Gene description for NDUFB9
Gene name NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 9, 22kDa
Gene symbol NDUFB9
Other names/aliases B22
CI-B22
LYRM3
UQOR22
Species Homo sapiens
 Database cross references - NDUFB9
ExoCarta ExoCarta_4715
Vesiclepedia VP_4715
Entrez Gene 4715
HGNC 7704
MIM 601445
UniProt Q9Y6M9  
 NDUFB9 identified in exosomes derived from the following tissue/cell type
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
 Gene ontology annotations for NDUFB9
Molecular Function
    protein binding GO:0005515 IPI
    NADH dehydrogenase (ubiquinone) activity GO:0008137 NAS
Biological Process
    mitochondrial electron transport, NADH to ubiquinone GO:0006120 NAS
    sensory perception of sound GO:0007605 TAS
    aerobic respiration GO:0009060 NAS
    mitochondrial respiratory chain complex I assembly GO:0032981 IMP
    proton motive force-driven mitochondrial ATP synthesis GO:0042776 NAS
    proton transmembrane transport GO:1902600 IEA
Subcellular Localization
    mitochondrion GO:0005739 HTP
    mitochondrion GO:0005739 IDA
    mitochondrial inner membrane GO:0005743 IDA
    mitochondrial inner membrane GO:0005743 TAS
    respiratory chain complex I GO:0045271 IBA
    respiratory chain complex I GO:0045271 IDA
    respiratory chain complex I GO:0045271 NAS
 Experiment description of studies that identified NDUFB9 in exosomes
1
Experiment ID 489
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 6
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
2
Experiment ID 490
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 7
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
3
Experiment ID 491
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 8
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
4
Experiment ID 492
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 9
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
 Protein-protein interactions for NDUFB9
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 POR 5447
Co-fractionation Homo sapiens
2 RAB1A 5861
Co-fractionation Homo sapiens
3 NDUFS1 4719
Co-fractionation Homo sapiens
Co-fractionation Homo sapiens
4 BCAT2 587
Affinity Capture-MS Homo sapiens
5 ABCC1 4363
Co-fractionation Homo sapiens
6 GDF9 2661
Two-hybrid Homo sapiens
7 NDUFB5 4711
Co-fractionation Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
8 HSPA1L 3305
Co-fractionation Homo sapiens
9 UBC 7316
Reconstituted Complex Homo sapiens
10 NDUFA12 55967
Co-fractionation Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Co-fractionation Homo sapiens
11 SYNE2 23224
Co-fractionation Homo sapiens
12 PRRT2  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
13 NDUFA4 4697
Affinity Capture-MS Homo sapiens
14 STX4 6810
Co-fractionation Homo sapiens
15 CPT1A 1374
Co-fractionation Homo sapiens
16 SPG7  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
17 CSGALNACT2 55454
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
18 MEF2A  
Two-hybrid Homo sapiens
19 NDUFS3 4722
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
20 NDUFB8 4714
Affinity Capture-MS Homo sapiens
Co-fractionation Homo sapiens
21 SDHB 6390
Co-fractionation Homo sapiens
Co-fractionation Homo sapiens
22 GPR34  
Affinity Capture-MS Homo sapiens
23 NDUFA7 4701
Co-fractionation Homo sapiens
Affinity Capture-MS Homo sapiens
24 TIMMDC1  
Affinity Capture-MS Homo sapiens
25 FBXW7  
Synthetic Lethality Homo sapiens
26 NDUFA5 4698
Co-fractionation Homo sapiens
Co-fractionation Homo sapiens
27 YIPF3 25844
Affinity Capture-MS Homo sapiens
28 PRPS1 5631
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
29 LAMTOR3 8649
Co-fractionation Homo sapiens
30 NDUFA8 4702
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Co-fractionation Homo sapiens
Affinity Capture-MS Homo sapiens
31 HLA-DQB1 3119
Affinity Capture-MS Homo sapiens
32 NDUFV1 4723
Co-fractionation Homo sapiens
33 PHB 5245
Co-fractionation Homo sapiens
34 NDUFV3 4731
Affinity Capture-MS Homo sapiens
35 ABCC2 1244
Co-fractionation Homo sapiens
36 ATP5H 10476
Co-fractionation Homo sapiens
37 NDUFA6  
Co-fractionation Homo sapiens
Co-fractionation Homo sapiens
38 NDUFS5 4725
Affinity Capture-MS Homo sapiens
Co-fractionation Homo sapiens
Affinity Capture-MS Homo sapiens
39 NDUFA1 4694
Affinity Capture-MS Homo sapiens
