Gene description for Myh10
Gene name myosin, heavy polypeptide 10, non-muscle
Gene symbol Myh10
Other names/aliases 5730504C04Rik
9330167F11Rik
Fltn
Myhn-2
Myhn2
NMHC II-B
NMHC-B
NMHCII-B
NMMHC II-b
NMMHC-B
NMMHC-IIB
SMemb
mKIAA3005
Species Mus musculus
 Database cross references - Myh10
ExoCarta ExoCarta_77579
Vesiclepedia VP_77579
Entrez Gene 77579
UniProt Q61879  
 Myh10 identified in exosomes derived from the following tissue/cell type
Pancreatic cells 19351151    
 Gene ontology annotations for Myh10
Molecular Function
    microfilament motor activity GO:0000146 IBA
    microfilament motor activity GO:0000146 ISO
    microfilament motor activity GO:0000146 ISO
    protein binding GO:0005515 IPI
    calmodulin binding GO:0005516 IEA
    ATP binding GO:0005524 ISO
    RNA stem-loop binding GO:0035613 ISO
    identical protein binding GO:0042802 ISO
    ADP binding GO:0043531 ISO
    mRNA 5'-UTR binding GO:0048027 ISO
    actin filament binding GO:0051015 IBA
    actin filament binding GO:0051015 ISO
    actin filament binding GO:0051015 ISO
Biological Process
    mitotic cytokinesis GO:0000281 IBA
    mitotic cytokinesis GO:0000281 IMP
    mitotic cytokinesis GO:0000281 ISO
    in utero embryonic development GO:0001701 IMP
    neuron migration GO:0001764 IMP
    plasma membrane repair GO:0001778 IMP
    cardiac septum development GO:0003279 IMP
    exocytosis GO:0006887 IMP
    substrate-dependent cell migration, cell extension GO:0006930 IMP
    nuclear migration GO:0007097 IMP
    cell adhesion GO:0007155 IEA
    cell adhesion GO:0007155 ISO
    axonogenesis GO:0007409 IMP
    axon guidance GO:0007411 IMP
    brain development GO:0007420 IMP
    heart development GO:0007507 IMP
    adult heart development GO:0007512 IMP
    regulation of cell shape GO:0008360 IBA
    regulation of cell shape GO:0008360 IMP
    fourth ventricle development GO:0021592 IMP
    lateral ventricle development GO:0021670 IMP
    third ventricle development GO:0021678 IMP
    cerebellar Purkinje cell layer development GO:0021680 IMP
    actin cytoskeleton organization GO:0030036 IGI
    actin filament-based movement GO:0030048 ISO
    myofibril assembly GO:0030239 IMP
    actomyosin structure organization GO:0031032 IBA
    actomyosin structure organization GO:0031032 ISO
    neuron projection development GO:0031175 IMP
    aorta development GO:0035904 IMP
    positive regulation of protein secretion GO:0050714 ISO
    neuromuscular process controlling balance GO:0050885 IMP
    actin filament bundle assembly GO:0051017 ISO
    cardiac myofibril assembly GO:0055003 IMP
    ventricular cardiac muscle cell development GO:0055015 IMP
    cardiac muscle cell proliferation GO:0060038 IMP
    retina development in camera-type eye GO:0060041 IMP
    coronary vasculature development GO:0060976 IMP
    actin filament bundle distribution GO:0070650 ISO
    modification of postsynaptic actin cytoskeleton GO:0098885 ISO
    postsynaptic actin cytoskeleton organization GO:0098974 IDA
    postsynaptic actin cytoskeleton organization GO:0098974 IMP
    regulation of modification of postsynaptic actin cytoskeleton GO:1905274 ISO
