Gene description for CHUK
Gene name conserved helix-loop-helix ubiquitous kinase
Gene symbol CHUK
Other names/aliases IKBKA
IKK-alpha
IKK1
IKKA
NFKBIKA
TCF16
Species Homo sapiens
 Database cross references - CHUK
ExoCarta ExoCarta_1147
Vesiclepedia VP_1147
Entrez Gene 1147
HGNC 1974
MIM 600664
UniProt O15111  
 CHUK identified in sEVs derived from the following tissue/cell type
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Mesenchymal stem cells 36408942    
Thymus 23844026    
 Gene ontology annotations for CHUK
Molecular Function
    protein kinase activity GO:0004672 IDA
    protein serine/threonine kinase activity GO:0004674 IBA
    protein serine/threonine kinase activity GO:0004674 IDA
    protein binding GO:0005515 IPI
    ATP binding GO:0005524 IEA
    IkappaB kinase activity GO:0008384 IDA
    IkappaB kinase activity GO:0008384 TAS
    protein homodimerization activity GO:0042803 IDA
    protein-containing complex binding GO:0044877 IEA
    protein heterodimerization activity GO:0046982 IDA
    scaffold protein binding GO:0097110 IDA
    transferrin receptor binding GO:1990459 IPI
Biological Process
    skeletal muscle contraction GO:0003009 IEA
    inflammatory response GO:0006954 TAS
    immune response GO:0006955 TAS
    canonical NF-kappaB signal transduction GO:0007249 IDA
    canonical NF-kappaB signal transduction GO:0007249 TAS
    response to xenobiotic stimulus GO:0009410 IEA
    response to virus GO:0009615 TAS
    response to toxic substance GO:0009636 IEA
    anatomical structure morphogenesis GO:0009653 TAS
    response to acetate GO:0010034 IEA
    negative regulation of NF-kappaB transcription factor activity GO:0032088 IMP
    positive regulation of interferon-alpha production GO:0032727 IMP
    response to hydroperoxide GO:0033194 IEA
    tumor necrosis factor-mediated signaling pathway GO:0033209 IBA
    tumor necrosis factor-mediated signaling pathway GO:0033209 IMP
    toll-like receptor 4 signaling pathway GO:0034142 IDA
    non-canonical NF-kappaB signal transduction GO:0038061 IDA
    positive regulation of canonical NF-kappaB signal transduction GO:0043123 IBA
    positive regulation of canonical NF-kappaB signal transduction GO:0043123 IDA
    positive regulation of canonical NF-kappaB signal transduction GO:0043123 IMP
    response to amino acid GO:0043200 IEA
    innate immune response GO:0045087 TAS
    positive regulation of transcription by RNA polymerase II GO:0045944 IBA
    positive regulation of transcription by RNA polymerase II GO:0045944 IDA
    positive regulation of NF-kappaB transcription factor activity GO:0051092 TAS
    striated muscle cell differentiation GO:0051146 IEA
    response to cholecystokinin GO:0061847 IEA
    cellular response to tumor necrosis factor GO:0071356 IDA
    cellular response to virus GO:0098586 IMP
Subcellular Localization
    nucleoplasm GO:0005654 IDA
    cytoplasm GO:0005737 IBA
    cytoplasm GO:0005737 IDA
    cytosol GO:0005829 IDA
    cytosol GO:0005829 TAS
    IkappaB kinase complex GO:0008385 IBA
    IkappaB kinase complex GO:0008385 IPI
    IkappaB kinase complex GO:0008385 TAS
    cytoplasmic side of plasma membrane GO:0009898 ISS
    CD40 receptor complex GO:0035631 ISS
 Experiment description of studies that identified CHUK in sEVs
1
Experiment ID 489
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 6
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
2
Experiment ID 490
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 7
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
3
Experiment ID 491
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 8
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
4
Experiment ID 492
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 9
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
5
Experiment ID 488
MISEV standards
✔
EM
Biophysical techniques
✔
CD9|CD81|CD63|GAPDH|SDCBP|LAMP1|TFRC|UCHL1|FLOT2|LAMP2|FLOT1|ICAM1|RAB5B|CD151|RAB35|TSG101|RAB5A|CD82
Enriched markers
✔
CANX
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Homo sapiens
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Mesenchymal stem cells
Sample name UCMSC
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
6
Experiment ID 217
MISEV standards
✔
EM
Biophysical techniques
✔
TSG101|CD81|CD9|CD63
Enriched markers
✘ Negative markers
✔
NTA
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23844026    
Organism Homo sapiens
Experiment description Characterization of human thymic exosomes.