40 MCCC2 64087
Co-fractionation Homo sapiens
41 NDUFB1 4707
Co-fractionation Homo sapiens
42 APOO 79135
Proximity Label-MS Homo sapiens
43 E2F4  
Affinity Capture-MS Homo sapiens
44 ENPP6 133121
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
45 S100A2 6273
Affinity Capture-MS Homo sapiens
46 MPV17 4358
Co-fractionation Homo sapiens
47 NDUFB7 4713
Co-fractionation Homo sapiens
Co-fractionation Homo sapiens
Affinity Capture-MS Homo sapiens
48 STOM 2040
Co-fractionation Homo sapiens
49 XRN1 54464
Two-hybrid Homo sapiens
50 ATP5O 539
Co-fractionation Homo sapiens
51 SH3GL3  
Two-hybrid Homo sapiens
52 CYB5A 1528
Co-fractionation Homo sapiens
53 GALNT6 11226
Affinity Capture-MS Homo sapiens
54 P4HB 5034
Co-fractionation Homo sapiens
55 UQCRC1 7384
Co-fractionation Homo sapiens
56 ACTB 60
Co-fractionation Homo sapiens
57 COX7B 1349
Co-fractionation Homo sapiens
58 DNAJC30  
Affinity Capture-MS Homo sapiens
59 MYL12A 10627
Co-fractionation Homo sapiens
60 VDAC2 7417
Co-fractionation Homo sapiens
Co-fractionation Homo sapiens
61 NIPSNAP1 8508
Co-fractionation Homo sapiens
62 ATP5B 506
Co-fractionation Homo sapiens
Co-fractionation Homo sapiens
63 COX4I1 1327
Proximity Label-MS Homo sapiens
64 MTG2  
Affinity Capture-MS Homo sapiens
65 HAP1  
Two-hybrid Homo sapiens
66 RBBP6 5930
Two-hybrid Homo sapiens
67 GJA8  
Affinity Capture-MS Homo sapiens
68 C15orf48  
Affinity Capture-MS Homo sapiens
69 C9orf72  
Affinity Capture-MS Homo sapiens
70 HADHB 3032
Co-fractionation Homo sapiens
71 VAPB 9217
Co-fractionation Homo sapiens
72 NDUFB10 4716
Co-fractionation Homo sapiens
Co-fractionation Homo sapiens
73 NDUFA13 51079
Affinity Capture-MS Homo sapiens
74 NDUFA9 4704
Affinity Capture-MS Homo sapiens
Co-fractionation Homo sapiens
75 MAGEA11  
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
76 UQCRC2 7385
Co-fractionation Homo sapiens
77 LYRM5  
Co-fractionation Homo sapiens
78 CRELD1 78987
Affinity Capture-MS Homo sapiens
79 BCAP31 10134
Co-fractionation Homo sapiens
80 ATP5F1 515
Co-fractionation Homo sapiens
Co-fractionation Homo sapiens
81 FAHD1 81889
Affinity Capture-MS Homo sapiens
82 CORO1C 23603
Co-fractionation Homo sapiens
83 NXF1 10482
Affinity Capture-RNA Homo sapiens
84 MRPS28  
Co-fractionation Homo sapiens
85 PHB2 11331
Co-fractionation Homo sapiens
86 ATP5J2 9551
Co-fractionation Homo sapiens
87 NDUFB3 4709
Affinity Capture-MS Homo sapiens
88 COX6C 1345
Co-fractionation Homo sapiens
89 LMNB1 4001
Affinity Capture-MS Homo sapiens
90 CYP2J2  
Affinity Capture-MS Homo sapiens
91 MSLN 10232
Co-fractionation Homo sapiens
92 RHPN1  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
93 RPN1 6184
Co-fractionation Homo sapiens
94 VDAC1 7416
Co-fractionation Homo sapiens
95 CLTC 1213
Co-fractionation Homo sapiens
96 NDUFV2 4729
Affinity Capture-MS Homo sapiens
97 NDUFC2 4718
Affinity Capture-MS Homo sapiens
98 MTCH2 23788
Co-fractionation Homo sapiens
Co-fractionation Homo sapiens
99 CORO1B 57175
Co-fractionation Homo sapiens
100 FUT1  
Affinity Capture-MS Homo sapiens
101 IMMT 10989
Two-hybrid Homo sapiens
102 IKBKAP 8518
Two-hybrid Homo sapiens
103 FEZ1  
Two-hybrid Homo sapiens
104 FASN 2194
Positive Genetic Homo sapiens
105 TACR1  
Affinity Capture-MS Homo sapiens
106 ILF3 3609
Co-fractionation Homo sapiens
107 NDUFAF2  
Affinity Capture-MS Homo sapiens
108 COX5A 9377
Co-fractionation Homo sapiens
109 Htt  
Affinity Capture-MS Mus musculus
110 NUP35 129401
Proximity Label-MS Homo sapiens
111 DDX58 23586
Affinity Capture-RNA Homo sapiens
112 NDUFS8 4728
Co-fractionation Homo sapiens
113 NDUFA2 4695
Co-fractionation Homo sapiens
Co-fractionation Homo sapiens
114 COX7A2 1347
Co-fractionation Homo sapiens
115 KLHL22 84861
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
116 EPHA2 1969
Proximity Label-MS Homo sapiens
117 ATP5C1 509
Co-fractionation Homo sapiens
118 COX7C 1350
Co-fractionation Homo sapiens
119 NDUFB11 54539
Affinity Capture-MS Homo sapiens
Co-fractionation Homo sapiens
Affinity Capture-MS Homo sapiens
120 NDUFS6  
Affinity Capture-MS Homo sapiens
Co-fractionation Homo sapiens
Affinity Capture-MS Homo sapiens
121 TOMM5  
Co-fractionation Homo sapiens
122 NDUFS7 374291
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
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