Gene description for PCM1
Gene name pericentriolar material 1
Gene symbol PCM1
Other names/aliases PTC4
Species Homo sapiens
 Database cross references - PCM1
ExoCarta ExoCarta_5108
Vesiclepedia VP_5108
Entrez Gene 5108
HGNC 8727
MIM 600299
UniProt Q15154  
 PCM1 identified in exosomes derived from the following tissue/cell type
Mesenchymal stem cells 36408942    
 Gene ontology annotations for PCM1
Molecular Function
    protein binding GO:0005515 IPI
    identical protein binding GO:0042802 ISS
    molecular adaptor activity GO:0060090 IDA
Biological Process
    neuron migration GO:0001764 IEA
    centrosome cycle GO:0007098 IMP
    interkinetic nuclear migration GO:0022027 ISS
    cytoplasmic microtubule organization GO:0031122 IMP
    cytoplasmic microtubule organization GO:0031122 IMP
    microtubule anchoring GO:0034453 ISS
    microtubule anchoring at centrosome GO:0034454 IBA
    social behavior GO:0035176 IEA
    intraciliary transport involved in cilium assembly GO:0035735 IMP
    negative regulation of neurogenesis GO:0050768 ISS
    cilium assembly GO:0060271 IMP
    regulation of protein complex stability GO:0061635 IDA
    protein localization to centrosome GO:0071539 IBA
    protein localization to centrosome GO:0071539 IMP
    protein localization to centrosome GO:0071539 ISS
    positive regulation of intracellular protein transport GO:0090316 IMP
    neuronal stem cell population maintenance GO:0097150 IEA
    protein-containing complex localization to centriolar satellite GO:0140706 IDA
    non-motile cilium assembly GO:1905515 IBA
    non-motile cilium assembly GO:1905515 IMP
Subcellular Localization
    pericentriolar material GO:0000242 ISS
    nucleoplasm GO:0005654 IDA
    cytoplasm GO:0005737 ISS
    centrosome GO:0005813 IDA
    centrosome GO:0005813 IDA
    centrosome GO:0005813 ISS
    centriole GO:0005814 IEA
    cytosol GO:0005829 IDA
    cytosol GO:0005829 TAS
    membrane GO:0016020 HDA
    nuclear membrane GO:0031965 IDA
    protein-containing complex GO:0032991 IDA
    centriolar satellite GO:0034451 IBA
    centriolar satellite GO:0034451 IDA
    centriolar satellite GO:0034451 IDA
    ciliary transition zone GO:0035869 IDA
    ciliary basal body GO:0036064 IBA
    apical part of cell GO:0045177 IEA
    non-motile cilium GO:0097730 IDA
 Experiment description of studies that identified PCM1 in exosomes
1
Experiment ID 488
MISEV standards
✔
EM
Biophysical techniques
✔
CD9|CD81|CD63|GAPDH|SDCBP|LAMP1|TFRC|UCHL1|FLOT2|LAMP2|FLOT1|ICAM1|RAB5B|CD151|RAB35|TSG101|RAB5A|CD82
Enriched markers
✔
CANX
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Homo sapiens
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Mesenchymal stem cells
Sample name UCMSC
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
 Protein-protein interactions for PCM1
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 LSM2 57819
Two-hybrid Homo sapiens
2 INTS4  
Two-hybrid Homo sapiens
3 SPATS2  
Proximity Label-MS Homo sapiens
4 VPS35 55737
Affinity Capture-MS Homo sapiens
5 KRT73 319101
Affinity Capture-MS Homo sapiens
6 ISG15 9636
Affinity Capture-MS Homo sapiens
7 CLTC 1213
Affinity Capture-MS Homo sapiens
8 TPGS1  
Affinity Capture-MS Homo sapiens
Proximity Label-MS Homo sapiens
9 ZNF24  
Affinity Capture-MS Homo sapiens
10 RASSF8 11228
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
11 CAMSAP1 157922
Proximity Label-MS Homo sapiens
12 KRT1 3848
Affinity Capture-MS Homo sapiens
13 CEP89 84902
Proximity Label-MS Homo sapiens
14 CENPE 1062
Affinity Capture-MS Homo sapiens
Proximity Label-MS Homo sapiens
15 CCNB2  
Affinity Capture-MS Homo sapiens
Proximity Label-MS Homo sapiens
16 SRGAP1 57522
Proximity Label-MS Homo sapiens
17 CKAP2L  
Proximity Label-MS Homo sapiens
18 TUBB4B 10383
