Gene description for MLLT3
Gene name myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 3
Gene symbol MLLT3
Other names/aliases AF9
YEATS3
Species Homo sapiens
 Database cross references - MLLT3
ExoCarta ExoCarta_4300
Entrez Gene 4300
HGNC 7136
MIM 159558
UniProt P42568  
 MLLT3 identified in exosomes derived from the following tissue/cell type
Urine 19056867    
 Gene ontology annotations for MLLT3
Molecular Function
    protein binding GO:0005515 IPI
Biological Process
    segment specification GO:0007379 IEA
    regulation of transcription, DNA-templated GO:0006355 IEA
    negative regulation of canonical Wnt signaling pathway GO:0090090 IGI
    transcription, DNA-templated GO:0006351 IEA
    anterior/posterior pattern specification GO:0009952 IEA
    positive regulation of Wnt signaling pathway, planar cell polarity pathway GO:2000096 IGI
Subcellular Localization
    nucleus GO:0005634 TAS
    transcription elongation factor complex GO:0008023 IDA
    extracellular exosome GO:0070062 IDA
 Experiment description of studies that identified MLLT3 in exosomes
1
Experiment ID 63
ISEV standards
EV Biophysical techniques
EV Cytosolic markers
AQP2
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 19056867    
Organism Homo sapiens
Experiment description Large-scale proteomics and phosphoproteomics of urinary exosomes.
Authors Gonzales PA, Pisitkun T, Hoffert JD, Tchapyjnikov D, Star RA, Kleta R, Wang NS, Knepper MA
Journal name JASN
Publication year 2009
Sample Urine
Sample name Urine - Normal
Isolation/purification methods Differential centrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry [LTQ]
Western blotting
 Protein-protein interactions for MLLT3
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 DKFZP564O0523  
Two-hybrid Homo sapiens
2 APPBP2  
Two-hybrid Homo sapiens
3 PTN  
Two-hybrid Homo sapiens
4 MCM6 4175
Two-hybrid Homo sapiens
5 EEF1A1 1915
Two-hybrid Homo sapiens
6 RIF1  
Two-hybrid Homo sapiens
7 BCOR  
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
View the network image/svg+xml
 Pathways in which MLLT3 is involved
No pathways found





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