GOLGA2
EV Negative markers
✘ EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23333927    
Organism Homo sapiens
Experiment description Characterization and proteomic analysis of ovarian cancer-derived exosomes.
Authors Liang B, Peng P, Chen S, Li L, Zhang M, Cao D, Yang J, Li H, Gui T, Li X, Shen K.
Journal name J Proteomics
Publication year 2013
Sample Ovarian cancer cells
Sample name OVCAR-3
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient
Flotation density 1.09-1.15 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for POR
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 CYP2C9  
Invitro Homo sapiens
2 CYP2E1  
Invitro Homo sapiens
3 CYP2C19  
Invitro Homo sapiens
4 CYP17A1 1586
Invivo Homo sapiens
5 CYP1A2  
Invitro Homo sapiens
View the network image/svg+xml
 Pathways in which POR is involved
No pathways found





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