Gene description for ZDHHC17
Gene name zinc finger, DHHC-type containing 17
Gene symbol ZDHHC17
Other names/aliases HIP14
HIP3
HSPC294
HYPH
Species Homo sapiens
 Database cross references - ZDHHC17
ExoCarta ExoCarta_23390
Vesiclepedia VP_23390
Entrez Gene 23390
HGNC 18412
MIM 607799
UniProt Q8IUH5  
 ZDHHC17 identified in exosomes derived from the following tissue/cell type
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Retinal pigment epithelial cells 35333565    
Retinal pigment epithelial cells 35333565    
 Gene ontology annotations for ZDHHC17
Molecular Function
    signaling receptor binding GO:0005102 IEA
    protein binding GO:0005515 IPI
    palmitoyltransferase activity GO:0016409 IDA
    palmitoyltransferase activity GO:0016409 IMP
    protein-cysteine S-myristoyltransferase activity GO:0019705 IEA
    protein-cysteine S-palmitoyltransferase activity GO:0019706 IDA
    identical protein binding GO:0042802 IPI
    protein-cysteine S-stearoyltransferase activity GO:0140439 IEA
Biological Process
    axonogenesis GO:0007409 IBA
    axonogenesis GO:0007409 ISS
    protein palmitoylation GO:0018345 IDA
    protein palmitoylation GO:0018345 IMP
    lipoprotein transport GO:0042953 IDA
    regulation of programmed cell death GO:0043067 IDA
    positive regulation of canonical NF-kappaB signal transduction GO:0043123 HMP
    regulation of neurotrophin TRK receptor signaling pathway GO:0051386 ISS
    regulation of ERK1 and ERK2 cascade GO:0070372 ISS
    regulation of modification of synapse structure, modulating synaptic transmission GO:0098987 IEA
Subcellular Localization
    Golgi membrane GO:0000139 IDA
    Golgi apparatus GO:0005794 IDA
    Golgi-associated vesicle membrane GO:0030660 IDA
    presynaptic membrane GO:0042734 IEA
    cell projection GO:0042995 IEA
    intracellular membrane-bounded organelle GO:0043231 IDA
    glutamatergic synapse GO:0098978 IEA
    perforant pathway to dendrate granule cell synapse GO:0140240 IEA
    postsynaptic Golgi apparatus GO:0150051 IEA
 Experiment description of studies that identified ZDHHC17 in exosomes
1
Experiment ID 489
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 6
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
2
Experiment ID 490
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 7
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
3
Experiment ID 491
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 8
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
4
Experiment ID 492
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 9
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
5
Experiment ID 834
MISEV standards
✔
EM
Biophysical techniques
✔
LAMP2|CD63|FLOT1|ITGA2B|ICAM1|CD9|CD151|TFRC|RAB5A|GAPDH|AQP1|TSG101
Enriched markers
✔
CANX
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 35333565    
Organism Homo sapiens
Experiment description LAMP2A regulates the loading of proteins into exosomes
Authors "Ferreira JV, da Rosa Soares A, Ramalho J, Máximo Carvalho C, Cardoso MH, Pintado P, Carvalho AS, Beck HC, Matthiesen R, Zuzarte M, Girão H, van Niel G, Pereira P"
Journal name Sci Adv
Publication year 2022
Sample Retinal pigment epithelial cells
Sample name ARPE-19
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
6
Experiment ID 835
MISEV standards
✔
EM
Biophysical techniques
✔
CD63|FLOT1|ITGA2B|ICAM1|CD9|CD151|TFRC|RAB5A|GAPDH|AQP1|TSG101
Enriched markers
✔
CANX
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 35333565    