Authors "Skogberg G, Gudmundsdottir J, van der Post S, Sandstrom K, Bruhn S, Benson M, Mincheva-Nilsson L, Baranov V, Telemo E, Ekwall O."
Journal name PLoS One
Publication year 2013
Sample Thymus
Sample name Normal-Thymus
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for CHUK
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 ATR  
Two-hybrid Homo sapiens
2 TNFAIP3 7128
Affinity Capture-Western Homo sapiens
3 CUEDC2  
Affinity Capture-Western Homo sapiens
Two-hybrid Homo sapiens
4 PRKCD 5580
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
5 IRF5  
Affinity Capture-Western Homo sapiens
6 SRPK2 6733
Biochemical Activity Homo sapiens
7 COPS5 10987
Biochemical Activity Homo sapiens
8 RPA2 6118
Proximity Label-MS Homo sapiens
9 TRADD 8717
Co-fractionation Homo sapiens
10 UBC 7316
Reconstituted Complex Homo sapiens
11 CSNK2A1 1457
Biochemical Activity Homo sapiens
12 NLRP2  
Affinity Capture-Western Homo sapiens
13 RIPK1 8737
Co-fractionation Homo sapiens
14 STAP2 55620
Affinity Capture-Western Homo sapiens
15 PRKDC 5591
Biochemical Activity Homo sapiens
Reconstituted Complex Homo sapiens
16 NFKB1 4790
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Biochemical Activity Homo sapiens
17 MRFAP1L1  
Affinity Capture-MS Homo sapiens
18 NCOR1  
Biochemical Activity Homo sapiens
19 LRRC14 9684
Affinity Capture-Western Homo sapiens
20 HSP90AA1 3320
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
21 USP18  
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
22 ERC1 23085
Co-purification Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
23 PSMD9 5715
Affinity Capture-Western Homo sapiens
Phenotypic Suppression Homo sapiens
Affinity Capture-Western Homo sapiens
24 SRC 6714
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
25 NCOA3  
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Reconstituted Complex Homo sapiens
Biochemical Activity Homo sapiens
Biochemical Activity Homo sapiens
Co-localization Homo sapiens
26 MAP3K3 4215
Co-localization Homo sapiens
27 TRAF6 7189
Affinity Capture-Western Homo sapiens
28 SHC4  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
29 RIPK2  
Biochemical Activity Homo sapiens
30 FAM196A  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
31 CUL1 8454
Affinity Capture-Western Homo sapiens
32 BTRC 8945
Biochemical Activity Homo sapiens
33 NPAS1  
Affinity Capture-MS Homo sapiens
34 TNFRSF1B  
Affinity Capture-Western Homo sapiens
35 TNF  
Affinity Capture-MS Homo sapiens
Phenotypic Suppression Homo sapiens
36 SAMHD1 25939
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
37 PPM1B 5495
Affinity Capture-Western Homo sapiens
Co-localization Homo sapiens
Affinity Capture-Western Homo sapiens
38 HIST2H3C 126961
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
39 EIF2AK2 5610
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
40 SEMA4C 54910
Affinity Capture-MS Homo sapiens
41 COMMD7 149951
Affinity Capture-Western Homo sapiens
42 PLBD1 79887
Affinity Capture-MS Homo sapiens
43 IRAK1  
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
44 PARK2  
Affinity Capture-MS Homo sapiens
45 CLU 1191
Affinity Capture-Western Homo sapiens
46 NCOR2  
Biochemical Activity Homo sapiens
Biochemical Activity Homo sapiens
47 NBR1 4077
Affinity Capture-Western Homo sapiens
48 CCT8L2  
Affinity Capture-MS Homo sapiens
49 HTT 3064
Biochemical Activity Homo sapiens
50 DCUN1D5 84259
Biochemical Activity Homo sapiens
51 UBE2I 7329
Biochemical Activity Homo sapiens
52 ERBB2IP 55914
Biochemical Activity Homo sapiens
53 NTRK1 4914
Affinity Capture-MS Homo sapiens
54 SMAD3 4088
Affinity Capture-Western Homo sapiens
55 TAB2  
Affinity Capture-Western Homo sapiens
56 PPP2CA 5515
