Gene description for RPGRIP1L
Gene name RPGRIP1-like
Gene symbol RPGRIP1L
Other names/aliases CORS3
FTM
JBTS7
MKS5
NPHP8
PPP1R134
Species Homo sapiens
 Database cross references - RPGRIP1L
ExoCarta ExoCarta_23322
Vesiclepedia VP_23322
Entrez Gene 23322
HGNC 29168
MIM 610937
UniProt Q68CZ1  
 RPGRIP1L identified in exosomes derived from the following tissue/cell type
Neuroblastoma cells 25944692    
 Gene ontology annotations for RPGRIP1L
Molecular Function
    protein binding GO:0005515 IPI
    thromboxane A2 receptor binding GO:0031870 IPI
Biological Process
    in utero embryonic development GO:0001701 IEA
    cilium assembly GO:0042384 IEA
    corpus callosum development GO:0022038 IEA
    olfactory bulb development GO:0021772 IEA
    lateral ventricle development GO:0021670 IEA
    determination of left/right symmetry GO:0007368 IEA
    establishment or maintenance of cell polarity GO:0007163 IEA
    liver development GO:0001889 IEA
    embryonic hindlimb morphogenesis GO:0035116 IEA
    negative regulation of G-protein coupled receptor protein signaling pathway GO:0045744 IDA
    establishment of planar polarity GO:0001736 IEA
    neural tube patterning GO:0021532 IEA
    embryonic forelimb morphogenesis GO:0035115 IEA
    cochlea development GO:0090102 IEA
    kidney development GO:0001822 IEA
    regulation of smoothened signaling pathway GO:0008589 IEA
    cerebellum development GO:0021549 IEA
    pericardium development GO:0060039 IEA
    nose development GO:0043584 IEA
    organelle organization GO:0006996 TAS
    camera-type eye development GO:0043010 IEA
Subcellular Localization
    centrosome GO:0005813 IDA
    cytosol GO:0005829 TAS
    ciliary basal body GO:0036064 IDA
    ciliary transition zone GO:0035869 IEA
    cell-cell junction GO:0005911 IDA
    cytoplasm GO:0005737 IDA
    axoneme GO:0005930 IDA
    bicellular tight junction GO:0005923 IEA
    cilium GO:0005929 IDA
 Experiment description of studies that identified RPGRIP1L in exosomes
1
Experiment ID 224
MISEV standards
EM|AFM
EV Biophysical techniques
Alix|TSG101|CD63|CD81
EV Enriched markers
GOLGA2
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25944692    
Organism Homo sapiens
Experiment description Proteogenomic analysis reveals exosomes are more oncogenic than ectosomes
Authors Keerthikumar S, Gangoda L, Liem M, Fonseka P, Atukorala I, Ozcitti C, Mechler A, Adda CG, Ang CS, Mathivanan S
Journal name Oncotarget
Publication year 2015
Sample Neuroblastoma cells
Sample name SH-SY5Y
Isolation/purification methods Differential centrifugation
Ultracentrifugation
OptiPrep density gradient
Flotation density 1.10 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
Western blotting
 Protein-protein interactions for RPGRIP1L
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which RPGRIP1L is involved
PathwayEvidenceSource
Anchoring of the basal body to the plasma membrane TAS Reactome
Hedgehog 'off' state TAS Reactome





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