Organism Homo sapiens
Experiment description LAMP2A regulates the loading of proteins into exosomes
Authors "Ferreira JV, da Rosa Soares A, Ramalho J, Máximo Carvalho C, Cardoso MH, Pintado P, Carvalho AS, Beck HC, Matthiesen R, Zuzarte M, Girão H, van Niel G, Pereira P"
Journal name Sci Adv
Publication year 2022
Sample Retinal pigment epithelial cells
Sample name ARPE-19
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
 Protein-protein interactions for ZDHHC17
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 TACR3  
Affinity Capture-MS Homo sapiens
2 CBS 875
Two-hybrid Homo sapiens
3 MYBPHL  
Two-hybrid Homo sapiens
4 GPM6A 2823
Affinity Capture-Western Homo sapiens
Two-hybrid Homo sapiens
Affinity Capture-Western Homo sapiens
5 F11R 50848
Affinity Capture-MS Homo sapiens
6 GATA1  
Two-hybrid Homo sapiens
7 CCNE2  
Two-hybrid Homo sapiens
8 NCBP1 4686
Two-hybrid Homo sapiens
9 CNKSR1  
Two-hybrid Homo sapiens
10 TOX  
Two-hybrid Homo sapiens
11 ACRBP  
Affinity Capture-MS Homo sapiens
12 KRTAP11-1  
Two-hybrid Homo sapiens
13 ZNF341  
Two-hybrid Homo sapiens
14 KLK8 11202
Two-hybrid Homo sapiens
Affinity Capture-Western Homo sapiens
15 EEF1G 1937
Two-hybrid Homo sapiens
16 SNAP23 8773
Two-hybrid Homo sapiens
Affinity Capture-Western Homo sapiens
17 TNFSF10 8743
Two-hybrid Homo sapiens
18 SPRED2 200734
Affinity Capture-MS Homo sapiens
Two-hybrid Homo sapiens
Affinity Capture-Western Homo sapiens
19 MSRB2  
Two-hybrid Homo sapiens
20 PTMA 5757
Two-hybrid Homo sapiens
21 LGALS9C  
Two-hybrid Homo sapiens
22 HCST  
Affinity Capture-MS Homo sapiens
23 SCNM1  
Two-hybrid Homo sapiens
24 LPAR6  
Affinity Capture-MS Homo sapiens
25 KRT17 3872
Two-hybrid Homo sapiens
26 BTF3 689
Two-hybrid Homo sapiens
27 NFYC 4802
Two-hybrid Homo sapiens
28 ARSE 415
Affinity Capture-MS Homo sapiens
29 PLSCR4  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
30 MIIP 60672
Two-hybrid Homo sapiens
31 BSCL2  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
32 SRPR 6734
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
33 MDFI  
Affinity Capture-MS Homo sapiens
34 TYROBP  
Affinity Capture-MS Homo sapiens
35 NPFF  
Two-hybrid Homo sapiens
36 CNP 1267
Two-hybrid Homo sapiens
Affinity Capture-Western Homo sapiens
37 CSTA 1475
Two-hybrid Homo sapiens
38 MANF 7873
Two-hybrid Homo sapiens
39 DHX57 90957
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
40 TXNDC12 51060
Two-hybrid Homo sapiens
41 PLAC8L1  
Affinity Capture-MS Homo sapiens
42 FAM207A  
Two-hybrid Homo sapiens
43 EVL 51466
Two-hybrid Homo sapiens
Affinity Capture-Western Homo sapiens
44 SETDB1  
Two-hybrid Homo sapiens
Affinity Capture-Western Homo sapiens
45 TAF8  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Two-hybrid Homo sapiens
46 ZNF597  
Two-hybrid Homo sapiens
47 ANKRD50 57182
Two-hybrid Homo sapiens
48 GSK3A 2931
Two-hybrid Homo sapiens
Affinity Capture-Western Homo sapiens
49 DAXX  
Two-hybrid Homo sapiens
Affinity Capture-Western Homo sapiens
50 SLC9A9 285195
Two-hybrid Homo sapiens
Affinity Capture-Western Homo sapiens
51 KIAA0141  
Two-hybrid Homo sapiens
52 RSBN1L  
Two-hybrid Homo sapiens
53 DLK1  
Two-hybrid Homo sapiens
54 ABCG4  
Two-hybrid Homo sapiens
55 LOC401296  
Two-hybrid Homo sapiens
56 UBE2K 3093
Two-hybrid Homo sapiens
57 STK25 10494
Two-hybrid Homo sapiens
58 GABPB2  
Two-hybrid Homo sapiens
59 GABBR1  
Affinity Capture-MS Homo sapiens
60 FAM8A1 51439
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
