Gene description for CTR9
Gene name CTR9, Paf1/RNA polymerase II complex component
Gene symbol CTR9
Other names/aliases SH2BP1
TSBP
p150
p150TSP
Species Homo sapiens
 Database cross references - CTR9
ExoCarta ExoCarta_9646
Vesiclepedia VP_9646
Entrez Gene 9646
HGNC 16850
MIM 609366
UniProt Q6PD62  
 CTR9 identified in exosomes derived from the following tissue/cell type
Mesenchymal stem cells 36408942    
Thymus 23844026    
 Gene ontology annotations for CTR9
Molecular Function
    RNA polymerase II complex binding GO:0000993 IBA
    protein binding GO:0005515 IPI
    SH2 domain binding GO:0042169 IEA
Biological Process
    negative regulation of transcription by RNA polymerase II GO:0000122 ISS
    endodermal cell fate commitment GO:0001711 ISS
    inner cell mass cell differentiation GO:0001826 IEA
    trophectodermal cell differentiation GO:0001829 IEA
    blastocyst growth GO:0001832 IEA
    blastocyst hatching GO:0001835 IEA
    transcription elongation by RNA polymerase II GO:0006368 IBA
    transcription elongation by RNA polymerase II GO:0006368 IDA
    cell surface receptor signaling pathway via JAK-STAT GO:0007259 ISS
    Wnt signaling pathway GO:0016055 IEA
    stem cell population maintenance GO:0019827 IDA
    negative regulation of myeloid cell differentiation GO:0045638 IDA
    negative regulation of gene expression, epigenetic GO:0045814 IEA
    positive regulation of transcription by RNA polymerase II GO:0045944 IDA
    interleukin-6-mediated signaling pathway GO:0070102 ISS
    cellular response to lipopolysaccharide GO:0071222 ISS
Subcellular Localization
    euchromatin GO:0000791 ISS
    nucleoplasm GO:0005654 IDA
    nucleoplasm GO:0005654 TAS
    Cdc73/Paf1 complex GO:0016593 IBA
    Cdc73/Paf1 complex GO:0016593 IDA
    nuclear speck GO:0016607 IEA
 Experiment description of studies that identified CTR9 in exosomes
1
Experiment ID 488
MISEV standards
✔
EM
Biophysical techniques
✔
CD9|CD81|CD63|GAPDH|SDCBP|LAMP1|TFRC|UCHL1|FLOT2|LAMP2|FLOT1|ICAM1|RAB5B|CD151|RAB35|TSG101|RAB5A|CD82
Enriched markers
✔
CANX
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Homo sapiens
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Mesenchymal stem cells
Sample name UCMSC
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
2
Experiment ID 217
MISEV standards
✔
EM
Biophysical techniques
✔
TSG101|CD81|CD9|CD63
Enriched markers
✘ Negative markers
✔
NTA
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23844026    
Organism Homo sapiens
Experiment description Characterization of human thymic exosomes.
Authors "Skogberg G, Gudmundsdottir J, van der Post S, Sandstrom K, Bruhn S, Benson M, Mincheva-Nilsson L, Baranov V, Telemo E, Ekwall O."
Journal name PLoS One
Publication year 2013
Sample Thymus
Sample name Normal-Thymus
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for CTR9
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 SIAH1  
Two-hybrid Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
2 UBE2H 7328
Affinity Capture-MS Homo sapiens
3 ADRBK1 156
Affinity Capture-MS Homo sapiens
4 DGCR8  
Affinity Capture-MS Homo sapiens
5 HIST2H2BE 8349
Affinity Capture-MS Homo sapiens
6 RIT1 6016
Negative Genetic Homo sapiens
7 EIF4G3 8672
Affinity Capture-MS Homo sapiens
8 POLR2G 5436
Affinity Capture-MS Homo sapiens
9 MYLIP  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
10 TCEB1 6921
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
11 COIL  
Proximity Label-MS Homo sapiens
12 DNAJC8 22826
Proximity Label-MS Homo sapiens
13 TOP2B 7155
Cross-Linking-MS (XL-MS) Homo sapiens
14 ARHGAP26 23092
Affinity Capture-MS Homo sapiens
15 FKBP15 23307
Affinity Capture-MS Homo sapiens
16 DHX8 1659
Proximity Label-MS Homo sapiens
17 ERGIC1 57222
Affinity Capture-MS Homo sapiens
18 APBA3  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
19 CSNK2A1 1457
Co-fractionation Homo sapiens
20 PPP1R10  
Affinity Capture-MS Homo sapiens
21 SNRPF 6636
Affinity Capture-MS Homo sapiens
22 TACC2 10579
Affinity Capture-MS Homo sapiens
23 DNAJB6 10049
Proximity Label-MS Homo sapiens
24 TCEA1 6917