Affinity Capture-MS Homo sapiens
19 NCKAP5L  
Proximity Label-MS Homo sapiens
20 PLK1 5347
Proximity Label-MS Homo sapiens
21 MAGEL2  
Proximity Label-MS Homo sapiens
22 YWHAE 7531
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Two-hybrid Homo sapiens
23 PHLPP1  
Proximity Label-MS Homo sapiens
24 FAM9B  
Affinity Capture-MS Homo sapiens
25 CCDC183  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
26 SMG7  
Proximity Label-MS Homo sapiens
27 Ndc80  
Affinity Capture-MS Mus musculus
28 GOLGA6A  
Affinity Capture-MS Homo sapiens
29 USP9X 8239
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Co-localization Homo sapiens
30 EPS8 2059
Two-hybrid Homo sapiens
31 CCNB1IP1  
Affinity Capture-MS Homo sapiens
32 KIF7 374654
Affinity Capture-MS Homo sapiens
Proximity Label-MS Homo sapiens
33 KAT5  
Two-hybrid Homo sapiens
34 DISC1 27185
Affinity Capture-MS Homo sapiens
35 TRIOBP 11078
Proximity Label-MS Homo sapiens
36 CCDC65  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
37 NUF2  
Proximity Label-MS Homo sapiens
38 HMMR  
Proximity Label-MS Homo sapiens
39 LUZP1 7798
Proximity Label-MS Homo sapiens
40 APEX1 328
Affinity Capture-RNA Homo sapiens
41 CAPZB 832
Affinity Capture-MS Homo sapiens
42 DDX23 9416
Two-hybrid Homo sapiens
43 SCLT1 132320
Proximity Label-MS Homo sapiens
44 PCNT  
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Proximity Label-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Proximity Label-MS Homo sapiens
45 STRN 6801
Affinity Capture-MS Homo sapiens
46 PRC1 9055
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
47 NECAB2  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
48 CEP57L1  
Proximity Label-MS Homo sapiens
49 NAV1 89796
Proximity Label-MS Homo sapiens
50 FILIP1  
Affinity Capture-MS Homo sapiens
51 Cep55 74107
Affinity Capture-MS Mus musculus
52 CCDC14  
Affinity Capture-MS Homo sapiens
Proximity Label-MS Homo sapiens
Proximity Label-MS Homo sapiens
53 DIAPH3 81624
Proximity Label-MS Homo sapiens
54 CEP112  
Proximity Label-MS Homo sapiens
55 Cetn2  
Affinity Capture-MS Mus musculus
56 Cep170  
Affinity Capture-MS Mus musculus
Affinity Capture-MS Mus musculus
57 ERC1 23085
Proximity Label-MS Homo sapiens
58 Fgfr1op  
Affinity Capture-MS Mus musculus
59 Ankrd26  
Affinity Capture-MS Mus musculus
60 PLEKHG1  
Proximity Label-MS Homo sapiens
61 TANC1 85461
Proximity Label-MS Homo sapiens
62 OBSL1 23363
Affinity Capture-MS Homo sapiens
63 EWSR1 2130
Affinity Capture-MS Homo sapiens
64 IFT81 28981
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Proximity Label-MS Homo sapiens
65 Cenpe  
Affinity Capture-MS Mus musculus
66 Mib1  
Affinity Capture-MS Mus musculus
67 MAP7D3 79649
Proximity Label-MS Homo sapiens
68 CCDC112  
Proximity Label-MS Homo sapiens
69 DYNLL1 8655
Affinity Capture-MS Homo sapiens
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
70 HAUS6  
Affinity Capture-MS Homo sapiens
Proximity Label-MS Homo sapiens
71 CCDC53 51019
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
72 CCDC18  
Proximity Label-MS Homo sapiens
73 RGPD6  
Proximity Label-MS Homo sapiens
74 HAP1  
Two-hybrid Homo sapiens
75 KRT83  
Affinity Capture-MS Homo sapiens
76 Haus1  
Affinity Capture-MS Mus musculus
77 LATS1  
Proximity Label-MS Homo sapiens
78 TTLL5  
Proximity Label-MS Homo sapiens
79 KIF15 56992
Proximity Label-MS Homo sapiens
80 KNSTRN  
Affinity Capture-MS Homo sapiens
81 TRO  
Proximity Label-MS Homo sapiens
82 CEP131 22994
Reconstituted Complex Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Proximity Label-MS Homo sapiens
83 VAPA 9218
Affinity Capture-MS Homo sapiens
84 Cep120  
Affinity Capture-MS Mus musculus
85 HAUS4  
Affinity Capture-MS Homo sapiens
Proximity Label-MS Homo sapiens
Affinity Capture-MS Homo sapiens
86 TEX9  