61 USP18  
Two-hybrid Homo sapiens
62 LASP1 3927
Two-hybrid Homo sapiens
Affinity Capture-Western Homo sapiens
63 AK3 50808
Two-hybrid Homo sapiens
64 C9orf3 84909
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
65 GPR55  
Affinity Capture-MS Homo sapiens
66 WASF2 10163
Two-hybrid Homo sapiens
Affinity Capture-Western Homo sapiens
67 ADD1 118
Two-hybrid Homo sapiens
68 TNFRSF19  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
69 AMIGO3  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
70 FBXO18 84893
Two-hybrid Homo sapiens
71 RAD51  
Two-hybrid Homo sapiens
72 OTUD7B 56957
Two-hybrid Homo sapiens
73 SCAP  
Affinity Capture-MS Homo sapiens
74 EIF3E 3646
Two-hybrid Homo sapiens
Affinity Capture-Western Homo sapiens
75 NFATC2IP  
Two-hybrid Homo sapiens
76 SOX14  
Two-hybrid Homo sapiens
77 EXD2  
Proximity Label-MS Homo sapiens
78 ZFP2  
Two-hybrid Homo sapiens
79 ITGA8 8516
Affinity Capture-MS Homo sapiens
80 DGCR2 9993
Affinity Capture-MS Homo sapiens
81 TPGS2  
Two-hybrid Homo sapiens
82 HYPM  
Two-hybrid Homo sapiens
83 F2RL1  
Affinity Capture-MS Homo sapiens
84 SLC25A31 83447
Two-hybrid Homo sapiens
Affinity Capture-Western Homo sapiens
85 RAB39B 116442
Two-hybrid Homo sapiens
Affinity Capture-Western Homo sapiens
86 CSNK1D 1453
Two-hybrid Homo sapiens
Affinity Capture-Western Homo sapiens
87 ASF1A 25842
Two-hybrid Homo sapiens
88 SMARCB1 6598
Two-hybrid Homo sapiens
89 HIST1H3H 8357
Two-hybrid Homo sapiens
90 UBAC1 10422
Two-hybrid Homo sapiens
91 EEF1A1 1915
Two-hybrid Homo sapiens
Affinity Capture-Western Homo sapiens
92 TMC6 11322
Two-hybrid Homo sapiens
93 ERCC6L 54821
Two-hybrid Homo sapiens
94 IFT20 90410
Two-hybrid Homo sapiens
Affinity Capture-Western Homo sapiens
95 EXOSC9 5393
Two-hybrid Homo sapiens
96 LIN28A  
Two-hybrid Homo sapiens
97 PLEKHB1 58473
Two-hybrid Homo sapiens
Affinity Capture-Western Homo sapiens
98 CLRN3 119467
Two-hybrid Homo sapiens
99 GOLGA2 2801
Two-hybrid Homo sapiens
Affinity Capture-Western Homo sapiens
100 TTLL7  
Two-hybrid Homo sapiens
101 ZDHHC17 23390
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
102 ATF2  
Two-hybrid Homo sapiens
Affinity Capture-Western Homo sapiens
103 SLC1A3 6507
Two-hybrid Homo sapiens
104 CHMP1A 5119
Two-hybrid Homo sapiens
105 FOXD4L6  
Two-hybrid Homo sapiens
106 BEX2  
Two-hybrid Homo sapiens
107 TMEM115 11070
Two-hybrid Homo sapiens
108 FKBP6  
Two-hybrid Homo sapiens
Affinity Capture-Western Homo sapiens
109 RNF38  
Two-hybrid Homo sapiens
110 FAM122C  
Two-hybrid Homo sapiens
111 P2RY8  
Affinity Capture-MS Homo sapiens
112 LCTL  
Affinity Capture-MS Homo sapiens
113 TEAD1  
Two-hybrid Homo sapiens
114 OPTN 10133
Two-hybrid Homo sapiens
Affinity Capture-Western Homo sapiens
115 BCAS3 54828
Two-hybrid Homo sapiens
116 HOXA3  
Two-hybrid Homo sapiens
117 GPR35  
Affinity Capture-MS Homo sapiens
118 HTT 3064
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
Affinity Capture-Western Homo sapiens
Two-hybrid Homo sapiens
Reconstituted Complex Homo sapiens
Two-hybrid Homo sapiens
119 LCA5L  
Two-hybrid Homo sapiens
120 APBB1IP 54518
Two-hybrid Homo sapiens
Affinity Capture-Western Homo sapiens
121 DNAJC5 80331
Proximity Label-MS Homo sapiens
Affinity Capture-MS Homo sapiens
122 CCDC120  
Two-hybrid Homo sapiens
123 ZCCHC17  
Two-hybrid Homo sapiens
124 RAP1B 5908
Two-hybrid Homo sapiens
125 SREBF2 6721
Two-hybrid Homo sapiens
126 YIF1A 10897
Two-hybrid Homo sapiens
127 LOC554206  