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
25 TCEB3 6924
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
26 C9orf78 51759
Affinity Capture-MS Homo sapiens
27 DDX23 9416
Proximity Label-MS Homo sapiens
28 MBIP  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
29 Pip4k2c  
Affinity Capture-MS Mus musculus
30 TAOK3 51347
Affinity Capture-MS Homo sapiens
31 AFF4 27125
Affinity Capture-MS Homo sapiens
32 PPP2R5D 5528
Affinity Capture-MS Homo sapiens
33 NFIC 4782
Affinity Capture-MS Homo sapiens
34 STAT3 6774
Affinity Capture-Western Homo sapiens
35 SNRPC 6631
Affinity Capture-MS Homo sapiens
36 CNTNAP2  
Two-hybrid Homo sapiens
37 ELOF1  
Affinity Capture-MS Homo sapiens
38 POLR1E  
Proximity Label-MS Homo sapiens
39 SYT2  
Affinity Capture-MS Homo sapiens
40 SUGP1  
Affinity Capture-MS Homo sapiens
41 TCEANC2  
Affinity Capture-MS Homo sapiens
42 SLX4  
Affinity Capture-MS Homo sapiens
43 LEO1 123169
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Co-fractionation Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Co-fractionation Homo sapiens
Affinity Capture-MS Homo sapiens
44 POLR2C 5432
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
45 PMS2  
Affinity Capture-MS Homo sapiens
46 SERF2 10169
Affinity Capture-MS Homo sapiens
47 TULP2  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
48 CSNK2B 1460
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
49 YAF2  
Affinity Capture-MS Homo sapiens
50 GAR1 54433
Affinity Capture-MS Homo sapiens
51 YWHAB 7529
Affinity Capture-MS Homo sapiens
52 CHD1 1105
Co-fractionation Homo sapiens
53 KLF16  
Affinity Capture-MS Homo sapiens
54 HMGA1 3159
Affinity Capture-MS Homo sapiens
55 VEZF1  
Affinity Capture-MS Homo sapiens
56 HIST1H4A 8359
Affinity Capture-MS Homo sapiens
57 DDX21 9188
Affinity Capture-MS Homo sapiens
58 PARK2  
Affinity Capture-MS Homo sapiens
59 SUPT5H 6829
Co-fractionation Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
60 ACACA 31
Affinity Capture-MS Homo sapiens
61 DNMT3A 1788
Affinity Capture-MS Homo sapiens
62 RTF1 23168
Affinity Capture-Western Homo sapiens
Co-fractionation Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Co-fractionation Homo sapiens
63 WDR61 80349
Affinity Capture-Western Homo sapiens
Co-fractionation Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
64 IWS1  
Co-fractionation Homo sapiens
Affinity Capture-MS Homo sapiens
65 RCCD1  
Affinity Capture-MS Homo sapiens
66 SREBF2 6721
Negative Genetic Homo sapiens
67 C9orf72  
Affinity Capture-MS Homo sapiens
68 ATP9A 10079
Affinity Capture-MS Homo sapiens
69 NTRK1 4914
Affinity Capture-MS Homo sapiens
70 FOXK2  
Affinity Capture-MS Homo sapiens
71 HIST1H1E 3008
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
72 RAD18  
Affinity Capture-MS Homo sapiens
73 TOX4  
Affinity Capture-MS Homo sapiens
74 ALDH3B1 221
Affinity Capture-MS Homo sapiens
75 HIST1H1C 3006
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
76 COG3 83548
Co-fractionation Homo sapiens
77 GSG2  
Affinity Capture-MS Homo sapiens
78 POLR2B 5431
Affinity Capture-MS Homo sapiens
79 TMEM131  
Affinity Capture-MS Homo sapiens
80 SUPT6H 6830
Affinity Capture-MS Homo sapiens
81 LYPD4  
Affinity Capture-MS Homo sapiens
82 PRPF31 26121
Affinity Capture-MS Homo sapiens
83 CEBPA  
Proximity Label-MS Homo sapiens
84 CCNT1  
Affinity Capture-MS Homo sapiens
85 ACSS2 55902
Affinity Capture-MS Homo sapiens
86 CD3EAP  
Proximity Label-MS Homo sapiens
87 ELL2 22936
Affinity Capture-MS Homo sapiens
88 ANLN 54443
Affinity Capture-MS Homo sapiens
89 RPRD2  
Affinity Capture-MS Homo sapiens
90 PTPN11 5781
Affinity Capture-Western Homo sapiens
Proximity Label-MS Homo sapiens
91 HIST1H3A 8350
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
92 KMT2A  
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
93 CDC73  
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Co-fractionation Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Co-fractionation Homo sapiens
Co-fractionation Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
94 CIAO1 9391
Affinity Capture-MS Homo sapiens
95 XPO1 7514
