Gene description for IKBKAP
Gene name
inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase complex-associated protein
Gene symbol
IKBKAP
Other names/aliases
DYS ELP1 FD IKAP IKI3 TOT1
Species
Homo sapiens
Database cross references - IKBKAP
ExoCarta
ExoCarta_8518
Entrez Gene
8518
HGNC
5959
MIM
603722
UniProt
O95163
IKBKAP identified in exosomes derived from the following tissue/cell type
Ovarian cancer cells
23333927
Ovarian cancer cells
23333927
Thymus
23844026
Gene ontology annotations for IKBKAP
Experiment description of studies that identified IKBKAP in exosomes
1
Experiment ID
211
ISEV standards
✔
EM
EV Biophysical techniques
✔
TSG101|Alix
EV Cytosolic markers
✔
EpCAM|TFRC
EV Membrane markers
✔
cytochrome c|GOLGA2
EV Negative markers
✘
EV Particle analysis
Identified molecule
protein
Identification method
Mass spectrometry
PubMed ID
23333927
Organism
Homo sapiens
Experiment description
Characterization and proteomic analysis of ovarian cancer-derived exosomes.
Authors
Liang B, Peng P, Chen S, Li L, Zhang M, Cao D, Yang J, Li H, Gui T, Li X, Shen K.
Journal name
J Proteomics
Publication year
2013
Sample
Ovarian cancer cells
Sample name
IGROV1
Isolation/purification methods
Differential centrifugation Ultracentrifugation Sucrose density gradient
Flotation density
1.09-1.15 g/mL
Molecules identified in the study
Protein
Methods used in the study
Mass spectrometry
2
Experiment ID
212
ISEV standards
✔
CEM
EV Biophysical techniques
✔
TSG101|Alix
EV Cytosolic markers
✔
EpCAM|TFRC
EV Membrane markers
✔
Cytochrome C|GOLGA2
EV Negative markers
✘
EV Particle analysis
Identified molecule
protein
Identification method
Mass spectrometry
PubMed ID
23333927
Organism
Homo sapiens
Experiment description
Characterization and proteomic analysis of ovarian cancer-derived exosomes.
Authors
Liang B, Peng P, Chen S, Li L, Zhang M, Cao D, Yang J, Li H, Gui T, Li X, Shen K.
Journal name
J Proteomics
Publication year
2013
Sample
Ovarian cancer cells
Sample name
OVCAR-3
Isolation/purification methods
Differential centrifugation Ultracentrifugation Sucrose density gradient
Flotation density
1.09-1.15 g/mL
Molecules identified in the study
Protein
Methods used in the study
Mass spectrometry
3
Experiment ID
217
ISEV standards
✔
EM
EV Biophysical techniques
✔
TSG101
EV Cytosolic markers
✔
CD81|CD9|CD63
EV Membrane markers
✘
EV Negative markers
✔
NTA
EV Particle analysis
Identified molecule
protein
Identification method
Mass spectrometry
PubMed ID
23844026
Organism
Homo sapiens
Experiment description
Characterization of human thymic exosomes.
Authors
Skogberg G, Gudmundsdottir J, van der Post S, Sandstrom K, Bruhn S, Benson M, Mincheva-Nilsson L, Baranov V, Telemo E, Ekwall O.
Journal name
PLoS One
Publication year
2013
Sample
Thymus
Sample name
Normal-Thymus
Isolation/purification methods
Differential centrifugation Filtration Ultracentrifugation
Flotation density
-
Molecules identified in the study
Protein
Methods used in the study
Mass spectrometry
Protein-protein interactions for IKBKAP
Protein Interactor
ExoCarta ID
Identification method
PubMed
Species
1
SDHAF2
54949
Two-hybrid
Homo sapiens
2
NIPSNAP3A
Two-hybrid
Homo sapiens
3
BAG6
7917
Two-hybrid
Homo sapiens
4
TTR
7276
Two-hybrid
Homo sapiens
5
PLP2
5355
Two-hybrid
Homo sapiens
6
MAPK8
5599
Two-hybrid
Homo sapiens
Affinity Capture-Western
Homo sapiens
Reconstituted Complex
Homo sapiens
Biochemical Activity
Homo sapiens
7
ELP3
55140
Invivo
Homo sapiens
Invitro
Homo sapiens
Co-purification
Homo sapiens
Affinity Capture-Western
Homo sapiens
Co-purification
Homo sapiens
8
NDUFB9
Two-hybrid
Homo sapiens
9
CDKN2B
1030
Two-hybrid
Homo sapiens
10
TAC3
Two-hybrid
Homo sapiens
11
SNAPIN
Two-hybrid
Homo sapiens
12
MRPL42
Two-hybrid
Homo sapiens
13
IKBKB
3551
Invivo
Homo sapiens
Invitro
Homo sapiens
14
MAN2A2
Two-hybrid
Homo sapiens
15
CHUK
1147
Invivo
Homo sapiens
Invitro
Homo sapiens
16
CCT5
22948
Two-hybrid
Homo sapiens
17
CSTF2
Two-hybrid
Homo sapiens
18
TXNDC9
Two-hybrid
Homo sapiens
19
MAP3K14
Invivo
Homo sapiens
Invitro
Homo sapiens
20
ELP4
Co-purification
Homo sapiens
21
ELP2
55250
Co-purification
Homo sapiens
View the network
image/svg+xml
Pathways in which IKBKAP is involved