Gene description for ELL2
Gene name elongation factor, RNA polymerase II, 2
Gene symbol ELL2
Other names/aliases -
Species Homo sapiens
 Database cross references - ELL2
ExoCarta ExoCarta_22936
Entrez Gene 22936
HGNC 17064
MIM 601874
UniProt O00472  
 ELL2 identified in exosomes derived from the following tissue/cell type
Hepatocytes 26054723    
 Gene ontology annotations for ELL2
Biological Process
    transcription elongation from RNA polymerase II promoter GO:0006368 IEA
    regulation of transcription, DNA-templated GO:0006355 IEA
    snRNA transcription from RNA polymerase II promoter GO:0042795 IMP
Subcellular Localization
    nucleoplasm GO:0005654 IDA
    centrosome GO:0005813 IDA
    cytoplasm GO:0005737 IDA
    transcription elongation factor complex GO:0008023 IDA
 Experiment description of studies that identified ELL2 in exosomes
1
Experiment ID 237
ISEV standards
EM
EV Biophysical techniques
TSG101|Alix|HSC70|GAPDH
EV Cytosolic markers
EV Membrane markers
HSP90B1
EV Negative markers
qNano
EV Particle analysis
Identified molecule mRNA
Identification method RNA Sequencing
PubMed ID 26054723    
Organism Homo sapiens
Experiment description Hepatocellular carcinoma-derived exosomes promote motility of immortalized hepatocyte through transfer of oncogenic proteins and RNAs
Authors He M, Qin H, Poon TC, Sze SC, Ding X, Co NN, Ngai SM, Chan TF, Wong N
Journal name Carcinogenesis
Publication year 2015
Sample Hepatocytes
Sample name MIHA
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.13-1.19 g/mL
Molecules identified in the study Protein
RNA
Methods used in the study Western blotting
Mass spectrometry
RNA Sequencing
 Protein-protein interactions for ELL2
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 EAF1  
Affinity Capture-Western Homo sapiens
View the network image/svg+xml
 Pathways in which ELL2 is involved
No pathways found





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