Subcellular Localization
    stress fiber GO:0001725 IDA
    stress fiber GO:0001725 IMP
    stress fiber GO:0001725 ISO
    cytoplasm GO:0005737 IBA
    cytoplasm GO:0005737 IDA
    cytoplasm GO:0005737 ISO
    spindle GO:0005819 IDA
    cytosol GO:0005829 ISO
    cytosol GO:0005829 TAS
    brush border GO:0005903 IDA
    cell cortex GO:0005938 IDA
    cell cortex GO:0005938 ISO
    cytoplasmic side of plasma membrane GO:0009898 IDA
    myosin complex GO:0016459 IDA
    myosin II complex GO:0016460 IBA
    myosin II complex GO:0016460 IDA
    myosin II complex GO:0016460 ISO
    sarcoplasm GO:0016528 IDA
    lamellipodium GO:0030027 IEA
    lamellipodium GO:0030027 ISO
    axon GO:0030424 IDA
    growth cone GO:0030426 IDA
    midbody GO:0030496 ISO
    neuromuscular junction GO:0031594 IDA
    cleavage furrow GO:0032154 ISO
    myosin filament GO:0032982 IBA
    actomyosin GO:0042641 ISO
    neuron projection GO:0043005 IDA
    neuronal cell body GO:0043025 IDA
    dendritic spine GO:0043197 IDA
    myosin II filament GO:0097513 ISO
    postsynaptic actin cytoskeleton GO:0098871 ISO
    glutamatergic synapse GO:0098978 IDA
    glutamatergic synapse GO:0098978 IMP
    glutamatergic synapse GO:0098978 ISO
 Experiment description of studies that identified Myh10 in exosomes
1
Experiment ID 188
MISEV standards
EM
Biophysical techniques
GAPDH|UCHL1|HSP90
Enriched markers
Negative markers
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 19351151    
Organism Mus musculus
Experiment description Characterization of vesicles secreted from insulinoma NIT-1 cells.
Authors "Lee HS, Jeong J, Lee KJ."
Journal name J Proteome Res
Publication year 2009
Sample Pancreatic cells
Sample name Pancreatic beta cell (NIT-1)
Isolation/purification methods Differential centrifugation
Sucrose density gradient
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for Myh10
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 ABCG2 9429
Affinity Capture-MS Homo sapiens
2 ACTR2 10097
Affinity Capture-MS Homo sapiens
3 ARHGAP21 57584
Affinity Capture-MS Homo sapiens
4 SPECC1L 23384
Affinity Capture-MS Homo sapiens
5 AP2B1 163
Affinity Capture-MS Homo sapiens
6 PPP1CB 5500
Affinity Capture-MS Homo sapiens
7 ARPC5L 81873
Affinity Capture-MS Homo sapiens
8 TRRAP 8295
Affinity Capture-MS Homo sapiens
9 CPM 1368
Affinity Capture-MS Homo sapiens
10 ARPC2 10109
Affinity Capture-MS Homo sapiens
11 KIAA1958  
Affinity Capture-MS Homo sapiens
12 TPM2 7169
Affinity Capture-MS Homo sapiens
13 ARPC4 10093
Affinity Capture-MS Homo sapiens
14 CARD10  
Affinity Capture-MS Homo sapiens
15 DBN1 1627
Affinity Capture-MS Homo sapiens
16 LIMS1 3987
Affinity Capture-MS Homo sapiens
17 STON2 85439
Affinity Capture-MS Homo sapiens
18 EPS15 2060
Affinity Capture-MS Homo sapiens
19 GNAQ 2776
Affinity Capture-MS Homo sapiens
20 GRIPAP1 56850
Affinity Capture-MS Homo sapiens
21 CALM1 801
Affinity Capture-MS Homo sapiens
22 CFL1 1072
Affinity Capture-MS Homo sapiens
23 CLTB 1212
Affinity Capture-MS Homo sapiens
24 Ywhaz 22631
Affinity Capture-MS Mus musculus
25 AMOTL1 154810
Affinity Capture-MS Homo sapiens
26 CAPZB 832
Affinity Capture-MS Homo sapiens