Affinity Capture-Western Homo sapiens
57 PAX8  
Two-hybrid Homo sapiens
58 SMAD2 4087
Affinity Capture-Western Homo sapiens
59 MYH14 79784
Co-fractionation Homo sapiens
60 NFKB2 4791
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Biochemical Activity Homo sapiens
61 MYL12A 10627
Co-fractionation Homo sapiens
62 SRPK1 6732
Biochemical Activity Homo sapiens
63 UBXN6 80700
Affinity Capture-MS Homo sapiens
64 USP32 84669
Affinity Capture-MS Homo sapiens
65 KDF1  
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
66 RSL1D1 26156
Cross-Linking-MS (XL-MS) Homo sapiens
67 PSG11  
Affinity Capture-MS Homo sapiens
68 ZBED6CL  
Affinity Capture-MS Homo sapiens
69 CD40 958
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
70 UBE2N 7334
Biochemical Activity Homo sapiens
71 DUSP1  
Affinity Capture-Western Homo sapiens
72 WHAMMP3  
Affinity Capture-MS Homo sapiens
73 CDC73  
Co-fractionation Homo sapiens
74 AMBRA1  
Affinity Capture-Western Homo sapiens
Biochemical Activity Homo sapiens
75 XPO1 7514
Affinity Capture-MS Homo sapiens
76 EGLN3  
Affinity Capture-Western Homo sapiens
77 NLRC5  
Affinity Capture-Western Homo sapiens
78 GGH 8836
Affinity Capture-MS Homo sapiens
79 CTNNB1 1499
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Biochemical Activity Homo sapiens
80 NFKBIA  
Reconstituted Complex Homo sapiens
Biochemical Activity Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Biochemical Activity Homo sapiens
Biochemical Activity Homo sapiens
Biochemical Activity Homo sapiens
Biochemical Activity Homo sapiens
Biochemical Activity Homo sapiens
Biochemical Activity Homo sapiens
Biochemical Activity Homo sapiens
Biochemical Activity Homo sapiens
Biochemical Activity Homo sapiens
Biochemical Activity Homo sapiens
Biochemical Activity Homo sapiens
Biochemical Activity Homo sapiens
Biochemical Activity Homo sapiens
Biochemical Activity Homo sapiens
Biochemical Activity Homo sapiens
Biochemical Activity Homo sapiens
Biochemical Activity Homo sapiens
Biochemical Activity Homo sapiens
Biochemical Activity Homo sapiens
Biochemical Activity Homo sapiens
Biochemical Activity Homo sapiens
Biochemical Activity Homo sapiens
Biochemical Activity Homo sapiens
Biochemical Activity Homo sapiens
Biochemical Activity Homo sapiens
Biochemical Activity Homo sapiens
Biochemical Activity Homo sapiens
Biochemical Activity Homo sapiens
Biochemical Activity Homo sapiens
Biochemical Activity Homo sapiens
Biochemical Activity Homo sapiens
Affinity Capture-Western Homo sapiens
Biochemical Activity Homo sapiens
Biochemical Activity Homo sapiens
Biochemical Activity Homo sapiens
Biochemical Activity Homo sapiens
81 TNFRSF1A 7132
Affinity Capture-Western Homo sapiens
Biochemical Activity Homo sapiens
82 HSP90AB1 3326
Affinity Capture-MS Homo sapiens
83 CUL3 8452
Affinity Capture-MS Homo sapiens
84 RICTOR 253260
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
85 CARD11  
Co-localization Homo sapiens
Affinity Capture-Western Homo sapiens
86 ATM 472
Affinity Capture-Western Homo sapiens
Biochemical Activity Homo sapiens
87 GLI1  
Affinity Capture-Western Homo sapiens
88 MAP3K1 4214
Biochemical Activity Homo sapiens
Biochemical Activity Homo sapiens
Biochemical Activity Homo sapiens
Affinity Capture-Western Homo sapiens
89 HNRNPA1 3178
Far Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
90 MAP3K8  
Biochemical Activity Homo sapiens
Affinity Capture-Western Homo sapiens
91 METTL21B  
Affinity Capture-MS Homo sapiens
92 MAP3K7  
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Co-localization Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
93 TP73  
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
94 TNIP2  
