Gene description for CTR9
Gene name CTR9, Paf1/RNA polymerase II complex component
Gene symbol CTR9
Other names/aliases SH2BP1
TSBP
p150
p150TSP
Species Homo sapiens
 Database cross references - CTR9
ExoCarta ExoCarta_9646
Entrez Gene 9646
HGNC 16850
MIM 609366
UniProt Q6PD62  
 CTR9 identified in exosomes derived from the following tissue/cell type
Thymus 23844026    
 Gene ontology annotations for CTR9
Molecular Function
    protein binding GO:0005515 IPI
    RNA polymerase II core binding GO:0000993 IBA
    SH2 domain binding GO:0042169 IEA
Biological Process
    negative regulation of mRNA polyadenylation GO:1900364 IMP
    positive regulation of histone H3-K4 methylation GO:0051571 IMP
    stem cell maintenance GO:0019827 IDA
    histone H2B ubiquitination GO:0033523 IDA
    endodermal cell fate commitment GO:0001711 ISS
    negative regulation of myeloid cell differentiation GO:0045638 IDA
    positive regulation of transcription from RNA polymerase II promoter GO:0045944 IDA
    cellular response to lipopolysaccharide GO:0071222 ISS
    histone monoubiquitination GO:0010390 IDA
    histone H3-K4 trimethylation GO:0080182 IMP
    positive regulation of histone H2B ubiquitination GO:2001168 IMP
    positive regulation of transcription elongation from RNA polymerase II promoter GO:0032968 IDA
    interleukin-6-mediated signaling pathway GO:0070102 ISS
    transcription, DNA-templated GO:0006351 IEA
    Wnt signaling pathway GO:0016055 IEA
    negative regulation of transcription from RNA polymerase II promoter GO:0000122 ISS
    JAK-STAT cascade GO:0007259 ISS
    positive regulation of histone H3-K79 methylation GO:2001162 IMP
Subcellular Localization
    transcriptionally active chromatin GO:0035327 ISS
    nuclear speck GO:0016607 IEA
    Cdc73/Paf1 complex GO:0016593 IDA
 Experiment description of studies that identified CTR9 in exosomes
1
Experiment ID 217
ISEV standards
EM
EV Biophysical techniques
TSG101
EV Cytosolic markers
CD81|CD9|CD63
EV Membrane markers
EV Negative markers
NTA
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23844026    
Organism Homo sapiens
Experiment description Characterization of human thymic exosomes.
Authors Skogberg G, Gudmundsdottir J, van der Post S, Sandstrom K, Bruhn S, Benson M, Mincheva-Nilsson L, Baranov V, Telemo E, Ekwall O.
Journal name PLoS One
Publication year 2013
Sample Thymus
Sample name Normal-Thymus
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for CTR9
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 BLK 640
Invitro Homo sapiens
View the network image/svg+xml
 Pathways in which CTR9 is involved
No pathways found





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