Gene description for PAF1
Gene name Paf1, RNA polymerase II associated factor, homolog (S. cerevisiae)
Gene symbol PAF1
Other names/aliases F23149_1
PD2
Species Homo sapiens
 Database cross references - PAF1
ExoCarta ExoCarta_54623
Entrez Gene 54623
HGNC 25459
MIM 610506
UniProt Q8N7H5  
 PAF1 identified in exosomes derived from the following tissue/cell type
Thymus 23844026    
 Gene ontology annotations for PAF1
Molecular Function
    chromatin binding GO:0003682 IEA
    protein binding GO:0005515 IPI
    RNA polymerase II core binding GO:0000993 IDA
Biological Process
    negative regulation of myeloid cell differentiation GO:0045638 IDA
    endodermal cell fate commitment GO:0001711 ISS
    protein localization to nucleus GO:0034504 IMP
    positive regulation of histone methylation GO:0031062 IMP
    positive regulation of transcription from RNA polymerase II promoter GO:0045944 IDA
    positive regulation of transcription elongation from RNA polymerase II promoter GO:0032968 IDA
    positive regulation of mRNA 3'-end processing GO:0031442 IMP
    cellular response to lipopolysaccharide GO:0071222 ISS
    negative regulation of transcription from RNA polymerase II promoter GO:0000122 ISS
    Wnt signaling pathway GO:0016055 IEA
    mRNA polyadenylation GO:0006378 IMP
    histone monoubiquitination GO:0010390 IDA
    nucleosome positioning GO:0016584 IMP
    transcription, DNA-templated GO:0006351 IEA
    stem cell maintenance GO:0019827 IEA
    histone H2B ubiquitination GO:0033523 IDA
Subcellular Localization
    cytoplasm GO:0005737 IDA
    Cdc73/Paf1 complex GO:0016593 IDA
    membrane GO:0016020 IDA
 Experiment description of studies that identified PAF1 in exosomes
1
Experiment ID 217
ISEV standards
EM
EV Biophysical techniques
TSG101
EV Cytosolic markers
CD81|CD9|CD63
EV Membrane markers
EV Negative markers
NTA
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23844026    
Organism Homo sapiens
Experiment description Characterization of human thymic exosomes.
Authors Skogberg G, Gudmundsdottir J, van der Post S, Sandstrom K, Bruhn S, Benson M, Mincheva-Nilsson L, Baranov V, Telemo E, Ekwall O.
Journal name PLoS One
Publication year 2013
Sample Thymus
Sample name Normal-Thymus
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for PAF1
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which PAF1 is involved
No pathways found





Perform bioinformatics analysis of your extracellular vesicle data set using FunRich, a open access standalone tool. NEW UPDATED VERSION OF FunRich available for download (12/09/2016) from here