27 LAMTOR1 55004
Affinity Capture-MS Homo sapiens
28 GNG12 55970
Affinity Capture-MS Homo sapiens
29 PPP1R12A 4659
Affinity Capture-MS Homo sapiens
30 CORO1B 57175
Affinity Capture-MS Homo sapiens
31 ABLIM1 3983
Affinity Capture-MS Homo sapiens
32 MYO5B 4645
Affinity Capture-MS Homo sapiens
33 ACTR3 10096
Affinity Capture-MS Homo sapiens
34 AP2A1 160
Affinity Capture-MS Homo sapiens
35 PGS1 9489
Affinity Capture-MS Homo sapiens
36 CEP162  
Affinity Capture-MS Homo sapiens
37 MYO1B 4430
Affinity Capture-MS Homo sapiens
38 TMOD1  
Affinity Capture-MS Homo sapiens
39 TPRN 286262
Affinity Capture-MS Homo sapiens
40 CD44 960
Affinity Capture-MS Homo sapiens
41 LAMTOR4 389541
Affinity Capture-MS Homo sapiens
42 ARHGEF17 9828
Affinity Capture-MS Homo sapiens
43 CEP131 22994
Affinity Capture-MS Homo sapiens
44 CYBRD1 79901
Affinity Capture-MS Homo sapiens
45 MPRIP 23164
Affinity Capture-MS Homo sapiens
46 TES 26136
Affinity Capture-MS Homo sapiens
47 MYL6 4637
Affinity Capture-MS Homo sapiens
48 COBL  
Affinity Capture-MS Homo sapiens
49 MYO18A 399687
Affinity Capture-MS Homo sapiens
50 CAPZA1 829
Affinity Capture-MS Homo sapiens
51 SORBS2  
Affinity Capture-MS Homo sapiens
52 LUZP1 7798
Affinity Capture-MS Homo sapiens
53 RAI14 26064
Affinity Capture-MS Homo sapiens
54 GNAI1 2770
Affinity Capture-MS Homo sapiens
55 LYN 4067
Affinity Capture-MS Homo sapiens
56 CLTCL1 8218
Affinity Capture-MS Homo sapiens
57 POC1A  
Affinity Capture-MS Homo sapiens
58 LRRFIP2 9209
Affinity Capture-MS Homo sapiens
59 NUMB 8650
Affinity Capture-MS Homo sapiens
60 MYH9 4627
Affinity Capture-MS Homo sapiens
61 ACTN4 81
Affinity Capture-MS Homo sapiens
62 ARHGAP11A  
Affinity Capture-MS Homo sapiens
63 BMP2K 55589
Affinity Capture-MS Homo sapiens
64 DDX1 1653
Affinity Capture-MS Homo sapiens
65 GNAI2 2771
Affinity Capture-MS Homo sapiens
66 ARPC5 10092
Affinity Capture-MS Homo sapiens
67 PIK3C2A 5286
Affinity Capture-MS Homo sapiens
68 CEP72  
Affinity Capture-MS Homo sapiens
69 FLOT2 2319
Affinity Capture-MS Homo sapiens
70 MYL12A 10627
Affinity Capture-MS Homo sapiens
71 ACTG1 71
Affinity Capture-MS Homo sapiens
72 ST5 6764
Affinity Capture-MS Homo sapiens
73 Homer1  
Affinity Capture-MS Mus musculus
74 GPRC5A 9052
Affinity Capture-MS Homo sapiens
75 EFHC1  
Affinity Capture-MS Homo sapiens
76 PPP1R12B 4660
Affinity Capture-MS Homo sapiens
77 Ubc  
Reconstituted Complex Mus musculus
78 LIMA1 51474
Affinity Capture-MS Homo sapiens
79 CLINT1 9685
Affinity Capture-MS Homo sapiens
80 GNB4 59345
Affinity Capture-MS Homo sapiens
81 ECD  
Affinity Capture-MS Homo sapiens
82 ARPC1B 10095
Affinity Capture-MS Homo sapiens
83 ARPC3 10094
Affinity Capture-MS Homo sapiens
84 CORO7 79585
Affinity Capture-MS Homo sapiens
85 LMO7 4008
Affinity Capture-MS Homo sapiens
86 CTTN 2017
Affinity Capture-MS Homo sapiens
87 SPECC1 92521
Affinity Capture-MS Homo sapiens
88 MYO5A 4644
Affinity Capture-MS Homo sapiens
89 PACSIN3 29763
Affinity Capture-MS Homo sapiens
90 CD59 966
Affinity Capture-MS Homo sapiens
91 CORO1C 23603
Affinity Capture-MS Homo sapiens
92 BASP1 10409
Affinity Capture-MS Homo sapiens
93 MYO1C 4641
Affinity Capture-MS Homo sapiens