Two-hybrid Homo sapiens
128 SPRY4 81848
Two-hybrid Homo sapiens
Affinity Capture-Western Homo sapiens
129 ZNF333  
Two-hybrid Homo sapiens
130 TIGD1  
Two-hybrid Homo sapiens
131 GPR182  
Affinity Capture-MS Homo sapiens
132 KIAA1456  
Affinity Capture-MS Homo sapiens
133 TRIP10 9322
Two-hybrid Homo sapiens
Affinity Capture-Western Homo sapiens
134 EYA3  
Two-hybrid Homo sapiens
135 IPPK  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
136 PDZK1IP1 10158
Two-hybrid Homo sapiens
137 COG3 83548
Two-hybrid Homo sapiens
138 LRRC45  
Two-hybrid Homo sapiens
139 PIK3R1 5295
Two-hybrid Homo sapiens
Affinity Capture-Western Homo sapiens
140 B4GALT3 8703
Affinity Capture-MS Homo sapiens
141 HMBS 3145
Two-hybrid Homo sapiens
142 AIDA 64853
Two-hybrid Homo sapiens
143 CCDC7  
Two-hybrid Homo sapiens
144 RCAN3  
Two-hybrid Homo sapiens
145 FAM9A  
Two-hybrid Homo sapiens
146 FEZ2 9637
Two-hybrid Homo sapiens
Affinity Capture-Western Homo sapiens
147 SF3A3 10946
Two-hybrid Homo sapiens
148 SP2  
Two-hybrid Homo sapiens
149 USP32 84669
Two-hybrid Homo sapiens
Affinity Capture-Western Homo sapiens
150 SHOX2  
Two-hybrid Homo sapiens
151 VSX2 338917
Two-hybrid Homo sapiens
152 LY6G6C  
Two-hybrid Homo sapiens
153 RBM5  
Two-hybrid Homo sapiens
154 VIPR2  
Affinity Capture-MS Homo sapiens
155 MAP2K7 5609
Affinity Capture-Western Homo sapiens
156 OFCC1  
Two-hybrid Homo sapiens
157 MLH3  
Two-hybrid Homo sapiens
158 KRTAP9-2  
Two-hybrid Homo sapiens
159 AHDC1  
Two-hybrid Homo sapiens
160 NRSN2  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
161 ZSCAN9  
Two-hybrid Homo sapiens
162 E2F8  
Two-hybrid Homo sapiens
163 ODF2 4957
Two-hybrid Homo sapiens
164 SRSF4 6429
Two-hybrid Homo sapiens
165 PTH2R  
Affinity Capture-MS Homo sapiens
166 ALKBH3  
Two-hybrid Homo sapiens
167 NEBL 10529
Two-hybrid Homo sapiens
168 IFT57 55081
Two-hybrid Homo sapiens
Affinity Capture-Western Homo sapiens
169 TMEM186  
Two-hybrid Homo sapiens
170 PDE4D  
Two-hybrid Homo sapiens
Affinity Capture-Western Homo sapiens
171 HIST1H2BH 8345
Two-hybrid Homo sapiens
172 OBFC1 79991
Two-hybrid Homo sapiens
173 DIXDC1  
Two-hybrid Homo sapiens
174 PDPK1 5170
Two-hybrid Homo sapiens
Affinity Capture-Western Homo sapiens
175 TMTC1  
Two-hybrid Homo sapiens
176 ZFYVE19 84936
Two-hybrid Homo sapiens
177 LPAR1 1902
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
178 TBXA2R 6915
Affinity Capture-MS Homo sapiens
179 PPP1R21 129285
Two-hybrid Homo sapiens
180 FUT3 2525
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
181 GRB10 2887
Two-hybrid Homo sapiens
182 PRMT5 10419
Two-hybrid Homo sapiens
183 TTC23  
Two-hybrid Homo sapiens
184 CTCFL  
Two-hybrid Homo sapiens
185 KNSTRN  
Two-hybrid Homo sapiens
186 ZNF624 57547
Two-hybrid Homo sapiens
187 MSANTD3  
Two-hybrid Homo sapiens
188 ZCCHC6 79670
Two-hybrid Homo sapiens
189 VN1R10P  
Two-hybrid Homo sapiens
190 CIB1 10519
Two-hybrid Homo sapiens
191 MRFAP1  
Two-hybrid Homo sapiens
192 FAM135B  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Two-hybrid Homo sapiens
193 PHF5A 84844
Two-hybrid Homo sapiens
194 GABPB1  
Two-hybrid Homo sapiens
195 MAP3K19 80122
Two-hybrid Homo sapiens
196 ZNF667-AS1  
Two-hybrid Homo sapiens
197 C1orf216  
Two-hybrid Homo sapiens
198 SNW1 22938
Two-hybrid Homo sapiens
Affinity Capture-Western Homo sapiens
199 SEMA4G  
Two-hybrid Homo sapiens
200 KRAS 3845
Two-hybrid Homo sapiens
201 INPP5D 3635
Two-hybrid Homo sapiens
202 HLA-A 3105
Two-hybrid Homo sapiens