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Biochemical Activity Homo sapiens
95 PRKCI 5584
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
96 FKBP5 2289
Affinity Capture-Luminescence Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
97 C12orf74  
Affinity Capture-MS Homo sapiens
98 PIAS1 8554
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
99 MYC  
Affinity Capture-Western Homo sapiens
FRET Homo sapiens
Affinity Capture-Western Homo sapiens
Biochemical Activity Homo sapiens
Affinity Capture-Western Homo sapiens
100 DNAI2  
Affinity Capture-MS Homo sapiens
101 MTOR 2475
Affinity Capture-Western Homo sapiens
Co-purification Homo sapiens
Affinity Capture-Western Homo sapiens
102 TRIM22 10346
Affinity Capture-Western Homo sapiens
103 TP63  
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
104 TRIM27  
Affinity Capture-Western Homo sapiens
Biochemical Activity Homo sapiens
105 Pebp1 29542
Reconstituted Complex Rattus norvegicus
Affinity Capture-Western Rattus norvegicus
106 PRKY  
Affinity Capture-MS Homo sapiens
107 TRIM40 135644
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
108 AKT1 207
Affinity Capture-Western Homo sapiens
Biochemical Activity Homo sapiens
Affinity Capture-Western Homo sapiens
Co-localization Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
109 CHUK 1147
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Biochemical Activity Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Biochemical Activity Homo sapiens
Reconstituted Complex Homo sapiens
110 STUB1 10273
Affinity Capture-Western Homo sapiens
111 TRAF4 9618
Biochemical Activity Homo sapiens
112 RELA 5970
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Biochemical Activity Homo sapiens
Biochemical Activity Homo sapiens
Affinity Capture-MS Homo sapiens
Biochemical Activity Homo sapiens
113 IKBKAP 8518
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
114 HNRNPCL2 440563
Affinity Capture-MS Homo sapiens
115 MAP3K14  
Two-hybrid Homo sapiens
Reconstituted Complex Homo sapiens
Biochemical Activity Homo sapiens
Affinity Capture-Western Homo sapiens
Biochemical Activity Homo sapiens
Affinity Capture-Western Homo sapiens
Biochemical Activity Homo sapiens
Co-localization Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
116 TANK 10010
Affinity Capture-Western Homo sapiens
117 TRAF3IP2  
Affinity Capture-Western Homo sapiens
Co-fractionation Homo sapiens
118 FOXO3  
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
119 PAF1 54623
Co-fractionation Homo sapiens
120 TRAF2 7186
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Co-localization Homo sapiens
Affinity Capture-Western Homo sapiens
121 SMN1 6606
Affinity Capture-Western Homo sapiens
122 PSG1  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
123 CPSF6 11052
Affinity Capture-MS Homo sapiens
124 TP53 7157
Affinity Capture-Western Homo sapiens
125 IKBKE 9641
Biochemical Activity Homo sapiens
126 PYCARD 29108
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
127 KCTD14 65987
Affinity Capture-MS Homo sapiens
128 MAP3K4 4216
Biochemical Activity Homo sapiens
129 CDC37 11140
Affinity Capture-Luminescence Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
130 IKBKG 8517
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Luminescence Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Co-fractionation Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Protein-peptide Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Luminescence Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Co-purification Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Biochemical Activity Homo sapiens
Affinity Capture-Western Homo sapiens
