Gene description for COG3
Gene name component of oligomeric golgi complex 3
Gene symbol COG3
Other names/aliases SEC34
Species Homo sapiens
 Database cross references - COG3
ExoCarta ExoCarta_83548
Entrez Gene 83548
HGNC 18619
MIM 606975
UniProt Q96JB2  
 COG3 identified in exosomes derived from the following tissue/cell type
Hepatocytes 26054723    
Thymus 23844026    
 Gene ontology annotations for COG3
Molecular Function
    protein transporter activity GO:0008565 IDA
    protein binding GO:0005515 IPI
Biological Process
    intra-Golgi vesicle-mediated transport GO:0006891 IDA
    protein stabilization GO:0050821 IMP
    retrograde vesicle-mediated transport, Golgi to ER GO:0006890 IMP
    ER to Golgi vesicle-mediated transport GO:0006888 IDA
    Golgi organization GO:0007030 IMP
    protein glycosylation GO:0006486 IMP
    intracellular protein transport GO:0006886 IEA
    retrograde transport, vesicle recycling within Golgi GO:0000301 IBA
    protein localization to organelle GO:0033365 IMP
Subcellular Localization
    Golgi apparatus GO:0005794 IDA
    cis-Golgi network GO:0005801 IEA
    Golgi transport complex GO:0017119 IDA
    cytoplasm GO:0005737 IDA
    nucleoplasm GO:0005654 IDA
    Golgi cisterna membrane GO:0032580 IEA
    plasma membrane GO:0005886 IDA
 Experiment description of studies that identified COG3 in exosomes
1
Experiment ID 237
ISEV standards
EM
EV Biophysical techniques
TSG101|Alix|HSC70|GAPDH
EV Cytosolic markers
EV Membrane markers
HSP90B1
EV Negative markers
qNano
EV Particle analysis
Identified molecule mRNA
Identification method RNA Sequencing
PubMed ID 26054723    
Organism Homo sapiens
Experiment description Hepatocellular carcinoma-derived exosomes promote motility of immortalized hepatocyte through transfer of oncogenic proteins and RNAs
Authors He M, Qin H, Poon TC, Sze SC, Ding X, Co NN, Ngai SM, Chan TF, Wong N
Journal name Carcinogenesis
Publication year 2015
Sample Hepatocytes
Sample name MIHA
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.13-1.19 g/mL
Molecules identified in the study Protein
RNA
Methods used in the study Western blotting
Mass spectrometry
RNA Sequencing
2
Experiment ID 217
ISEV standards
EM
EV Biophysical techniques
TSG101
EV Cytosolic markers
CD81|CD9|CD63
EV Membrane markers
EV Negative markers
NTA
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23844026    
Organism Homo sapiens
Experiment description Characterization of human thymic exosomes.
Authors Skogberg G, Gudmundsdottir J, van der Post S, Sandstrom K, Bruhn S, Benson M, Mincheva-Nilsson L, Baranov V, Telemo E, Ekwall O.
Journal name PLoS One
Publication year 2013
Sample Thymus
Sample name Normal-Thymus
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for COG3
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 COG1 9382
Invivo Homo sapiens
Invivo Homo sapiens
2 COG2 22796
Invivo Homo sapiens
Invivo Homo sapiens
Invitro Homo sapiens
Invitro Homo sapiens
View the network image/svg+xml
 Pathways in which COG3 is involved
No pathways found





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