Affinity Capture-MS Homo sapiens
96 SNAPC4  
Affinity Capture-MS Homo sapiens
97 NCAPH2  
Affinity Capture-MS Homo sapiens
98 SNRPB 6628
Affinity Capture-MS Homo sapiens
99 POLR1D 51082
Affinity Capture-MS Homo sapiens
100 MYH14 79784
Co-fractionation Homo sapiens
101 ANO3  
Affinity Capture-MS Homo sapiens
102 NFS1 9054
Affinity Capture-MS Homo sapiens
103 ACTBL2 345651
Affinity Capture-MS Homo sapiens
104 SGOL1  
Affinity Capture-MS Homo sapiens
105 UBE2E1  
Affinity Capture-Western Homo sapiens
106 AKR7A2 8574
Affinity Capture-MS Homo sapiens
107 LYZL1  
Affinity Capture-MS Homo sapiens
108 FUS 2521
Affinity Capture-MS Homo sapiens
109 METTL21B  
Affinity Capture-MS Homo sapiens
110 POLR2A 5430
Affinity Capture-MS Homo sapiens
111 HNRNPCL2 440563
Affinity Capture-MS Homo sapiens
112 NXF1 10482
Affinity Capture-RNA Homo sapiens
113 G6PD 2539
Affinity Capture-MS Homo sapiens
114 POLR2D  
Affinity Capture-MS Homo sapiens
115 AGO4  
Affinity Capture-MS Homo sapiens
116 DNMT3B  
Affinity Capture-MS Homo sapiens
117 MYC  
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
118 HECW2  
Affinity Capture-MS Homo sapiens
119 SMAD9  
Two-hybrid Homo sapiens
120 ZC3H18  
Affinity Capture-MS Homo sapiens
121 DNAJC9 23234
Proximity Label-MS Homo sapiens
122 ING5  
Affinity Capture-MS Homo sapiens
123 MAPKAP1 79109
Affinity Capture-MS Homo sapiens
124 TOP1 7150
Affinity Capture-MS Homo sapiens
125 RPL12 6136
Co-fractionation Homo sapiens
126 ZFP91 80829
Affinity Capture-MS Homo sapiens
127 HIST1H1A 3024
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
128 TCEB2 6923
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
129 CETN2 1069
Affinity Capture-MS Homo sapiens
130 NEUROG3  
Affinity Capture-MS Homo sapiens
131 FGD6  
Affinity Capture-MS Homo sapiens
132 PXK 54899
Affinity Capture-MS Homo sapiens
133 SUPT16H 11198
Co-fractionation Homo sapiens
Co-fractionation Homo sapiens
134 Paf1 54624
Affinity Capture-Western Mus musculus
135 KRT18 3875
Cross-Linking-MS (XL-MS) Homo sapiens
136 FN1 2335
Affinity Capture-MS Homo sapiens
137 ELL  
Affinity Capture-MS Homo sapiens
138 PLEKHA4 57664
Affinity Capture-MS Homo sapiens
139 FASN 2194
Negative Genetic Homo sapiens
140 POLR2F  
Affinity Capture-MS Homo sapiens
141 SIRT6  
Affinity Capture-MS Homo sapiens
142 PARP1 142
Proximity Label-MS Homo sapiens
Proximity Label-MS Homo sapiens
143 CPSF6 11052
Affinity Capture-MS Homo sapiens
144 TRIM52  
Affinity Capture-MS Homo sapiens
145 SNRPA 6626
Affinity Capture-MS Homo sapiens
146 SOX4  
Two-hybrid Homo sapiens
147 PRSS23 11098
Affinity Capture-MS Homo sapiens
148 SHMT2 6472
Affinity Capture-MS Homo sapiens
149 RABL6 55684
Co-fractionation Homo sapiens
150 MAGEA9  
Affinity Capture-MS Homo sapiens
151 DDX58 23586
Affinity Capture-RNA Homo sapiens
152 CHD2 1106
Co-fractionation Homo sapiens
153 DHX40  
Proximity Label-MS Homo sapiens
154 Rprd1b  
Affinity Capture-MS Mus musculus
155 PSMA5 5686
Affinity Capture-MS Homo sapiens
156 INF2 64423
Affinity Capture-MS Homo sapiens
157 FAM161A  
Affinity Capture-MS Homo sapiens
158 CDK9 1025
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
159 CIT 11113
Affinity Capture-MS Homo sapiens
160 BEX1  
Affinity Capture-MS Homo sapiens
161 NDEL1 81565
Affinity Capture-MS Homo sapiens
162 PTGES3 10728
Affinity Capture-MS Homo sapiens
163 KRAS 3845
Negative Genetic Homo sapiens
164 DNAJC17  
Proximity Label-MS Homo sapiens
165 AR 367
Proximity Label-MS Homo sapiens
166 SRP9 6726
Affinity Capture-MS Homo sapiens
167 PAF1 54623
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Co-fractionation Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Co-fractionation Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
168 SSRP1 6749
Affinity Capture-MS Homo sapiens
Co-fractionation Homo sapiens
169 RPA3 6119
Proximity Label-MS Homo sapiens
170 RPP38 10557
Affinity Capture-MS Homo sapiens
171 CDK11A 728642
Co-fractionation Homo sapiens
172 EP300 2033
Affinity Capture-MS Homo sapiens
173 TJAP1 93643
Affinity Capture-MS Homo sapiens
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