Co-fractionation Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Biochemical Activity Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
131 CASP8 841
Affinity Capture-Western Homo sapiens
132 RPTOR 57521
Affinity Capture-Western Homo sapiens
133 SQSTM1 8878
Proximity Label-MS Homo sapiens
134 HSPB1 3315
Affinity Capture-Western Homo sapiens
135 ELAVL1 1994
Affinity Capture-Western Homo sapiens
136 CREBBP  
Two-hybrid Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Biochemical Activity Homo sapiens
137 NLRP4  
Affinity Capture-Western Homo sapiens
138 BCL10  
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Biochemical Activity Homo sapiens
139 PRKCQ 5588
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
140 IRS1 3667
Affinity Capture-Western Homo sapiens
141 ESR1  
Co-localization Homo sapiens
142 DHX40  
Co-fractionation Homo sapiens
143 C10orf88  
Affinity Capture-MS Homo sapiens
144 E2F4  
Biochemical Activity Homo sapiens
145 MAGED1 9500
Affinity Capture-Western Homo sapiens
146 BCL2  
Affinity Capture-Western Homo sapiens
147 SASH1 23328
Affinity Capture-Western Homo sapiens
148 PRKCA 5578
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
149 MAP3K11 4296
Biochemical Activity Homo sapiens
150 CUL4A 8451
Affinity Capture-MS Homo sapiens
151 RPL27 6155
Two-hybrid Homo sapiens
152 GTF2E1 2960
Affinity Capture-MS Homo sapiens
153 SHARPIN  
Affinity Capture-Western Homo sapiens
154 EVA1B 55194
Affinity Capture-MS Homo sapiens
155 FAM96A  
Affinity Capture-MS Homo sapiens
156 NFKBIB  
Affinity Capture-MS Homo sapiens
Biochemical Activity Homo sapiens
Affinity Capture-Western Homo sapiens
Biochemical Activity Homo sapiens
157 PRKCB 5579
Co-localization Homo sapiens
158 ARRB2 409
Affinity Capture-MS Homo sapiens
Co-localization Homo sapiens
159 HSPA12A 259217
Affinity Capture-MS Homo sapiens
160 IKBKB 3551
Affinity Capture-Western Homo sapiens
Co-purification Homo sapiens
Co-purification Homo sapiens
Affinity Capture-Western Homo sapiens
Biochemical Activity Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Co-localization Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Co-purification Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Biochemical Activity Homo sapiens
Biochemical Activity Homo sapiens
Affinity Capture-Western Homo sapiens
Co-purification Homo sapiens
Co-fractionation Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
161 DHX29 54505
Co-fractionation Homo sapiens
162 KLHL21 9903
Affinity Capture-Western Homo sapiens
163 TRPC4AP  
Affinity Capture-Western Homo sapiens
164 EP300 2033
Co-localization Homo sapiens
165 FANCA  
Two-hybrid Homo sapiens
Affinity Capture-Western Homo sapiens
166 TRAF1 7185
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
View the network image/svg+xml
 Pathways in which CHUK is involved
PathwayEvidenceSource
Activation of NF-kappaB in B cells IEA Reactome
Activation of NF-kappaB in B cells TAS Reactome
Adaptive Immune System TAS Reactome
Adaptive Immune System IEA Reactome
AKT phosphorylates targets in the cytosol TAS Reactome
Antigen processing-Cross presentation TAS Reactome
Antiviral mechanism by IFN-stimulated genes TAS Reactome
C-type lectin receptors (CLRs) TAS Reactome
Cellular responses to mechanical stimuli TAS Reactome
Cellular responses to stimuli TAS Reactome
Class I MHC mediated antigen processing & presentation TAS Reactome
CLEC7A (Dectin-1) signaling TAS Reactome
Constitutive Signaling by AKT1 E17K in Cancer TAS Reactome
Cytokine Signaling in Immune system TAS Reactome
Cytosolic sensors of pathogen-associated DNA TAS Reactome
DDX58/IFIH1-mediated induction of interferon-alpha/beta TAS Reactome
Death Receptor Signaling TAS Reactome