94 AP2M1 1173
Affinity Capture-MS Homo sapiens
95 Nphp4  
Affinity Capture-MS Mus musculus
96 TPM1 7168
Affinity Capture-MS Homo sapiens
97 CORO2A  
Affinity Capture-MS Homo sapiens
98 MYO6 4646
Affinity Capture-MS Homo sapiens
99 GNB2 2783
Affinity Capture-MS Homo sapiens
100 NAP1L1 4673
Affinity Capture-MS Homo sapiens
101 TMOD3 29766
Affinity Capture-MS Homo sapiens
102 Grin1  
Affinity Capture-MS Mus musculus
103 FLII 2314
Affinity Capture-MS Homo sapiens
104 ABCA2 20
Affinity Capture-MS Homo sapiens
105 AKAP2 11217
Affinity Capture-MS Homo sapiens
106 CLTC 1213
Affinity Capture-MS Homo sapiens
107 MSN 4478
Affinity Capture-MS Homo sapiens
108 LIMCH1 22998
Affinity Capture-MS Homo sapiens
109 TPM4 7171
Affinity Capture-MS Homo sapiens
110 FLOT1 10211
Affinity Capture-MS Homo sapiens
111 FARP1 10160
Affinity Capture-MS Homo sapiens
112 Fancd2  
Affinity Capture-MS Mus musculus
113 TPM3 7170
Affinity Capture-MS Homo sapiens
114 SPTBN1 6711
Affinity Capture-MS Homo sapiens
115 SLC4A2 6522
Affinity Capture-MS Homo sapiens
116 GSN 2934
Affinity Capture-MS Homo sapiens
117 ARAP3 64411
Affinity Capture-MS Homo sapiens
118 JUP 3728
Affinity Capture-MS Homo sapiens
119 SNCA 6622
Affinity Capture-MS Homo sapiens
120 NEXN 91624
Affinity Capture-MS Homo sapiens
121 PHB2 11331
Affinity Capture-MS Homo sapiens
122 SPTAN1 6709
Affinity Capture-MS Homo sapiens
123 CLIC1 1192
Affinity Capture-MS Homo sapiens
124 MEF2BNB  
Affinity Capture-MS Homo sapiens
125 DAB2 1601
Affinity Capture-MS Homo sapiens
126 SVIL 6840
Affinity Capture-MS Homo sapiens
127 SSFA2 6744
Affinity Capture-MS Homo sapiens
128 Eed  
Affinity Capture-MS Mus musculus
129 MISP 126353
Affinity Capture-MS Homo sapiens
130 MYO5C 55930
Affinity Capture-MS Homo sapiens
131 Atxn1  
Proximity Label-MS Mus musculus
132 SIPA1L3  
Affinity Capture-MS Homo sapiens
133 Kctd13  
Affinity Capture-MS Mus musculus
134 CAPZA2 830
Affinity Capture-MS Homo sapiens
135 ITPR3 3710
Affinity Capture-MS Homo sapiens
136 Iqcb1  
Affinity Capture-MS Mus musculus
137 GNB1 2782
Affinity Capture-MS Homo sapiens
138 Herc2  
Affinity Capture-MS Mus musculus
139 Mettl21e  
Affinity Capture-MS Mus musculus
140 PBX1 5087
Two-hybrid Homo sapiens
141 MAU2  
Affinity Capture-MS Homo sapiens
142 ACTA1 58
Affinity Capture-MS Homo sapiens
143 AFAP1 60312
Affinity Capture-MS Homo sapiens
144 Atg5  
Affinity Capture-RNA Mus musculus
145 INF2 64423
Affinity Capture-MS Homo sapiens
146 SYNPO 11346
Affinity Capture-MS Homo sapiens
147 DAPK3 1613
Affinity Capture-MS Homo sapiens
148 FLNA 2316
Affinity Capture-MS Homo sapiens
149 PCM1 5108
Affinity Capture-MS Homo sapiens
150 CLTA 1211
Affinity Capture-MS Homo sapiens
151 MYO1E 4643
Affinity Capture-MS Homo sapiens
152 ITPR1 3708
Affinity Capture-MS Homo sapiens
153 GNAI3 2773
Affinity Capture-MS Homo sapiens
154 Cntnap2  
Affinity Capture-MS Mus musculus
155 DSG2 1829
Affinity Capture-MS Homo sapiens
View the network image/svg+xml



Perform bioinformatics analysis of your extracellular vesicle data set using FunRich, a open access standalone tool. NEW UPDATED VERSION OF FunRich available for download (12/09/2016) from here