Gene description for MLLT3
Gene name myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 3
Gene symbol MLLT3
Other names/aliases AF9
YEATS3
Species Homo sapiens
 Database cross references - MLLT3
ExoCarta ExoCarta_4300
Vesiclepedia VP_4300
Entrez Gene 4300
HGNC 7136
MIM 159558
UniProt P42568  
 MLLT3 identified in exosomes derived from the following tissue/cell type
Urine 19056867    
 Gene ontology annotations for MLLT3
Molecular Function
    DNA binding GO:0003677 IEA
    chromatin binding GO:0003682 IBA
    chromatin binding GO:0003682 IDA
    protein binding GO:0005515 IPI
    histone binding GO:0042393 IDA
    molecular adaptor activity GO:0060090 EXP
    lysine-acetylated histone binding GO:0070577 IBA
    lysine-acetylated histone binding GO:0070577 IDA
    modification-dependent protein binding GO:0140030 IDA
Biological Process
    segment specification GO:0007379 IEA
    anterior/posterior pattern specification GO:0009952 IEA
    gene expression GO:0010467 IEA
    positive regulation of DNA-templated transcription GO:0045893 IBA
    positive regulation of DNA-templated transcription GO:0045893 IDA
    hematopoietic stem cell differentiation GO:0060218 IDA
    negative regulation of canonical Wnt signaling pathway GO:0090090 IDA
    negative regulation of canonical Wnt signaling pathway GO:0090090 IGI
    regulation of chromatin organization GO:1902275 IMP
    regulation of stem cell division GO:2000035 IDA
    positive regulation of Wnt signaling pathway, planar cell polarity pathway GO:2000096 IGI
Subcellular Localization
    nucleus GO:0005634 TAS
    nucleoplasm GO:0005654 IDA
    nucleoplasm GO:0005654 TAS
    chromosome GO:0005694 IEA
    cytosol GO:0005829 IDA
    transcription elongation factor complex GO:0008023 IBA
    transcription elongation factor complex GO:0008023 IDA
    extracellular exosome GO:0070062 HDA
 Experiment description of studies that identified MLLT3 in exosomes
1
Experiment ID 63
MISEV standards
Biophysical techniques
AQP2
Enriched markers
Negative markers
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 19056867    
Organism Homo sapiens
Experiment description Large-scale proteomics and phosphoproteomics of urinary exosomes.
Authors "Gonzales PA, Pisitkun T, Hoffert JD, Tchapyjnikov D, Star RA, Kleta R, Wang NS, Knepper MA"
Journal name JASN
Publication year 2009
Sample Urine
Sample name Urine - Normal
Isolation/purification methods Differential centrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry [LTQ]
Western blotting
 Protein-protein interactions for MLLT3
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 APP 351
Reconstituted Complex Homo sapiens
2 ELL2 22936
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
3 CAMKV 79012
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
4 PLCD4  
Affinity Capture-MS Homo sapiens
5 PTN  
Two-hybrid Homo sapiens
6 ARRB2 409
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
7 H3F3A 3020
Reconstituted Complex Homo sapiens
Co-crystal Structure Homo sapiens
Affinity Capture-Western Homo sapiens
8 FGF11  
Affinity Capture-MS Homo sapiens
9 MLLT1 4298
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
10 RNF151  
Affinity Capture-MS Homo sapiens
11 SGK1  
Biochemical Activity Homo sapiens
12 SNX24  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
13 COIL  
Proximity Label-MS Homo sapiens
14 KMT2A  
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
15 CEP89 84902
Affinity Capture-MS Homo sapiens
16 EXOSC3 51010
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
17 PES1 23481
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
18 XPO1 7514
Affinity Capture-MS Homo sapiens
19 MDK 4192
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
20 EPB41L3 23136
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
21 FGF12  
Affinity Capture-MS Homo sapiens
22 EEF2 1938
Affinity Capture-MS Homo sapiens
23 PAF1 54623
Affinity Capture-Western Homo sapiens
24 EPB41L5 57669
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
25 PCGF1 84759
Affinity Capture-MS Homo sapiens
26 PLCD3 113026
Affinity Capture-MS Homo sapiens
27 MIIP 60672
Two-hybrid Homo sapiens
Affinity Capture-MS Homo sapiens
28 SKP1 6500
Affinity Capture-MS Homo sapiens
29 EEF1A1 1915
Two-hybrid Homo sapiens
30 RASA2 5922
Affinity Capture-MS Homo sapiens
31 CHD4 1108
Affinity Capture-MS Homo sapiens
32 AFF1  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
33 CDK6 1021
Biochemical Activity Homo sapiens
34 EPB41L2 2037
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
35 RBM48  
Two-hybrid Homo sapiens
36 HSP90B1 7184
Affinity Capture-Western Homo sapiens
Co-localization Homo sapiens
Affinity Capture-MS Homo sapiens
Reconstituted Complex Homo sapiens
37 DOT1L 84444
Two-hybrid Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Co-localization Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
38 EPB41L1 2036
Affinity Capture-MS Homo sapiens
39 LRIF1  
Two-hybrid Homo sapiens
40 APPBP2  
Two-hybrid Homo sapiens
41 ELL  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
42 ELL3  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
43 KCNE3  
Affinity Capture-MS Homo sapiens
44 PIP4K2A 5305
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
45 EDA  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
46 Cbx8  
Affinity Capture-Western Mus musculus
Two-hybrid Mus musculus
47 SULF2 55959
Affinity Capture-MS Homo sapiens
48 SMOC1 64093
Affinity Capture-MS Homo sapiens
49 FAM9A  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Two-hybrid Homo sapiens
50 DENND2D  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
51 DYRK1A 1859
Affinity Capture-MS Homo sapiens
52 AFF4 27125
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
53 ALKBH4  
Two-hybrid Homo sapiens
54 EAF1  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
55 MLLT10  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
56 BPIFB1 92747
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
57 ZNF572  
Two-hybrid Homo sapiens
58 NIPBL 25836
Affinity Capture-MS Homo sapiens
59 CCNT2  
Affinity Capture-MS Homo sapiens
60 Mllt1  
Affinity Capture-MS Mus musculus
61 NDUFAF4 29078
Affinity Capture-MS Homo sapiens
62 RNF2  
Affinity Capture-MS Homo sapiens
63 CT45A5  
Affinity Capture-MS Homo sapiens
64 ACACA 31
Affinity Capture-MS Homo sapiens
65 VAX1  
Two-hybrid Homo sapiens
66 SIRT1  
Affinity Capture-MS Homo sapiens
67 MCM6 4175
Two-hybrid Homo sapiens
68 SYT2  
Affinity Capture-MS Homo sapiens
69 CDK9 1025
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
70 AFF3  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
71 Aff1  
Affinity Capture-MS Mus musculus
72 LRRK2 120892
Reconstituted Complex Homo sapiens
73 DAXX  
Affinity Capture-MS Homo sapiens
74 TULP3 7289
Affinity Capture-MS Homo sapiens
75 MLLT6  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
76 CCNT1  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
77 CREB3L3  
Affinity Capture-MS Homo sapiens
78 BCOR  
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
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