Proximity Label-MS Homo sapiens
87 Haus4  
Affinity Capture-MS Mus musculus
Affinity Capture-MS Mus musculus
88 TFIP11  
Two-hybrid Homo sapiens
89 MED4 29079
Affinity Capture-MS Homo sapiens
Proximity Label-MS Homo sapiens
Affinity Capture-MS Homo sapiens
90 TRIM37  
Proximity Label-MS Homo sapiens
91 CASK 8573
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
92 Sdccag8  
Affinity Capture-MS Mus musculus
93 E2F4  
Two-hybrid Homo sapiens
94 AURKA 6790
Affinity Capture-MS Homo sapiens
95 CCDC172  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
96 PRPF6 24148
Two-hybrid Homo sapiens
97 HAUS2  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Proximity Label-MS Homo sapiens
98 S100A2 6273
Affinity Capture-MS Homo sapiens
99 PPIB 5479
Affinity Capture-MS Homo sapiens
100 C6orf118  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
101 MIB1 57534
Affinity Capture-Western Homo sapiens
Proximity Label-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Co-localization Homo sapiens
Proximity Label-MS Homo sapiens
Affinity Capture-MS Homo sapiens
102 Klc4  
Two-hybrid Mus musculus
103 SPATA24  
Proximity Label-MS Homo sapiens
104 CEP55 55165
Proximity Label-MS Homo sapiens
105 RB1CC1 9821
Affinity Capture-MS Homo sapiens
106 FOPNL  
Proximity Label-MS Homo sapiens
107 KLC1 3831
Two-hybrid Homo sapiens
108 RASSF7  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
109 SNAP91 9892
Affinity Capture-MS Homo sapiens
110 CEP192 55125
Proximity Label-MS Homo sapiens
111 KLC4 89953
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
112 MAPRE1 22919
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
113 Cep104  
Affinity Capture-MS Mus musculus
114 PPIE 10450
Two-hybrid Homo sapiens
115 MAGED1 9500
Proximity Label-MS Homo sapiens
116 OFD1 8481
Affinity Capture-MS Homo sapiens
Proximity Label-MS Homo sapiens
117 Immt  
Affinity Capture-MS Mus musculus
118 MCM10 55388
Proximity Label-MS Homo sapiens
119 GCC2 9648
Proximity Label-MS Homo sapiens
120 CEP152  
Proximity Label-MS Homo sapiens
121 TXLNG  
Proximity Label-MS Homo sapiens
122 PIBF1  
Proximity Label-MS Homo sapiens
123 CEP162  
Proximity Label-MS Homo sapiens
124 SP110  
Affinity Capture-MS Homo sapiens
125 MTMR7  
Affinity Capture-MS Homo sapiens
126 HAUS8  
Affinity Capture-MS Homo sapiens
Proximity Label-MS Homo sapiens
127 GABARAP 11337
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Protein-peptide Homo sapiens
128 TRIM21 6737
Affinity Capture-MS Homo sapiens
129 NTRK1 4914
Affinity Capture-MS Homo sapiens
130 TRAF3IP1 26146
Proximity Label-MS Homo sapiens
131 PPP1R13B  
Proximity Label-MS Homo sapiens
132 CCP110  
Proximity Label-MS Homo sapiens
133 PPP2CA 5515
Affinity Capture-MS Homo sapiens
134 KRT14 3861
Affinity Capture-MS Homo sapiens
135 BICD2 23299
Two-hybrid Homo sapiens
Proximity Label-MS Homo sapiens
136 YWHAQ 10971
Reconstituted Complex Homo sapiens
137 Bag2  
Affinity Capture-MS Mus musculus
138 CSNK1E 1454
Affinity Capture-MS Homo sapiens
Proximity Label-MS Homo sapiens
139 CCDC22 28952
Affinity Capture-MS Homo sapiens
Proximity Label-MS Homo sapiens
140 KRT2 3849
Affinity Capture-MS Homo sapiens
141 BBS4 585
Two-hybrid Homo sapiens
142 CEP85L  
Proximity Label-MS Homo sapiens
143 SREBF2 6721
Positive Genetic Homo sapiens
144 KIAA1217 56243
Proximity Label-MS Homo sapiens
145 LCA5  
Proximity Label-MS Homo sapiens
146 CEP72  
Affinity Capture-MS Homo sapiens
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
Proximity Label-MS Homo sapiens
147 Cdk5rap2  
Affinity Capture-MS Mus musculus
148 LATS2 26524
Proximity Label-MS Homo sapiens
149 ANKRD26 22852
Proximity Label-MS Homo sapiens
150 HAUS7  
Affinity Capture-MS Homo sapiens
Proximity Label-MS Homo sapiens
151 CEBPA  
Protein-peptide Homo sapiens
152 USP28 57646