Dectin-1 mediated noncanonical NF-kB signaling TAS Reactome
Disease TAS Reactome
Diseases associated with the TLR signaling cascade TAS Reactome
Diseases of Immune System TAS Reactome
Diseases of signal transduction by growth factor receptors and second messengers TAS Reactome
Downstream signaling events of B Cell Receptor (BCR) IEA Reactome
Downstream signaling events of B Cell Receptor (BCR) TAS Reactome
Downstream TCR signaling TAS Reactome
ER-Phagosome pathway TAS Reactome
Fc epsilon receptor (FCERI) signaling TAS Reactome
FCERI mediated NF-kB activation TAS Reactome
IkBA variant leads to EDA-ID TAS Reactome
IKBKB deficiency causes SCID TAS Reactome
IKBKG deficiency causes anhidrotic ectodermal dysplasia with immunodeficiency (EDA-ID) (via TLR) TAS Reactome
IKK complex recruitment mediated by RIP1 TAS Reactome
Immune System TAS Reactome
Immune System IEA Reactome
Infectious disease TAS Reactome
Innate Immune System TAS Reactome
Interferon Signaling TAS Reactome
Interleukin-1 family signaling TAS Reactome
Interleukin-1 signaling TAS Reactome
Interleukin-17 signaling TAS Reactome
Intracellular signaling by second messengers TAS Reactome
IRAK1 recruits IKK complex TAS Reactome
IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation TAS Reactome
MAP kinase activation TAS Reactome
MAP3K8 (TPL2)-dependent MAPK1/3 activation TAS Reactome
MyD88 cascade initiated on plasma membrane TAS Reactome
MyD88 dependent cascade initiated on endosome TAS Reactome
MyD88-independent TLR4 cascade TAS Reactome
MyD88:MAL(TIRAP) cascade initiated on plasma membrane TAS Reactome
NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10 TAS Reactome
NIK-->noncanonical NF-kB signaling TAS Reactome
NOD1/2 Signaling Pathway TAS Reactome
Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways TAS Reactome
PI3K/AKT Signaling in Cancer TAS Reactome
PIP3 activates AKT signaling TAS Reactome
PKR-mediated signaling TAS Reactome
Regulation of NF-kappa B signaling TAS Reactome
Regulation of TNFR1 signaling TAS Reactome
Response of endothelial cells to shear stress TAS Reactome
RIP-mediated NFkB activation via ZBP1 TAS Reactome
SARS-CoV Infections TAS Reactome
SARS-CoV-2 activates/modulates innate and adaptive immune responses TAS Reactome
SARS-CoV-2 Infection TAS Reactome
SARS-CoV-2-host interactions TAS Reactome
Signal Transduction TAS Reactome
Signaling by Interleukins TAS Reactome
Signaling by the B Cell Receptor (BCR) IEA Reactome
Signaling by the B Cell Receptor (BCR) TAS Reactome
SLC15A4:TASL-dependent IRF5 activation TAS Reactome
TAK1-dependent IKK and NF-kappa-B activation TAS Reactome
TCR signaling TAS Reactome
TICAM1, RIP1-mediated IKK complex recruitment TAS Reactome
TNF signaling TAS Reactome
TNFR1-induced NF-kappa-B signaling pathway TAS Reactome
TNFR2 non-canonical NF-kB pathway TAS Reactome
Toll Like Receptor 10 (TLR10) Cascade TAS Reactome
Toll Like Receptor 2 (TLR2) Cascade TAS Reactome
Toll Like Receptor 3 (TLR3) Cascade TAS Reactome
Toll Like Receptor 4 (TLR4) Cascade TAS Reactome
Toll Like Receptor 5 (TLR5) Cascade TAS Reactome
Toll Like Receptor 7/8 (TLR7/8) Cascade TAS Reactome
Toll Like Receptor 9 (TLR9) Cascade TAS Reactome
Toll Like Receptor TLR1:TLR2 Cascade TAS Reactome
Toll Like Receptor TLR6:TLR2 Cascade TAS Reactome
Toll-like Receptor Cascades TAS Reactome
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation TAS Reactome
TRAF6 mediated NF-kB activation TAS Reactome
TRIF (TICAM1)-mediated TLR4 signaling TAS Reactome
Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells TAS Reactome
Viral Infection Pathways TAS Reactome
ZBP1(DAI) mediated induction of type I IFNs TAS Reactome





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