Gene description for TBXA2R
Gene name thromboxane A2 receptor
Gene symbol TBXA2R
Other names/aliases BDPLT13
TXA2-R
Species Homo sapiens
 Database cross references - TBXA2R
ExoCarta ExoCarta_6915
Entrez Gene 6915
HGNC 11608
MIM 188070
UniProt P21731  
 TBXA2R identified in exosomes derived from the following tissue/cell type
Platelets 25332113    
Platelets 25332113    
Platelets 25332113    
 Gene ontology annotations for TBXA2R
Molecular Function
    guanyl-nucleotide exchange factor activity GO:0005085 TAS
    thromboxane A2 receptor activity GO:0004961 TAS
    protein binding GO:0005515 IPI
Biological Process
    blood coagulation GO:0007596 TAS
    positive regulation of GTPase activity GO:0043547 TAS
    positive regulation of smooth muscle contraction GO:0045987 IEA
    second-messenger-mediated signaling GO:0019932 IEA
    response to drug GO:0042493 IEA
    thromboxane A2 signaling pathway GO:0038193 TAS
    response to lipopolysaccharide GO:0032496 IEA
    positive regulation of blood pressure GO:0045777 IEA
    response to nutrient GO:0007584 IEA
    positive regulation of angiogenesis GO:0045766 IEA
    G-protein coupled receptor signaling pathway GO:0007186 TAS
    platelet activation GO:0030168 TAS
    inflammatory response GO:0006954 IEA
    positive regulation of cytosolic calcium ion concentration GO:0007204 IEA
    positive regulation of vasoconstriction GO:0045907 IEA
Subcellular Localization
    plasma membrane GO:0005886 TAS
    integral component of plasma membrane GO:0005887 TAS
    cytosol GO:0005829 IEA
    acrosomal vesicle GO:0001669 IEA
 Experiment description of studies that identified TBXA2R in exosomes
1
Experiment ID 231
ISEV standards
✘ EV Biophysical techniques
✔
Alix
EV Cytosolic markers
✔
CD63|CD9
EV Membrane markers
✘ EV Negative markers
✔
NTA
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25332113    
Organism Homo sapiens
Experiment description Lipidomic and proteomic characterization of platelet extracellular vesicle subfractions from senescent platelets
Authors Pienimaeki-Roemer A, Kuhlmann K, Bottcher A, Konovalova T, Black A, Orso E, Liebisch G, Ahrens M, Eisenacher M, Meyer HE, Schmitz G.
Journal name Transfusion
Publication year 2015
Sample Platelets
Sample name PL-Exs - Rep 1
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Optiprep density gradient
Flotation density 1.12-1.15 g/mL
Molecules identified in the study Protein
Lipids
Methods used in the study Western blotting
Mass spectrometry
2
Experiment ID 232
ISEV standards
✘ EV Biophysical techniques
✘ EV Cytosolic markers
✘ EV Membrane markers
✘ EV Negative markers
✘ EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25332113    
Organism Homo sapiens
Experiment description Lipidomic and proteomic characterization of platelet extracellular vesicle subfractions from senescent platelets
Authors Pienimaeki-Roemer A, Kuhlmann K, Bottcher A, Konovalova T, Black A, Orso E, Liebisch G, Ahrens M, Eisenacher M, Meyer HE, Schmitz G.
Journal name Transfusion
Publication year 2015
Sample Platelets
Sample name PL-Exs - Rep 2
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Optiprep density gradient
Flotation density 1.12-1.15 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
3
Experiment ID 233
ISEV standards
✘ EV Biophysical techniques
✘ EV Cytosolic markers
✘ EV Membrane markers
✘ EV Negative markers
✘ EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25332113    
Organism Homo sapiens
Experiment description Lipidomic and proteomic characterization of platelet extracellular vesicle subfractions from senescent platelets
Authors Pienimaeki-Roemer A, Kuhlmann K, Bottcher A, Konovalova T, Black A, Orso E, Liebisch G, Ahrens M, Eisenacher M, Meyer HE, Schmitz G.
Journal name Transfusion
Publication year 2015
Sample Platelets
Sample name PL-Exs - Rep 3
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Optiprep density gradient
Flotation density 1.12-1.15 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for TBXA2R
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 TBXA2R 6915
Invitro Homo sapiens
Invitro Homo sapiens
2 GNA12 2768
Invivo Homo sapiens
3 GNA13 10672
Invivo Homo sapiens
4 GNAQ 2776
Affinity Capture-Western Homo sapiens
View the network image/svg+xml



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