Affinity Capture-MS Homo sapiens
153 FGFR1OP  
Affinity Capture-MS Homo sapiens
154 2700060E02Rik 68045
Two-hybrid Mus musculus
155 TXNDC11 51061
Affinity Capture-MS Homo sapiens
156 ING2  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
157 CCDC85C  
Proximity Label-MS Homo sapiens
158 Cep290  
Affinity Capture-MS Mus musculus
159 Cep131  
Affinity Capture-MS Mus musculus
Affinity Capture-MS Mus musculus
160 Ppp2r1a 51792
Affinity Capture-MS Mus musculus
161 NEURL4  
Affinity Capture-MS Homo sapiens
162 CETN1  
Affinity Capture-MS Homo sapiens
163 Ccp110  
Affinity Capture-MS Mus musculus
164 DKK3 27122
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
165 ATG16L1 55054
Affinity Capture-MS Homo sapiens
166 CEP128  
Proximity Label-MS Homo sapiens
167 KIF1B 23095
Proximity Label-MS Homo sapiens
168 RBM5  
Two-hybrid Homo sapiens
169 TBC1D31  
Proximity Label-MS Homo sapiens
170 FAM184B  
Proximity Label-MS Homo sapiens
171 KIZ  
Proximity Label-MS Homo sapiens
172 MAP7 9053
Affinity Capture-MS Homo sapiens
173 LARP4 113251
Two-hybrid Homo sapiens
174 Cit 12704
Affinity Capture-MS Mus musculus
175 CEP63  
Proximity Label-MS Homo sapiens
176 NDUFA9 4704
Two-hybrid Homo sapiens
177 CNTLN 54875
Proximity Label-MS Homo sapiens
178 KRT86  
Affinity Capture-MS Homo sapiens
179 SIRT7  
Affinity Capture-MS Homo sapiens
180 LCA5L  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
181 CCDC57 284001
Proximity Label-MS Homo sapiens
182 CAMSAP3  
Proximity Label-MS Homo sapiens
183 AKAP9 10142
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
184 PDZRN3 23024
Proximity Label-MS Homo sapiens
185 MIS18A  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
186 C11orf49  
Affinity Capture-MS Homo sapiens
Proximity Label-MS Homo sapiens
187 CEP95  
Proximity Label-MS Homo sapiens
188 NEBL 10529
Affinity Capture-MS Homo sapiens
189 IFT57 55081
Proximity Label-MS Homo sapiens
190 GAS8  
Proximity Label-MS Homo sapiens
191 CUL3 8452
Affinity Capture-MS Homo sapiens
192 YWHAZ 7534
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
193 Dlg5  
Affinity Capture-MS Mus musculus
194 BTF3 689
Affinity Capture-MS Homo sapiens
195 TTK 7272
Proximity Label-MS Homo sapiens
196 HOOK3 84376
Proximity Label-MS Homo sapiens
197 ODF2 4957
Proximity Label-MS Homo sapiens
198 CCDC66  
Proximity Label-MS Homo sapiens
199 FUS 2521
Affinity Capture-MS Homo sapiens
200 ATG14  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
201 MORF4L1  
Two-hybrid Homo sapiens
202 DUSP16  
Affinity Capture-MS Homo sapiens
203 SLC25A41  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
204 SASS6 163786
Proximity Label-MS Homo sapiens
205 Cep152  
Affinity Capture-MS Mus musculus
206 CDC42 998
Two-hybrid Homo sapiens
207 PRKCI 5584
Two-hybrid Homo sapiens
208 CEP164  
Proximity Label-MS Homo sapiens
209 KRT15 3866
Two-hybrid Homo sapiens
210 CEP250 11190
Affinity Capture-MS Homo sapiens
211 CAMSAP2  
Proximity Label-MS Homo sapiens
212 Cep72  
Affinity Capture-MS Mus musculus
213 SLAIN2  
Affinity Capture-MS Homo sapiens
214 KIAA0586  
Proximity Label-MS Homo sapiens
215 MYO6 4646
Proximity Label-MS Homo sapiens
216 Uso1 56041
Affinity Capture-MS Mus musculus
217 NIN 51199
Two-hybrid Homo sapiens
Proximity Label-MS Homo sapiens
Proximity Label-MS Homo sapiens
218 CNTROB  
Proximity Label-MS Homo sapiens
219 CEP170B  
Proximity Label-MS Homo sapiens
220 SAV1  
Proximity Label-MS Homo sapiens
221 ODF2L  
Proximity Label-MS Homo sapiens
222 ING5  
Affinity Capture-MS Homo sapiens
Two-hybrid Homo sapiens
223 GOLGA1  
Proximity Label-MS Homo sapiens
224 Uba1 22201
Two-hybrid Mus musculus
225 Cep78  
Affinity Capture-MS Mus musculus
226 Bbs5  
Two-hybrid Mus musculus
227 NDC80 10403
Proximity Label-MS Homo sapiens
Proximity Label-MS Homo sapiens
228 C2CD3